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51. 发明授权

US5507294A Ultrasound diagnostic probe having non-rotating acoustic imaging waveguide 失效
标题翻译：超声诊断探头具有非旋转声波成像波导
公开(公告)号：US5507294A
公开(公告)日：1996-04-16
申请号：US373676
申请日：1995-01-17
申请人： Paul Lum , Michael Greenstein , Edward Verdonk
发明人： Paul Lum , Michael Greenstein , Edward Verdonk
IPC分类号： A61B8/00 , A61B8/06 , A61B8/12
CPC分类号： A61B8/06 , A61B8/12 , A61B8/445 , A61B8/4461
摘要： A catheter apparatus for obtaining an image of interior surface characteristics of a vascular vessel is provided. The catheter apparatus comprises an outer tubular element adapted for insertion into the vascular vessel, a rotatable inner tubular element disposed within the outer tubular element, and a non-rotating acoustic waveguide disposed within the inner tubular element and coupled to a source of an ultrasonic signal located external to the vascular vessel. The inner tubular element is rotated about an axis of the vascular vessel by use of an external driving member, such as a motor. The inner tubular element is provided with an acoustic reflecting or refracting element that directs the ultrasonic signal from a distal end of the acoustic waveguide through the outer tubular element at an angle relative to the axis of the vascular vessel. Sterile fluid disposed between the outer and inner tubular elements provides for acoustic coupling of the ultrasonic signal into the vessel, and further provides for lubrication of the rotating elements.
摘要翻译：提供一种用于获得血管容器的内表面特征的图像的导管装置。导管装置包括适于插入血管容器的外部管状元件，设置在外部管状元件内的可旋转内部管状元件，以及设置在内部管状元件内并耦合到超声波信号源的非旋转声波导位于血管的外部。内部管状元件通过使用诸如马达的外部驱动构件围绕血管的轴线旋转。内部管状元件设置有声反射或折射元件，其将来自声波导的远端的超声波信号通过外部管状元件以相对于血管容器的轴线成一定角度引导。设置在外部管状元件和内部管状元件之间的无菌流体提供超声波信号到容器中的声学耦合，并进一步提供旋转元件的润滑。

52. 发明授权

US5381386A Membrane hydrophone 失效
标题翻译：膜水听器
公开(公告)号：US5381386A
公开(公告)日：1995-01-10
申请号：US64611
申请日：1993-05-19
申请人： Paul Lum , Michael Greenstein
发明人： Paul Lum , Michael Greenstein
IPC分类号： G01L1/16 , B06B1/06 , H01L41/09 , H04R1/44 , H04R17/00
CPC分类号： B06B1/0688 , H04R1/44 , Y10S310/80
摘要： A method of fabricating a membrane acoustic device includes utilizing integrated circuit fabrication techniques to form a support structure for a piezoelectric membrane, to pattern interconnect schemes on the membrane and on a semiconductor substrate, and to form electronic components for amplifying and driving signals generated at one or more piezoelectrically strong active areas. The support structure is a lithographically patterned metal layer on the semiconductor substrate. A matching metallization on the piezoelectric membrane is conductively bonded to the metal support structure of the semiconductor substrate. An acoustic cavity area is etched through the semiconductor substrate to the back surface of the membrane. An extremely small membrane hydrophone can thereby be fabricated for operation at frequencies above 50 MHz.
摘要翻译：一种制造膜声学装置的方法包括利用集成电路制造技术来形成用于压电膜的支撑结构，以在膜上和半导体衬底上形成互连方案，并形成用于放大和驱动在一个或更多的压电强度有限的区域。支撑结构是在半导体衬底上的光刻图案化的金属层。压电膜上的匹配金属化导电结合到半导体衬底的金属支撑结构。将声腔区域通过半导体衬底蚀刻到膜的后表面。因此，可以制造极小的膜水听器以在高于50MHz的频率下操作。

53. 发明授权

US5381385A Electrical interconnect for multilayer transducer elements of a two-dimensional transducer array 失效
标题翻译：用于二维换能器阵列的多层换能器元件的电互连
公开(公告)号：US5381385A
公开(公告)日：1995-01-10
申请号：US101867
申请日：1993-08-04
申请人： Michael Greenstein
发明人： Michael Greenstein
IPC分类号： A61B8/00 , B06B1/06 , H04R17/00
CPC分类号： B06B1/064
摘要： A multilayer two-dimensional array of ultrasonic transducer elements includes four via segments at the four corners of each transducer element. A first pair of diagonally opposed via segments provide signals to signal electrode layers of each transducer element. A second pair of diagonally opposed via segments interconnect ground electrode layers. Thus, a redundant interconnection scheme is achieved. If the transducer elements include piezoelectric layers having a square cross section parallel to a transducer radiating surface, four-fold symmetry is maintained, despite the formation of the four via segments. Also disclosed is a method of forming a two-dimensional array.
摘要翻译：超声换能器元件的多层二维阵列包括在每个换能器元件的四个角处的四个通路段。第一对对角相对的通孔段向每个换能器元件的信号电极层提供信号。第二对对角相对的通孔段将接地电极层互相连接。因此，实现了冗余互连方案。如果换能器元件包括具有平行于换能器辐射表面的正方形横截面的压电层，则尽管形成了四个通孔段，仍维持四重对称性。还公开了形成二维阵列的方法。

54. 发明授权

US4970198A Antitumor antibiotics (LL-E33288 complex) 失效
标题翻译：抗肿瘤抗生素（LL-E33288复合物）
公开(公告)号：US4970198A
公开(公告)日：1990-11-13
申请号：US9321
申请日：1987-01-30
申请人： May D. Lee , Michael Greenstein , David P. Labeda , Amedeo A. Fantini
发明人： May D. Lee , Michael Greenstein , David P. Labeda , Amedeo A. Fantini
IPC分类号： C07H15/203 , C12P1/06 , C12P19/60
CPC分类号： C07H15/203 , C12P1/06 , C12P19/60 , C12R1/29 , Y10S435/867
摘要： Antibacterial and antitumor agents designated LL-E33288 complex and their production by new strains of Micromonospora echinospora ssp. calichensis NNRL-15839, NRRL-15975 and NRRL-18149, are disclosed.
摘要翻译：名称为LL-E33288复合物的抗菌剂和抗肿瘤剂及其通过新型小单孢菌属 calichensis NNRL-15839，NRRL-15975和NRRL-18149。

55. 发明授权

US4845037A Process for producing antibiotic LL-D42067.alpha. 失效
标题翻译：生产抗生素LL-D42067α的方法
公开(公告)号：US4845037A
公开(公告)日：1989-07-04
申请号：US891082
申请日：1986-07-31
申请人： Taikwang M. Lee , Joseph J. Goodman , Michael Greenstein , Donald B. Borders
发明人： Taikwang M. Lee , Joseph J. Goodman , Michael Greenstein , Donald B. Borders
IPC分类号： C12N1/20 , A61K20060101 , A61K31/535 , A61K35/74 , A61P31/04 , A61P33/10 , C07G11/00 , C12N20060101 , C12N1/00 , C12N1/06 , C12N5/00 , C12N15/00 , C12P1/00 , C12P1/06 , C12P17/16 , C12P17/18 , C12R1/29
CPC分类号： C12R1/29 , Y10S435/867
摘要： A biologically pure culture of Micromonospora purpureochromogenes ssp. Wuxiensis and its use in an aerobic fermentation process to produce the antibacterial and antiparasitic agent LL-D42067.alpha..
摘要翻译：一种生物学纯培养的小单孢菌紫色荧光发生物无锡植物及其在好氧发酵过程中的应用，产生抗菌和抗寄生虫剂LL-D42067α。

56. 发明授权

US4705688A Antibiotic LL-E19020 .alpha. and .beta. 失效
标题翻译：抗生素LL-E19020α和β
公开(公告)号：US4705688A
公开(公告)日：1987-11-10
申请号：US880230
申请日：1986-06-30
申请人： Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
发明人： Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
IPC分类号： C12P1/06 , A61K35/74
CPC分类号： C12P1/06
摘要： This invention relates to antibiotic LL-E19020.alpha. and LL-E19020.beta. derived from the microorganism Streptomyces lydicus subspecies tanzanius NRRL 18036, which are useful as an antibacterial agent.
摘要翻译：本发明涉及衍生自微生物链霉菌属（Streptomyces lydicus subspecies tanzanius）NRRL 18036的抗生素LL-E19020α和LL-E19020ββ，其可用作抗菌剂。

57. 发明授权

US07780631B2 Apparatus and method for penetration with shaft having a sensor for sensing penetration depth 有权
标题翻译：用于穿透轴的装置和方法具有用于感测穿透深度的传感器
公开(公告)号：US07780631B2
公开(公告)日：2010-08-24
申请号：US10008159
申请日：2001-11-06
申请人： Paul Lum , Hewlett E. Melton, Jr. , Tad Decataur Simons , Michael Greenstein , Dominique M. Freeman
发明人： Paul Lum , Hewlett E. Melton, Jr. , Tad Decataur Simons , Michael Greenstein , Dominique M. Freeman
IPC分类号： A61M5/00
CPC分类号： A61B5/053 , A61B5/150022 , A61B5/15003 , A61B5/150137 , A61B5/150167 , A61B5/150175 , A61B5/150389 , A61B5/150412 , A61B5/15117 , A61B5/15121 , A61B5/15125 , A61B5/15128 , A61B5/15194 , A61B18/14 , A61B2018/00738 , A61B2018/00755 , A61B2018/00875 , A61B2018/126 , A61B2018/1425 , A61B2090/062 , A61M5/46
摘要： An apparatus having a shaft that can sense the depth of penetration, for penetrating into an object (the substrate). The substrate being penetrated has impedance that varies according to the depth under a surface of the substrate. The shaft has a tip for penetration and has conductive ends near to the tip of the shaft. A change of impedance of material of the object between the conductive ends can be sensed to provide information on the depth of penetration. A processor can be provided external to the object being penetrated by the shaft to gather and process the impedance information to determine whether the desired depth has been achieved.
摘要翻译：一种具有可以感测穿透深度的轴的装置，用于穿透物体（基底）。穿透的衬底具有根据衬底表面下方的深度而变化的阻抗。轴具有用于穿透的尖端并且具有靠近轴的尖端的导电端。可以感测导电端之间的物体的材料阻抗的变化，以提供关于穿透深度的信息。处理器可以设置在被轴穿透的对象的外部，以收集和处理阻抗信息以确定是否已经实现期望的深度。

58. 发明授权

US07709620B2 Non-ribosomal peptide synthetases and associated biosynthetic genes 失效
标题翻译：非核糖体肽合成酶和相关生物合成基因
公开(公告)号：US07709620B2
公开(公告)日：2010-05-04
申请号：US11687152
申请日：2007-03-16
申请人： John A. Hucul , Nathan Magarvey , Michael Greenstein
发明人： John A. Hucul , Nathan Magarvey , Michael Greenstein
IPC分类号： C12N15/52 , C12N9/00 , C12N15/74 , C12N15/76 , C12N1/21 , C07H21/04
CPC分类号： C12N9/93 , A61K38/00 , C07K14/36
摘要： The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.
摘要翻译：本发明描述了来自吸水链霉菌的新型非核糖体肽合成酶和相关生物合成基因的鉴定。本发明还提供从这些合成酶和相关基因产生新型化合物如抗生素的方法。

59. 发明申请

US20090321263A1 CLINICAL ANALYSIS APPARATUS 审中-公开
标题翻译：临床分析仪器
公开(公告)号：US20090321263A1
公开(公告)日：2009-12-31
申请号：US12377516
申请日：2007-09-17
申请人： Youichi Endo , Yoshihiro Seto , Shinji Satomura , Masayoshi Hayashi , Mitsuo Watanabe , Colin Kennedy , Michael Greenstein , Cheryl Cathey
发明人： Youichi Endo , Yoshihiro Seto , Shinji Satomura , Masayoshi Hayashi , Mitsuo Watanabe , Colin Kennedy , Michael Greenstein , Cheryl Cathey
IPC分类号： G01N27/26
CPC分类号： G01N35/028 , B01L3/5027 , B01L13/02 , B01L2200/027 , B01L2400/0421 , B01L2400/0487 , G01N21/6456 , G01N35/025
摘要： To enable reuse of expensive microchips in a clinical analysis apparatus, while constantly and efficiently obtaining accurate analysis results. A clinical apparatus employs microchips to analyze substances, which are contained in samples and are targets of measurement. The clinical analysis apparatus is equipped with: a stocking section; a dispensing mechanism, for dispensing reagents stocked in the stocking section and samples to the microchips; and a measuring section, for measuring the measurement target substance within the samples. The measuring section includes: a dispensing station, at which the microchips are provided; a detecting station, for detecting the measurement target substance; and a cleansing station, at which microchips are cleansed following detection of the measurement target substance. The dispensing station, the detecting station, and the cleansing station are provided at a predetermined pitch from upstream to downstream positions. The microchips are continuously rotated through the stations to perform measurement repeatedly.
摘要翻译：为了在临床分析仪器中重新使用昂贵的微芯片，同时不断有效地获得准确的分析结果。临床装置采用微芯片分析样品中含有的物质，是测量对象。临床分析仪器配有：放养部分; 分配机构，用于分配储存在放养部分中的试剂和样品到微芯片; 以及用于测量样品内的测量目标物质的测量部分。测量部分包括：分配站，在其上提供微芯片; 用于检测测量目标物质的检测站; 以及在检测到测定对象物质之后清洁微芯片的清洁台。从上游到下游位置以预定间距设置分配站，检测站和清洁站。微型芯片连续旋转通过台站进行重复测量。

60. 发明申请

US20060269994A1 Non-ribosomal peptide synthetases and associated biosynthetic genes 失效
公开(公告)号：US20060269994A1
公开(公告)日：2006-11-30
申请号：US11357566
申请日：2006-02-17
申请人： John Hucul , Nathan Magarvey , Michael Greenstein
发明人： John Hucul , Nathan Magarvey , Michael Greenstein
IPC分类号： G01N33/554 , C07H21/04 , C12P21/06 , C12N9/48 , C12N1/21
CPC分类号： C12N9/93 , C07K2319/00
摘要： The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.

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