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1. 发明专利

JP2009092508A Method for predicting effect of rheumatic therapeutic agent 审中-公开
标题翻译：预防治疗效果的方法
公开(公告)号：JP2009092508A
公开(公告)日：2009-04-30
申请号：JP2007263300
申请日：2007-10-09
申请人： Chugai Pharmaceut Co Ltd , Dna Chip Research Inc , Kyo Mima , Norihiro Nishimoto , 中外製薬株式会社 , 株式会社Dnaチップ研究所 , 亨美馬 , 憲弘西本
发明人： NISHIMOTO NORIHIRO , MIMA KYO , MATSUBARA KENICHI , KAWADA YUICHI
IPC分类号： G01N33/53 , A61K39/395 , A61P29/00
摘要： PROBLEM TO BE SOLVED: To provide a method for predicting a curative effect of a rheumatic therapeutic agent before the rheumatic therapeutic agent is given.
SOLUTION: The method for predicting the effect of the rheumatic therapeutic agent is disclosed, and measures a manifestation of one or genes selected from a gene group having base sequences described as sequence numbers 1-196 or their complementary sequences. The method for predicting an effect of an anti-IL-6 receptor antibody on an IL-6 related disorder is also disclosed. The method can be implemented by the steps (a)-(c): The step (a) of providing a sample obtained from a rheumatic patient. The step (b) of measuring the manifestation of one or genes selected from the gene group having the base sequences described as sequence numbers 1-196 or their complementary sequences in the sample provided in the step (a). The step (c) of comparing the manifestation of the genes measured in the step (b) with the manifestation of the genes in the comparison sample obtained from a healthy subject.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种在给予风湿性治疗剂之前预测风湿治疗剂的疗效的方法。公开了用于预测风湿性治疗剂的作用的方法，并且测量了选自具有描述为序列号1-196的碱基序列的基因组或其互补序列的一个或多个基因的表现。还公开了用于预测抗IL-6受体抗体对IL-6相关病症的作用的方法。该方法可以通过步骤（a） - （c）来实现：提供从风湿病人获得的样品的步骤（a）。测量在步骤（a）中提供的具有序列号1-196的碱基序列的基因组或其互补序列中选出的一个或多个基因的表现的步骤（b）。将步骤（b）中测量的基因的表现与从健康受试者获得的比较样品中的基因的表现进行比较的步骤（c）。版权所有（C）2009，JPO＆INPIT

2. 发明授权

US08617550B2 Treatment of vasculitis with IL-6 antagonist 有权
标题翻译：用IL-6拮抗剂治疗血管炎
公开(公告)号：US08617550B2
公开(公告)日：2013-12-31
申请号：US10596429
申请日：2004-12-17
申请人： Norihiro Nishimoto , Tadamitsu Kishimoto , Hideko Nakahara
发明人： Norihiro Nishimoto , Tadamitsu Kishimoto , Hideko Nakahara
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： To provide a preventive and/or therapeutic agent for vasculitis such as polyarteritis nodosa, the aortitis syndrome, and a vasculitis that is associated with immunological abnormalities, said agent comprising an interleukin-6 (IL-6) antagonist as an active ingredient.
摘要翻译：为了提供血管炎的预防和/或治疗剂，例如结节性多动脉炎，主动脉炎综合征和与免疫学异常相关的血管炎，所述药物包含白细胞介素-6（IL-6）拮抗剂作为活性成分。

3. 发明授权

US08562990B2 Method of treating psoriatic arthritis with an IL-6 receptor antibody 有权
标题翻译：用IL-6受体抗体治疗银屑病关节炎的方法
公开(公告)号：US08562990B2
公开(公告)日：2013-10-22
申请号：US13160800
申请日：2011-06-15
申请人： Hiroaki Ito , Kazuyuki Yoshizaki , Norihiro Nishimoto , Tadamitsu Kishimoto , Shin Shimaoka , Hidetomo Kitamura , Masamichi Sugimoto , Kenichi Akamatsu
发明人： Hiroaki Ito , Kazuyuki Yoshizaki , Norihiro Nishimoto , Tadamitsu Kishimoto , Shin Shimaoka , Hidetomo Kitamura , Masamichi Sugimoto , Kenichi Akamatsu
IPC分类号： A61K39/395
CPC分类号： C07K16/248 , A61K2039/505 , C07K16/2866
摘要： A method for treating psoriatic arthritis comprising an interleukin-6 (IL-6) antagonist such as, for example, an antibody against IL-6 receptor.
摘要翻译：一种治疗银屑病关节炎的方法，包括白细胞介素-6（IL-6）拮抗剂，例如抗IL-6受体的抗体。

4. 发明申请

US20100008907A1 MUSCLE REGENERATION PROMOTER 有权
标题翻译：肌肉再生促进剂
公开(公告)号：US20100008907A1
公开(公告)日：2010-01-14
申请号：US12296193
申请日：2007-04-06
申请人： Norihiro Nishimoto , Yoshinobu Ohira
发明人： Norihiro Nishimoto , Yoshinobu Ohira
IPC分类号： A61K39/395 , A61P21/00
CPC分类号： C07K16/248 , A61K38/204 , A61K2039/505 , C07K16/2866
摘要： The present inventors studied the effects of inhibiting the IL-6 signaling pathway on muscle cell growth. As a result, they discovered that, administering an IL-6 inhibitor can promote the adhesion, proliferation, and differentiation of satellite cells and therefore muscle regeneration.
摘要翻译：本发明人研究了抑制IL-6信号通路对肌细胞生长的作用。结果发现，施用IL-6抑制剂可以促进卫星细胞的粘附，增殖和分化，从而促进肌肉再生。

5. 发明申请

US20070148169A1 Therapeutic agent for chronic arthritides diseases of childhood-related diseases 有权
标题翻译：慢性关节炎的治疗剂儿童相关疾病的疾病
公开(公告)号：US20070148169A1
公开(公告)日：2007-06-28
申请号：US11704233
申请日：2007-02-09
申请人： Kazuyuki Yoshizaki , Norihiro Nishimoto , Masahiro Iwamoto , Seiji Minota , Shumpei Yokota , Takako Miyamae
发明人： Kazuyuki Yoshizaki , Norihiro Nishimoto , Masahiro Iwamoto , Seiji Minota , Shumpei Yokota , Takako Miyamae
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K9/0019 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/248 , C07K2317/14 , C07K2317/24 , C07K2317/76 , Y10S514/825
摘要： A therapeutic agent for chronic arthritides diseases of childhood-related diseases, for example chronic arthritides diseases of childhood, Still's disease and the like, comprising an interleukin-6 (IL-6) antagonist as an active ingredient.
摘要翻译：儿童相关疾病慢性关节炎疾病的治疗剂，例如儿童慢性关节炎疾病，Still氏病等，其包含白细胞介素-6（IL-6）拮抗剂作为活性成分。

6. 发明申请

US20070098714A1 Preventive agent for vasculitis 有权
标题翻译：血管炎预防剂
公开(公告)号：US20070098714A1
公开(公告)日：2007-05-03
申请号：US10596429
申请日：2004-12-17
申请人： Norihiro Nishimoto , Tadamitsu Kishimoto , Hideko Nakahara
发明人： Norihiro Nishimoto , Tadamitsu Kishimoto , Hideko Nakahara
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： To provide a preventive and/or therapeutic agent for vasculitis such as polyarteritis nodosa, the aortitis syndrome, and a vasculitis that is associated with immunological abnormalities, said agent comprising an interleukin-6 (IL-6) antagonist as an active ingredient.
摘要翻译：为了提供血管炎的预防和/或治疗剂，例如结节性多动脉炎，主动脉炎综合征和与免疫学异常相关的血管炎，所述药物包含白细胞介素-6（IL-6）拮抗剂作为活性成分。

7. 发明授权

US08173126B2 Blood VEGF level-lowering agent containing IL-6 antagonist as the active ingredient 有权
标题翻译：血液中VEGF含量降低剂含有IL-6拮抗剂作为活性成分
公开(公告)号：US08173126B2
公开(公告)日：2012-05-08
申请号：US11812296
申请日：2007-06-18
申请人： Kazuyuki Yoshizaki , Norihiro Nishimoto
发明人： Kazuyuki Yoshizaki , Norihiro Nishimoto
IPC分类号： A61K39/395 , A61P7/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/248
摘要： A blood vascular endothelial growth factor (VEGF) level-lowering agent comprising an interleukin-6 (IL-6) antagonist as an active ingredient.
摘要翻译：包含白细胞介素-6（IL-6）拮抗剂作为活性成分的血管内皮生长因子（VEGF）水平降低剂。

8. 发明申请

US20110268734A1 PREVENTIVE OR THERAPEUTIC AGENT FOR PSORIATIC ARTHRITIS COMPRISING IL-6 ANTAGONIST AS ACTIVE INGREDIENT 有权
标题翻译：包含IL-6拮抗剂作为活性成分的PSORIATIC ARTHRITIS的预防或治疗药物
公开(公告)号：US20110268734A1
公开(公告)日：2011-11-03
申请号：US13160800
申请日：2011-06-15
申请人： Hiroaki Ito , Kazuyuki Yoshizaki , Norihiro Nishimoto , Tadamitsu Kishimoto , Shin Shimaoka , Hidetomo Kitamura , Masamichi Sugimoto , Kenichi Akamatsu
发明人： Hiroaki Ito , Kazuyuki Yoshizaki , Norihiro Nishimoto , Tadamitsu Kishimoto , Shin Shimaoka , Hidetomo Kitamura , Masamichi Sugimoto , Kenichi Akamatsu
IPC分类号： A61K39/395 , A61P17/06
CPC分类号： C07K16/248 , A61K2039/505 , C07K16/2866
摘要： A method for treating psoriatic arthritis comprising an interleukin-6 (IL-6) antagonist such as, for example, an antibody against IL-6 receptor.
摘要翻译：一种治疗银屑病关节炎的方法，包括白细胞介素-6（IL-6）拮抗剂，例如针对IL-6受体的抗体。

9. 发明授权

US07955598B2 Therapeutic agent for chronic arthritides diseases of childhood-related diseases 有权
标题翻译：慢性关节炎的治疗剂儿童相关疾病的疾病
公开(公告)号：US07955598B2
公开(公告)日：2011-06-07
申请号：US11704233
申请日：2007-02-09
申请人： Kazuyuki Yoshizaki , Norihiro Nishimoto , Masahiro Iwamoto , Seiji Minota , Shumpei Yokota , Takako Miyamae
发明人： Kazuyuki Yoshizaki , Norihiro Nishimoto , Masahiro Iwamoto , Seiji Minota , Shumpei Yokota , Takako Miyamae
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K9/0019 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/248 , C07K2317/14 , C07K2317/24 , C07K2317/76 , Y10S514/825
摘要： A therapeutic agent for chronic arthritides diseases of childhood-related diseases, for example chronic arthritides diseases of childhood, Still's disease and the like, comprising an interleukin-6 (IL-6) antagonist as an active ingredient.
摘要翻译：儿童相关疾病慢性关节炎疾病的治疗剂，例如儿童慢性关节炎疾病，Still氏病等，其包含白细胞介素-6（IL-6）拮抗剂作为活性成分。

10. 发明申请

US20060292147A1 Blood MMP-3 level-lowering agent comprising IL-6 antagonist as active ingredient 审中-公开
标题翻译：含有IL-6拮抗剂作为活性成分的血液MMP-3水平降低剂
公开(公告)号：US20060292147A1
公开(公告)日：2006-12-28
申请号：US11514217
申请日：2006-09-01
申请人： Kazuyuki Yoshizaki , Norihiro Nishimoto , Yasunori Okada , Ken-ichi Obata
发明人： Kazuyuki Yoshizaki , Norihiro Nishimoto , Yasunori Okada , Ken-ichi Obata
IPC分类号： A61K39/395 , G01N33/567 , C07K16/24
CPC分类号： C07K16/248 , A61K2039/505
摘要： A blood matrix metalloprotease-3 (MMP-3) level-lowering agent comprising an interleukin-6 (IL-6) antagonist as an active ingredient.
摘要翻译：包含白细胞介素-6（IL-6）拮抗剂作为活性成分的血液基质金属蛋白酶-3（MMP-3）水平降低剂。

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