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    • 82. 发明申请
    • PHARMACEUTICAL COMPOSITION COMPRISING EXTRACT OF PUERARIAE FLOS FOR PREVENTION AND TREATMENT OF ENDOMETRIOSIS
    • 包含用于预防和治疗内膜炎的PUERARIAE FLOS提取物的药物组合物
    • US20140234451A1
    • 2014-08-21
    • US14346667
    • 2012-09-24
    • UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
    • Jung-Hye ChoiJi-Hyyun Kim
    • A61K36/488
    • A61K36/488A23L33/105
    • The present invention relates to a pharmaceutical composition containing Puerariae Flos extracts as active ingredients for preventing or treating endometriosis and the complications thereof. More particularly, Puerariae Flos extracts exhibit the activity of inhibiting the migration and adhesion of endometriosis cells, inhibiting the expressions of MMP-2 and MMP-9, which are factors associated with migration and adhesion, inhibiting the expression of COX-2, which is a factor associated with pain, and inhibiting the expression of MCP-1, which is a cytokine associated with inflammation, and RANTES. Therefore, the Puerariae Flos extracts of the present invention can be effectively used as active ingredients for a pharmaceutical composition for preventing and treating endometriosis and the complications thereof, and for a health food.
    • 本发明涉及含有葛根提取物作为预防或治疗子宫内膜异位症及其并发症的有效成分的药物组合物。 更具体地说,葛根提取物表现出抑制子宫内膜异位细胞迁移和粘附的活性,抑制MMP-2和MMP-9的表达,MMP-2和MMP-9是与迁移和粘附相关的因子,抑制COX-2的表达, 与疼痛相关的因素,以及抑制作为与炎症相关的细胞因子的MCP-1和RANTES的表达。 因此,本发明的葛根提取物可以有效地用作用于预防和治疗子宫内膜异位症及其并发症的药物组合物和健康食品的活性成分。