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1. 发明授权

US5752235A Electronic medication monitoring and dispensing method 失效
标题翻译：电子药物监测和分配方法
公开(公告)号：US5752235A
公开(公告)日：1998-05-12
申请号：US556626
申请日：1990-07-23
申请人： Bruce A. Kehr , David Lerner , Richard D. Demenus , Michael J. Edl
发明人： Bruce A. Kehr , David Lerner , Richard D. Demenus , Michael J. Edl
IPC分类号： A61J7/04 , G06F19/00 , G07F11/62 , G08B21/24 , G06F15/02
CPC分类号： A61J7/0481 , A61J7/0084 , A61J7/0418 , A61J7/0436 , A61J7/0454 , G06F19/3462 , G07F11/62 , G07F17/0092 , G08B21/24 , A61J2200/30 , A61J2205/70 , A61J7/0409 , A61J7/0445
摘要： A device for monitoring medication of a patient and for prompting the patient into certain medication taking schedule and/or certain programming steps and routines. The device has a plurality of compartments, each of which may store medication, and an electrical signaling system to emit medication alert signals from time-to-time, each of which said signals indicates (a) that medication should be taken, (b) from which compartment the medication should be taken, (c) and the quantity of medication to be taken. If a designated compartment is not opened and closed within a predetermined period of time, the electrical signaling system will display an alarm and the event will be recorded as a missed medication event, unless the patient then opens the designated compartment. If each designated compartment is opened and closed, the take-medication signal and the alarm (if operating) are turned off and the event is recorded for later review. The device may be constructed in one piece with hinged doors for each pill compartment, or each pill compartment may be a separate "drawer" sliding into a main unit.
摘要翻译：一种用于监测患者的药物并用于促使患者进入某些药物的装置，其采取计划和/或某些编程步骤和例程。该装置具有多个隔间，每个隔间可以存储药物，以及一个电信号系统，用于不时地发出药物警报信号，每个隔间都表示（a）应该服用药物，（b）应从哪个隔间取药物，（c）和服用药物的数量。如果在预定时间段内没有打开和关闭指定的隔间，则电信号系统将显示警报，并且事件将被记录为错过的药物事件，除非患者然后打开指定的隔间。如果每个指定的隔间被打开和关闭，则取消药物信号和警报（如果操作）被关闭，事件被记录以备以后审查。该装置可以用于每个药丸隔室的铰接门构成一体，或者每个药丸隔室可以是滑入主单元的单独的“抽屉”。

2. 发明授权

US5200891A Electronic medication dispensing method 失效
标题翻译：电子药物分配方法
公开(公告)号：US5200891A
公开(公告)日：1993-04-06
申请号：US464877
申请日：1990-01-17
申请人： Bruce A. Kehr , David Lerner , Richard D. Demenus , Michael J. Edl
发明人： Bruce A. Kehr , David Lerner , Richard D. Demenus , Michael J. Edl
IPC分类号： A61J7/04 , G06F19/00 , G07F11/62 , G08B21/24
CPC分类号： G08B21/24 , A61J7/0084 , A61J7/0418 , A61J7/0436 , A61J7/0454 , A61J7/0481 , G06F19/3462 , G07F11/62 , G07F17/0092 , A61J2200/30 , A61J2205/70 , A61J7/0409 , A61J7/0445
摘要： A device for monitoring medication of a patient and for prompting the patient into certain medication taking schedule and/or certain programming steps and routines. The device has a plurality of compartments, each of which may store medication and an electrical signaling system to emit medication alert signals from time-to-time, each of which the signals indicates (a) that medication should be taken, (b) from which compartment the medication should be taken, (c) and the quantity of medication to be taken. If a designated compartment is not opened and closed within a predetermined period of time, the electrical signaling system will sound an alarm. If each designated compartment is opened and closed, the take-medication signal and the alarm (if operating) are turned off and the event is recorded for later review. The device includes a display having a substantially continuous display area having portions thereof closely adjacent to each compartment.
摘要翻译：一种用于监测患者的药物并用于促使患者进入某些药物的装置，其采取计划和/或某些编程步骤和例程。该装置具有多个隔室，每个隔间可以存储药物和电信号系统，以不时地发出药物警报信号，每个隔间信号表示（a）应该服用药物，（b）从应该采取哪个隔间药物，（c）和服用药物的数量。如果在预定时间段内没有打开和关闭指定的隔间，则电子信号系统将发出警报。如果每个指定的隔间被打开和关闭，则取消药物信号和警报（如果操作）被关闭，事件被记录以备以后审查。该装置包括具有基本上连续的显示区域的显示器，其具有与每个隔室紧密相邻的部分。

3. 发明申请

US20070203232A1 Propargylated aminoindans, processes for preparation, and uses thereof 有权
标题翻译：炔丙基化氨基茚满，制备方法及其应用
公开(公告)号：US20070203232A1
公开(公告)日：2007-08-30
申请号：US11710118
申请日：2007-02-23
申请人： Victor Piryatinsky , Bronka Cohen , David Lerner , Dalia Pinkert , Istvan Miskolczi , Yaacov Herzig , Hugo Gottlieb
发明人： Victor Piryatinsky , Bronka Cohen , David Lerner , Dalia Pinkert , Istvan Miskolczi , Yaacov Herzig , Hugo Gottlieb
IPC分类号： A61K31/325 , C07C271/20
CPC分类号： C07C271/48 , A61K31/27 , A61K31/325 , C07B2200/07 , C07C271/44 , C07C2602/08
摘要： This invention provides compounds having the structure: wherein R1 is methyl and R2 is H, or R1 is ethyl and R2 is hydroxymethyl; R3 is H or propargyl; and R4 is either H or t-butyloxycarbonyl; or an enantiomer or a pharmaceutically acceptable salt thereof. This invention further provides the use of a therapeutically effective amount of such compounds to treat a subject afflicted with a psychiatric disorder, Parkinson's disease, Alzheimer's disease, dementia, or a neurological disorder.
摘要翻译：本发明提供具有以下结构的化合物：其中R 1是甲基，R 2是H，或R 1是乙基，R 1是H， 2是羟甲基; R 3是H或炔丙基; 和R 4是H或叔丁氧基羰基; 或其对映异构体或其药学上可接受的盐。本发明进一步提供了治疗有效量的这些化合物用于治疗患有精神障碍，帕金森病，阿尔茨海默病，痴呆或神经障碍的受试者的用途。

4. 发明申请

US20060165617A1 Cosmetic Composition and Method 审中-公开
标题翻译：化妆品成分及方法
公开(公告)号：US20060165617A1
公开(公告)日：2006-07-27
申请号：US11278461
申请日：2006-04-03
申请人： David Lerner , Gregory Schultz
发明人： David Lerner , Gregory Schultz
IPC分类号： A61K8/97 , A61K31/56 , A61K31/704
CPC分类号： A61K8/42 , A61K8/492 , A61K8/4986 , A61K8/602 , A61K8/63 , A61K8/97 , A61K31/56 , A61K31/567 , A61K31/704 , A61K2800/782 , A61Q19/00 , A61Q19/08
摘要： A cosmetic topical formulation and method are directed toward diminishing skin wrinkling and fine lines and improving skin tone. It contains a matrix metalloproteinase inhibitor, MMPI, e.g. batimastat or marimastat, and a natural estrogen, e.g., a true estrogen compound, such as 17-beta estradiol, or an estrogen-like steroid (such as various phytoestrogens found in herbal preparations). Exemplary phytoestrogens include triterpenoid glycosides. Certain compositions of this invention are useful for minimizing photodamage to skin, while in other embodiments, a composition according to this invention is useful to prevent or minimize the adverse effects on skin induced by cigarette smoking. The method of the invention involves administering the components such as in a dermal preparation.
摘要翻译：化妆品局部制剂和方法旨在减少皮肤皱纹和细纹并改善肤色。它含有基质金属蛋白酶抑制剂，MMPI，巴马司他或马拉马斯特，以及天然雌激素，例如真正的雌激素化合物，如17-β雌二醇，或雌激素样类固醇（如草药制剂中发现的各种植物雌激素）。示例性植物雌激素包括三萜糖苷。本发明的某些组合物可用于最小化对皮肤的光损伤，而在其它实施方案中，根据本发明的组合物可用于防止或最小化由吸烟引起的对皮肤的不利影响。本发明的方法涉及给予诸如皮肤制剂中的组分。

5. 发明申请

US20060094783A1 Use of R-enantiomer of N-propargyl-1-aminoindan, salts, compositions and uses thereof 审中-公开
标题翻译： N-炔丙基-1-氨基茚满的R-对映异构体的用途，其盐，组合物和用途
公开(公告)号：US20060094783A1
公开(公告)日：2006-05-04
申请号：US11155864
申请日：2005-06-17
申请人： Moussa Youdim , John Finberg , Ruth Levy , Jeffrey Sterling , David Lerner , Tirtsah Berger-Paskin , Haim Yellin , Tzila Yellin , Alex Veinberg , Veinberg Alexander
发明人： Moussa Youdim , John Finberg , Ruth Levy , Jeffrey Sterling , David Lerner , Tirtsah Berger-Paskin , Haim Yellin , Tzila Yellin , Alex Veinberg , Veinberg Alexander
IPC分类号： A61K31/205 , A61K31/135
CPC分类号： C07C211/42 , A61K31/135 , A61K31/195 , A61K31/205 , A61K31/215 , A61K45/06 , C07C211/30 , C07C2602/08 , A61K2300/00
摘要： The subject invention provides methods of treating a subject afflicted with Parkinson's disease, memory disorder, depression, hyperactive syndrome, Attention Deficit Disorder, dementia, brain ischemia, stroke, head trauma injury, spinal trauma injury, neurotrauma, neurodegenerative disease, neurotoxic injury, multiple sclerosis, nerve damage, affective illness, schizophrenia or symptoms of withdrawal from an addictive substance, using the mesylate salt of R(+)-N-propargyl-1-aminoindan.
摘要翻译：本发明提供治疗患有帕金森病，记忆障碍，抑郁症，多动症综合征，注意力缺陷障碍，痴呆，脑缺血，中风，头部损伤，脊髓损伤，神经损伤，神经变性疾病，神经毒性损伤，多发性神经损伤使用R（+） - N-炔丙基-1-氨基茚满的甲磺酸盐，发生硬化，神经损伤，情感疾病，精神分裂症或从成瘾物质中撤出的症状。

6. 发明授权

US07023604B2 Three dimensional optical switches and beam steering modules 有权
标题翻译：三维光开关和光束转向模块
公开(公告)号：US07023604B2
公开(公告)日：2006-04-04
申请号：US09812066
申请日：2001-03-17
申请人： Behrang Behin , Robert Conant , Michael J. Daneman , David Horsley , Meng-Hsiung Kiang , David Lerner , Satinderpall Pannu
发明人： Behrang Behin , Robert Conant , Michael J. Daneman , David Horsley , Meng-Hsiung Kiang , David Lerner , Satinderpall Pannu
IPC分类号： C02B26/00 , C02B26/08 , C02B6/26
CPC分类号： G02B6/3556 , G02B6/3512 , G02B6/3588
摘要： A beam steering module comprised of a mirror stack array in close proximity to a collimator array controllably steers photons along two axis and in a direction substantially less than 90 degrees to the collimator orientation. Several configurations of the module are described using single and double axis mirror rotation and relay optics. Optical telecommunications switches are shown using modules coupled to each other along flat and curved surfaces, with and without use of fold mirror and enabling a plurality of configuration options including photodetector optical power monitoring schemes that require no external power taps.
摘要翻译：光束转向模块包括靠近准直器阵列的反射镜堆叠阵列，其可控制地沿着两个轴线并且沿与准直器取向基本上小于90度的方向导引光子。使用单轴和双轴镜旋转和中继光学器件描述了该模块的几种配置。光通信开关被示出为使用具有和不使用折叠镜的平面和弯曲表面彼此耦合的模块，并且实现多个配置选项，包括不需要外部电源抽头的光电检测器光功率监控方案。

7. 发明申请

US20050197365A1 Diamino thiazoloindan derivatives and their use 审中-公开
标题翻译：二氨基噻唑烷衍生物及其用途
公开(公告)号：US20050197365A1
公开(公告)日：2005-09-08
申请号：US11067110
申请日：2005-02-25
申请人： Jeffrey Sterling , Liat Hayardeny-Nisimov , David Lerner , Yaacov Herzig , Eliezer Falb , Gyorgy Toth , Sandor Molnar , Dalia Pinkert
发明人： Jeffrey Sterling , Liat Hayardeny-Nisimov , David Lerner , Yaacov Herzig , Eliezer Falb , Gyorgy Toth , Sandor Molnar , Dalia Pinkert
IPC分类号： A61K31/428 , C07D277/84
CPC分类号： A61K31/428 , C07C211/42 , C07C211/60 , C07C233/14 , C07C233/41 , C07C271/24 , C07C2602/08 , C07D277/60
摘要： The subject invention provides a compound having the structure: wherein Y is O, NR3R4 or NOR6; R3 is H, alkyl, aralkyl, alkynyl, trifluoroacetyl, t-butoxycarbonyl or an acyl group; R4 is H, alkyl, aralkyl, or alkynyl; R6 is H or C1-C4 alkyl; R1 and R2 are each independently H, alkyl, aralkyl, or alkynyl; the curved line drawn from S to the center of the phenyl ring and the straight line drawn from N to the center of the ring indicate that S and N are part of a 5 membered ring which shares two carbons with the phenyl ring; and the dashed line drawn from the carbon atom on the cyclopentyl ring to Y represents a bond when Y is O or NOR6 and is absent when Y is NR3R4, and wherein wherein X is H or O; and R5 is H, alkyl, trifluoroacetyl, t-butoxycarbonyl or an acyl group, or an enantiomer, or a tautomer, or a pharmaceutically acceptable salt thereof, a process for preparing the compounds and a method of treating Parknison's disease, multiple sclerosis or depression with the compounds of the invention.
摘要翻译：本发明提供具有以下结构的化合物：其中Y为O，NR 3 R 4或NOR 6; R 3是H，烷基，芳烷基，炔基，三氟乙酰基，叔丁氧基羰基或酰基; R 4是H，烷基，芳烷基或炔基; R 6是H或C 1 -C 4烷基; R 1和R 2各自独立地为H，烷基，芳烷基或炔基; 从S到苯环中心的曲线和从N到环的中心的直线表示S和N是与苯环共享两个碳的5元环的一部分; 在Y为O或NOR 6时，从环戊基环上的碳原子取代的虚线表示Y，当Y为NR 3 R时，不存在 > 4，并且其中X是H或O; R 5是H，烷基，三氟乙酰基，叔丁氧基羰基或酰基，或其对映体或其互变异构体或其药学上可接受的盐，该化合物的制备方法和用本发明的化合物治疗帕金森病，多发性硬化或抑郁症。

8. 发明授权

US5786390A Pharmaceutical compositions of the R-enantiomer of N-propargyl -1-aminoindan 失效
标题翻译： N-炔丙基-1-氨基茚满的R-对映异构体的药物组合物
公开(公告)号：US5786390A
公开(公告)日：1998-07-28
申请号：US470161
申请日：1995-06-06
申请人： Moussa B. H. Youdim , John P. M. Finberg , Ruth Levy , Jeffrey Sterling , David Lerner , Tirtsah Berger-Paskin , Haim Yellin , Alex Veinberg
发明人： Moussa B. H. Youdim , John P. M. Finberg , Ruth Levy , Jeffrey Sterling , David Lerner , Tirtsah Berger-Paskin , Haim Yellin , Alex Veinberg
IPC分类号： C07C211/38 , A61K31/00 , A61K31/13 , A61K31/135 , A61K31/195 , A61K31/215 , A61K45/06 , A61P25/00 , A61P25/16 , A61P25/24 , A61P25/28 , C07C209/88 , C07C211/30 , C07C211/42 , C12N9/99
CPC分类号： C07C211/30 , A61K31/135 , A61K31/195 , A61K31/215 , A61K45/06 , C07C211/42 , C07C2102/08
摘要： The subject invention relates to pharmaceutical composition of R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及R（+） - N-炔丙基-1-氨基茚满及其药学上可接受的盐的药物组合物。

9. 发明授权

US5744500A Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof 失效
标题翻译： N-炔丙基-1-氨基茚满的R-对映异构体，其盐及其组合物的用途
公开(公告)号：US5744500A
公开(公告)日：1998-04-28
申请号：US446439
申请日：1995-05-22
申请人： Moussa B. H. Youdim , John P. M. Finberg , Ruth Levy , Jeffrey Sterling , David Lerner , Haim Yellin , Alex Veinberg
发明人： Moussa B. H. Youdim , John P. M. Finberg , Ruth Levy , Jeffrey Sterling , David Lerner , Haim Yellin , Alex Veinberg
IPC分类号： A61P9/10 , A61K20060101 , A61K31/135 , A61K31/136 , A61K31/137 , A61K31/195 , A61K31/215 , A61K45/06 , A61P20060101 , A61P9/00 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , C07C20060101 , C07C211/30 , C07C211/38 , C07C211/42
CPC分类号： C07C211/42 , A61K31/135 , A61K31/195 , A61K31/205 , A61K31/215 , A61K45/06 , C07C211/30 , C07C2102/08
摘要： The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injury, stroke, brain ischemia, a head trauma injury, a spinal trauma injury, neurotrauma, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan.
摘要翻译：本发明提供了R（+） - N-炔丙基-1-氨基茚满及其药学上可接受的盐，以及含有它们的药物组合物。本发明还提供了治疗患有帕金森病，记忆障碍，痴呆，抑郁症，多动症综合征，情感疾病，神经变性疾病，神经毒性损伤，中风，脑缺血，头部外伤损伤，脊髓损伤的受试者的方法使用R（+） - N-炔丙基-1-氨基茚满或本发明的药学上可接受的盐，创伤，神经损伤，精神分裂症，注意力缺陷障碍，多发性硬化或戒断症状。本发明进一步提供一种预防受试者的神经损伤的方法。最后，本发明提供了制备R（+） - N-炔丙基-1-氨基茚满其盐和外消旋的N-炔丙基-1-氨基茚满的方法。

10. 发明授权

US5387612A Use of the R-enantiomers of N-propargyl-1-aminoindan compounds for treating Parkinson's disease 失效
标题翻译： N-炔丙基-1-氨基茚满化合物的R-对映异构体用于治疗帕金森病的用途
公开(公告)号：US5387612A
公开(公告)日：1995-02-07
申请号：US63455
申请日：1993-05-18
申请人： Mussa B. H. Youdim , John P. M. Finberg , Ruth Levy , Jeffrey Sterling , David Lerner , Tirtsah Berger-Paskin , Haim Yellin
发明人： Mussa B. H. Youdim , John P. M. Finberg , Ruth Levy , Jeffrey Sterling , David Lerner , Tirtsah Berger-Paskin , Haim Yellin
IPC分类号： C07C211/38 , A61K31/00 , A61K31/13 , A61K31/135 , A61K31/195 , A61K31/215 , A61K45/06 , A61P25/00 , A61P25/16 , A61P25/24 , A61P25/28 , C07C209/88 , C07C211/30 , C07C211/42 , C12N9/99
CPC分类号： C07C211/30 , A61K31/135 , A61K31/195 , A61K31/215 , A61K45/06 , C07C211/42 , C07C2102/08
摘要： R(+)-N-propargyl-1-aminoindan, its preparation and use and pharmaceutical compositions containing it. The novel compound was found to be useful for the treatment of human patients for Parkinson's disease, memory disorders, dementia of the Alzheimer type (DAT), depression and the hyperactive syndrome.
摘要翻译： R（+） - N-炔丙基-1-氨基茚满，其制备和用途以及含有它的药物组合物。发现该新化合物可用于治疗帕金森病，记忆障碍，阿尔茨海默氏型痴呆（DAT），抑郁症和多动症综合征的人类患者。

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