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1. 发明申请

US20200062768A1 CX3CR1 Small Molecule Antagonists, and Methods Using Same 审中-公开
公开(公告)号：US20200062768A1
公开(公告)日：2020-02-27
申请号：US16610450
申请日：2018-05-01
申请人： Joseph M. SALVINO , Xin FENG , Alessandro FATATIS , Fei SHEN , Olimpia MEUCCI
发明人： Joseph M. SALVINO , Xin FENG , Alessandro FATATIS , Fei SHEN , Olimpia MEUCCI
IPC分类号： C07D487/04 , C07D519/00 , A61P35/00
摘要： The invention provides compounds that are fractalkine receptor agonists and useful in treating, preventing or minimizing metastasis in a subject diagnosed with cancer. The compounds of the invention are further useful in treating central nervous system diseases (such as, but not limited to, HIV Associated Neurocognitive Disorders (HAND), and/or Alzheimer's disease), pain, inflammation (such as, but not limited to, arthritis), cardiovascular disease (such as, but not limited to, undesired vascular smooth muscle proliferation, atherosclerosis, coronary vascular endothelial dysfunction, and/or coronary artery disease), and/or multiple sclerosis.

2. 发明申请

US20140057939A1 5-HT4 RECEPTOR AGONIST COMPOUNDS FOR TREATMENT OF COGNITIVE DISORDERS 审中-公开
标题翻译：用于治疗认知障碍的5-HT4受体激动剂化合物
公开(公告)号：US20140057939A1
公开(公告)日：2014-02-27
申请号：US13771685
申请日：2013-02-20
申请人： David Beattie , Fei Shen , Jacqueline A.M. Smith
发明人： David Beattie , Fei Shen , Jacqueline A.M. Smith
IPC分类号： A61K31/46 , A61K31/4545 , A61K31/445
CPC分类号： A61K31/46 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K45/06 , A61K2300/00
摘要： The invention provides methods for the treatment of cognitive disorders utilizing specific 5-HT4 receptor agonist compounds, in particular, methods utilizing these compounds in combination with other agents, specifically acetylcholinesterase inhibitors, for the treatment of Alzheimer's disease and other cognitive disorders.
摘要翻译：本发明提供了使用特定的5-HT 4受体激动剂化合物治疗认知障碍的方法，特别是利用这些化合物与其它试剂，特别是乙酰胆碱酯酶抑制剂联合用于治疗阿尔茨海默氏病和其他认知障碍的方法。

3. 发明授权

US08506812B2 Method, equipment and specific drawer for membrane separation utilizing concentration polarization 有权
标题翻译：使用浓度极化的膜分离方法，设备和特定抽屉
公开(公告)号：US08506812B2
公开(公告)日：2013-08-13
申请号：US13555668
申请日：2012-07-23
申请人： Yinhua Wan , Xiangrong Chen , Zhiguo Su , Guanghui Ma , Xiaoguang Jiao , Fei Shen , Zhanfeng Cui
发明人： Yinhua Wan , Xiangrong Chen , Zhiguo Su , Guanghui Ma , Xiaoguang Jiao , Fei Shen , Zhanfeng Cui
IPC分类号： B01D33/44 , B01D29/075
CPC分类号： B01D65/08 , B01D61/145 , B01D61/147 , B01D63/082 , B01D2321/26
摘要： The present invention relates to a membrane separation method and a relevant equipment, in particular to a method and an equipment for membrane separation utilizing concentration polarization during membrane filtration process, especially, to a concentration process and equipment and a drawer special for drawing a concentration polarization layer. The direct removal of the concentration polarization layer from membrane surface not only decreases the adverse influence of concentration polarization on membrane separation but also obtains concentrated retention components, thereby significantly improving the ability to maintain membrane flux, solving the twinborn problems concerning concentration polarization and membrane fouling during the membrane separation process, and achieving a high-efficiency concentration for retention components. The method and equipment of the present invention can be widely applied in various membrane techniques, in particular in a membrane separation process for concentrating biomacromolecule and organic micromolecule products such as sugars, organic acids and polypeptides etc.
摘要翻译：本发明涉及一种膜分离方法和相关设备，特别涉及在膜过滤过程中利用浓度极化的膜分离方法和设备，特别涉及浓缩过程和设备以及特别用于绘制浓缩极化的抽屉层。从膜表面直接除去浓缩极化层不仅降低了浓度极化对膜分离的不利影响，而且获得了浓缩的保留成分，从而显着提高了保持膜通量的能力，解决了浓度极化和膜污染的双胎问题在膜分离过程中，并且实现保留成分的高效浓缩。本发明的方法和设备可以广泛地应用于各种膜技术中，特别是在用于浓缩生物大分子和有机小分子产物如糖，有机酸和多肽等的膜分离方法中。

4. 发明申请

US20100166033A1 SEMICONDUCTOR LIGHT-EMITTING DEVICE 有权
标题翻译：半导体发光器件
公开(公告)号：US20100166033A1
公开(公告)日：2010-07-01
申请号：US12347392
申请日：2008-12-31
申请人： Ming-Ta CHIN , Kuo-Feng HUANG , Ping-Fei SHEN , Ching-Jen WANG , Shih-Pang CHANG
发明人： Ming-Ta CHIN , Kuo-Feng HUANG , Ping-Fei SHEN , Ching-Jen WANG , Shih-Pang CHANG
IPC分类号： H01S5/00
CPC分类号： H01S5/343 , B82Y20/00 , H01L33/06 , H01L33/30 , H01S5/0216 , H01S5/0217 , H01S5/309 , H01S5/3407
摘要： A semiconductor light-emitting device includes a substrate, a first cladding layer over the substrate, an active region on the first cladding layer, and a second cladding layer on the active region, wherein the active region includes a first type barrier layer that is doped and a second type barrier layer that is undoped, the first type barrier layer being closer to the first cladding layer than the second type barrier layer.
摘要翻译：一种半导体发光器件，包括：衬底，衬底上的第一覆层，第一覆层上的有源区和有源区上的第二覆层，其中有源区包括掺杂的第一类阻挡层以及不掺杂的第二类型阻挡层，所述第一类型阻挡层比所述第二类型阻挡层更靠近所述第一包覆层。

5. 发明申请

US20100104517A1 Anhydrous Antiperspirant Compositions 审中-公开
标题翻译：无水止汗剂组合物
公开(公告)号：US20100104517A1
公开(公告)日：2010-04-29
申请号：US12603605
申请日：2009-10-22
申请人： Yan-fei Shen
发明人： Yan-fei Shen
IPC分类号： A61K9/12
CPC分类号： A61K8/046 , A61K8/26 , A61K8/28 , A61K8/34 , A61K8/585 , A61K2800/31 , A61Q15/00
摘要： An anhydrous aerosol antiperspirant composition comprising a concentrate comprising at least about 40%, by weight of the concentrate, of an alcohol; an antiperspirant active dissolved in the alcohol; and at least one volatile silicone oil that is miscible in the alcohol and antiperspirant active solution and that has a viscosity of less than 10 centistokes at 25° C.
摘要翻译：一种无水气溶胶止汗组合物，其包含浓缩物，其包含至少约40重量％的浓缩物，醇; 溶于酒精的止汗剂; 和至少一种在醇和止汗活性溶液中可混溶并且在25℃下粘度小于10厘沲的挥发性硅油。

6. 发明授权

US07026329B2 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 失效
公开(公告)号：US07026329B2
公开(公告)日：2006-04-11
申请号：US10319789
申请日：2002-12-13
申请人： Stanley M. Crain , Ke-fei Shen
发明人： Stanley M. Crain , Ke-fei Shen
IPC分类号： A61K31/485
CPC分类号： A61K31/00 , A61K31/485 , A61K38/33 , G01N33/94 , G01N33/9486 , G01N2500/10 , Y10S514/812 , A61K2300/00 , A61K31/4468 , A61K31/135
摘要： This invention relates to a method for selectively enhancing the analgesic potency of a bimodally-acting opioid agonist such as morphine and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects associated with the administration of the bimodally-acting opioid agonist. The method of the present invention comprises administering to a subject an analgesic or sub-analgesic amount of a bimodally-acting opioid agonist such as morphine and an amount of an excitatory opioid receptor antagonist such as naltrexone or nalmefene effective to enhance the analgesic potency of the bimodally-acting opioid agonist and attenuate the anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects of the bimodally-acting opioid agonist.

7. 发明申请

US20050036968A1 Enhanced efficacy antiperspirant compositions containing strontium 有权
公开(公告)号：US20050036968A1
公开(公告)日：2005-02-17
申请号：US10641348
申请日：2003-08-14
申请人： Yan-Fei Shen
发明人： Yan-Fei Shen
IPC分类号： A61K8/19 , A61K8/20 , A61K8/28 , A61K8/44 , A61Q15/00 , A61K7/34
CPC分类号： A61K8/44 , A61K8/19 , A61K8/26 , A61K8/28 , A61K8/365 , A61K2800/58 , A61Q15/00
摘要： The present invention relates to enhanced efficacy antiperspirant salts containing strontium and an amino acid or a hydroxy acid and particularly to stabilized aqueous solutions of such salts. The present invention also embraces methods of making these antiperspirant salts and solutions and compositions containing same.

8. 发明授权

US06737400B2 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists 失效
标题翻译：使用低剂量的阿片受体拮抗剂治疗肠易激综合征的方法和组合物
公开(公告)号：US06737400B2
公开(公告)日：2004-05-18
申请号：US10114909
申请日：2002-04-03
申请人： Stanley M. Crain , Ke-fei Shen , Gerald M. Fleischner
发明人： Stanley M. Crain , Ke-fei Shen , Gerald M. Fleischner
IPC分类号： A61K3800
CPC分类号： A61K31/485 , A61K31/00
摘要： This invention relates to a method for treating a subject with irritable bowel syndrome (“IBS”) which comprises long-term administration of an opioid receptor antagonist at an appropriately low dose which will selectively antagonize excitatory opioid receptor functions, but not inhibitory opioid receptor functions, in myenteric neurons in the intestinal tract as well as in neurons of the central nervous system (“CNS”). The administration of the opioid receptor antagonist at a low dose enhances the potency of the inhibitory effects of endogenous opioid peptides present in the intestinal tract and the CNS, thereby reducing abdominal pain and stool frequency resulting from abnormally supersensitized excitatory opioid receptor functions. The invention also relates to a composition for treating a subject with IBS, which comprises an effective dose of an opioid receptor antagonist, and a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及用于治疗肠易激综合征（“IBS”）的受试者的方法，其包括以适当低剂量长期施用阿片受体拮抗剂，其将选择性拮抗兴奋性阿片受体功能，但不抑制阿片受体功能，在肠道的肠系膜神经元以及中枢神经系统的神经元（“CNS”）中。以低剂量施用阿片样物质受体拮抗剂增强了存在于肠道和CNS中的内源性阿片样物质肽的抑制作用的效力，从而降低了由异常超敏刺激性阿片受体功能引起的腹痛和大便频率。本发明还涉及用IBS治疗受试者的组合物，其包含有效剂量的阿片受体拮抗剂和药学上可接受的载体。

9. 发明授权

US5635155A Hydrothermal synthesis of octahedral molecular sieve 失效
标题翻译：八面体分子筛的水热合成
公开(公告)号：US5635155A
公开(公告)日：1997-06-03
申请号：US712136
申请日：1996-09-11
申请人： Chi-Lin O'Young , Yan-Fei Shen , Richard P. Zerger , Steven L. Suib
发明人： Chi-Lin O'Young , Yan-Fei Shen , Richard P. Zerger , Steven L. Suib
IPC分类号： B01J20/02 , C01B37/00 , C01B39/00 , C01G45/00 , C01G45/02 , C01G45/12
CPC分类号： C01G45/02 , C01B37/00 , C01G45/00 , C01P2002/02 , C01P2002/72 , C01P2002/77 , C01P2002/88
摘要： A process of synthesizing synthetic manganese oxide hydrates having various structures including hollandite and todorokite structure by hydrothermal synthesis. The products have a high degree of crystallinity, and thermal stability.
摘要翻译：通过水热合成合成具有各种结构的合成氧化锰水合物的方法，包括胡萝卜素和硬球形结构。该产品具有高度的结晶度和热稳定性。

10. 发明授权

US5585348A Use of excitatory opioid receptor antagonists to prevent growth factor-induced hyperalgesia 失效
标题翻译：兴奋性阿片样物质受体拮抗剂用于预防生长因子诱导的痛觉过敏
公开(公告)号：US5585348A
公开(公告)日：1996-12-17
申请号：US106401
申请日：1993-08-13
申请人： Stanley M. Crain , Ke-fei Shen , John A. Kessler , Stuart C. Apfel
发明人： Stanley M. Crain , Ke-fei Shen , John A. Kessler , Stuart C. Apfel
IPC分类号： A61K31/00 , A61K31/485 , A61K38/33 , A61K38/00
CPC分类号： A61K31/00 , A61K31/485 , A61K38/33
摘要： This invention relates to a method of preventing hyperalgesia and other undesirable side-effects associated with the administration of growth factor, including nerve growth factor, utilizing an antagonist capable of inactivating excitatory opioid receptor-mediated functions on neurons in the nociceptive pathway. In addition, this invention relates to a composition comprising a growth factor and an antagonist capable of inactivating excitatory opioid receptor-mediated functions on neurons in the nociceptive pathway.
摘要翻译：本发明涉及一种利用能够使兴奋性阿片样物质受体介导的功能在伤害感受途径中的神经元上失活的拮抗剂来预防痛觉过敏和与施用生长因子（包括神经生长因子）相关的其它不期望的副作用的方法。此外，本发明涉及一种组合物，其包含生长因子和能够灭活兴奋性阿片样物质受体介导的伤害感受途径神经元功能的拮抗剂。

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