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1. 发明授权

US09375442B2 Method of treating malignant solid tumors using transcatheter arterial chemoembolization (TACE) 有权
标题翻译：使用经导管动脉化学栓塞（TACE）治疗恶性实体瘤的方法
公开(公告)号：US09375442B2
公开(公告)日：2016-06-28
申请号：US13620313
申请日：2012-09-14
申请人： Liangxuan Zhang , Florencia Lim
发明人： Liangxuan Zhang , Florencia Lim
IPC分类号： A61K9/14 , A61K31/704 , A61K31/407 , A61K33/24 , A61K9/00 , A61K9/50
CPC分类号： A61K31/704 , A61K9/0019 , A61K9/5084 , A61K31/407 , A61K33/24 , A61K2300/00
摘要： This invention is directed to methods of treating solid tumor cancers, particularly refractory cancers by administration of two pluralities of microparticles, one comprising drug-carrying microparticles sized to lodge at the tumor preferably in the capillary bed of the tumor and the other comprising non-drug-carrying microparticles sized to lodge in the arterial system servicing the tumor so as to embolize the tumor.
摘要翻译：本发明涉及通过施用两个多个微粒来治疗实体肿瘤癌症，特别是难治性癌症的方法，一种包含药物载体微粒，其尺寸设置为优选在肿瘤的毛细血管床中提供肿瘤，另一种包括非药物携带的微粒尺寸设置在服务于肿瘤的动脉系统中以栓塞肿瘤。

2. 发明授权

US08661630B2 Coating comprising an amorphous primer layer and a semi-crystalline reservoir layer 有权
标题翻译：包含非晶底漆层和半结晶储层的涂层
公开(公告)号：US08661630B2
公开(公告)日：2014-03-04
申请号：US12124991
申请日：2008-05-21
申请人： Florencia Lim , Mikael Trollsas , Syed F. A. Hossainy , Stephen D. Pacetti
发明人： Florencia Lim , Mikael Trollsas , Syed F. A. Hossainy , Stephen D. Pacetti
IPC分类号： A61L27/54 , A61L27/58 , A61P9/00 , A61P9/10
CPC分类号： A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/606 , Y10T24/258 , C08L67/04
摘要： The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.
摘要翻译：本发明提供一种包含储存层的涂层，其包含半结晶聚合物和在可植入装置上包含无定形聚合物的底漆层及其制备和使用该涂层的方法。

3. 发明申请

US20120121684A1 Coating Comprising A Poly(Ethylene Glycol)-Poly(Lactide-Glycolide-Caprolactone) Interpenetrating Network 审中-公开
标题翻译：包含聚（乙二醇） - 聚（丙交酯 - 乙交酯 - 己内酯）互穿网络的涂料
公开(公告)号：US20120121684A1
公开(公告)日：2012-05-17
申请号：US13356457
申请日：2012-01-23
申请人： Mikael Trollsas , Florencia Lim , Syed F.A. Hossainy
发明人： Mikael Trollsas , Florencia Lim , Syed F.A. Hossainy
IPC分类号： A61F2/82 , A61K31/337 , A61K31/565 , A61K38/44 , A61K31/4468 , A61P9/00 , A61K31/573 , A61K31/506 , A61K31/553 , A61P9/10 , A61P7/02 , A61P7/04 , A61K9/00 , A61K31/436
CPC分类号： A61L31/10 , Y10S623/926 , C08L71/02 , C08L67/04
摘要： Implantable medical devices are disclosed. The devices comprise a coating comprising an interpenetrating network or semi-interpenetrating network. The interpenetrating network or semi-interpenetrating network comprises poly(ethylene glycol) and an aliphatic polyester copolymer. A method of using the implantable device is also provided.
摘要翻译：公开了可植入的医疗装置。这些装置包括包含互穿网络或半互穿网络的涂层。互穿网络或半互穿网络包括聚（乙二醇）和脂族聚酯共聚物。还提供了一种使用可植入装置的方法。

4. 发明授权

US07981244B2 Catheter balloon having impregnated balloon skirt sections 有权
标题翻译：导管球囊已浸渍气囊裙部
公开(公告)号：US07981244B2
公开(公告)日：2011-07-19
申请号：US11585071
申请日：2006-10-23
申请人： Florencia Lim , Jeong S Lee , Edwin Wang
发明人： Florencia Lim , Jeong S Lee , Edwin Wang
IPC分类号： B29C65/00 , B32B37/00
CPC分类号： A61M25/104 , A61L29/06 , A61L29/085 , A61M2025/1075 , C08L79/02 , C08L75/04
摘要： A balloon catheter and a method of making a balloon catheter, having a balloon with a first layer and a second layer, the first layer having at least one impregnated section impregnated with a polymeric material compatible with a polymeric material forming the catheter shaft. At least a portion of the impregnated section is fusion bonded to the shaft. In a presently preferred embodiment, the impregnated section is adjacent to a section of the first layer which is not impregnated with the compatible polymeric material. The impregnated section provides improved bonding of the balloon to the catheter shaft while minimizing the effect of the bond on catheter performance characteristics such as profile and flexibility.
摘要翻译：气囊导管和制造球囊导管的方法，具有具有第一层和第二层的气囊，所述第一层具有浸渍有与形成导管轴的聚合物材料相容的聚合材料的至少一个浸渍部分。浸渍部分的至少一部分熔合在轴上。在目前优选的实施方案中，浸渍的部分邻近第一层的不被相容的聚合物材料浸渍的部分。浸渍部分提供了球囊与导管轴的改善的粘合，同时最小化粘合对导管性能特征如轮廓和柔性的影响。

5. 发明申请

US20070118076A1 Catheter balloon liner with variable thickness and method for making same 审中-公开
标题翻译：导管气球衬垫可变厚度及其制作方法
公开(公告)号：US20070118076A1
公开(公告)日：2007-05-24
申请号：US11642294
申请日：2006-12-20
申请人： Florencia Lim , Edwin Wang
发明人： Florencia Lim , Edwin Wang
IPC分类号： A61M29/00
CPC分类号： A61M25/1029 , A61M25/1034 , A61M2025/1075
摘要： A method of making a catheter balloon, and a balloon catheter formed thereby, in which a layer of a catheter balloon is formed by providing a tubular member to serve as a non porous liner for cooperation with a polymeric tube, and enlarging radially a central or working section of the tubular member such that a first end of the tubular member is smaller in the radial direction with respect to the working section. The tubular member may also have a thickness at the working section that is less than a thickness of the first and second end portions. The first end section of the tubular member is bonded to a catheter shaft having a first outer diameter to form at least a portion of a skirt section of the balloon, and the second end section is bonded to the catheter shaft having a second outer diameter to form a portion of a skirt section, where the skirt sections have an improved high rupture pressure.
摘要翻译：一种制造导管球囊的方法和由此形成的气囊导管，其中通过提供用于与聚合物管配合的无孔衬垫的管状构件形成导管球囊层，并且径向扩大中心或所述管状构件的工作部分使得所述管状构件的第一端相对于所述工作部在径向方向上较小。管状构件还可以具有在工作部分处的厚度小于第一和第二端部的厚度。管状构件的第一端部结合到具有第一外径的导管轴，以形成气囊的裙部的至少一部分，并且第二端部接合到具有第二外径的导管轴形成裙部的一部分，其中裙部具有改善的高破裂压力。

6. 发明授权

US07147817B1 Method of making a low profile balloon 有权
标题翻译：制作低调气球的方法
公开(公告)号：US07147817B1
公开(公告)日：2006-12-12
申请号：US10335484
申请日：2002-12-31
申请人： Florencia Lim , Timothy Owens , Srinivasan Sridharan , Chi Le Long
发明人： Florencia Lim , Timothy Owens , Srinivasan Sridharan , Chi Le Long
IPC分类号： B29C49/22 , B29C49/64
CPC分类号： B29C61/006 , A61M25/0045 , A61M25/1006 , A61M25/1036 , A61M25/1038 , A61M25/104 , A61M2025/1031 , A61M2025/1075 , A61M2025/1081 , B29L2022/025 , B29L2031/7542
摘要： A method of making a catheter balloon or other expandable tubular medical device or component thereof, in which an assembly of heat shrink material on an outer surface of coaxially disposed first and second tubes is heated to radially shrink the heat shrink material and reduce the outer diameter of the first tube. In a presently preferred embodiment, the heat shrink material extends at least along a central section of the first tube to reduce the outer diameter of the first tube at least along the central section of the first tube. The first and second tubes form the outer and inner layers, respectively, of a multilayered balloon, which has an improved low profile outer diameter.
摘要翻译：一种制造导管球囊或其它可扩张的管状医疗装置或其组件的方法，其中在同轴设置的第一和第二管的外表面上的热收缩材料的组件被加热以径向收缩热收缩材料并减小外径的第一管。在目前优选的实施例中，热收缩材料至少沿着第一管的中心部分延伸，以至少沿着第一管的中心部分减小第一管的外径。第一和第二管分别形成多层气囊的外层和内层，其具有改进的低外形外径。

7. 发明授权

US08785382B2 Lipid therapy 失效
标题翻译：脂质治疗
公开(公告)号：US08785382B2
公开(公告)日：2014-07-22
申请号：US11694793
申请日：2007-03-30
申请人： Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
发明人： Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
IPC分类号： A61K38/00 , A61N1/30 , A61M31/00
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/1275 , A61K9/1617 , A61K9/1658 , A61M1/3472 , A61M1/3486 , A61M2202/0456 , A61K2300/00
摘要： A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.
摘要翻译：一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。一种组合物，其包含Apo A1和选择用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。

8. 发明授权

US07892469B2 Method of making a non-compliant balloon for a catheter 有权
标题翻译：为导管制造非顺应性球囊的方法
公开(公告)号：US07892469B2
公开(公告)日：2011-02-22
申请号：US10802225
申请日：2004-03-16
申请人： Florencia Lim , NianJiong Bei , Chi Le Long
发明人： Florencia Lim , NianJiong Bei , Chi Le Long
IPC分类号： B29C47/00 , B29C71/02 , B29C49/04
CPC分类号： A61L29/049 , A61F2/958 , A61M25/1027 , A61M25/1029 , A61M25/104 , A61M29/02 , B29C47/00 , B29C47/0023 , B29C47/065 , B29C55/24 , B29K2075/00 , B29L2022/022 , B29L2031/7542
摘要： An intravascular catheter system for properly implanting a stent in a body lumen generally comprising a catheter having an elongated shaft with an inflatable balloon formed of compliant material and a stent mounted on the working length of the balloon. The balloon material is compliant within the working range of the balloon to provide substantial radial expansion. The wingless radially expansive balloon expands in a uniform manner, thereby producing uniform expansion and implantation of the stent. Another embodiment is directed to a balloon catheter, having a semi-compliant balloon or a noncompliant balloon formed at least in part of a block copolymer.
摘要翻译：一种用于将支架适当地植入体腔内的血管内导管系统，其通常包括具有细长轴的导管，所述导管具有由顺应性材料形成的可膨胀气囊和安装在所述气囊的工作长度上的支架。球囊材料在气球的工作范围内是柔顺的，以提供显着的径向膨胀。无翼状径向膨胀气囊以均匀的方式膨胀，从而产生支架的均匀膨胀和植入。另一个实施方案涉及一种球囊导管，其具有至少部分由嵌段共聚物形成的半顺应性气囊或不合适气囊。

9. 发明申请

US20110020427A1 Method Of Treating Malignant Solid Tumors Using Transcatheter Arterial Chemoembolization (TACE) 有权
标题翻译：使用经导管动脉化学栓塞治疗恶性实体肿瘤的方法（TACE）
公开(公告)号：US20110020427A1
公开(公告)日：2011-01-27
申请号：US12509338
申请日：2009-07-24
申请人： Liangxuan Zhang , Florencia Lim
发明人： Liangxuan Zhang , Florencia Lim
IPC分类号： A61K9/127 , A61K9/50 , A61K31/351
CPC分类号： A61K31/704 , A61K9/0019 , A61K9/5084 , A61K31/407 , A61K33/24 , A61K2300/00
摘要： This invention is directed to methods of treating solid tumor cancers, particularly refractory cancers by administration of two pluralities of microparticles, one comprising drug-carrying microparticles sized to lodge at the tumor preferably in the capillary bed of the tumor and the other comprising non-drug-carrying microparticles sized to lodge in the arterial system servicing the tumor so as to embolize the tumor.
摘要翻译：本发明涉及通过施用两个多个微粒来治疗实体肿瘤癌症，特别是难治性癌症的方法，一种包含药物载体微粒，其尺寸设置为优选在肿瘤的毛细血管床中提供肿瘤，另一种包括非药物携带的微粒尺寸设置在服务于肿瘤的动脉系统中以栓塞肿瘤。

10. 发明申请

US20100047319A1 Biodegradable Poly(Ester-Amide) And Poly(Amide) Coatings For Implantable Medical Devices With Enhanced Bioabsorption Times 审中-公开
标题翻译：可生物降解的聚（酯 - 酰胺）和聚（酰胺）涂层，用于具有增强的生物吸收时间的可植入医疗器械
公开(公告)号：US20100047319A1
公开(公告)日：2010-02-25
申请号：US12196143
申请日：2008-08-21
申请人： Michael Huy Ngo , Syed F. A. Hossainy , Florencia Lim , Mikael O. Trollsas
发明人： Michael Huy Ngo , Syed F. A. Hossainy , Florencia Lim , Mikael O. Trollsas
IPC分类号： A61K9/00
CPC分类号： A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/602 , A61L2300/604 , A61L2420/06 , C08L77/00 , C08L77/12
摘要： This invention is generally related to coating layers for implantable medical devices, such as drug delivery vascular stents, and methods of fabricating coated implantable medical devices. Specifically various embodiments of the present invention include methods of fabricating and modulating of coating layers to enhance bioabsorption. The coating layers include poly(ester-amide) and/or poly(amide) polymers.
摘要翻译：本发明通常涉及用于可植入医疗装置的涂层，例如药物输送血管支架，以及制造涂覆的可植入医疗装置的方法。具体地，本发明的各种实施方案包括制备和调节涂层以增强生物吸收的方法。涂层包括聚（酯 - 酰胺）和/或聚（酰胺）聚合物。

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