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1. 发明申请

WO1998021177A1 BENZENESULFONAMIDE DERIVATIVES AND DRUGS CONTAINING THE SAME 审中-公开
标题翻译：苯并呋喃衍生物和含有它们的药物
公开(公告)号：WO1998021177A1
公开(公告)日：1998-05-22
申请号：PCT/JP1997004125
申请日：1997-11-12
申请人： HOKURIKU SEIYAKU CO., LTD. , YASUDA, Shingo , OGAWA, Nobuo , SAKURAI, Shunichiro
发明人： HOKURIKU SEIYAKU CO., LTD.
IPC分类号： C07C311/19
CPC分类号： C07C311/19 , C07C311/29 , C07D333/24
摘要： Novel benzenesulfonamide derivatives of general formula (I); (wherein R is hydrogen, halogeno, lower alkyl, lower alkoxy or nitro; R is C4-C8 alkyl substituted with one or more fluorine atoms; R is hydrogen or lower alkyl; X is sulfur or CH=CH; and n is an integer of 2 to 4). Drugs containing the derivatives as the active ingredient are usable for the invention and/or treatment of thrombosis, asthma or allergic diseases.
摘要翻译：通式（I）的新型苯磺酰胺衍生物; （其中R 1是氢，卤代，低级烷基，低级烷氧基或硝基）; R 2是被一个或多个氟原子取代的C 4 -C 8烷基; R 3是氢或低级烷基; X是硫或 CH = CH; n为2〜4的整数）。含有衍生物作为活性成分的药物可用于本发明和/或治疗血栓形成，哮喘或过敏性疾病。

2. 发明申请

WO1996038436A1 (2-THIENYL)ALKANOIC ACID DERIVATIVES 审中-公开
标题翻译：（2-噻吩基）烷基酸衍生物
公开(公告)号：WO1996038436A1
公开(公告)日：1996-12-05
申请号：PCT/JP1996001430
申请日：1996-05-28
申请人： HOKURIKU SEIYAKU CO., LTD. , ITO, Yasuo , KATO, Hideo , YASUDA, Shingo , OGAWA, Nobuo , SAKURAI, Shunichiro
发明人： HOKURIKU SEIYAKU CO., LTD.
IPC分类号： C07D333/24
CPC分类号： C07D333/24
摘要： Compounds represented by general formula (I) or a salt of the same, wherein R represents hydrogen, halogeno, lower alkyl, lower alkoxy or nitro; R represents C1-10 alkyl, C3-8 cycloalkyl optionally having lower alkyl on its ring or C1-6 alkyl substituted by C3-8 cycloalkyl; R represents hydrogen or lower alkyl; and n is an integer of from 2 to 4. The compounds have thromboxane A2 and leukotriene D4 antagonisms and are useful in the prevention and/or treatment of diseases selected from the group consisting of ischemic heart diseases, cerebrovascular disorders, thrombosis, asthma and allergic inflammation.
摘要翻译：由通式（I）表示的化合物或其盐，其中R 1表示氢，卤代，低级烷基，低级烷氧基或硝基; R 2表示C 1-10烷基，任选在其环上具有低级烷基的C 3-8环烷基或被C 3-8环烷基取代的C 1-6烷基; R 3表示氢或低级烷基; 并且n为2至4的整数。该化合物具有血栓素A2和白三烯D4拮抗剂，并且可用于预防和/或治疗选自缺血性心脏病，脑血管障碍，血栓形成，哮喘和过敏的疾病炎。

3. 发明申请

WO1994007848A1 BENZENESULFONAMIDE DERIVATIVE AND USE THEREOF 审中-公开
标题翻译：苯并呋喃衍生物及其用途
公开(公告)号：WO1994007848A1
公开(公告)日：1994-04-14
申请号：PCT/JP1993001382
申请日：1993-09-29
申请人： HOKURIKU SEIYAKU CO., LTD. , ITO, Yasuo , KATO, Hideo , YASUDA, Shingo , OGAWA, Nobuo , SAKURAI, Shunichiro , SUZUKI, Tomio
发明人： HOKURIKU SEIYAKU CO., LTD.
IPC分类号： C07C311/19
CPC分类号： C07C311/29 , C07C311/19
摘要： A benzenesulfonamide derivative represented by general formula (I) and a pharmacologically acceptable salt thereof, wherein R1 represents hydrogen, lower alkyl, lower alkoxy or halogen; R2 represents C1-C10 linear or branched alkyl, C3-C8 cycloalkyl optionally substituted by C1-C6 alkyl, C1-C6 alkyl substituted by C3-C8 cycloalkyl, 1-adamantylmethyl, 2-norbornylmethyl or phenyl-substituted C1-C6 alkyl which may be substituted on the benzene ring; R3 represents hydrogen or lower alkyl; and n represents an integer of 2 to 4. The compound has a thromboxane A2 antagonism, a leucotriene antagonism, and so on, thus being useful as platelet aggregation inhibitor, antithrombotic, antiasthmatic, and antiallergic.
摘要翻译：由通式（I）表示的苯磺酰胺衍生物及其药理学上可接受的盐，其中R1表示氢，低级烷基，低级烷氧基或卤素; R 2表示C 1 -C 10直链或支链烷基，任选被C 1 -C 6烷基取代的C 3 -C 8环烷基，被C 3 -C 8环烷基取代的C 1 -C 6烷基，1-金刚烷甲基，2-降冰片基甲基或苯基取代的C 1 -C 6烷基，在苯环上取代; R3代表氢或低级烷基; n表示2〜4的整数。该化合物具有血栓素A2拮抗作用，白三烯拮抗作用等，因此可用作血小板聚集抑制剂，抗血栓形成，抗哮喘药和抗过敏药。

4. 发明申请

WO1992017440A1 TRICYCLIC COMPOUND 审中-公开
标题翻译：三聚体化合物
公开(公告)号：WO1992017440A1
公开(公告)日：1992-10-15
申请号：PCT/JP1992000365
申请日：1992-03-26
申请人： HOKURIKU SEIYAKU CO., LTD. , SAWANISHI, Hiroyuki , ITO, Yasuo , KATO, Hideo , KOSHINAKA, Eiichi , OGAWA, Nobuo , MORIKAWA, Kouji
发明人： HOKURIKU SEIYAKU CO., LTD.
IPC分类号： C07C229/14
CPC分类号： C07D313/14 , C07C229/14 , C07C2603/32 , C07D311/82 , C07D313/12
摘要： Tricyclic compounds represented by general formula (I), pharmacologically acceptable salts thereof, and a process for producing the same. In formula (I) X represents -CH=CH-, -CH2O- or -O-; R1 represents lower alkyl; R2 represents hydrogen or lower alkyl; and n represents an integer of 1 to 5. They have antiallergic and antihistaminic activities with alleviated side effects and hence are useful as an antiallergic and antihistaminic.

5. 发明申请

WO0187846A3 TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：作为蛋白激酶抑制剂的三聚吡唑衍生物
公开(公告)号：WO0187846A3
公开(公告)日：2002-03-21
申请号：PCT/US0116153
申请日：2001-05-17
申请人： KNOLL GMBH , DOYLE KEVIN J , RAFFERTY PAUL , STEELE ROBERT W , WILKINS DAVID J , ARNOLD LEE D , HOCKLEY MICHAEL , ERICSSON ANNA M , IWASAKI NOBUHIKO , OGAWA NOBUO
发明人： DOYLE KEVIN J , RAFFERTY PAUL , STEELE ROBERT W , WILKINS DAVID J , ARNOLD LEE D , HOCKLEY MICHAEL , ERICSSON ANNA M , IWASAKI NOBUHIKO , OGAWA NOBUO
IPC分类号： A61K31/416 , A61K31/4162 , A61K31/4178 , A61K31/4196 , A61K31/427 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/69 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/08 , A61P43/00 , C07D231/54 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07D451/02 , C07D451/04 , C07D491/04 , C07D491/048 , C07D495/04
CPC分类号： C07D401/04 , C07D231/54 , C07D401/06 , C07D401/12 , C07D403/10 , C07D403/12 , C07D409/04 , C07D409/14 , C07D417/12 , C07D451/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of formula I which are inhibitors of protein kinase activity, of which some are novel compounds, to pharmaceutical compositions containing these pyrazoles and to processes for preparing these pyrazoles.
摘要翻译：本发明涉及作为蛋白激酶活性抑制剂的式I化合物，其中有些是新化合物，含有这些吡唑的药物组合物和制备这些吡唑的方法。

6. 发明申请

WO1993013057A1 SUBSTITUTED BENZENESULFONAMIDE DERIVATIVE 审中-公开
标题翻译：取代的苯并呋喃衍生物
公开(公告)号：WO1993013057A1
公开(公告)日：1993-07-08
申请号：PCT/JP1992001643
申请日：1992-12-17
申请人： HOKURIKU PHARMACEUTICAL CO., LTD. , ITO, Yasuo , KATO, Hideo , YASUDA, Shingo , OGAWA, Nobuo , SAKURAI, Shunichiro , SUZUKI, Tomio
发明人： HOKURIKU PHARMACEUTICAL CO., LTD.
IPC分类号： C07C311/19
CPC分类号： C07D307/54 , C07C311/19 , C07D333/24
摘要： A substituted benzenesulfonamide derivative represented by general formula (I), a pharmacologically acceptable salt thereof, and a process for the production thereof. In formula (I), R represents hydrogen, lower alkyl, lower alkoxy or halogen; R represents optionally substituted phenyl, thienyl or furyl; R represents hydrogen or lower alkyl; and n represents an integer of 1 to 5. The compound has platelet agglutination inhibitory, antithrombotic and antiasthmatic activities. The invention also provides a platelet agglutination inhibitor, antithrombotic and antiasthmatic containing the compound.
摘要翻译：由通式（I）表示的取代苯磺酰胺衍生物及其药理学上可接受的盐及其制备方法。在式（I）中，R 1表示氢，低级烷基，低级烷氧基或卤素; R 2表示任选取代的苯基，噻吩基或呋喃基; R 3表示氢或低级烷基; n表示1〜5的整数。该化合物具有血小板凝集抑制，抗血栓形成和止喘活性。本发明还提供含有该化合物的血小板凝集抑制剂，抗血栓形成和抗哮喘药。

7. 发明专利

JP2000257132A PASSING-THROUGH DEVICE FOR CLOGGED PIPE 失效
公开(公告)号：JP2000257132A
公开(公告)日：2000-09-19
申请号：JP6596199
申请日：1999-03-12
申请人： OGAWA NOBUO
发明人： OGAWA NOBUO
IPC分类号： E03C1/302
摘要： PROBLEM TO BE SOLVED: To provide a passing-through device for a clogged pipe capable of greatly promoting the elimination work of foreign matters by providing strong water pressure variations in piping and being easily and surely mounted to the piping. SOLUTION: A passing-through device 1 is so constituted that an introduced pipe 4 is mounted to the front end of a cylindrical body 2 by a joint pipe 3. A piston faucet 6 capable of making reciprocating motion is provided in the inside of the cylindrical body 2 by a control rod 5. A cylindrical faucet 7 of an elastic body is mounted to the front end of the introduced pipe 4. When the piston faucet 6 is approached to the water surface in the cylindrical body 2, an inside passage of the piston faucet 6 is opened to exhaust air to the upper side from the lower side and, at the same time, an opening and closing valve for cutting off the inside passage is provided in the piston faucet 6 in the case of reciprocating motion of the piston faucet 6. When foreign matters in a drain pipe are eliminated, the cylindrical faucet 7 is expanded by an air injection pipe 8 to close a gap between the drain pipe and the introduced pipe 4, and the reciprocating motion of the piston faucet 6 is made to provide water pressure variations in the drain pipe.

8. 发明专利

JP2000120936A FIXING AUXILIARY TOOL FOR FRAME 失效
公开(公告)号：JP2000120936A
公开(公告)日：2000-04-28
申请号：JP29541998
申请日：1998-10-16
申请人： OGAWA NOBUO
发明人： OGAWA NOBUO
IPC分类号： F16L3/12 , F16L3/24
摘要： PROBLEM TO BE SOLVED: To accurately and firmly fix a piping, a tank, and an apparatus on a frame, formed of an angle and a channel, through a simple work and besides to perform high reliable fixing work without lowering the strength of the frame. SOLUTION: A fixing auxiliary tool 10 comprises a vertical plate part l5, a horizontal plate part 16, a lock part 17, a lock plate part 18, and a support part 19. A bed plate 11a and a rib plate 11b are formed at an angle 11. When a piping P is fixed at the angle 11, the piping P is placed on the bed plate 11a, the lock part 17 is then fitted in the lower end of the rib plate 11b, and the vertical plate part 15 and the horizontal plate part 16 are brought into contact with the rib plate 11b and the bed plate 11a. The lock plate 18 is arranged in a manner to extend to the front of the bed surface of the bed plate 11a. A U-bolt then spans the piping P, the U-bolt 12 is inserted in the bolt hole of the lock plate part 18, and fastened by a nut 13 from the back side of the lock plate part 18.

9. 发明专利

JP2000042980A CUTTING MACHINE FOR PLASTIC WASTE 失效
公开(公告)号：JP2000042980A
公开(公告)日：2000-02-15
申请号：JP20751698
申请日：1998-07-23
申请人： OGAWA NOBUO
发明人： KUSUMOTO KATSUMI
IPC分类号： B26D7/18 , B26D1/14
摘要： PROBLEM TO BE SOLVED: To provide a cutting machine capable of simply and efficiently cutting a large amount of plastic wastes applied with waste treatment after use, for instance, in agricultural and marine products industry. SOLUTION: Waste is cut by a rotary blade 16 and a fixed blade 15, here the waste is cut in a closely collected condition by the rotary blade formed in shape with an edge point recessed in bow shape. The waste is compressed by applying a load thereto by vertically movable rollers 11, 12 particularly in the case of feeding the waste to its cutting part. Further, cutting chips of the waste are conveyed and discharged by an air stream generated by rotary vanes 18 provided in a wheel 17 holding a rotary blade 18. In addition, feeding of the waste can be stopped or retracted by a safety mechanism.

10. 发明专利

JPH05164113A FLUID ELEMENT 失效
公开(公告)号：JPH05164113A
公开(公告)日：1993-06-29
申请号：JP32268891
申请日：1991-12-06
申请人： OGAWA NOBUO
发明人： OGAWA NOBUO
IPC分类号： F15C1/20
摘要： PURPOSE:To provide a fluid element with a simple structure having a high responsiveness for changing over a flow path. CONSTITUTION:At least a pair of fluid discharging means 12, 13 disposed opposedly to each other and coaxially with the axis to discharge fluid and a fluid center axis disturbing means 18 for giving turbulent flow onto the center axis 22 of fluid discharged from the respective fluid discharging means are provided in housing provided in at least two positions with the fluid discharge means.

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