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71. 发明授权

US6114143A Anti-HIV monoclonal antibody 失效
标题翻译：抗HIV单克隆抗体
公开(公告)号：US6114143A
公开(公告)日：2000-09-05
申请号：US513968
申请日：1995-09-11
申请人： Yasuyuki Eda , Hiroaki Maeda , Keiichi Makizumi , Kouichi Shiosaki , Kiyoshi Osatomi , Kazuhiko Kimachi , Hirofumi Higuchi , Sachio Tokiyoshi
发明人： Yasuyuki Eda , Hiroaki Maeda , Keiichi Makizumi , Kouichi Shiosaki , Kiyoshi Osatomi , Kazuhiko Kimachi , Hirofumi Higuchi , Sachio Tokiyoshi
IPC分类号： A61K38/00 , C07K16/10 , C12P21/04 , C12P21/08 , C12N15/09 , A61K39/395 , C12P11/00
CPC分类号： C07K16/1063 , A61K38/00 , C07K2317/24
摘要： A monoclonal antibody useful for clinical application which recognizes the conserved region of V3-PND region of glycoprotein antigen having a molecular weight of about 1.2.times.10.sup.5 daltons (gp120) on a coating membrane of human immunodeficiency virus (HIV) and which has an ability to neutralize a broad range of various HIV variants, or a fragment thereof, and the chimeric and humanized antibodies derived therefrom are provided. By using as an immunogen a plurality of peptides having PND-Tip region containing the highly conserved GPGR sequence within PND of HIV gp120, a monoclonal antibody having a neutralizing activity to many HIV variants can be prepared. By transplanting the gene fragment coding for the variable region of said monoclonal antibody or complementarity determining region (CDR) of said region to a human antibody gene, a chimeric antibody or a reshaped antibody having an anti-HIV neutralizing activity which are effective for clinical application can be obtained.
摘要翻译： PCT No.PCT / JP94 / 00371 Sec。 371 1995年9月11日第 102（e）1995年9月11日PCT PCT 1994年3月9日PCT公布。公开号WO94 / 20632 日期1994年9月15日一种可用于临床应用的单克隆抗体，其识别在人免疫缺陷病毒（HIV）的包被膜上具有约1.2×10 5道尔顿（gp120）分子量的糖蛋白抗原的V3-PND区的保守区，具有中和各种各样的HIV变体或其片段的能力，并且提供了由其衍生的嵌合和人源化抗体。通过使用多种具有含有HIV gp120的PND内的高度保守的GPGR序列的PND-Tip区的肽，可以制备对许多HIV变体具有中和活性的单克隆抗体。通过将编码所述区域的所述单克隆抗体或互补决定区（CDR）的可变区的基因片段移植到人抗体基因，嵌合抗体或具有抗HIV中和活性的重构抗体，其对临床应用有效可以获得。

72. 发明授权

US5434620A Image sensor 失效
标题翻译：图像传感器
公开(公告)号：US5434620A
公开(公告)日：1995-07-18
申请号：US127475
申请日：1993-09-28
申请人： Hirofumi Higuchi , Yasuaki Makino
发明人： Hirofumi Higuchi , Yasuaki Makino
IPC分类号： H04N1/028 , H04N1/19 , H04N5/217 , H04N5/335 , H04N5/341 , H04N5/357 , H04N5/361 , H04N5/365 , H04N5/369 , H04N5/372 , H04N5/374 , H04N5/376 , H04N5/378
CPC分类号： H04N5/3575 , H04N5/361 , H04N5/365 , H04N5/374
摘要： An image sensor can reduce fixed pattern noise (FPN) caused by transistors used for reading pixel signals. The image sensor comprises photodiodes D.sub.1, D.sub.2, . . . connected to a precharge line L.sub.PR through respective precharge transistors (Tr1).sub.1, (Tr1).sub.2 ; and pixel amplification transistors (Tr2).sub.1, (Tr2).sub.2, . . . , one end thereof being connected to a signal read line L.sub.RE, the other end thereof being grounded through respective pixel switching transistors (Tr3).sub.1, (Tr3).sub.2, . . . , and the gates thereof being connected to respective nodes between the precharge transistors Tr1, (Tr1).sub.2, . . . and the photodiodes D.sub.1, D.sub.2, . . . According to signals provided by a timing signal generator 3, the pixel switching transistors (Tr3).sub.1, (Tr3).sub.2, . . . are sequentially turned ON and OFF one after another. During ON and OFF states of each of the pixel switching transistors, a correlated double sampling circuit provides a difference between values read out of the signal read line L.sub.RE.
摘要翻译：图像传感器可以减少由用于读取像素信号的晶体管引起的固定图案噪声（FPN）。图像传感器包括光电二极管D1，D2。。。通过相应的预充电晶体管（Tr1）1，（Tr1）2连接到预充电线路LPR; 和像素放大晶体管（Tr2）1，（Tr2）2，...。。。，其一端连接到信号读取线LRE，其另一端通过各个像素开关晶体管（Tr3）1，（Tr3）2接地。。。，其栅极连接到预充电晶体管Tr1，（Tr1）2之间的各个节点。。。和光电二极管D1，D2。。。根据由定时信号发生器3提供的信号，像素开关晶体管（Tr3）1，（Tr3）2，...，。。依次顺序地打开和关闭。在每个像素开关晶体管的ON和OFF状态期间，相关双采样电路提供从信号读取线LRE读出的值之间的差异。

73. 发明授权

US5371273A Process for producing methyl methacrylate 失效
标题翻译：生产甲基丙烯酸甲酯的方法
公开(公告)号：US5371273A
公开(公告)日：1994-12-06
申请号：US135066
申请日：1993-10-12
申请人： Yoshikazu Shima , Takafumi Abe , Hirofumi Higuchi
发明人： Yoshikazu Shima , Takafumi Abe , Hirofumi Higuchi
IPC分类号： B01J29/08 , C07B61/00 , C07C67/327 , C07C69/54 , C07C67/00
CPC分类号： C07C67/327
摘要： There is disclosed a process for producing methyl methacrylate through gas-phase catalytic reaction of methyl .alpha.-hydroxyisobutyrate which comprises feeding methanol in an amount by weight of 0.1 to 3.0 times the methyl .alpha.-hydroxyisobutyrate in a reactor along therewith and proceeding with the reaction at a reaction temperature in the range of 230.degree. to 300.degree. C. by the use of a transition-type synthetic faujasite zeolite having a specific lattice constant and a specific Na content (Na/Al) as the catalyst. The process is capable of stably producing the objective product having excellent quality in high yield for a long period of time while preventing the problems of early deterioration of the catalyst and coloring of reaction product.
摘要翻译：公开了一种通过甲基α-羟基异丁酸甲酯的气相催化反应生产甲基丙烯酸甲酯的方法，该方法包括在反应器中沿着反应器进料甲醇的量为0.1-3.0倍的甲基α-羟基异丁酸甲酯，并进行反应通过使用具有特定晶格常数和特定Na含量（Na / Al）作为催化剂的过渡型合成八面沸石，反应温度在230℃至300℃的范围内。该方法能够长期稳定地生产高质量的高品质的目标产物，同时防止催化剂的早期劣化和反应产物的着色。

74. 发明授权

US5225594A Process for producing methacrylic acid 失效
标题翻译：生产甲基丙烯酸的方法
公开(公告)号：US5225594A
公开(公告)日：1993-07-06
申请号：US759468
申请日：1991-09-13
申请人： Yoshikazu Shima , Takafumi Abe , Hirofumi Higuchi
发明人： Yoshikazu Shima , Takafumi Abe , Hirofumi Higuchi
IPC分类号： B01J23/34 , B01J23/72 , B01J23/755 , C07B61/00 , C07C51/377 , C07C57/04 , C07C57/065 , C07C67/20
CPC分类号： C07C51/377 , C07C67/20 , Y02P20/582
摘要： A process for producing methacrylic acid which comprises: (I) producing acetonecyanohydrin from prussic acid and acetone; (II) hydrating the acetonecyanohydrin obtained in step (I) to form .alpha.-hydroxyisobutyric acid amide; (III) reacting the .alpha.-hydroxyisobutyric acid amide obtained in step (II) with methyl formate or with methanol and carbon monoxide to form methyl .alpha.-hydroxyisobutyrate and formamide; (IV) hydrolyzing the methyl .alpha.-hydroxyisobutyrate obtained in step (III) to form .alpha.-hydroxyisobutyric acid; (V) dehydrating the .alpha.-hydroxyisobutyric acid obtained in step (IV) to form methacrylic acid; and (VI) dehydrating the formamide separated from the products obtained in step (III) to form prussic acid and recycling the prussic acid to step (I) as a starting material. The process is capable of producing methacrylic acid from readily available starting materials with a high yield and selectivity, without forming undesirable by-product or waste materials, such as ammonium sulfate.

75. 发明授权

US5087736A Process for producing methyl methacrylate 失效
标题翻译：生产甲基丙烯酸甲酯的方法
公开(公告)号：US5087736A
公开(公告)日：1992-02-11
申请号：US530089
申请日：1990-05-29
申请人： Hirofumi Higuchi , Koichi Kida
发明人： Hirofumi Higuchi , Koichi Kida
IPC分类号： C07C67/317 , C07C67/20 , C07C67/327 , C07C69/54
CPC分类号： C07C67/20 , C07C67/327
摘要： Disclosed is a process for producing methyl methacrylate which comprises:(I) a step of reacting acetone and prussic acid to form acetonecyanhydrin;(II) a step of hydrating the acetonecyanhydrin obtained in the step (I) to form .alpha.-hydroxyisobutyric acid amide;(III) a step of reacting the .alpha.-hydroxyisobutyric acid amide obtained in the step (II) which methyl formate to form methyl .alpha.-hydroxyisobutyrate and formamide;(IV) a step of dehydrating the methyl .alpha.-hydroxyisobutyrate obtained in the step (III) to form methyl methancrylate; and(V) a step of decomposing the formamide obtained in the step (IV) into ammonia and carbon monoxide.The process can produce methyl methacrylate at high yields without by-production of acidic ammonium sulfate.

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