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61. 发明授权

US06914045B2 Glycopeptide antibiotics 有权
公开(公告)号：US06914045B2
公开(公告)日：2005-07-05
申请号：US10131890
申请日：2002-04-25
申请人： Darren Robert Abbanat , Valerie Sue Bernan , Russell George Dushin , Michael Greenstein , Haiyin He , Stanley Albert Lang , Howard Newman , Subas Sakya , Phaik-Eng Sum , Alan Gordon Sutherland , Ting-Zhong Wang , Jason Arnold Lotvin , Mark Edward Ruppen , Arthur Emergy Bailey , Ping Cai , Bo Shen , Fangming Kong
发明人： Darren Robert Abbanat , Valerie Sue Bernan , Russell George Dushin , Michael Greenstein , Haiyin He , Stanley Albert Lang , Howard Newman , Subas Sakya , Phaik-Eng Sum , Alan Gordon Sutherland , Ting-Zhong Wang , Jason Arnold Lotvin , Mark Edward Ruppen , Arthur Emergy Bailey , Ping Cai , Bo Shen , Fangming Kong
IPC分类号： A61K38/00 , C07H15/203 , C07H19/04 , C07K9/00
CPC分类号： C07H15/203 , A61K38/00 , C07H19/04 , C07K9/008
摘要： The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.

62. 发明申请

US20050019213A1 Methods and systems for processing microscale devices for reuse 有权
标题翻译：用于处理微量元件进行再利用的方法和系统
公开(公告)号：US20050019213A1
公开(公告)日：2005-01-27
申请号：US10861784
申请日：2004-06-04
申请人： Persefoni Kechagia , Michael Greenstein , Bruce Brogden , Ed Donlon , Masayoshi Hayashi , Aaron Rulison
发明人： Persefoni Kechagia , Michael Greenstein , Bruce Brogden , Ed Donlon , Masayoshi Hayashi , Aaron Rulison
IPC分类号： B01L3/00 , B01L9/00 , B01L99/00 , B81B1/00 , G01N1/40 , G01N27/447 , G01N33/00
CPC分类号： B01L9/527 , B01L3/5027 , B01L3/502715 , B01L99/00 , B01L2300/022 , B01L2300/024 , B01L2400/0415 , B01L2400/0487 , G01N1/40 , G01N27/44704 , G01N27/44773 , G01N27/44791
摘要： This invention provides methods and systems for flushing, washing, and priming microscale devices for reuse. Washing and priming methods include flowing solutions from a manifold to flush wells and microchannels of a microfluidic chip. Systems include manifolds adapted to seal and flow solutions or gasses into chip wells. Devices include microfluidic devices with data storage modules to track the reprocessing status of the microscale devices.
摘要翻译：本发明提供用于冲洗，洗涤和引发微型装置以重新使用的方法和系统。洗涤和引发方法包括从歧管流动的溶液冲洗微流体芯片的阱和微通道。系统包括适于密封并将溶液或气体流入芯片井的歧管。设备包括具有数据存储模块的微流体设备，以跟踪微型设备的再处理状态。

63. 发明授权

US06391005B1 Apparatus and method for penetration with shaft having a sensor for sensing penetration depth 失效
标题翻译：用于穿透轴的装置和方法具有用于感测穿透深度的传感器
公开(公告)号：US06391005B1
公开(公告)日：2002-05-21
申请号：US09050853
申请日：1998-03-30
申请人： Paul Lum , Hewlett E. Melton, Jr. , Tad Decataur Simons , Michael Greenstein
发明人： Paul Lum , Hewlett E. Melton, Jr. , Tad Decataur Simons , Michael Greenstein
IPC分类号： A61M500
CPC分类号： A61B5/053 , A61B5/150022 , A61B5/15003 , A61B5/150137 , A61B5/150167 , A61B5/150175 , A61B5/150389 , A61B5/150412 , A61B5/15117 , A61B5/15121 , A61B5/15125 , A61B5/15128 , A61B5/15194 , A61B18/14 , A61B2018/00738 , A61B2018/00755 , A61B2018/00875 , A61B2018/126 , A61B2018/1425 , A61B2090/062 , A61M5/46
摘要： An apparatus having a shaft that can sense the depth of penetration, for penetrating into an object (the substrate). The substrate being penetrated has impedance that varies according to the depth under a surface of the substrate. The shaft has a tip for penetration and has conductive ends near to the tip of the shaft. A change of impedance of material of the object between the conductive ends can be sensed to provide information on the depth of penetration. A processor can be provided external to the object being penetrated by the shaft to gather and process the impedance information to determine whether the desired depth has been achieved.
摘要翻译：一种具有可以感测穿透深度的轴的装置，用于穿透物体（基底）。穿透的衬底具有根据衬底表面下方的深度而变化的阻抗。轴具有用于穿透的尖端并且具有靠近轴的尖端的导电端。可以感测导电端之间的物体的材料阻抗的变化，以提供关于穿透深度的信息。处理器可以设置在被轴穿透的对象的外部，以收集和处理阻抗信息以确定是否已经实现期望的深度。

64. 发明授权

US6132449A Extraction and transportation of blood for analysis 失效
公开(公告)号：US6132449A
公开(公告)日：2000-10-17
申请号：US264597
申请日：1999-03-08
申请人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
发明人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
IPC分类号： A61B5/00 , A61B5/15 , A61B17/32
CPC分类号： A61B5/15144 , A61B5/150022 , A61B5/150099 , A61B5/150106 , A61B5/150427 , A61B5/150969 , A61B5/150984 , A61B5/15113 , A61B5/14532
摘要： A device for sampling blood from the skin of a patient by puncture. The device includes one or more lancets for lancing the skin and a fluid-conducting plate unit for transporting blood from the lancing wound. The plate unit has one or more channels for conducting fluid to one or more target locations. Preferably there is a first channel for conducting away a first portion of fluid that contains more of a fluid that is emitted initially (initial fluid) from the puncture wound and a second channel for conducting a second portion of fluid that contains less of the initial fluid from the puncture wound. Blood is drawn into the channels by capillary force. The device can be used to lance the skin and obtain a representative sample of blood with relatively simple procedures.

65. 发明授权

US5871494A Reproducible lancing for sampling blood 失效
标题翻译：可重复采血采血
公开(公告)号：US5871494A
公开(公告)日：1999-02-16
申请号：US985303
申请日：1997-12-04
申请人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
发明人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
IPC分类号： A61B5/15 , A61B17/14
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/15019 , A61B5/150358 , A61B5/150412 , A61B5/15109 , A61B5/15117 , A61B5/15194
摘要： A blood analysis apparatus for obtaining blood for analysis from the skin of a patient with a controlled degree of lancing. The apparatus including a cartridge and a driver. The cartridge includes a cartridge case and a lancet. The lancet has a tip and is housed in the cartridge case. The lancet can be driven to extend the tip outside the cartridge case through an opening for lancing the skin of the patient to yield blood. The driver drives the lancet to move the tip distally to lance the skin. The driver is triggerable by the skin which is to be lanced exerting a force exceeding a preset amount against the triggering mechanism of the apparatus, to drive the lancet toward the skin.
摘要翻译：一种血液分析装置，用于从具有受控的穿刺程度的患者的皮肤获得用于分析的血液。该装置包括一个盒和一个驱动器。药筒包括药筒盒和刺血针。刺血针具有尖端并且容纳在盒壳体中。可以驱动刺血针以通过用于使病人的皮肤穿刺以产生血液的开口将尖端延伸到药筒壳体外部。驾驶员驱动刺血针向远端移动尖端以刺激皮肤。驱动器可以由皮肤触发，该皮肤将针对装置的触发机构施加超过预设量的力，以将刺血针驱动到皮肤。

66. 发明授权

US5592730A Method for fabricating a Z-axis conductive backing layer for acoustic transducers using etched leadframes 失效
标题翻译：用于使用蚀刻引线框架制造用于声学换能器的Z轴导电背衬层的方法
公开(公告)号：US5592730A
公开(公告)日：1997-01-14
申请号：US283136
申请日：1994-07-29
申请人： Michael Greenstein , Henry Yoshida
发明人： Michael Greenstein , Henry Yoshida
IPC分类号： G01N29/24 , A61B8/00 , B06B1/02 , B06B1/06 , H04R17/00 , H04R31/00 , H01L41/22
CPC分类号： B06B1/0622 , Y10T29/42 , Y10T29/49005 , Y10T29/49121
摘要： A Z-axis backing layer for an acoustic transducer is provided, which comprises a matrix of electrical conductors disposed in parallel and potted within an electrically insulating acoustic backing material. The acoustic transducers are disposed on a first end of the backing layer, with each individual transducer element connecting electrically to a respective one of the conductors. At the other end of the backing layer, the conductors connect electrically to a corresponding circuit element. The backing layer is fabricated from a plurality of leadframes each having an outer frame member and a plurality of conductors extending in parallel across the leadframes terminating at the frame members at opposite ends thereof. The plurality of leadframes are stacked such that respective conductors of adjacent ones of the leadframes are disposed in parallel with a space provided between the respective conductors equivalent to a width of one of the leadframes. Acoustic backing material is poured onto the stacked plurality of leadframes to completely fill the spaces between conductors. The frame members and excess acoustic backing material are then removed from the stacked and poured plurality of leadframes.
摘要翻译：提供了一种用于声学换能器的Z轴背衬层，其包括平行放置并封装在电绝缘声学背衬材料内的电导体矩阵。声学传感器设置在背衬层的第一端上，每个单独的换能器元件电连接到相应的导体之一。在背衬层的另一端，电导体与相应的电路元件电连接。背衬层由多个引线框架制成，每个引线框架具有外框架构件和多个导体，跨过引线框架并联延伸，终端于框架构件的相对端。多个引线框架被堆叠，使得相邻的引线框架的各个导体与设置在相当于引线框之一的宽度的各个导体之间的空间平行设置。声学衬垫材料被倒在堆叠的多个引线框架上以完全填充导体之间的空间。然后将框架构件和多余的声学衬垫材料从堆叠和倒入的多个引线框架中移除。

67. 发明授权

US5479377A Membrane-supported electronics for a hydrophone 失效
标题翻译：用于水听器的膜支持电子设备
公开(公告)号：US5479377A
公开(公告)日：1995-12-26
申请号：US359156
申请日：1994-12-19
申请人： Paul Lum , Michael Greenstein , Belinda Kendle
发明人： Paul Lum , Michael Greenstein , Belinda Kendle
IPC分类号： G01N29/24 , A61B8/00 , B06B1/06 , H01L41/08 , H04R1/44 , H04R17/00
CPC分类号： B06B1/0688 , H04R1/44 , H04R17/00 , Y10T29/42
摘要： A transducer device and method include affixing a preamplifier or other suitable circuit to a thin piezoelectric membrane. The membrane fully supports the circuit at an inactive region of the membrane. The membrane has at least one piezoelectrically active region that is connected to the circuit by a signal line. Preferably, the signal line is fabricated onto the membrane using integrated circuit fabrication techniques. In the preferred embodiment, the piezoelectrically active region has a diameter of less than one hundred microns and the membrane has a thickness of less than ten microns. A potting compound provides structural support of the membrane and insulates the on-membrane circuit.
摘要翻译：换能器装置和方法包括将前置放大器或其他合适的电路固定到薄压电膜。膜完全支撑在膜的非活性区域的电路。膜具有至少一个通过信号线连接到电路的压电有源区域。优选地，使用集成电路制造技术将信号线制造到膜上。在优选实施例中，压电有源区的直径小于一百微米，膜的厚度小于10微米。灌封化合物提供膜的结构支撑并隔离膜电路。

68. 发明授权

US5381067A Electrical impedance normalization for an ultrasonic transducer array 失效
标题翻译：超声换能器阵列的电阻抗归一化
公开(公告)号：US5381067A
公开(公告)日：1995-01-10
申请号：US29212
申请日：1993-03-10
申请人： Michael Greenstein , Hewlett E. Melton, Jr.
发明人： Michael Greenstein , Hewlett E. Melton, Jr.
IPC分类号： B06B1/06 , H01L41/08
CPC分类号： B06B1/0622
摘要： A two-dimensional ultrasonic transducer array includes a plurality of transducer elements, with each element having a plurality of piezoelectric layers. The transducer elements vary in transverse areas of radiating regions. The effect of the variations in transverse areas on the electrical impedances of the elements is at least partially offset by varying the specific impedance, i.e., impedance per unit area, of the transducer elements in the array. In a preferred embodiment, the specific impedance is varied by selecting the electrical arrangements of piezoelectric layers in each element according to the transverse area of the element. Series, parallel and series-parallel arrangements are employed. This impedance normalization improves the electrical connection of the transducer elements to driving circuitry. In alternative embodiments, impedance normalization is achieved by varying element thicknesses, element materials and/or degrees of poling across the two-dimensional array.
摘要翻译：二维超声换能器阵列包括多个换能器元件，每个元件具有多个压电层。换能器元件在辐射区域的横向区域中变化。通过改变阵列中的换能器元件的特定阻抗，即单位面积的阻抗，至少部分地抵消横向区域中的变化对元件的电阻的影响。在优选实施例中，通过根据元件的横向区域选择每个元件中的压电层的电气布置来改变特定阻抗。采用串联，并联和串并联装置。该阻抗归一化改善了换能器元件与驱动电路的电连接。在替代实施例中，通过改变元件厚度，元件材料和/或穿过二维阵列的极化程度来实现阻抗归一化。

69. 发明授权

US5339290A Membrane hydrophone having inner and outer membranes 失效
标题翻译：膜水听器具有内膜和外膜
公开(公告)号：US5339290A
公开(公告)日：1994-08-16
申请号：US49681
申请日：1993-04-16
申请人： Michael Greenstein
发明人： Michael Greenstein
IPC分类号： B06B1/06 , H04R17/00
CPC分类号： H04R17/005 , B06B1/0688 , Y10S310/80
摘要： An acoustic device, such as a membrane hydrophone, includes a support structure and an outer membrane that suspends a transducer membrane within the interior of the support structure. The transducer membrane is selected for its acoustic and piezoelectric properties and is preferably a polymer such as P(VDF-TrFE). The outer suspension membrane is selected primarily for its mechanical properties. Portions of the suspension membrane may be removed in order to reduce mechanical drag encountered during movement of the device in a liquid. The transducer membrane includes at least one active area that is poled to provide a piezoelectrically strong region. Electrical charge generated at the active area is amplified at a preamp for transmission to remote equipment.
摘要翻译：诸如膜式水听器的声学装置包括将换能器膜悬挂在支撑结构内部的支撑结构和外膜。选择换能器膜的声学和压电性质，并且优选为诸如P（VDF-TrFE）的聚合物。外悬浮膜主要是为了其机械性能而选择的。悬浮膜的部分可以被去除，以便减少装置在液体中运动期间遇到的机械阻力。换能器膜包括至少一个有源区域，其被极化以提供压电强区域。在有源区产生的电荷在前置放大器放大以传输到远程设备。

70. 发明授权

US5106994A Agents and method of production thereof 失效
标题翻译：试剂及其生产方法
公开(公告)号：US5106994A
公开(公告)日：1992-04-21
申请号：US732252
申请日：1985-05-10
申请人： Guy T. Carter , Margaret J. Torrey , Michael Greenstein
发明人： Guy T. Carter , Margaret J. Torrey , Michael Greenstein
IPC分类号： A01N63/02 , C07H19/01 , C12P1/06
CPC分类号： C07H19/01 , A01N63/02 , C12P1/06 , Y10S435/886
摘要： This invention relates to new agents designated LL-F28249.alpha., LL-F28249.beta., LL-F28249.gamma., LL-F28249.delta., LLF28249.epsilon., LL-F28249.zeta., LL-F28249.eta., LL-F28249.theta., LL-F28249.iota., LL-F28249.kappa., LL-F28249.lambda., LL-F28249.mu., LL-F28249.nu., and LL-F28249.omega., to their production by fermentation, to methods for their recovery and concentration from crude solutions, to processes for their purification and to pharmaceutically and pharmacologically-acceptable salts thereof. The present invention includes within its scope the biologically pure culture which produces there agents, derived from a newly-discovered and previously uncultured microorganism, Streptomyces cyaneogriseus subsp. noncyanogenus, NRRL 15773.
摘要翻译：本发明涉及称为LL-F28249α，LL-F28249β，LL-F28249γ，LL-F28249Δ，LLF28249ε，LL-F28249zeta，LL-F28249 eta，LL-F28249θ，LL-F28249Iota， LL-F28249 kappa，LL-F28249 lambda，LL-F28249 mu，LL-F28249 nu和LL-F28249 omega，通过发酵生产，从其回收和从粗溶液中浓缩的方法，其纯化方法和其药学上可接受的盐。本发明在其范围内包括衍生自新发现和先前未培养的微生物Streptomyces cyaneogriseus subsp。的生物纯培养物。非花青素，NRRL 15773。

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