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1. 发明授权

US07326238B1 Method and apparatus for treating vulnerable plaque 有权
标题翻译：治疗易损斑块的方法和装置
公开(公告)号：US07326238B1
公开(公告)日：2008-02-05
申请号：US10262149
申请日：2002-09-30
申请人： Deborah Kilpatrick , Murthy Simhambhatla , Santosh Prabhu , Shawn Chin Quee
发明人： Deborah Kilpatrick , Murthy Simhambhatla , Santosh Prabhu , Shawn Chin Quee
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B17/22 , A61B2017/22077 , A61B2017/22082 , A61F2/86 , A61F2/90 , A61F2/958 , A61F2002/075 , A61F2250/0067 , A61L27/3808 , A61L27/3843 , A61L31/16 , A61M25/0084 , A61M29/02 , A61M2025/0086
摘要： An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.
摘要翻译：一种治疗易损斑块的装置和方法。在一个实施方案中，该装置具有治疗闭塞性斑块的医疗装置，并且还适于释放生物活性剂以治疗位于封闭斑块下游的易损斑块。在替代实施例中，该装置具有连接到支架的内表面的可扩张管和接种在可扩张管的内表面上的内皮细胞层。可扩张管屏蔽易损斑块与体腔。

2. 发明申请

US20050287184A1 Drug-delivery stent formulations for restenosis and vulnerable plaque 审中-公开
标题翻译：用于再狭窄和易损斑块的药物输送支架制剂
公开(公告)号：US20050287184A1
公开(公告)日：2005-12-29
申请号：US10881540
申请日：2004-06-29
申请人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
IPC分类号： A61K31/4745 , A61K31/56 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译：提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。支架可用于治疗诸如再狭窄和易损斑块的疾病。

3. 发明申请

US20050222584A1 Device for treating vulnerable plaque 有权
标题翻译：治疗易损斑块的装置
公开(公告)号：US20050222584A1
公开(公告)日：2005-10-06
申请号：US11140240
申请日：2005-05-26
申请人： Deborah Kilpatrick , Robert Ainsworth , Murthy Simhambhatla , Jeong Lee
发明人： Deborah Kilpatrick , Robert Ainsworth , Murthy Simhambhatla , Jeong Lee
IPC分类号： A61F2/06 , A61F2/84 , A61F11/00 , A61M29/00
CPC分类号： A61F2/958 , A61B2017/22081
摘要： A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.
摘要翻译：一种治疗易损斑块的方法，包括使用从无翅未膨胀直径膨胀至有限扩张直径的无翼气球故意破坏或破裂易损斑块。该过程在损伤或破裂部位产生ECM合成的显着增加。因此，该方法可加强易损斑块，同时最大限度地减少或避免对体腔周围壁的损害或损坏被认为是易损斑块的稳定斑块。本发明的方法特别可用于治疗纤维腺瘤型易损斑块。在一个实施例中，气囊是自限制性的，使得其在初始充气压力下顺应地膨胀，并且在额定压力之上，其膨胀不顺利。在替代实施例中，使用直径限制装置（例如限制气囊中的充气压力或膨胀流体的体积的装置）使球囊膨胀。

4. 发明授权

US07329223B1 Catheter with optical fiber sensor 有权
标题翻译：导管与光纤传感器
公开(公告)号：US07329223B1
公开(公告)日：2008-02-12
申请号：US09872310
申请日：2001-05-31
申请人： Robert Ainsworth , Deborah Kilpatrick , Jeong S. Lee , Bridget A. Hurley , Jeffrey T. Ellis
发明人： Robert Ainsworth , Deborah Kilpatrick , Jeong S. Lee , Bridget A. Hurley , Jeffrey T. Ellis
IPC分类号： A61B5/00
CPC分类号： A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/02154 , A61B5/1459 , A61B5/6853 , A61B2017/22001
摘要： An apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment, the apparatus includes an intravascular device to perform a therapeutic treatment and at least one optical fiber disposed through the intravascular device. The optical fiber is configured to provide diagnostic information before, during, and after the therapeutic treatment. In an embodiment, diagnostic information includes vessel and blood characteristics such as hemodynamic characteristics, hematological parameters related to blood and blood components, and thermal parameters of the vasculature.
摘要翻译：通过使用其中设置有光纤的血管内装置来对患者的脉管系统进行治疗处理和诊断的装置和方法。在一个实施例中，该装置包括执行治疗性处理的血管内装置和通过血管内装置设置的至少一个光纤。光纤被配置为在治疗之前，期间和之后提供诊断信息。在一个实施方案中，诊断信息包括血管和血液特征，例如血液动力学特征，与血液和血液成分有关的血液学参数，以及脉管系统的热参数。

5. 发明申请

US20060129041A1 Guidewire with chemical sensing capabilities 有权
公开(公告)号：US20060129041A1
公开(公告)日：2006-06-15
申请号：US11346771
申请日：2006-02-03
申请人： Jeffrey Ellis , Robert Ainsworth , Deborah Kilpatrick , Alex Tilson , Bridget Hurley
发明人： Jeffrey Ellis , Robert Ainsworth , Deborah Kilpatrick , Alex Tilson , Bridget Hurley
IPC分类号： A61B5/00 , A61B5/05 , A61M25/00
CPC分类号： A61B5/14542 , A61B5/14552 , A61B5/1459 , A61B5/6851
摘要： A guidewire with a sensor which can detect NO and/or superoxide levels is disclosed. This invention can be useful for in vivo analysis of vascular health.

6. 发明授权

US08785382B2 Lipid therapy 失效
标题翻译：脂质治疗
公开(公告)号：US08785382B2
公开(公告)日：2014-07-22
申请号：US11694793
申请日：2007-03-30
申请人： Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
发明人： Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
IPC分类号： A61K38/00 , A61N1/30 , A61M31/00
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/1275 , A61K9/1617 , A61K9/1658 , A61M1/3472 , A61M1/3486 , A61M2202/0456 , A61K2300/00
摘要： A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.
摘要翻译：一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。一种组合物，其包含Apo A1和选择用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。

7. 发明授权

US07783338B2 Catheter with optical fiber sensor 有权
标题翻译：导管与光纤传感器
公开(公告)号：US07783338B2
公开(公告)日：2010-08-24
申请号：US12008381
申请日：2008-01-09
申请人： Robert Ainsworth , Deborah Kilpatrick , Jeong S. Lee , Bridget A. Hurley , Jeffrey T. Ellis
发明人： Robert Ainsworth , Deborah Kilpatrick , Jeong S. Lee , Bridget A. Hurley , Jeffrey T. Ellis
IPC分类号： A61B5/00
CPC分类号： A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/02154 , A61B5/1459 , A61B5/6853 , A61B2017/22001
摘要： An apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment, the apparatus includes an intravascular device to perform a therapeutic treatment and at least one optical fiber disposed through the intravascular device. The optical fiber is configured to provide diagnostic information before, during, and after the therapeutic treatment. In an embodiment, diagnostic information includes vessel and blood characteristics such as hemodynamic characteristics, hematological parameters related to blood and blood components, and thermal parameters of the vasculature.
摘要翻译：通过使用其中设置有光纤的血管内装置来对患者的脉管系统进行治疗处理和诊断的装置和方法。在一个实施例中，该装置包括执行治疗性处理的血管内装置和通过血管内装置设置的至少一个光纤。光纤被配置为在治疗之前，期间和之后提供诊断信息。在一个实施方案中，诊断信息包括血管和血液特征，例如血液动力学特征，与血液和血液成分有关的血液学参数，以及脉管系统的热参数。

8. 发明申请

US20080139897A1 Catheter with optical fiber sensor 有权
公开(公告)号：US20080139897A1
公开(公告)日：2008-06-12
申请号：US12008381
申请日：2008-01-09
申请人： Robert D. Ainsworth , Deborah Kilpatrick , Jeong S. Lee , Bridget A. Hurley , Jeffrey T. Ellis
发明人： Robert D. Ainsworth , Deborah Kilpatrick , Jeong S. Lee , Bridget A. Hurley , Jeffrey T. Ellis
IPC分类号： A61B5/00 , A61M29/02
CPC分类号： A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/02154 , A61B5/1459 , A61B5/6853 , A61B2017/22001
摘要： An apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment, the apparatus includes an intravascular device to perform a therapeutic treatment and at least one optical fiber disposed through the intravascular device. The optical fiber is configured to provide diagnostic information before, during, and after the therapeutic treatment. In an embodiment, diagnostic information includes vessel and blood characteristics such as hemodynamic characteristics, hematological parameters related to blood and blood components, and thermal parameters of the vasculature.

9. 发明申请

US20070232539A1 LIPID THERAPY 失效
标题翻译：脂肪疗法
公开(公告)号：US20070232539A1
公开(公告)日：2007-10-04
申请号：US11694793
申请日：2007-03-30
申请人： Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
发明人： Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/1275 , A61K9/1617 , A61K9/1658 , A61M1/3472 , A61M1/3486 , A61M2202/0456 , A61K2300/00
摘要： A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.
摘要翻译：一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。一种组合物，其包含Apo A1和选择用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。

10. 发明申请

US20060135943A1 Method and apparatus for treating vulnerable plaque 审中-公开
公开(公告)号：US20060135943A1
公开(公告)日：2006-06-22
申请号：US11283032
申请日：2005-11-17
申请人： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy
发明人： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy
IPC分类号： A61M31/00
CPC分类号： A61M25/0084 , A61B2017/22081 , A61M25/0026 , A61M25/1006 , A61M2025/0096
摘要： An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.

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