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1. 发明申请

US20070071824A1 Treatment of mucositis using N-acetylcysteine 审中-公开
标题翻译：使用N-乙酰半胱氨酸治疗粘膜炎
公开(公告)号：US20070071824A1
公开(公告)日：2007-03-29
申请号：US11540357
申请日：2006-09-29
申请人： Gary Rosenthal , Jeffrey Etter , Timothy Rodell , Wren Schauer , Adrian Samaniego
发明人： Gary Rosenthal , Jeffrey Etter , Timothy Rodell , Wren Schauer , Adrian Samaniego
IPC分类号： A61K31/198 , A61K9/14
CPC分类号： A61K31/195 , A61K9/0014 , A61K9/006 , A61K9/06 , A61K31/198 , A61K47/10 , A61K47/34
摘要： This present invention provides a therapeutic composition for use in the treatment of mucositis and a method for using such a therapeutic composition. The therapeutic composition includes a pharmaceutical substance effective for treating mucositis formulated with a biocompatible polymer, such as a biocompatible reverse-thermal gelation polymer.
摘要翻译：本发明提供了用于治疗粘膜炎的治疗组合物和使用这种治疗组合物的方法。治疗组合物包括有效治疗由生物相容性聚合物如生物相容的反向热凝胶化聚合物配制的粘膜炎的药物。

2. 发明申请

US20070014860A1 Treatment of esophagitis 审中-公开
标题翻译：治疗食管炎
公开(公告)号：US20070014860A1
公开(公告)日：2007-01-18
申请号：US11525752
申请日：2006-09-22
申请人： Gary Rosenthal , Jeffrey Etter , Timothy Rodell , Wren Schauer , Adrian Samaniego
发明人： Gary Rosenthal , Jeffrey Etter , Timothy Rodell , Wren Schauer , Adrian Samaniego
IPC分类号： A61K9/14
CPC分类号： A61K31/195 , A61K9/0014 , A61K9/006 , A61K9/06 , A61K31/198 , A61K47/10 , A61K47/34
摘要： A method for treatment of esophagitis is disclosed in which a therapeutic composition is introduced into the esophagus to contact a mucosal surface within the esophagus. The pharmaceutical composition comprises a reverse-thermal gelation polyoxyalkylene block copolymer, a pharmaceutical substance and a pharmaceutical substance selected from the group consisting of glutathione and a precursor for glutathione biosynthesis.
摘要翻译：公开了治疗食管炎的方法，其中将治疗组合物引入食道以接触食道内的粘膜表面。药物组合物包含反热凝胶聚氧化烯嵌段共聚物，药物物质和选自谷胱甘肽和谷胱甘肽生物合成前体的药物。

3. 发明授权

US07090681B2 Methods and apparatus for delivery of ocular implants 有权
公开(公告)号：US07090681B2
公开(公告)日：2006-08-15
申请号：US10666872
申请日：2003-09-18
申请人： David A. Weber , Ingrid Kane , Mike Rehal , Robert L. Lathrop, III , Kenny Aptekarev , Jeffrey Etter
发明人： David A. Weber , Ingrid Kane , Mike Rehal , Robert L. Lathrop, III , Kenny Aptekarev , Jeffrey Etter
IPC分类号： A61F9/00
CPC分类号： A61M37/0069 , A61F2/167 , A61F9/0017
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.

4. 发明申请

US20050147684A1 Composition for delivery of hematopoietic growth factor 审中-公开
公开(公告)号：US20050147684A1
公开(公告)日：2005-07-07
申请号：US11073253
申请日：2005-03-04
申请人： Gary Rosenthal , Jeffrey Etter
发明人： Gary Rosenthal , Jeffrey Etter
IPC分类号： A61K9/00 , A61K9/52 , A61K38/18 , A61K38/19 , A61K38/20 , A61K47/10 , A61K47/36 , A61K47/38 , C12N5/02 , A61K9/14
CPC分类号： A61K9/0024 , A61K31/505 , A61K31/513 , A61K35/545 , A61K38/18 , A61K38/193 , A61K38/2046 , A61K47/10 , A61K47/36 , A61K47/38 , A61K2300/00
摘要： A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition exhibits reverse-thermal viscosity behavior, due to interaction between the first biocompatible polymer and the liquid vehicle. The second biocompatible polymer helps to protect the first biocompatible polymer from being dissolved in vivo following administration to a host.

5. 发明授权

US07468065B2 Apparatus for delivery of ocular implants 有权
标题翻译：用于输送眼部植入物的装置
公开(公告)号：US07468065B2
公开(公告)日：2008-12-23
申请号：US11021947
申请日：2004-12-23
申请人： David A. Weber , Ingrid Kane , Mike Rehal , Robert L. Lathrop, III , Kenny Aptekarev , Jeffrey Etter , Scott Gerondale , Rahul Bhagat , Shawn Davis
发明人： David A. Weber , Ingrid Kane , Mike Rehal , Robert L. Lathrop, III , Kenny Aptekarev , Jeffrey Etter , Scott Gerondale , Rahul Bhagat , Shawn Davis
IPC分类号： A61F9/00
CPC分类号： A61F2/167 , A61F9/0017 , A61F9/007
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：用于输送眼部植入物或微量植入物的装置和方法。该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。提供小尺寸插管用于自密封输送方法。

6. 发明申请

US20070293698A1 Compositions of Allosteric Hemoglobin Modifiers and Methods of Making the Same 审中-公开
标题翻译：变构血红蛋白改性剂的组成及其制备方法
公开(公告)号：US20070293698A1
公开(公告)日：2007-12-20
申请号：US10598874
申请日：2005-04-22
申请人： Al Quick , Antonio Santos , Alexandre J.G. Carvalho , Douglas Johnson , Jeffrey Etter , Chris Murray
发明人： Al Quick , Antonio Santos , Alexandre J.G. Carvalho , Douglas Johnson , Jeffrey Etter , Chris Murray
IPC分类号： C07C233/01 , C07C231/00 , G01N30/00 , C07C233/00
CPC分类号： A61K31/195
摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.
摘要翻译：本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。本发明还包括用于纯化通过本发明方法形成的产品的改进方法。新颖的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）提取粗组合物以降低杂质量，特别是聚合物杂质。还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。

7. 发明申请

US20050239893A1 Compositions of allosteric hemoglobin modifiers and methods of making the same 有权
标题翻译：变构血红蛋白修饰剂的组成及其制备方法
公开(公告)号：US20050239893A1
公开(公告)日：2005-10-27
申请号：US11112389
申请日：2005-04-22
申请人： Al Quick , Antonio Santos , Alexandre Carvalho , Douglas Johnson , Jeffrey Etter , Christopher Murray
发明人： Al Quick , Antonio Santos , Alexandre Carvalho , Douglas Johnson , Jeffrey Etter , Christopher Murray
IPC分类号： A61K31/195
CPC分类号： A61K31/195
摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.
摘要翻译：本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。本发明还包括用于纯化通过本发明方法形成的产品的改进方法。新的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）萃取粗组合物以降低杂质量，特别是聚合物杂质。还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。

8. 发明申请

US20060241650A1 Methods and apparatus for delivery of ocular implants 有权
标题翻译：用于输送眼部植入物的方法和装置
公开(公告)号：US20060241650A1
公开(公告)日：2006-10-26
申请号：US11475268
申请日：2006-06-26
申请人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter
发明人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter
IPC分类号： A61F9/00
CPC分类号： A61M37/0069 , A61F2/167 , A61F9/0017
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：用于输送眼部植入物或微量植入物的装置和方法。该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。提供小尺寸插管用于自密封输送方法。

9. 发明申请

US20050203542A1 Apparatus for delivery of ocular implants with reduced incidence of ocular adverse events 审中-公开
标题翻译：用于递送眼部植入物的装置，其具有减少眼部不良事件的发生率
公开(公告)号：US20050203542A1
公开(公告)日：2005-09-15
申请号：US10917909
申请日：2004-08-13
申请人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter , Scott Whitcup
发明人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter , Scott Whitcup
IPC分类号： A61F2/16 , A61F9/00
CPC分类号： A61F9/0017 , A61F2/167 , A61M37/0069
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：用于输送眼部植入物或微量植入物的装置和方法。该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。提供小尺寸插管用于自密封输送方法。

10. 发明申请

US20050147683A1 Composition for delivery of hematopoietic growth factor 审中-公开
公开(公告)号：US20050147683A1
公开(公告)日：2005-07-07
申请号：US11073240
申请日：2005-03-04
申请人： Gary Rosenthal , Jeffrey Etter
发明人： Gary Rosenthal , Jeffrey Etter
IPC分类号： A61K9/00 , A61K9/52 , A61K38/18 , A61K38/19 , A61K38/20 , A61K47/10 , A61K47/36 , A61K47/38 , C12N5/02 , A61K9/14
CPC分类号： A61K9/0024 , A61K31/505 , A61K31/513 , A61K35/545 , A61K38/18 , A61K38/193 , A61K38/2046 , A61K47/10 , A61K47/36 , A61K47/38 , A61K2300/00
摘要： A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition exhibits reverse-thermal viscosity behavior, due to interaction between the first biocompatible polymer and the liquid vehicle. The second biocompatible polymer helps to protect the first biocompatible polymer from being dissolved in vivo following administration to a host.

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