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    • 1. 发明申请
    • ELECTROCHEMICAL CELL
    • 电化学细胞
    • US20120145539A1
    • 2012-06-14
    • US13357318
    • 2012-01-24
    • Alastair McIndoe HodgesThomas William BeckOddvar Johansen
    • Alastair McIndoe HodgesThomas William BeckOddvar Johansen
    • C25B9/00
    • G01N27/403C12Q1/004G01N27/3272G01N27/3273Y10T29/49117
    • Devices and methods are provided for determining the concentration of a reduced form of a redox species. For example, a device can include a working electrode and a counter electrode spaced by a predetermined distance so that reaction produces from the counter electrode arrive at the working electrode. An electric potential difference can be applied between the electrodes, and the potential of the working electrode can be selected such that the rate of electro-oxidation of the reduced form of the species is diffusion controlled. Current as a function of time can be determined, the magnitude of the steady state current can be estimated, and a value indicative of the diffusion coefficient and/or of the concentration of the reduced form of the species can be obtained from the change in current with time and the magnitude of the steady state current. Other embodiments of apparatuses, devices, and methods are also provided.
    • 提供了用于确定还原形式的氧化还原物质的浓度的装置和方法。 例如,器件可以包括隔开预定距离的工作电极和对电极,使得从反电极产生的反应到达工作电极。 可以在电极之间施加电位差,并且可以选择工作电极的电位,使得物种的还原形式的电氧化速率被扩散控制。 可以确定作为时间的函数的电流,可以估计稳态电流的大小,并且可以从电流的变化获得指示物种的还原形式的扩散系数和/或浓度的值 随着时间和稳态电流的大小。 还提供了装置,装置和方法的其他实施例。
    • 5. 发明授权
    • Electrochemical cell
    • 电化学电池
    • US08101056B2
    • 2012-01-24
    • US12567433
    • 2009-09-25
    • Alastair McIndoe HodgesThomas William BeckOddvar Johansen
    • Alastair McIndoe HodgesThomas William BeckOddvar Johansen
    • G01N27/403G01N27/327
    • G01N27/403C12Q1/004G01N27/3272G01N27/3273Y10T29/49117
    • A hollow electrochemical cell is provided. In one exemplary embodiment, a hollow electrochemical cell includes two sets of electrodes and an opening for admitting an analyte to the cell. At least one of the two sets of electrodes can be in fluid communication with the opening. Further, a first set of electrodes can include a working electrode spaced from a counter or counter/reference electrode by less than 500 μm one embodiment the working and counter or counter/reference electrodes are not co-planer. In another embodiment the working and counter or counter/reference electrodes are of substantially corresponding area. In yet another embodiment the working and counter or counter/reference electrodes are spaced from 100 to 200 μm apart. The first set of electrodes and the second set of electrodes can be spaced apart by greater than about 500 μm. Other embodiments of a hollow electrochemical cell are also provided, as are several embodiments of a glucose sensor.
    • 提供了一种中空的电化学电池。 在一个示例性实施例中,中空电化学电池包括两组电极和用于允许分析物进入细胞的开口。 两组电极中的至少一个可以与开口流体连通。 此外,第一组电极可以包括与计数器或对准/参考电极间隔小于500μm的工作电极。 在一个实施例中,工作和计数器或计数器/参考电极不是共平面的。 在另一个实施例中,工作和计数器或计数器/参考电极具有基本对应的区域。 在又一个实施例中,工作和计数器或对准/参考电极间隔开100至200微米。 第一组电极和第二组电极可间隔开大于约500μm。 还提供了中空电化学电池的其它实施方案,葡萄糖传感器的几个实施方案也是如此。
    • 10. 发明授权
    • Electrochemical cell
    • 电化学电池
    • US08075760B2
    • 2011-12-13
    • US12560773
    • 2009-09-16
    • Alastair McIndoe HodgesThomas William BeckOddvar Johansen
    • Alastair McIndoe HodgesThomas William BeckOddvar Johansen
    • G01N27/327
    • G01N27/403C12Q1/004G01N27/3272G01N27/3273Y10T29/49117
    • A method for determining the concentration of a reduced or oxidized form of a redox species is provided. In one exemplary embodiment, an electrochemical apparatus is provided in which the apparatus includes a hollow electrochemical cell for measuring a concentration of glucose in a blood sample, a current of the cell is measured, and a concentration of a redox mediator is determined, at least in part from, a measured current of the cell. The hollow electrochemical cell can include at least one non-metal working electrode, at least one counter electrode or counter/reference electrode, and a spacer interposed between the working electrode and the counter or counter/reference electrode. In one embodiment the working electrode and the counter or counter/reference electrode are not co-planer and are separated by a distance of from about 20 microns to about 200 microns. In another embodiment the working electrode and the counter or counter/reference electrode are not co-planer and the cell has an effective cell volume of less than 1.5 microliters.
    • 提供了确定还原或氧化形式的氧化还原物质的浓度的方法。 在一个示例性实施例中,提供了一种电化学装置,其中所述装置包括用于测量血液样品中葡萄糖浓度的中空电化学电池,测量电池的电流,并且至少确定氧化还原介体的浓度 部分来自电池的测量电流。 中空电化学电池可以包括至少一个非金属工作电极,至少一个对电极或对置/参考电极,以及插入在工作电极和计数器或反/参比电极之间的间隔物。 在一个实施例中,工作电极和计数器或对位/参比电极不是共平面的并且分开约20微米至约200微米的距离。 在另一个实施例中,工作电极和计数器或对准/参比电极不是共平面的,并且电池具有小于1.5微升的有效电池容积。