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1. 发明授权

US08597644B2 Method for treating psoriasis by administering an antibody to interleukin-6 receptor 有权
标题翻译：通过给白细胞介素-6受体的抗体治疗银屑病的方法
公开(公告)号：US08597644B2
公开(公告)日：2013-12-03
申请号：US11947267
申请日：2007-11-29
申请人： Hiroaki Ito , Kazuyuki Yoshizaki , Norihiro Nishimoto , Tadamitsu Kishimoto , Shin Shimaoka , Hidetomo Kitamura , Masamichi Sugimoto , Kenichi Akamatsu
发明人： Hiroaki Ito , Kazuyuki Yoshizaki , Norihiro Nishimoto , Tadamitsu Kishimoto , Shin Shimaoka , Hidetomo Kitamura , Masamichi Sugimoto , Kenichi Akamatsu
IPC分类号： A61K39/395
CPC分类号： C07K16/248 , A61K2039/505 , C07K16/2866
摘要： A method for treating psoriasis comprising an interleukin-6 (IL-6) antagonist such as, for example, an antibody against IL-6 receptor.
摘要翻译：一种治疗银屑病的方法，其包含白细胞介素-6（IL-6）拮抗剂，例如针对IL-6受体的抗体。

2. 发明授权

US07037717B1 Cell line and screening method with the use of the same 失效
标题翻译：细胞系和筛选方法使用相同
公开(公告)号：US07037717B1
公开(公告)日：2006-05-02
申请号：US09380372
申请日：1998-03-06
申请人： Hidetomo Kitamura
发明人： Hidetomo Kitamura
IPC分类号： C12N5/00
CPC分类号： G01N33/5073 , C12N5/0663 , C12N2503/02 , G01N33/5008 , G01N33/502 , G01N33/5026 , G01N33/5088
摘要： An object of the present invention is to establish a clonal cell line of undifferentiated mesenchymal cells capable of differentiating into chondrocytes and adipocytes from a normal adult animal and to establish a screening method for cell differentiation-controlling materials. According to the present invention, cell lines capable of differentiating into chondrocytes and adipocytes, which are derived from normal adult animals; screening methods for cell differentiation-controlling materials using said cell lines; screening kits comprising said cell lines; cell differentiation-controlling materials obtained by said screening methods; and drugs containing said differentiation-controlling materials are provided.
摘要翻译：本发明的目的是建立能够从正常成年动物分化成软骨细胞和脂肪细胞的未分化间充质细胞的克隆细胞系，并建立细胞分化控制材料的筛选方法。根据本发明，能够分化成来自正常成年动物的软骨细胞和脂肪细胞的细胞系; 使用所述细胞系的细胞分化控制材料的筛选方法; 包含所述细胞系的筛选试剂盒; 通过所述筛选方法获得的细胞分化控制材料; 并提供含有所述分化控制材料的药物。

3. 发明申请

US20100055092A1 Preventive or Remedy for Inflammatory Disease 有权
标题翻译：预防或治疗炎症性疾病
公开(公告)号：US20100055092A1
公开(公告)日：2010-03-04
申请号：US12303684
申请日：2007-06-08
申请人： Masakazu Hasegawa , Hidetomo Kitamura , Hideki Adachi , Keiko Kasutani
发明人： Masakazu Hasegawa , Hidetomo Kitamura , Hideki Adachi , Keiko Kasutani
IPC分类号： A61K39/395 , C07K16/00 , A61P29/00
CPC分类号： C07K16/2866 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K14/54 , C07K14/715 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present inventors obtained, from a phage library of human antibodies, an anti-mouse NR 10 neutralizing antibody-expressing BM095 clone that shows a strong proliferation-suppressing activity in an IL-31-dependent Ba/F3 cell proliferation assay system. When this anti-mouse NR 10 neutralizing antibody was administered to NC/Nga mice, a model of atopic dermatitis which is a mouse model of chronic dermatitis that arises as a result of repeated applications of picryl chloride, a mouse model of rheumatoid arthritis, and a mouse model of osteoarthritis, a significant effect of symptom suppression was observed. This revealed that the anti-NR 10 neutralizing antibody is indeed effective as a therapeutic agent for inflammatory diseases. In addition, the present inventors successfully obtained an anti-human NR 10 neutralizing antibody, providing extremely useful therapeutic agents with practical clinical applications.
摘要翻译：本发明人从人抗体的噬菌体文库获得了在IL-31依赖性Ba / F3细胞增殖分析系统中显示出强的增殖抑制活性的抗小鼠NR10中和抗体表达BM095克隆。当向NC / Nga小鼠施用这种抗小鼠NR 10中和抗体时，是由于重复使用苦基氯，类风湿性关节炎的小鼠模型和由此引起的慢性皮炎小鼠模型的特应性皮炎模型观察到骨关节炎的小鼠模型，观察到症状抑制的显着作用。这表明抗NR10中和抗体确实作为炎性疾病的治疗剂有效。此外，本发明人成功地获得了抗人NR10中和抗体，其具有实用的临床应用的非常有用的治疗剂。

4. 发明授权

US07642243B2 Method of treating arthritis and promoting growth of articular chondrocytes 有权
标题翻译：治疗关节炎和促进关节软骨细胞生长的方法
公开(公告)号：US07642243B2
公开(公告)日：2010-01-05
申请号：US10594920
申请日：2005-03-31
申请人： Kazuwa Nakao , Hidetomo Kitamura
发明人： Kazuwa Nakao , Hidetomo Kitamura
IPC分类号： A61K38/22 , A61K38/10 , C07K14/575 , C07K7/08
CPC分类号： A61K38/2242
摘要： This invention provides a new therapeutic or prophylactic agent for arthritis such as osteoarthritis. Specifically, it provides a therapeutic or prophylactic agent for arthritis such as osteoarthritis, or an agent for promoting the growth of articular chondrocyte, comprising a guanyl cyclase B (GC-B) activator as an active ingredient; or a method for inhibiting arthritis or for promoting the growth of articular chondrocyte by activating GC-B; or a method for screening an agent for promoting the growth of articular chondrocyte or an agent capable of treating arthritis using the GC-B activity as an indication.
摘要翻译：本发明提供了关节炎如骨关节炎的新型治疗或预防剂。具体地说，本发明提供了关节炎如骨关节炎或促进关节软骨细胞生长的试剂的治疗或预防剂，其包含鸟苷酰环化酶B（GC-B）活化剂作为活性成分; 或通过活化GC-B抑制关节炎或促进关节软骨细胞生长的方法; 或用于筛选用于促进关节软骨细胞生长的药剂或能够使用GC-B活性治疗关节炎的药剂作为适应症的方法。

5. 发明申请

US20080124325A1 PREVENTIVE OR THERAPEUTIC AGENT FOR PSORIASIS COMPRISING IL-6 ANTAGONIST AS ACTIVE INGREDIENT 有权
标题翻译：用于包含IL-6拮抗剂作为活性成分的PSORIASIS的预防或治疗剂
公开(公告)号：US20080124325A1
公开(公告)日：2008-05-29
申请号：US11947267
申请日：2007-11-29
申请人： Hiroaki Ito , Kazuyuki Yoshizaki , Norihiro Nishimoto , Tadamitsu Kishimoto , Shin Shimaoka , Hidetomo Kitamura , Masamichi Sugimoto , Kenichi Akamatsu
发明人： Hiroaki Ito , Kazuyuki Yoshizaki , Norihiro Nishimoto , Tadamitsu Kishimoto , Shin Shimaoka , Hidetomo Kitamura , Masamichi Sugimoto , Kenichi Akamatsu
IPC分类号： A61K39/395 , A61P17/06
CPC分类号： C07K16/248 , A61K2039/505 , C07K16/2866
摘要： A method for treating psoriasis comprising an interleukin-6 (IL-6) antagonist such as, for example, an antibody against IL-6 receptor.
摘要翻译：一种治疗银屑病的方法，其包含白细胞介素-6（IL-6）拮抗剂，例如针对IL-6受体的抗体。

6. 发明授权

US08815803B2 Method for increasing body height comprising systemic administration of CNP-53 有权
标题翻译：包括CNP-53的全身给药的增加体高的方法
公开(公告)号：US08815803B2
公开(公告)日：2014-08-26
申请号：US10594763
申请日：2005-03-31
申请人： Kazuwa Nakao , Akihiro Yasoda , Hidetomo Kitamura
发明人： Kazuwa Nakao , Akihiro Yasoda , Hidetomo Kitamura
IPC分类号： A61K38/22 , A61P19/08 , C07K14/475
CPC分类号： A61K38/2242 , C12Q1/527 , G01N33/6887 , G01N2500/04
摘要： This invention provides a composition for increasing a body height of a patient with short stature or an individual other than patients with short stature. More specifically, the invention provides: a composition for increasing the body height of an individual comprising a guanyl cyclase B (GC-B) activator as an active ingredient, the composition being to be administered to an individual free from FGFR3 abnormality; a method for increasing the body height of an individual free from FGFR3 abnormality which comprises activating GC-B; a method for screening an agent for increasing the body height of an individual which comprises selecting an agent for increasing the body height using GC-B activity as an indication; and a method for extending a cartilage bone free from FGFR3 abnormality which comprises activating GC-B in an individual.
摘要翻译：本发明提供了用于增加身材矮小的患者身体的身高或身材矮小的患者的组合物。更具体地，本发明提供：用于增加包含鸟苷酸环化酶B（GC-B）活化剂的个体的身高的组合物作为活性成分，该组合物施用于没有FGFR3异常的个体; 增加不含FGFR3异常的个体的体高的方法，其包括激活GC-B; 用于筛选用于增加个体身高的试剂的方法，其包括使用GC-B活性选择用于增加身高的试剂作为指示; 以及用于延伸无FGFR3异常的软骨的方法，其包括激活个体中的GC-B。

7. 发明授权

US08658373B2 Method of screening for an agent for treating arthritis and promoting growth of articular chondrocytes 有权
标题翻译：筛选用于治疗关节炎并促进关节软骨细胞生长的药物的方法
公开(公告)号：US08658373B2
公开(公告)日：2014-02-25
申请号：US12623936
申请日：2009-11-23
申请人： Kazuwa Nakao , Hidetomo Kitamura
发明人： Kazuwa Nakao , Hidetomo Kitamura
IPC分类号： G01N33/53 , C07K14/705
CPC分类号： A61K38/2242
摘要： This invention provides a new therapeutic or prophylactic agent for arthritis such as osteoarthritis. Specifically, it provides a therapeutic or prophylactic agent for arthritis such as osteoarthritis, or an agent for promoting the growth of articular chondrocyte, comprising a guanyl cyclase B (GC-B) activator as an active ingredient; or a method for inhibiting arthritis or for promoting the growth of articular chondrocyte by activating GC-B; or a method for screening an agent for promoting the growth of articular chondrocyte or an agent capable of treating arthritis using the GC-B activity as an indication.
摘要翻译：本发明提供了关节炎如骨关节炎的新型治疗或预防剂。具体地说，它提供了关节炎如骨关节炎或促进关节软骨细胞生长的药物的治疗或预防剂，其包含脯氨酰环化酶B（GC-B）活化剂作为活性成分; 或通过活化GC-B抑制关节炎或促进关节软骨细胞生长的方法; 或用于筛选用于促进关节软骨细胞生长的药剂或能够使用GC-B活性治疗关节炎的药剂作为适应症的方法。

8. 发明申请

US20100310556A1 THERAPEUTIC AGENT FOR PRURITUS 有权
标题翻译： PRURITUS治疗剂
公开(公告)号：US20100310556A1
公开(公告)日：2010-12-09
申请号：US12746229
申请日：2008-12-05
申请人： Yoshinobu Higuchi , Keiko Kasutani , Hidetomo Kitamura , Masakazu Hasegawa
发明人： Yoshinobu Higuchi , Keiko Kasutani , Hidetomo Kitamura , Masakazu Hasegawa
IPC分类号： A61K39/395
CPC分类号： C07K16/2869 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/76
摘要： The present inventors isolated clone BM095 from a human antibody phage library, which had a strong growth inhibitory activity in the IL-31-dependent Ba/F3 cell growth assay system. When administered to pruritus model mice, the anti-mouse NR10 neutralizing antibody exhibited a marked symptom-suppressing effect. Thus, it was revealed that anti-NR10 neutralizing antibodies are useful as therapeutic agents for pruritus.
摘要翻译：本发明人从人抗体噬菌体文库中分离克隆BM095，其在IL-31依赖性Ba / F3细胞生长测定系统中具有强的生长抑制活性。当施用于瘙痒模型小鼠时，抗小鼠NR10中和抗体表现出明显的症状抑制作用。因此，显示抗NR10中和抗体可用作瘙痒的治疗剂。

9. 发明申请

US20080312142A1 Composition for Increasing Body Height 有权
标题翻译：用于增加身高的组合
公开(公告)号：US20080312142A1
公开(公告)日：2008-12-18
申请号：US10594763
申请日：2005-03-31
申请人： Kazuwa Nakao , Akihiro Yasoda , Hidetomo Kitamura
发明人： Kazuwa Nakao , Akihiro Yasoda , Hidetomo Kitamura
IPC分类号： A61K38/17 , C07K2/00 , C12Q1/00 , C12Q1/68 , A61P19/00 , C12Q1/02 , C07K14/435
CPC分类号： A61K38/2242 , C12Q1/527 , G01N33/6887 , G01N2500/04
摘要： This invention provides a composition for increasing a body height of a patient with short stature or an individual other than patients with short stature. More specifically, the invention provides: a composition for increasing the body height of an individual comprising a guanyl cyclase B (GC-B) activator as an active ingredient, the composition being to be administered to an individual free from FGFR3 abnormality; a method for increasing the body height of an individual free from FGFR3 abnormality which comprises activating GC-B; a method for screening an agent for increasing the body height of an individual which comprises selecting an agent for increasing the body height using GC-B activity as an indication; and a method for extending a cartilage bone free from FGFR3 abnormality which comprises activating GC-B in an individual.
摘要翻译：本发明提供了用于增加身材矮小的患者身体的身高或身材矮小的患者的组合物。更具体地，本发明提供：用于增加包含鸟苷酸环化酶B（GC-B）活化剂的个体的身高的组合物作为活性成分，该组合物施用于没有FGFR3异常的个体; 增加不含FGFR3异常的个体的体高的方法，其包括激活GC-B; 用于筛选用于增加个体身高的试剂的方法，其包括使用GC-B活性选择用于增加身高的试剂作为指示; 以及用于延伸无FGFR3异常的软骨的方法，其包括激活个体中的GC-B。

10. 发明授权

US07320792B2 Preventives or remedies for psoriasis containing as the active ingredient IL-6 antagonist 有权
标题翻译：含有作为活性成分IL-6拮抗剂的牛皮癣的预防或补救措施
公开(公告)号：US07320792B2
公开(公告)日：2008-01-22
申请号：US10399979
申请日：2001-10-25
申请人： Hiroaki Ito , Kazuyuki Yoshizaki , Norihiro Nishimoto , Tadamitsu Kishimoto , Shin Shimaoka , Hidetomo Kitamura , Masamichi Sugimoto , Kenichi Akamatsu
发明人： Hiroaki Ito , Kazuyuki Yoshizaki , Norihiro Nishimoto , Tadamitsu Kishimoto , Shin Shimaoka , Hidetomo Kitamura , Masamichi Sugimoto , Kenichi Akamatsu
IPC分类号： A61K39/395
CPC分类号： C07K16/248 , A61K2039/505 , C07K16/2866
摘要： A preventive and therapeutic agent for psoriasis comprising an interleukin-6 (IL-6) antagonist such as, for example, an antibody against IL-6 receptor.
摘要翻译：一种银屑病预防和治疗剂，其包含白细胞介素-6（IL-6）拮抗剂，例如针对IL-6受体的抗体。

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