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1. 发明申请

US20050239893A1 Compositions of allosteric hemoglobin modifiers and methods of making the same 有权
标题翻译：变构血红蛋白修饰剂的组成及其制备方法
公开(公告)号：US20050239893A1
公开(公告)日：2005-10-27
申请号：US11112389
申请日：2005-04-22
申请人： Al Quick , Antonio Santos , Alexandre Carvalho , Douglas Johnson , Jeffrey Etter , Christopher Murray
发明人： Al Quick , Antonio Santos , Alexandre Carvalho , Douglas Johnson , Jeffrey Etter , Christopher Murray
IPC分类号： A61K31/195
CPC分类号： A61K31/195
摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.
摘要翻译：本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。本发明还包括用于纯化通过本发明方法形成的产品的改进方法。新的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）萃取粗组合物以降低杂质量，特别是聚合物杂质。还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。

2. 发明申请

US20050277827A1 Pleural fluid localization device and method of using 审中-公开
标题翻译：胸膜液定位装置及使用方法
公开(公告)号：US20050277827A1
公开(公告)日：2005-12-15
申请号：US10864762
申请日：2004-06-09
申请人： Alexandre Carvalho
发明人： Alexandre Carvalho
IPC分类号： A61B5/05 , A61B19/00
CPC分类号： A61B90/39 , A61B2090/376 , A61B2090/3937
摘要： A novel pleural fluid localization device and method of using is disclosed. The device includes a marker, having a top side, a bottom side adapted to be affixed to the body of a patient, a top edge, a first side edge, a second side edge, and a bottom edge; and a first plurality of markings on the marker to guide a clinician in localizing an area on the body a patient to perform a procedure on the patient. The method includes placing the marker on the body of the patient; imaging the patient; reading the location on the plurality of markings on the marker to localize the procedure on the patient; and performing the procedure on the patient at the location read on the plurality of markings on the marker during the step of reading the location on the plurality of markings on the marker to localize the procedure on the patient.
摘要翻译：公开了一种新颖的胸膜液定位装置和使用方法。该装置包括标记物，其具有顶侧，适于固定到患者身体的底侧，顶部边缘，第一侧边缘，第二侧边缘和底部边缘; 以及在所述标记上的第一多个标记，以引导临床医生将身体上的区域定位在患者身上以对患者执行手术。该方法包括将标记放置在患者的身体上; 成像患者; 读取标记上的多个标记上的位置以定位患者的程序; 以及在读取标记上的多个标记上的位置的步骤中对在患者上的多个标记上读取的位置处的患者执行该过程以定位患者的程序。

3. 发明授权

US06204368B1 Process for the purification of roxithromycin 有权
标题翻译：罗红霉素净化方法
公开(公告)号：US06204368B1
公开(公告)日：2001-03-20
申请号：US09372522
申请日：1999-08-11
申请人： William Heggie , Alexandre Carvalho , Luis Sobral
发明人： William Heggie , Alexandre Carvalho , Luis Sobral
IPC分类号： C07H100
CPC分类号： C07H17/08
摘要： A process for the purification of roxithromycin, an antibiotic for therapeutic purposes, in which the purification is carried out by the dissolution or suspension of the product in methanol followed by cooling. Purification may also be obtained by addition of a non-solvent and/or by concentration of the mixture, thus obtaining a purified product.
摘要翻译：用于纯化罗红霉素（用于治疗目的的抗生素）的方法，其中通过产物在甲醇中的溶解或悬浮进行纯化，然后冷却。还可以通过加入非溶剂和/或通过浓缩混合物来获得纯化，从而获得纯化的产物。

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