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1. 发明申请

US20120145539A1 ELECTROCHEMICAL CELL 失效
标题翻译：电化学细胞
公开(公告)号：US20120145539A1
公开(公告)日：2012-06-14
申请号：US13357318
申请日：2012-01-24
申请人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen
发明人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen
IPC分类号： C25B9/00
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： Devices and methods are provided for determining the concentration of a reduced form of a redox species. For example, a device can include a working electrode and a counter electrode spaced by a predetermined distance so that reaction produces from the counter electrode arrive at the working electrode. An electric potential difference can be applied between the electrodes, and the potential of the working electrode can be selected such that the rate of electro-oxidation of the reduced form of the species is diffusion controlled. Current as a function of time can be determined, the magnitude of the steady state current can be estimated, and a value indicative of the diffusion coefficient and/or of the concentration of the reduced form of the species can be obtained from the change in current with time and the magnitude of the steady state current. Other embodiments of apparatuses, devices, and methods are also provided.
摘要翻译：提供了用于确定还原形式的氧化还原物质的浓度的装置和方法。例如，器件可以包括隔开预定距离的工作电极和对电极，使得从反电极产生的反应到达工作电极。可以在电极之间施加电位差，并且可以选择工作电极的电位，使得物种的还原形式的电氧化速率被扩散控制。可以确定作为时间的函数的电流，可以估计稳态电流的大小，并且可以从电流的变化获得指示物种的还原形式的扩散系数和/或浓度的值随着时间和稳态电流的大小。还提供了装置，装置和方法的其他实施例。

2. 发明申请

US20100006452A1 Biosensor Apparatus and Methods of Use 有权
标题翻译：生物传感器装置和使用方法
公开(公告)号：US20100006452A1
公开(公告)日：2010-01-14
申请号：US12563091
申请日：2009-09-18
申请人： Alastair McIndoe Hodges , Ronald Chatelier , Dennis Rylatt
发明人： Alastair McIndoe Hodges , Ronald Chatelier , Dennis Rylatt
IPC分类号： C12Q1/00 , G01N27/26 , H05K3/00
CPC分类号： G01N33/5438 , G01N33/53 , G01N33/543 , G01N33/54326 , Y10T29/49124
摘要： Disclosed herein are methods and devices for detecting the presence of an analyte of interest. A biosensor device can include a reaction chamber and an electrochemical detection chamber. The reaction chamber can include at least one immobilized binding site and a probe conjugate adapted to bind to at least one of the target analyte and the immobilized binding site while the detection chamber can include electrodes for detecting an electrochemical reaction. If present, the target analyte in the fluid sample results in a change in the amount of probe conjugate bound in the reaction chamber, which can be detected electrochemically in the detection chamber.
摘要翻译：本文公开了用于检测感兴趣的分析物的存在的方法和装置。生物传感器装置可以包括反应室和电化学检测室。反应室可以包括至少一个固定的结合位点和适于结合至少一种目标分析物和固定的结合位点的探针共轭体，同时检测室可以包括用于检测电化学反应的电极。如果存在，则流体样品中的目标分析物导致在反应室中结合的探针结合物的量的变化，其可以在检测室中电化学检测。

3. 发明授权

US07604722B2 Electrochemical cell 有权
公开(公告)号：US07604722B2
公开(公告)日：2009-10-20
申请号：US10624823
申请日：2003-07-22
申请人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen
发明人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen
IPC分类号： G01N27/327
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： This invention relates to a biosensor and more particularly to an electrochemical biosensor for determining the concentration of an analyte in a carrier. The invention is particularly useful for determining the concentration of glucose in blood and is described herein with reference to that use but it should be understood that the invention is applicable to other analytic determinations.

4. 发明授权

US07403017B2 Methods of measuring barrier formation 有权
标题翻译：测量屏障形成的方法
公开(公告)号：US07403017B2
公开(公告)日：2008-07-22
申请号：US10541812
申请日：2004-01-16
申请人： Alastair McIndoe Hodges , Ronald Christopher Chatelier , Garry Chambers
发明人： Alastair McIndoe Hodges , Ronald Christopher Chatelier , Garry Chambers
IPC分类号： G01N27/02
CPC分类号： G01N27/44 , G01N33/4905 , G01N33/491 , G01N33/5438 , G01N33/80
摘要： There is disclosed a method of measuring formation of a barrier to restrict or reduce movement of an electroactive species. The method comprises providing an electrochemical cell having a working electrode and a counter electrode spaced from the working electrode, providing a subject component, a testing component and at least one electroactive species within the cell, the subject and testing components being intended to cause the formation of a barrier to restrict or reduce movement of an electroactive species, applying a potential between the working electrode and the counter electrode sufficient to produce a current proportional to the concentration of the electroactive species being measured, and measuring the current at the working electrode to obtain a measure of the formation of the barrier to restrict or reduce movement of the electroactive species.
摘要翻译：公开了一种测量阻挡层的形成以限制或减少电活性物质的运动的方法。该方法包括提供电化学电池，其具有与工作电极间隔开的工作电极和对电极，提供主体部件，测试部件和电池内的至少一个电活性物质，受试者和测试部件旨在引起形成限制或减少电活性物质的运动的障碍物，在工作电极和对电极之间施加足以产生与所测量的电活性物质的浓度成正比的电流，并测量工作电极处的电流以获得形成屏障以限制或减少电活性物质的运动的量度。

5. 发明授权

US07131342B2 Method of preventing short sampling of a capillary or wicking fill device 失效
公开(公告)号：US07131342B2
公开(公告)日：2006-11-07
申请号：US10408189
申请日：2003-04-03
申请人： Alastair McIndoe Hodges
发明人： Alastair McIndoe Hodges
IPC分类号： G01N1/12
CPC分类号： B01L3/502707 , A61B2562/0295 , B01L3/5023 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2300/0645 , B01L2300/069 , B01L2300/0825 , B01L2300/0887 , B01L2300/165 , B01L2400/0406 , Y10T29/49005 , Y10T29/49007 , Y10T29/49117 , Y10T436/2575
摘要： The current invention provides a device, and a method for using the device, for ensuring that a capillary or wicking fill device is fully filled. In particular this invention is directed to, but not limited to, use with capillary or wicking action filled electrochemical sensors suitable for use in analyzing blood or interstitial fluids.

6. 发明授权

US07045046B2 Sensor connection means 有权
公开(公告)号：US07045046B2
公开(公告)日：2006-05-16
申请号：US10012680
申请日：2001-11-13
申请人： Garry Chambers , Alastair McIndoe Hodges , Thomas William Beck , Ian Andrew Maxwell
发明人： Garry Chambers , Alastair McIndoe Hodges , Thomas William Beck , Ian Andrew Maxwell
IPC分类号： G01N27/28
CPC分类号： G01N27/3272
摘要： The invention relates to a sensor adapted for electrical connection to a power source having an electrical contact means (3). The sensor has a first insulating substrate (1) carrying a first electrode (2) and a second insulating substrate (7) carrying a second electrode (6). The electrodes are disposed to face each other in spaced apart relationship, sandwiching a spacer (4) therebetween. A first cut-out portion extends through the first insulating substrate (1) and a spacer (4) to expose a first contact area (23) on the second insulating substrate (7). This permits the electrical contact means (31) to effect electrical connection with the first contact (23) which in turn is in electrically conductive connection with the second electrode (6). A similar contact arrangement may be disposed on the opposite side of the sensor.

7. 发明授权

US06823750B2 Method of preventing short sampling of a capillary or wicking fill device 失效
公开(公告)号：US06823750B2
公开(公告)日：2004-11-30
申请号：US10408836
申请日：2003-04-04
申请人： Alastair McIndoe Hodges
发明人： Alastair McIndoe Hodges
IPC分类号： G01N1000
CPC分类号： B01L3/502707 , A61B2562/0295 , B01L3/5023 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2300/0645 , B01L2300/069 , B01L2300/0825 , B01L2300/0887 , B01L2300/165 , B01L2400/0406 , Y10T29/49005 , Y10T29/49007 , Y10T29/49117 , Y10T436/2575
摘要： The current invention provides a device, and a method for using the device, for ensuring that a capillary or wicking fill device is fully filled. In particular this invention is directed to, but not limited to, use with capillary or wicking action filled electrochemical sensors suitable for use in analyzing blood or interstitial fluids.

8. 发明授权

US06413410B1 Electrochemical cell 有权
公开(公告)号：US06413410B1
公开(公告)日：2002-07-02
申请号：US09618515
申请日：2000-07-18
申请人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen
发明人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen
IPC分类号： G01N2726
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： This invention relates to a biosensor and more particularly to an electrochemical biosensor for determining the concentration of an analyte in a carrier. The invention is particularly useful for determining the concentration of glucose in blood and is described herein with reference to that use but it should be understood that the invention is applicable to other analytic determinations.

9. 发明授权

US08709739B2 System and method for measuring an analyte in a sample 有权
公开(公告)号：US08709739B2
公开(公告)日：2014-04-29
申请号：US13619241
申请日：2012-09-14
申请人： Ronald C. Chatelier , Alastair McIndoe Hodges , Santhanagopalan Nandagopalan
发明人： Ronald C. Chatelier , Alastair McIndoe Hodges , Santhanagopalan Nandagopalan
IPC分类号： G01N27/327
CPC分类号： G01N27/4163 , C12Q1/006 , G01N27/3274
摘要： Methods of determining a corrected analyte concentration in view of some error source are provided herein. The methods can be utilized for the determination of various analytes and/or various sources of error. In one example, the method can be configured to determine a corrected glucose concentration in view of an extreme level of hematocrit found within the sample. In other embodiments, methods are provided for identifying various system errors and/or defects. For example, such errors can include partial-fill or double-fill situations, high track resistance, and/or sample leakage. Systems are also provided for determining a corrected analyte concentration and/or detecting some system error.

10. 发明授权

US08182765B2 Fluid transfer mechanism 有权
标题翻译：流体输送机构
公开(公告)号：US08182765B2
公开(公告)日：2012-05-22
申请号：US12280317
申请日：2007-02-15
申请人： Alastair Mcindoe Hodges , Ronald Christopher Chatelier , Garry Chambers
发明人： Alastair Mcindoe Hodges , Ronald Christopher Chatelier , Garry Chambers
IPC分类号： B01L3/00 , F04B19/00
CPC分类号： F16K99/0017 , B01L3/502738 , B01L2200/143 , B01L2300/0645 , B01L2300/0816 , B01L2300/0825 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , F16K99/0001 , F16K99/0025 , F16K2099/008 , F16K2099/0086 , Y10T436/25 , Y10T436/2575
摘要： A microfluidic device for transferring liquid from a first chamber to a second chamber is provided. The device has a first chamber; a second chamber; and a barrier between the first chamber and the second chamber, the barrier having least one opening fluidly connecting the first chamber to the second chamber, the at least one opening being sized such that a retention force, such as surface tension, keeps the liquid in the first chamber. The fluid is transferred from the first chamber to the second chamber when an initiation input such as fluid pressure is introduced to the liquid that is sufficient to overcome the retention force. The device may be a sensor strip.
摘要翻译：提供了用于将液体从第一室转移到第二室的微流体装置。该装置具有第一室; 第二个房间和所述第一腔室和所述第二腔室之间的阻挡件，所述阻挡件具有至少一个开口，其将所述第一腔室与所述第二腔室流体连接，所述至少一个开口的尺寸设定为使得诸如表面张力的保持力将所述液体保持在第一个房间当诸如流体压力的起始输入被引入到足以克服保持力的液体时，流体从第一室转移到第二室。该装置可以是传感器条。

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