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1. 发明授权

US08609719B2 Propargylated aminoindans, processes for preparation, and uses thereof 有权
标题翻译：炔丙基化氨基茚满，制备方法及其应用
公开(公告)号：US08609719B2
公开(公告)日：2013-12-17
申请号：US12582491
申请日：2009-10-20
申请人： Victor Piryatinsky , Bronka Cohen , David Lerner , Dalia Pinkert , Istvan Miskolczi , Yaacov Herzig , Hugo Gottlieb , Marta Weinstock-Rosin
发明人： Victor Piryatinsky , Bronka Cohen , David Lerner , Dalia Pinkert , Istvan Miskolczi , Yaacov Herzig , Hugo Gottlieb , Marta Weinstock-Rosin
IPC分类号： A61K31/13
CPC分类号： C07C271/48 , A61K31/27 , A61K31/325 , C07B2200/07 , C07C271/44 , C07C2602/08
摘要： A method for treating an individual who has been identified as having Alzheimer's disease by administering orally to the individual a therapeutically effective amount of ladostigil or a pharmaceutically active salt thereof, wherein the therapeutically effective amount is 70 mg per day, 140 mg per day, or 200 mg per day. Also, a unit dosage form of ladostigil or a pharmaceutically active salt thereof in an amount of 50 mg, 70 mg, 80 mg or 100 mg.
摘要翻译：治疗已被鉴定为患有阿尔茨海默病的个体的方法，其通过向个体口服施用治疗有效量的前消炎症或其药物活性盐，其中治疗有效量为每天70mg，每天140mg，或每天200毫克。而且，剂量为50mg，70mg，80mg或100mg的地斯达格或其药物活性盐的单位剂型。

2. 发明申请

US20100198098A1 System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject 审中-公开
标题翻译：用于预测，快速检测，警告，预防或控制受试者大脑活动状态变化的系统
公开(公告)号：US20100198098A1
公开(公告)日：2010-08-05
申请号：US12592990
申请日：2009-12-05
申请人： Ivan Osorio , Mark Frei , David Lerner , John Ralston , Josef Dorfmeister
发明人： Ivan Osorio , Mark Frei , David Lerner , John Ralston , Josef Dorfmeister
IPC分类号： A61B5/0476
CPC分类号： A61B5/048 , A61B5/4094 , A61B5/7257 , A61B5/726 , A61N1/08 , A61N1/36064 , A61N1/36082
摘要： A system (10) analyzes signals representative of a subject's brain activity in a signal processor (12) for information indicating the subject's current activity state and for predicting a change in the activity state. One preferred embodiment uses a combination of nonlinear filtering methods to perform real-time analysis of the electro-encephalogram (EEG) or electro-corticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.
摘要翻译：系统（10）在信号处理器（12）中分析表示受试者的大脑活动的信号，用于指示受试者的当前活动状态的信息，以及用于预测活动状态的变化。一个优选实施例使用非线性滤波方法的组合来执行来自对象患者的电脑电图（EEG）或电皮质图（ECoG）信号的实时分析，用于指示或预测癫痫发作的信息，并且完成至少在临床癫痫发作前需要进行分析。优选的系统然后执行输出任务以防止或减少缉获量，或用于记录相关数据。

3. 发明授权

US07294739B1 Basic amine esters or oleic acid and their use as anti-inflammatory or immunobodulatory agents 失效
标题翻译：碱性胺酯或油酸及其作为抗炎或免疫抑制剂的用途
公开(公告)号：US07294739B1
公开(公告)日：2007-11-13
申请号：US11594015
申请日：2006-11-06
申请人： Yaacov Herzig , David Lerner , Jeffrey Sterling
发明人： Yaacov Herzig , David Lerner , Jeffrey Sterling
IPC分类号： C07C61/00 , A01N37/00
CPC分类号： C07C219/28 , C07C219/06 , C07C219/22 , C07C219/24 , C07C2602/08
摘要： This invention is directed to compounds of the following formula (I): wherein R is either: wherein R1 and R2 are as defined in the specification; the use of these compounds for treating inflammatory disorders; and pharmaceutical compositions comprising a therapeutically effective amount of the above-defined compounds.
摘要翻译：本发明涉及下列通式（I）的化合物：其中R是：其中R 1和R 2均如说明书中所定义; 使用这些化合物治疗炎症性疾病; 以及包含治疗有效量的上述化合物的药物组合物。

4. 发明申请

US20050228903A1 Network storage target boot and network connectivity through a common network device 有权
标题翻译：网络存储目标引导和通过公共网络设备的网络连接
公开(公告)号：US20050228903A1
公开(公告)日：2005-10-13
申请号：US10822168
申请日：2004-04-08
申请人： David Lerner , Dave Matheny , Douglas Boom
发明人： David Lerner , Dave Matheny , Douglas Boom
IPC分类号： G06F9/445 , G06F13/00 , G06F15/16 , H05K7/10
CPC分类号： G06F15/177 , G06F9/4416
摘要： The present disclosure includes systems and techniques relating to booting to a network storage target. In general, in one implementation, a bus-to-network device driver is loaded during a machine boot, where the bus-to-network device driver is capable of sending machine bus commands over a network, providing access to the network for a network device driver, and distinguishing between received responses to the machine bus commands and other network traffic corresponding to the network device driver. Loading of the bus-to-network device driver can occur in response to an operating system load of bus drivers. For example, the bus-to-network device driver can be an iSCSI driver, and the operating system load of bus drivers can be the operating system load of SCSI drivers.
摘要翻译：本公开包括与引导到网络存储目标有关的系统和技术。通常，在一个实现中，在机器引导期间加载总线到网络设备驱动器，其中总线到网络设备驱动器能够通过网络发送机器总线命令，从而提供对网络的访问设备驱动程序，并区分接收到的对机器总线命令的响应和对应于网络设备驱动程序的其他网络流量。总线到网络设备驱动程序的加载可以响应于总线驱动程序的操作系统负载而发生。例如，总线到网络设备驱动程序可以是iSCSI驱动程序，并且总线驱动程序的操作系统负载可以是SCSI驱动程序的操作系统负载。

5. 发明授权

US06549804B1 System for the prediction, rapid detection, warning, prevention or control of changes in activity states in the brain of a subject 有权
标题翻译：用于预测，快速检测，警告，预防或控制受试者大脑活动状态变化的系统
公开(公告)号：US06549804B1
公开(公告)日：2003-04-15
申请号：US09329593
申请日：1999-06-10
申请人： Ivan Osorio , Mark Frei , David Lerner , John Ralston , Josef Dorfmeister
发明人： Ivan Osorio , Mark Frei , David Lerner , John Ralston , Josef Dorfmeister
IPC分类号： A61B504
CPC分类号： A61B5/415 , A61B5/048 , A61B5/4094 , A61B5/7257 , A61B5/726 , A61N1/08 , A61N1/36025 , A61N1/36064 , A61N1/36135 , G06F19/00
摘要： A system (10) analyzes signals representative of a subject's brain activity in a signal processor (12) for information indicating the subject's current activity state and for predicting a change in the activity state. One preferred embodiment uses a combination of nonlinear filtering methods to perform real-time analysis of the electro-encephalogram (EEG) or electro-corticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.
摘要翻译：系统（10）在信号处理器（12）中分析表示受试者的大脑活动的信号，用于指示受试者的当前活动状态的信息，以及用于预测活动状态的变化。一个优选实施例使用非线性滤波方法的组合来执行来自对象患者的电脑电图（EEG）或电皮质图（ECoG）信号的实时分析，用于指示或预测癫痫发作的信息，并且完成至少在临床癫痫发作前需要进行分析。优选的系统然后执行输出任务以防止或减少缉获量，或用于记录相关数据。

6. 发明授权

US5752235A Electronic medication monitoring and dispensing method 失效
标题翻译：电子药物监测和分配方法
公开(公告)号：US5752235A
公开(公告)日：1998-05-12
申请号：US556626
申请日：1990-07-23
申请人： Bruce A. Kehr , David Lerner , Richard D. Demenus , Michael J. Edl
发明人： Bruce A. Kehr , David Lerner , Richard D. Demenus , Michael J. Edl
IPC分类号： A61J7/04 , G06F19/00 , G07F11/62 , G08B21/24 , G06F15/02
CPC分类号： A61J7/0481 , A61J7/0084 , A61J7/0418 , A61J7/0436 , A61J7/0454 , G06F19/3462 , G07F11/62 , G07F17/0092 , G08B21/24 , A61J2200/30 , A61J2205/70 , A61J7/0409 , A61J7/0445
摘要： A device for monitoring medication of a patient and for prompting the patient into certain medication taking schedule and/or certain programming steps and routines. The device has a plurality of compartments, each of which may store medication, and an electrical signaling system to emit medication alert signals from time-to-time, each of which said signals indicates (a) that medication should be taken, (b) from which compartment the medication should be taken, (c) and the quantity of medication to be taken. If a designated compartment is not opened and closed within a predetermined period of time, the electrical signaling system will display an alarm and the event will be recorded as a missed medication event, unless the patient then opens the designated compartment. If each designated compartment is opened and closed, the take-medication signal and the alarm (if operating) are turned off and the event is recorded for later review. The device may be constructed in one piece with hinged doors for each pill compartment, or each pill compartment may be a separate "drawer" sliding into a main unit.
摘要翻译：一种用于监测患者的药物并用于促使患者进入某些药物的装置，其采取计划和/或某些编程步骤和例程。该装置具有多个隔间，每个隔间可以存储药物，以及一个电信号系统，用于不时地发出药物警报信号，每个隔间都表示（a）应该服用药物，（b）应从哪个隔间取药物，（c）和服用药物的数量。如果在预定时间段内没有打开和关闭指定的隔间，则电信号系统将显示警报，并且事件将被记录为错过的药物事件，除非患者然后打开指定的隔间。如果每个指定的隔间被打开和关闭，则取消药物信号和警报（如果操作）被关闭，事件被记录以备以后审查。该装置可以用于每个药丸隔室的铰接门构成一体，或者每个药丸隔室可以是滑入主单元的单独的“抽屉”。

7. 发明授权

US5646188A Polyamine derivatives of 1-aminoindan 失效
标题翻译： 1-氨基茚满的多胺衍生物
公开(公告)号：US5646188A
公开(公告)日：1997-07-08
申请号：US498095
申请日：1995-07-05
申请人： Gad Gilad , Varda Gilad , Jeffrey Sterling , Yaacov Herzig , David Lerner , Alex Veinberg , Isaac Milman , Nina Finkelstein
发明人： Gad Gilad , Varda Gilad , Jeffrey Sterling , Yaacov Herzig , David Lerner , Alex Veinberg , Isaac Milman , Nina Finkelstein
IPC分类号： A61K31/135 , A61K31/155 , C07C211/42 , C07C233/41 , C07C279/12
CPC分类号： C07C279/12 , A61K31/135 , A61K31/155 , C07C211/42 , C07C233/41 , C07C2102/24
摘要： A compound of general formula I ##STR1## wherein n is 1 or 2; R.sub.1 and R.sub.2 are each independently hydrogen, hydroxy, substituted or unsubstituted C.sub.1-4 alkyl, substituted or unsubstituted C.sub.1-4 alkoxy or halogeno;R.sub.5 is hydrogen, substituted or unsubstituted C.sub.1-4 alkyl, amino or NR.sub.6 R.sub.7 ;R.sub.3, R.sub.4, R.sub.6 and R.sub.7 are each independently hydrogen or (CH.sub.2).sub.m --[NH(CH.sub.2).sub.x ].sub.y --NHR.sub.11 wherein m is from 0-5, y is from 0-5 and each x is independently from 1-5 and R.sub.11 is hydrogen or C(NH)NH.sub.2 ;provided that when R.sub.3 and R.sub.4 are both hydrogen, R.sub.5 is amino or NR.sub.6 R.sub.7 ; pharmaceutically acceptable salts and optically active isomers thereof.
摘要翻译：通式I的化合物（I）其中n为1或2; R 1和R 2各自独立地为氢，羟基，取代或未取代的C 1-4烷基，取代或未取代的C 1-4烷氧基或卤素; R5是氢，取代或未取代的C1-4烷基，氨基或NR6R7; R3，R4，R6和R7各自独立地为氢或（CH2）m- [NH（CH2）x] y-NHR11，其中m为0-5，y为0-5，并且各x独立地为1-5 和R 11是氢或C（NH）NH 2; 条件是当R3和R4都是氢时，R5是氨基或NR6R7; 其药学上可接受的盐和旋光异构体。

8. 发明授权

US5200891A Electronic medication dispensing method 失效
标题翻译：电子药物分配方法
公开(公告)号：US5200891A
公开(公告)日：1993-04-06
申请号：US464877
申请日：1990-01-17
申请人： Bruce A. Kehr , David Lerner , Richard D. Demenus , Michael J. Edl
发明人： Bruce A. Kehr , David Lerner , Richard D. Demenus , Michael J. Edl
IPC分类号： A61J7/04 , G06F19/00 , G07F11/62 , G08B21/24
CPC分类号： G08B21/24 , A61J7/0084 , A61J7/0418 , A61J7/0436 , A61J7/0454 , A61J7/0481 , G06F19/3462 , G07F11/62 , G07F17/0092 , A61J2200/30 , A61J2205/70 , A61J7/0409 , A61J7/0445
摘要： A device for monitoring medication of a patient and for prompting the patient into certain medication taking schedule and/or certain programming steps and routines. The device has a plurality of compartments, each of which may store medication and an electrical signaling system to emit medication alert signals from time-to-time, each of which the signals indicates (a) that medication should be taken, (b) from which compartment the medication should be taken, (c) and the quantity of medication to be taken. If a designated compartment is not opened and closed within a predetermined period of time, the electrical signaling system will sound an alarm. If each designated compartment is opened and closed, the take-medication signal and the alarm (if operating) are turned off and the event is recorded for later review. The device includes a display having a substantially continuous display area having portions thereof closely adjacent to each compartment.
摘要翻译：一种用于监测患者的药物并用于促使患者进入某些药物的装置，其采取计划和/或某些编程步骤和例程。该装置具有多个隔室，每个隔间可以存储药物和电信号系统，以不时地发出药物警报信号，每个隔间信号表示（a）应该服用药物，（b）从应该采取哪个隔间药物，（c）和服用药物的数量。如果在预定时间段内没有打开和关闭指定的隔间，则电子信号系统将发出警报。如果每个指定的隔间被打开和关闭，则取消药物信号和警报（如果操作）被关闭，事件被记录以备以后审查。该装置包括具有基本上连续的显示区域的显示器，其具有与每个隔室紧密相邻的部分。

9. 发明申请

US20070203232A1 Propargylated aminoindans, processes for preparation, and uses thereof 有权
标题翻译：炔丙基化氨基茚满，制备方法及其应用
公开(公告)号：US20070203232A1
公开(公告)日：2007-08-30
申请号：US11710118
申请日：2007-02-23
申请人： Victor Piryatinsky , Bronka Cohen , David Lerner , Dalia Pinkert , Istvan Miskolczi , Yaacov Herzig , Hugo Gottlieb
发明人： Victor Piryatinsky , Bronka Cohen , David Lerner , Dalia Pinkert , Istvan Miskolczi , Yaacov Herzig , Hugo Gottlieb
IPC分类号： A61K31/325 , C07C271/20
CPC分类号： C07C271/48 , A61K31/27 , A61K31/325 , C07B2200/07 , C07C271/44 , C07C2602/08
摘要： This invention provides compounds having the structure: wherein R1 is methyl and R2 is H, or R1 is ethyl and R2 is hydroxymethyl; R3 is H or propargyl; and R4 is either H or t-butyloxycarbonyl; or an enantiomer or a pharmaceutically acceptable salt thereof. This invention further provides the use of a therapeutically effective amount of such compounds to treat a subject afflicted with a psychiatric disorder, Parkinson's disease, Alzheimer's disease, dementia, or a neurological disorder.
摘要翻译：本发明提供具有以下结构的化合物：其中R 1是甲基，R 2是H，或R 1是乙基，R 1是H， 2是羟甲基; R 3是H或炔丙基; 和R 4是H或叔丁氧基羰基; 或其对映异构体或其药学上可接受的盐。本发明进一步提供了治疗有效量的这些化合物用于治疗患有精神障碍，帕金森病，阿尔茨海默病，痴呆或神经障碍的受试者的用途。

10. 发明申请

US20060165617A1 Cosmetic Composition and Method 审中-公开
标题翻译：化妆品成分及方法
公开(公告)号：US20060165617A1
公开(公告)日：2006-07-27
申请号：US11278461
申请日：2006-04-03
申请人： David Lerner , Gregory Schultz
发明人： David Lerner , Gregory Schultz
IPC分类号： A61K8/97 , A61K31/56 , A61K31/704
CPC分类号： A61K8/42 , A61K8/492 , A61K8/4986 , A61K8/602 , A61K8/63 , A61K8/97 , A61K31/56 , A61K31/567 , A61K31/704 , A61K2800/782 , A61Q19/00 , A61Q19/08
摘要： A cosmetic topical formulation and method are directed toward diminishing skin wrinkling and fine lines and improving skin tone. It contains a matrix metalloproteinase inhibitor, MMPI, e.g. batimastat or marimastat, and a natural estrogen, e.g., a true estrogen compound, such as 17-beta estradiol, or an estrogen-like steroid (such as various phytoestrogens found in herbal preparations). Exemplary phytoestrogens include triterpenoid glycosides. Certain compositions of this invention are useful for minimizing photodamage to skin, while in other embodiments, a composition according to this invention is useful to prevent or minimize the adverse effects on skin induced by cigarette smoking. The method of the invention involves administering the components such as in a dermal preparation.
摘要翻译：化妆品局部制剂和方法旨在减少皮肤皱纹和细纹并改善肤色。它含有基质金属蛋白酶抑制剂，MMPI，巴马司他或马拉马斯特，以及天然雌激素，例如真正的雌激素化合物，如17-β雌二醇，或雌激素样类固醇（如草药制剂中发现的各种植物雌激素）。示例性植物雌激素包括三萜糖苷。本发明的某些组合物可用于最小化对皮肤的光损伤，而在其它实施方案中，根据本发明的组合物可用于防止或最小化由吸烟引起的对皮肤的不利影响。本发明的方法涉及给予诸如皮肤制剂中的组分。

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