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1. 发明授权

US07179654B2 Biochemical assay with programmable array detection 有权
标题翻译：具有可编程阵列检测的生化测定
公开(公告)号：US07179654B2
公开(公告)日：2007-02-20
申请号：US10100346
申请日：2002-03-18
申请人： Edward Verdonk , David Andrew King , Richard J. Pittaro
发明人： Edward Verdonk , David Andrew King , Richard J. Pittaro
IPC分类号： G01N21/76 , B32B5/02 , B32B27/12 , B32B27/04
CPC分类号： G01N21/6454 , G01N21/6428 , Y10T436/10
摘要： A biochemical sensor apparatus having an optical radiation source, a sensor array, and a photodetector array is disclosed. Each sensor of the sensor array includes fluorophores for fluorescence (generating response radiation) when mixed with analytes of interest and exposed to stimulus radiation. An array of photodetectors, such as a CMOS imaging array is used to detect the response radiation. The detected response radiation is converted to digital values and the digital values used to analyze various properties of the analytes present in the sensors.
摘要翻译：公开了一种具有光辐射源，传感器阵列和光电检测器阵列的生化传感器装置。传感器阵列的每个传感器包括与感兴趣的分析物混合并暴露于刺激辐射时用于荧光的荧光团（产生响应辐射）。使用诸如CMOS成像阵列的光电检测器阵列来检测响应辐射。检测到的响应辐射被转换为数字值，数字值用于分析传感器中存在的分析物的各种性质。

2. 发明申请

US20050101980A1 Method and apparatus for improving success rate of blood yield from a fingerstick 有权
标题翻译：用于提高指尖成功率的方法和装置
公开(公告)号：US20050101980A1
公开(公告)日：2005-05-12
申请号：US10363509
申请日：2002-06-12
申请人： Don Alden , Dominique Freeman , Paul Lum , Vladimir Drbal , Dirk Boecker , Edward Verdonk
发明人： Don Alden , Dominique Freeman , Paul Lum , Vladimir Drbal , Dirk Boecker , Edward Verdonk
IPC分类号： A61B5/15 , A61B17/32
CPC分类号： A61B5/150022 , A61B5/150061 , A61B5/150068 , A61B5/150083 , A61B5/150099 , A61B5/150167 , A61B5/150427 , A61B5/150503
摘要： Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analysed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of the device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniatuized and/or disposable.
摘要翻译：可以收集血液样本而没有来自环境空气的实质污染，使得可以准确地分析血液样品用于气体组分如氧气和二氧化碳。该装置的一个实施例具有集成的致动，采血和采样部件，其在一些实施例中是微型化和/或一次性的。

3. 发明授权

US06821793B2 Optical excitation/detection device and method for making same using discrete photoemitter devices 失效
标题翻译：光激励/检测装置及其使用离散光电发生器的方法
公开(公告)号：US06821793B2
公开(公告)日：2004-11-23
申请号：US10668435
申请日：2003-09-22
申请人： Edward Verdonk , Richard J. Pittaro , Shahida Rana , David Andrew King , Frederick A. Stawitcke , Richard D. Pering
发明人： Edward Verdonk , Richard J. Pittaro , Shahida Rana , David Andrew King , Frederick A. Stawitcke , Richard D. Pering
IPC分类号： H01L2100
CPC分类号： H01L27/14643 , H01L25/0753 , H01L25/167 , H01L2924/0002 , H01L2924/00
摘要： The disclosure is directed toward an optical excitation/detection device that includes an arrayed plurality of photodetectors and discrete photoemitters, as well as a method for making such a device. A CMOS fabricated photodetector array includes an arrayed plurality of photoreceptor areas and photoemitter areas, wherein each photoreceptor area includes a CMOS integrated photoreceptor and each photoemitter area includes at least two buried electric contact pads. The CMOS array is selectively etched back at the locations of the photoemitter areas for regions to reveal the buried contact pads. A plurality of discrete semiconductor photoemitter devices (such as, for example, light emitting diodes) are inserted into, and mechanically retained within, the regions of the CMOS fabricated photodetector array. The inserted discrete semiconductor photoemitter devices make electrical contact with the buried electric contact pads that are revealed within each of the regions to form the optical excitation/detection device from an arrayed plurality of photodetectors and discrete semiconductor photoemitters.
摘要翻译：本公开涉及包括阵列的多个光电探测器和分立光电发生器的光学激发/检测装置，以及用于制造这种装置的方法。 CMOS制造的光电检测器阵列包括阵列的多个感光体区域和光电发射器区域，其中每个感光体区域包括CMOS集成感光体，并且每个光电发射器区域包括至少两个埋入的电接触焊盘。 CMOS阵列在光电探测器区域的位置处被选择性地回蚀，用于区域以露出埋入的接触焊盘。多个分立的半导体光电探测器装置（例如，发光二极管）被插入并机械地保持在CMOS制造的光电检测器阵列的区域内。插入的分立半导体光电发生器装置与在每个区域内露出的掩埋电接触焊盘电接触，以从阵列的多个光电探测器和分立的半导体光电发生器形成光激发/检测装置。

4. 发明授权

US5640961A Device with aspherical compensation for focusing ultrasound 失效
标题翻译：具有聚焦超声的非球面补偿装置
公开(公告)号：US5640961A
公开(公告)日：1997-06-24
申请号：US533430
申请日：1995-09-25
申请人： Edward Verdonk
发明人： Edward Verdonk
IPC分类号： G01N29/26 , A61B8/12 , G10K11/30 , G10K11/35 , H04R17/00 , A61B8/00
CPC分类号： A61B8/12 , G10K11/30 , G10K11/355 , H04R17/00
摘要： An ultrasound probe having a substantially cylindrical acoustic case for intraluminal application in an object, a method of making such a probe, and a method of focusing ultrasound are provided. The probe has a substantially cylindrical acoustic case with a central axis and an ultrasonic transducer unit positioned in the acoustic case. The ultrasonic transducer unit is rotatable about the central axis of the acoustic case to transmit or receive ultrasonic beams in a direction at an angle to the central axis. The transducer unit has a transducer for generating or receiving ultrasound, a shaft operatively connected with the transducer and having an axis substantially coincident with the central axis for rotating the transducer around the central axis, and an aspherical lens coupled with the transducer in the acoustic case to reduce the distortion by the focusing effect of the acoustic case on ultrasound. In a preferred embodiment, the aspherical shape of the aspherical lens is determined by a method including: selecting a focal point at the target area as a hypothetical source of a hypothetical beam of ultrasound, calculating the velocity potential on the transducer based on the hypothetical beam of ultrasound, and calculating the aspherical shape of the aspherical lens based on the velocity potential.
摘要翻译：提供了具有用于管腔内应用于物体中的大致圆柱形声学病例的超声波探头，制造这种探针的方法以及聚焦超声波的方法。探针具有基本上圆柱形的具有中心轴线的声学壳体和位于声学壳体中的超声换能器单元。超声波换能器单元可围绕声学壳体的中心轴线旋转，以在与中心轴线成一角度的方向上发射或接收超声波束。换能器单元具有用于产生或接收超声波的换能器，与换能器可操作地连接的轴，并且具有与中心轴基本重合的轴线，用于围绕中心轴线旋转换能器;以及非球面透镜，与换能器在声学壳体以通过声学病例对超声波的聚焦效应来减少失真。在一个优选实施例中，非球面透镜的非球面形状通过一种方法确定，该方法包括：选择目标区域上的焦点作为假想超声波束的假想源，基于假设光束计算换能器上的速度电位的超声波，并且基于速度电位计算非球面透镜的非球面形状。

5. 发明授权

US5507294A Ultrasound diagnostic probe having non-rotating acoustic imaging waveguide 失效
标题翻译：超声诊断探头具有非旋转声波成像波导
公开(公告)号：US5507294A
公开(公告)日：1996-04-16
申请号：US373676
申请日：1995-01-17
申请人： Paul Lum , Michael Greenstein , Edward Verdonk
发明人： Paul Lum , Michael Greenstein , Edward Verdonk
IPC分类号： A61B8/00 , A61B8/06 , A61B8/12
CPC分类号： A61B8/06 , A61B8/12 , A61B8/445 , A61B8/4461
摘要： A catheter apparatus for obtaining an image of interior surface characteristics of a vascular vessel is provided. The catheter apparatus comprises an outer tubular element adapted for insertion into the vascular vessel, a rotatable inner tubular element disposed within the outer tubular element, and a non-rotating acoustic waveguide disposed within the inner tubular element and coupled to a source of an ultrasonic signal located external to the vascular vessel. The inner tubular element is rotated about an axis of the vascular vessel by use of an external driving member, such as a motor. The inner tubular element is provided with an acoustic reflecting or refracting element that directs the ultrasonic signal from a distal end of the acoustic waveguide through the outer tubular element at an angle relative to the axis of the vascular vessel. Sterile fluid disposed between the outer and inner tubular elements provides for acoustic coupling of the ultrasonic signal into the vessel, and further provides for lubrication of the rotating elements.
摘要翻译：提供一种用于获得血管容器的内表面特征的图像的导管装置。导管装置包括适于插入血管容器的外部管状元件，设置在外部管状元件内的可旋转内部管状元件，以及设置在内部管状元件内并耦合到超声波信号源的非旋转声波导位于血管的外部。内部管状元件通过使用诸如马达的外部驱动构件围绕血管的轴线旋转。内部管状元件设置有声反射或折射元件，其将来自声波导的远端的超声波信号通过外部管状元件以相对于血管容器的轴线成一定角度引导。设置在外部管状元件和内部管状元件之间的无菌流体提供超声波信号到容器中的声学耦合，并进一步提供旋转元件的润滑。

6. 发明申请

US20140045670A1 CENTRIFUGE APPARATUS, CENTRIFUGE TUBES, AND METHODS FOR AUTOMATED CELL PREPARATION 审中-公开
标题翻译：离心装置，离心管和自动细胞制备方法
公开(公告)号：US20140045670A1
公开(公告)日：2014-02-13
申请号：US13569119
申请日：2012-08-07
申请人： Thomas L. Smith , Bryan Wade , Edward Verdonk
发明人： Thomas L. Smith , Bryan Wade , Edward Verdonk
IPC分类号： B04B5/02 , B01L3/00 , B01D43/00
CPC分类号： B04B13/00 , B01L3/5021 , B01L2200/0668 , B01L2300/0858 , B04B5/0421 , B04B7/06 , B04B9/146
摘要： An automated centrifuge apparatus for conducting a cell preparation procedure is provided. A rotor assembly supports centrifuge tubes, which are installable at respective tube positions. The tube positions are indexable to an index location. A sensing module monitors the index location during a set of status checks, which relate to the centrifuge tubes. Logic signals generated by the sensing module are used to automatically determine whether the status checks are satisfied.
摘要翻译：提供了一种用于进行细胞制备程序的自动离心机。转子组件支撑离心管，其可安装在相应的管位置。管位置可以索引到索引位置。感测模块在与离心管相关的一组状态检查期间监测指示位置。由感测模块生成的逻辑信号用于自动确定是否满足状态检查。

7. 发明授权

US06927382B2 Optical excitation/detection device and method for making same using fluidic self-assembly techniques 有权
标题翻译：光学激发/检测装置及其使用流体自组装技术的方法
公开(公告)号：US06927382B2
公开(公告)日：2005-08-09
申请号：US10153243
申请日：2002-05-22
申请人： David Andrew King , Richard J. Pittaro , Shahida Rana , Edward Verdonk , Frederick A. Stawitcke , Richard D. Pering
发明人： David Andrew King , Richard J. Pittaro , Shahida Rana , Edward Verdonk , Frederick A. Stawitcke , Richard D. Pering
IPC分类号： H01L21/98 , H01L25/16 , H01L27/146 , H01L31/00 , H01L31/12
CPC分类号： H01L24/95 , H01L25/167 , H01L25/50 , H01L27/14683 , H01L31/125 , H01L2224/95085 , H01L2924/01013 , H01L2924/01015 , H01L2924/01027 , H01L2924/01033 , H01L2924/01049 , H01L2924/10158 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/00
摘要： The disclosure is directed toward an optical excitation/detection device that includes an arrayed plurality of photodetectors and separately formed photoemitters, as well as a method for making such a device. A CMOS fabricated photodetector array including a plurality of individual photoreceptors is selectively etched back between photoreceptor locations to reveal a plurality of recessed regions having a certain geographic profile. A plurality of semiconductor blocks, each having light emitting capability and each having a certain geometric profile that is complementary in size and shape to the certain geometric profile of the recessed regions, are separately fabricated. These blocks are included within a fluid to form a slurry. The slurry is then flowed over the CMOS fabricated photodetector array in accordance with a fluidic self-assembly technique, and the included semiconductor blocks are individually deposited within each of the plurality of recessed regions in the CMOS fabricated photodetector array. The deposited blocks are then attached within the recessed regions to form the optical excitation/detection device from an arrayed plurality of photodetectors and separately formed photoemitters.
摘要翻译：本公开涉及一种光激励/检测装置，其包括阵列的多个光电检测器和单独形成的光电发生器，以及用于制造这种装置的方法。包括多个单独光感受器的CMOS制造的光检测器阵列被选择性地在感光体位置之间回蚀刻以露出具有一定地理轮廓的多个凹陷区域。分别制造多个半导体块，每个半导体块具有发光能力，并且各自具有与凹陷区域的某些几何轮廓尺寸和形状互补的一定几何轮廓。这些块被包含在流体中以形成浆料。然后根据流体自组装技术将浆料流过CMOS制造的光电检测器阵列，并且将所包含的半导体块分别沉积在CMOS制造的光电检测器阵列中的多个凹陷区域的每一个内。然后将沉积的块附接在凹陷区域内，以从阵列的多个光电检测器和单独形成的光电发生器形成光学激发/检测装置。

8. 发明申请

US20050095599A1 Detection and identification of biopolymers using fluorescence quenching 审中-公开
标题翻译：使用荧光猝灭检测和鉴定生物聚合物
公开(公告)号：US20050095599A1
公开(公告)日：2005-05-05
申请号：US10699478
申请日：2003-10-30
申请人： Richard Pittaro , Edward Verdonk , Thomas Doherty
发明人： Richard Pittaro , Edward Verdonk , Thomas Doherty
IPC分类号： B01L3/00 , G01N21/64 , G01N33/542 , G01N33/68 , C12Q1/68 , C12M1/34 , G01N33/53
CPC分类号： G01N21/6428 , B01L3/5027 , B82Y15/00 , G01N33/48721 , G01N33/542 , G01N33/6803 , G01N2021/6432
摘要： The present invention provides an apparatus for detecting a nanoscale moiety and a method for sensing a nanoscale moiety. The apparatus includes a substrate having a nanopore, at least one excitable molecule attached to the substrate adjacent to the nanopore, and a light source for exciting the excitable molecule attached to the substrate adjacent to the nanopore wherein the excitable molecule is quenched by the quencher molecule on the nanoscale moiety as it passes by the excitable molecule. The invention also includes a method for detecting the presence or identity of the nanoscale moiety.
摘要翻译：本发明提供了一种用于检测纳米尺度部分的装置和用于感测纳米尺度部分的方法。该装置包括具有纳米孔的底物，与纳米孔相邻的至少一个可附着到基底上的可激发分子，以及用于激发附着于邻近纳米孔的底物的可激发分子的光源，其中可激发分子被猝灭剂分子淬灭在纳米级部分通过可兴奋分子时。本发明还包括用于检测纳米尺度部分的存在或身份的方法。

9. 发明授权

US5485845A Rotary encoder for intravascular ultrasound catheter 失效
标题翻译：旋转编码器用于血管内超声导管
公开(公告)号：US5485845A
公开(公告)日：1996-01-23
申请号：US434616
申请日：1995-05-04
申请人： Edward Verdonk , Michael Greenstein , Hewlett E. Melton, Jr. , Mir S. Seyed-Bolorforosh
发明人： Edward Verdonk , Michael Greenstein , Hewlett E. Melton, Jr. , Mir S. Seyed-Bolorforosh
IPC分类号： A61B8/12 , A61B19/00 , G01S5/24 , G01S15/74 , G01S15/87 , G01S15/89
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461 , G01S15/74 , G01S15/874 , G01S15/8943 , A61B2090/3929 , G01S5/24
摘要： An ultrasound system and method for intravascular ultrasonic imaging includes an array of beacons that are fixed to direct ultrasonic energy toward an imaging transducer, with individual beacons being identifiable in order to determine the angular position of the imaging transducer. Based upon the data related to beacon identification, operation of the imaging device is adaptively adjusted in order to compensate for variations in angular velocity of the transducer. Adaptive compensation may be performed by adjusting the pulse repetition rate of transmitted ultrasonic energy, by adjusting the scan conversion algorithm or mapping reflected ultrasonic energy, or by varying control of the drive structure for rotating the transducer. The beacons are preferably piezoelectrically active, but passive beacons may also be used. Position identification may be performed by techniques including amplitude sensing, phase sensing, pulse length sensing, and frequency sensing. As an alternative to rotation of the transducer, ultrasonic signals may be formed at a proximal end of a probe and then conducting the energy to the distal end via a waveguide.
摘要翻译：用于血管内超声成像的超声系统和方法包括固定以朝向成像换能器直接超声能量的信标阵列，其中各个信标是可识别的，以便确定成像换能器的角位置。基于与信标识别相关的数据，自适应地调整成像装置的操作，以补偿换能器的角速度的变化。可以通过调整扫描转换算法或映射反射的超声能量，或者通过改变用于旋转传感器的驱动结构的控制来调节发射的超声能量的脉冲重复率来执行自适应补偿。信标优选地是压电有源的，但也可以使用被动信标。可以通过包括幅度感测，相位感测，脉冲长度感测和频率感测的技术来执行位置识别。作为换能器旋转的替代方案，可以在探针的近端处形成超声波信号，然后经由波导将能量传导到远端。

10. 发明授权

US06657235B1 Optical excitation/detection device using discrete photoemitter devices 失效
标题翻译：光激励/检测装置采用离散光电发生器
公开(公告)号：US06657235B1
公开(公告)日：2003-12-02
申请号：US10153760
申请日：2002-05-22
申请人： Edward Verdonk , Richard J. Pittaro , Shahida Rana , David Andrew King , Frederick A. Stawitcke , Richard D. Pering
发明人： Edward Verdonk , Richard J. Pittaro , Shahida Rana , David Andrew King , Frederick A. Stawitcke , Richard D. Pering
IPC分类号： H01L2926
CPC分类号： H01L27/14643 , H01L25/0753 , H01L25/167 , H01L2924/0002 , H01L2924/00
摘要： The disclosure is directed toward an optical excitation/detection device that includes an arrayed plurality of photodetectors and discrete photoemitters, as well as a method for making such a device. A CMOS fabricated photodetector array includes an arrayed plurality of photoreceptor areas and photoemitter areas, wherein each photoreceptor area includes a CMOS integrated photoreceptor and each photoemitter area includes at least two buried electric contact pads. The CMOS array is selectively etched back at the locations of the photoemitter areas for regions to reveal the buried contact pads. A plurality of discrete semiconductor photoemitter devices (such as, for example, light emitting diodes) are inserted into, and mechanically retained within, the regions of the CMOS fabricated photodetector array. The inserted discrete semiconductor photoemitter devices make electrical contact with the buried electric contact pads that are revealed within each of the regions to form the optical excitation/detection device from an arrayed plurality of photodetectors and discrete semiconductor photoemitters.
摘要翻译：本公开涉及包括阵列的多个光电探测器和分立光电发生器的光学激发/检测装置，以及用于制造这种装置的方法。 CMOS制造的光电检测器阵列包括阵列的多个感光体区域和光电发射器区域，其中每个感光体区域包括CMOS集成感光体，并且每个光电发射器区域包括至少两个埋入的电接触焊盘。 CMOS阵列在光电探测器区域的位置处被选择性地回蚀，用于区域以露出埋入的接触焊盘。多个分立的半导体光电探测器装置（例如，发光二极管）被插入并机械地保持在CMOS制造的光电检测器阵列的区域内。插入的分立半导体光电发生器装置与在每个区域内露出的掩埋电接触焊盘电接触，以从阵列的多个光电探测器和分立的半导体光电发生器形成光激发/检测装置。

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