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1. 发明申请

WO1996038436A1 (2-THIENYL)ALKANOIC ACID DERIVATIVES 审中-公开
标题翻译：（2-噻吩基）烷基酸衍生物
公开(公告)号：WO1996038436A1
公开(公告)日：1996-12-05
申请号：PCT/JP1996001430
申请日：1996-05-28
申请人： HOKURIKU SEIYAKU CO., LTD. , ITO, Yasuo , KATO, Hideo , YASUDA, Shingo , OGAWA, Nobuo , SAKURAI, Shunichiro
发明人： HOKURIKU SEIYAKU CO., LTD.
IPC分类号： C07D333/24
CPC分类号： C07D333/24
摘要： Compounds represented by general formula (I) or a salt of the same, wherein R represents hydrogen, halogeno, lower alkyl, lower alkoxy or nitro; R represents C1-10 alkyl, C3-8 cycloalkyl optionally having lower alkyl on its ring or C1-6 alkyl substituted by C3-8 cycloalkyl; R represents hydrogen or lower alkyl; and n is an integer of from 2 to 4. The compounds have thromboxane A2 and leukotriene D4 antagonisms and are useful in the prevention and/or treatment of diseases selected from the group consisting of ischemic heart diseases, cerebrovascular disorders, thrombosis, asthma and allergic inflammation.
摘要翻译：由通式（I）表示的化合物或其盐，其中R 1表示氢，卤代，低级烷基，低级烷氧基或硝基; R 2表示C 1-10烷基，任选在其环上具有低级烷基的C 3-8环烷基或被C 3-8环烷基取代的C 1-6烷基; R 3表示氢或低级烷基; 并且n为2至4的整数。该化合物具有血栓素A2和白三烯D4拮抗剂，并且可用于预防和/或治疗选自缺血性心脏病，脑血管障碍，血栓形成，哮喘和过敏的疾病炎。

2. 发明申请

WO1996022988A1 QUINOLINECARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译：喹喔啉羧酸衍生物
公开(公告)号：WO1996022988A1
公开(公告)日：1996-08-01
申请号：PCT/JP1995002614
申请日：1995-12-20
申请人： HOKURIKU SEIYAKU CO., LTD. , ITO, Yasuo , KATO, Hideo , YASUDA, Shingo , KADO, Noriyuki , YOSHIDA, Toshihiko , YAMAMOTO, Yoichi
发明人： HOKURIKU SEIYAKU CO., LTD.
IPC分类号： C07D401/04
CPC分类号： A61K31/47 , C07D401/04
摘要： 5-Amino-7-((3S,4S)-3-amino-4-methyl(or ethyl)-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acids represented by general formula (I), pharmaceutically acceptable salts thereof, and an antibacterial agent containing the same as the active ingredient, wherein each asterisked asymmetric carbon atome has the S-configuration; an R represents methyl or ethyl.
摘要翻译： 5-氨基-7 - （（3S，4S）-3-氨基-4-甲基（或乙基）-1-吡咯烷基）-1-环丙基-6-氟-1,4-二氢-8-甲基-4- 由通式（I）表示的氧代喹啉-3-羧酸，其药学上可接受的盐和含有与活性成分相同的抗菌剂，其中每个星号的不对称碳原子具有S-构型; R 1表示甲基或乙基。

3. 发明申请

WO1994007848A1 BENZENESULFONAMIDE DERIVATIVE AND USE THEREOF 审中-公开
标题翻译：苯并呋喃衍生物及其用途
公开(公告)号：WO1994007848A1
公开(公告)日：1994-04-14
申请号：PCT/JP1993001382
申请日：1993-09-29
申请人： HOKURIKU SEIYAKU CO., LTD. , ITO, Yasuo , KATO, Hideo , YASUDA, Shingo , OGAWA, Nobuo , SAKURAI, Shunichiro , SUZUKI, Tomio
发明人： HOKURIKU SEIYAKU CO., LTD.
IPC分类号： C07C311/19
CPC分类号： C07C311/29 , C07C311/19
摘要： A benzenesulfonamide derivative represented by general formula (I) and a pharmacologically acceptable salt thereof, wherein R1 represents hydrogen, lower alkyl, lower alkoxy or halogen; R2 represents C1-C10 linear or branched alkyl, C3-C8 cycloalkyl optionally substituted by C1-C6 alkyl, C1-C6 alkyl substituted by C3-C8 cycloalkyl, 1-adamantylmethyl, 2-norbornylmethyl or phenyl-substituted C1-C6 alkyl which may be substituted on the benzene ring; R3 represents hydrogen or lower alkyl; and n represents an integer of 2 to 4. The compound has a thromboxane A2 antagonism, a leucotriene antagonism, and so on, thus being useful as platelet aggregation inhibitor, antithrombotic, antiasthmatic, and antiallergic.
摘要翻译：由通式（I）表示的苯磺酰胺衍生物及其药理学上可接受的盐，其中R1表示氢，低级烷基，低级烷氧基或卤素; R 2表示C 1 -C 10直链或支链烷基，任选被C 1 -C 6烷基取代的C 3 -C 8环烷基，被C 3 -C 8环烷基取代的C 1 -C 6烷基，1-金刚烷甲基，2-降冰片基甲基或苯基取代的C 1 -C 6烷基，在苯环上取代; R3代表氢或低级烷基; n表示2〜4的整数。该化合物具有血栓素A2拮抗作用，白三烯拮抗作用等，因此可用作血小板聚集抑制剂，抗血栓形成，抗哮喘药和抗过敏药。

4. 发明申请

WO1992017440A1 TRICYCLIC COMPOUND 审中-公开
标题翻译：三聚体化合物
公开(公告)号：WO1992017440A1
公开(公告)日：1992-10-15
申请号：PCT/JP1992000365
申请日：1992-03-26
申请人： HOKURIKU SEIYAKU CO., LTD. , SAWANISHI, Hiroyuki , ITO, Yasuo , KATO, Hideo , KOSHINAKA, Eiichi , OGAWA, Nobuo , MORIKAWA, Kouji
发明人： HOKURIKU SEIYAKU CO., LTD.
IPC分类号： C07C229/14
CPC分类号： C07D313/14 , C07C229/14 , C07C2603/32 , C07D311/82 , C07D313/12
摘要： Tricyclic compounds represented by general formula (I), pharmacologically acceptable salts thereof, and a process for producing the same. In formula (I) X represents -CH=CH-, -CH2O- or -O-; R1 represents lower alkyl; R2 represents hydrogen or lower alkyl; and n represents an integer of 1 to 5. They have antiallergic and antihistaminic activities with alleviated side effects and hence are useful as an antiallergic and antihistaminic.

5. 发明申请

WO1997005860A1 PHOTOSTABLE AQUEOUS SOLUTION CONTAINING BENZYL ALCOHOL DERIVATIVES 审中-公开
标题翻译：含有BENZYL ALCOHOL衍生物的可溶性水溶液
公开(公告)号：WO1997005860A1
公开(公告)日：1997-02-20
申请号：PCT/JP1996001950
申请日：1996-07-12
申请人： HOKURIKU SEIYAKU CO., LTD. , ITO, Yasuo , KATO, Hideo , KOSHINAKA, Eiichi , YAMAZAKI, Masahiro , MATSUO, Kazuya
发明人： HOKURIKU SEIYAKU CO., LTD.
IPC分类号： A61K31/135
CPC分类号： C07C215/60 , A61K31/137 , A61K47/10 , A61K47/26 , C07B2200/07 , Y10S514/935
摘要： A photostable aqueous solution containing optically active (-)-(R)- alpha -[(tert-butylamino)methyl]-2-chloro-4-hydroxybenzyl alcohol represented by formula (I) or a pharmacologically acceptable salt thereof and at least one photostabilizer selected from the group consisting of saccharides, sugar alcohols and polyhydric alcohols.
摘要翻译：由式（I）表示的光学活性（ - ） - （R）-α-[（叔丁基氨基）甲基] -2-氯-4-羟基苄醇或其药学上可接受的盐和至少一种选自糖，糖醇和多元醇的光稳定剂。

6. 发明申请

WO1997009330A1 CRYSTAL OF HYDRATE AND PROCESS FOR PREPARATION THEREOF 审中-公开
标题翻译：水合物晶体及其制备方法
公开(公告)号：WO1997009330A1
公开(公告)日：1997-03-13
申请号：PCT/JP1996002352
申请日：1996-08-23
申请人： HOKURIKU SEIYAKU CO., LTD. , ITO, Yasuo , KATO, Hideo , YASUDA, Shingo , KADO, Noriyuki , IWASAKI, Nobuhiko , NISHINO, Hiroyuki , TAKESHITA, Makoto
发明人： HOKURIKU SEIYAKU CO., LTD.
IPC分类号： C07D491/044
CPC分类号： C07D491/04
摘要： A novel crystal of dihydrate of 3-[4-(8-fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidino]propionic acid giving high-intensity diffraction peaks at angles of diffraction (2 theta ) of about 4.2 DEG , 17.0 DEG and 21.3 DEG in the powder X-ray diffractometry; a drug containing this novel crystal; and a process for the preparation of the novel crystal which comprises treating a crystalline substance containing a crystal of anhydride of the above acid with hydrous acetone and subjecting the obtained product to drying and moistening.
摘要翻译： 3- [4-（8-氟-5,11-二氢苯并[b]氧杂环庚烯并[4,3-b]吡啶-11-亚基）哌啶子基]丙酸的二水合物的新晶体在角度处产生高强度衍射峰在粉末X射线衍射中约为4.2°，17.0°和21.3°的衍射（2θ）; 含有这种新型晶体的药物; 以及制备新型晶体的方法，其包括用含水丙酮处理含有上述酸的无水物结晶的结晶物质，并使所得产物干燥和润湿。

7. 发明申请

WO1992014705A1 BENZAMIDE DERIVATIVE 审中-公开
标题翻译：苯甲酸衍生物
公开(公告)号：WO1992014705A1
公开(公告)日：1992-09-03
申请号：PCT/JP1992000134
申请日：1992-02-12
申请人： HOKURIKU SEIYAKU CO., LTD. , ITO, Yasuo , KATO, Hideo , YASUDA, Shingo , IWASAKI, Nobuhiko , NISHINO, Hiroyuki , TAKESHITA, Makoto
发明人： HOKURIKU SEIYAKU CO., LTD.
IPC分类号： C07D207/14
CPC分类号： C07D451/04 , C07D211/58 , C07D451/14
摘要： A benzamide derivative represented by general formula (I) and a pharmacologically acceptable salt thereof, wherein R represents hydrogen or lower alkanoyl; R represents hydrogen or halogen; R represents lower alkoxy; R represents hydrogen or lower alkyl; R represents hydrogen, lower alkyl or lower alkoxy; A represents C1 to C7 alkylene which may be substituted by lower alkyl; X represents methylene, oxygen or sulfur; m represents an integer of 0 to 3; n represents an integer of 0 to 3; and p represents an integer of 0 to 2. These compounds are useful because of their activity of enhancing the function of a digestive tract, and a pharmaceutical composition containing the same as the active ingredient is useful for treating digestive system diseases.
摘要翻译：由通式（I）表示的苯甲酰胺衍生物及其药学上可接受的盐，其中R 1表示氢或低级烷酰基; R 2表示氢或卤素; R 3代表低级烷氧基; R 4代表氢或低级烷基; R 5表示氢，低级烷基或低级烷氧基; A表示可以被低级烷基取代的C1〜C7亚烷基; X表示亚甲基，氧或硫; m表示0〜3的整数， n表示0〜3的整数， p表示0〜2的整数。这些化合物由于其增强消化道功能的活性而有用，含有与活性成分相同的药物组合物可用于治疗消化系统疾病。

8. 发明申请

WO1993013057A1 SUBSTITUTED BENZENESULFONAMIDE DERIVATIVE 审中-公开
标题翻译：取代的苯并呋喃衍生物
公开(公告)号：WO1993013057A1
公开(公告)日：1993-07-08
申请号：PCT/JP1992001643
申请日：1992-12-17
申请人： HOKURIKU PHARMACEUTICAL CO., LTD. , ITO, Yasuo , KATO, Hideo , YASUDA, Shingo , OGAWA, Nobuo , SAKURAI, Shunichiro , SUZUKI, Tomio
发明人： HOKURIKU PHARMACEUTICAL CO., LTD.
IPC分类号： C07C311/19
CPC分类号： C07D307/54 , C07C311/19 , C07D333/24
摘要： A substituted benzenesulfonamide derivative represented by general formula (I), a pharmacologically acceptable salt thereof, and a process for the production thereof. In formula (I), R represents hydrogen, lower alkyl, lower alkoxy or halogen; R represents optionally substituted phenyl, thienyl or furyl; R represents hydrogen or lower alkyl; and n represents an integer of 1 to 5. The compound has platelet agglutination inhibitory, antithrombotic and antiasthmatic activities. The invention also provides a platelet agglutination inhibitor, antithrombotic and antiasthmatic containing the compound.
摘要翻译：由通式（I）表示的取代苯磺酰胺衍生物及其药理学上可接受的盐及其制备方法。在式（I）中，R 1表示氢，低级烷基，低级烷氧基或卤素; R 2表示任选取代的苯基，噻吩基或呋喃基; R 3表示氢或低级烷基; n表示1〜5的整数。该化合物具有血小板凝集抑制，抗血栓形成和止喘活性。本发明还提供含有该化合物的血小板凝集抑制剂，抗血栓形成和抗哮喘药。

9. 发明专利

JP2001129433A AIR CLEANER 失效
公开(公告)号：JP2001129433A
公开(公告)日：2001-05-15
申请号：JP31542699
申请日：1999-11-05
申请人： FUJI ELECTRIC CO LTD , ITO YASUO
发明人： ITO YASUO , ZUKERAN AKIO , TAKAHASHI TAKEO , TAKAMATSU TAKESHI , KAWAKAMI KAZUMI , NAKAYAMA TSUTOMU
IPC分类号： B03C3/60 , B03C3/08
摘要： PROBLEM TO BE SOLVED: To clean the air containing dust in tunnel by preventing the dust form being rescattered. SOLUTION: When dust-containing air is introduced into a silent discharge type electric dust collector, particles 15 are charged in two poles of positive and negative at a silent discharge space between parallel plane plate electrodes and captured on the electrodes. When the polarity of an attracted electrode is positive, negatively charged particles are captured on the electrode. The negative charge of the particles is kept since a dielectric body 13 is allowed to exist between a metal electrode 12 and the charged particles. When the polarity of applied voltage is reversed and the polarity of an attracted electrode becomes negative, positively charged particle are captured on the electrode. The captured positively charged particles and the negatively charged particle on the electrodes are neutralized, and more electrostatic aggregation is not caused. That is, the aggregation between the particles on the electrode is suppressed. As a result, the particles are uniformly deposited on the surface of the electrode and rescattering is remarkably suppressed since the fluid resistance force of the deposited particles is low.

10. 发明专利

JP2001121031A ELECTRIC PRECIPITATOR 失效
公开(公告)号：JP2001121031A
公开(公告)日：2001-05-08
申请号：JP30848899
申请日：1999-10-29
申请人： ITO YASUO , FUJI ELECTRIC CO LTD
发明人： ITO YASUO , ZUKERAN AKIO , TAKAHASHI TAKEO , TAKAMATSU TAKESHI , KAWAKAMI KAZUMI , NAKAYAMA TSUTOMU
IPC分类号： B01D53/86 , B01J35/02 , B03C3/02 , B03C3/41 , B03C3/60
摘要： PROBLEM TO BE SOLVED: To remove dust particles and harmful gas at the same time with high efficiency. SOLUTION: A charge part 1 is constituted of a dielectric 4 comprising a photocatalytic substance or an electrode having a photocatalytic film to perform silent discharge and the energy of the light or active seed generated by silent discharge is accumulated on the surface of the photocatalytic electrode to be converted to the electrode surface energy of the dielectric 4 and this converted energy is allowed to contribute to the removal of harmful gas such as NOx or the like.

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