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1. 发明授权

US08852605B2 Vibrio cholerae O139 conjugate vaccines 有权
标题翻译：霍乱弧菌O139结合疫苗
公开(公告)号：US08852605B2
公开(公告)日：2014-10-07
申请号：US11695735
申请日：2007-04-03
申请人： Shousun Chen Szu , Zuzana Kossaczka , John B. Robbins
发明人： Shousun Chen Szu , Zuzana Kossaczka , John B. Robbins
IPC分类号： A61K39/00 , A61K39/38 , A61K39/40 , A61K39/385 , A61K39/116 , A61K39/02 , A61K39/106 , A61K38/00 , A61K38/16 , A61K39/395 , A61K31/415 , A01N43/46
CPC分类号： A61K39/107 , A61K47/646
摘要： The disclosure pertains to conjugates of the capsular polysaccharide of Vibrio cholerae O139, or a structurally and/or immunologically related oligo- or poly-saccharide, and a carrier. These conjugates are useful as pharmaceutical compositions and/or vaccines to induce serum antibodies which have bactericidal (vibriocidal) activity against V. cholerae, in particular V. cholerae O139, and are useful to prevent, treat and/or reduce the severity of disease caused by V. cholerae infection, such as cholera. The present disclosure also relates to diagnostic tests for V. cholerae infection, and/or cholera caused by V. cholerae infection, using one or more of the oligo- or poly-saccharide-carrier conjugates or antibodies described above.
摘要翻译：本公开涉及霍乱弧菌O139的荚膜多糖或结构和/或免疫相关的寡糖或多糖和载体的缀合物。这些缀合物可用作药物组合物和/或疫苗以诱导对霍乱弧菌（特别是霍乱弧菌O139）具有杀菌（弧菌）活性）的血清抗体，并且可用于预防，治疗和/或降低引起的疾病的严重性霍乱弧菌感染，如霍乱。本公开还涉及使用一种或多种上述寡糖或多糖 - 载体缀合物或抗体的霍乱弧菌感染和/或由霍乱弧菌感染引起的霍乱的诊断测试。

2. 发明授权

US08703150B2 Methods of using Bacillus anthracis protective antigen sequences for vaccination 有权
标题翻译：使用炭疽芽孢杆菌保护性抗原序列进行疫苗接种的方法
公开(公告)号：US08703150B2
公开(公告)日：2014-04-22
申请号：US13244060
申请日：2011-09-23
申请人： Stephen H. Leppla , Rachel Schneerson , John B. Robbins
发明人： Stephen H. Leppla , Rachel Schneerson , John B. Robbins
IPC分类号： A61K39/07 , A61P31/04 , A61P37/04 , C07K14/32 , C12N1/21
CPC分类号： C07H21/04 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/32
摘要： The invention relates to improved methods of producing and recovering B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
摘要翻译：本发明涉及生产和回收炭疽芽孢杆菌保护性抗原（PA），特别是蛋白酶抗性的经修饰的PA的改进方法，以及使用这些PA或编码这些PA的核酸在人体中引发免疫原性应答的方法，包括对炭疽杆菌细菌感染提供保护或降低其严重程度的反应，其可用于预防和/或治疗由炭疽芽孢杆菌引起的疾病，例如吸入性炭疽，皮肤炭疽和胃肠道炭疽。

3. 发明申请

US20120009219A1 BACILLUS ANTHRACIS PROTECTIVE ANTIGEN SEQUENCES 有权
标题翻译： BACILLUS ANTHRACIS保护性抗原序列
公开(公告)号：US20120009219A1
公开(公告)日：2012-01-12
申请号：US13244060
申请日：2011-09-23
申请人： Stephen H. Leppla , Yogendra Singh , Kurt Klimpel , Rachel Schneerson , John B. Robbins
发明人： Stephen H. Leppla , Yogendra Singh , Kurt Klimpel , Rachel Schneerson , John B. Robbins
IPC分类号： A61K39/07 , A61P31/04 , A61P37/04 , C07K14/32 , C12N1/21
CPC分类号： C07H21/04 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/32
摘要： The invention relates to improved methods of producing and recovering B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
摘要翻译：本发明涉及生产和回收炭疽芽孢杆菌保护性抗原（PA），特别是蛋白酶抗性的经修饰的PA的改进方法，以及使用这些PA或编码这些PA的核酸在人体中引发免疫原性应答的方法，包括对炭疽杆菌细菌感染提供保护或降低其严重程度的反应，其可用于预防和/或治疗由炭疽芽孢杆菌引起的疾病，例如吸入性炭疽，皮肤炭疽和胃肠道炭疽。

4. 发明申请

US20100239601A1 METHOD OF IMMUNIZING HUMANS AGAINST SALMONELLA TYPHI USING A VI-REPA CONJUGATE VACCINE 有权
标题翻译：使用维生素C联合疫苗免疫沙门氏菌的人类免疫方法
公开(公告)号：US20100239601A1
公开(公告)日：2010-09-23
申请号：US12790258
申请日：2010-05-28
申请人： Zuzana Kossaczka , Shousun Chen Szu , John B. Robbins , Rachel Schneerson , Joseph Shiloach
发明人： Zuzana Kossaczka , Shousun Chen Szu , John B. Robbins , Rachel Schneerson , Joseph Shiloach
IPC分类号： A61K39/385 , A61P31/04
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
摘要翻译：本发明涉及伤寒沙门氏菌的Vi多糖与载体铜绿假单胞菌重组外蛋白A（rEPA）的缀合物及其组合物，以及这些缀合物和/或其组合物用于在人体中诱导免疫原性应答的方法，包括提供防治或减轻伤寒沙门菌细菌感染严重性的反应。缀合物及其组合物可用作诱导针对伤寒沙雷氏菌的血清抗体的疫苗，并且可用于预防和/或治疗由伤寒沙门氏菌引起的疾病。

5. 发明授权

US07763451B2 Methods for preparing Bacillus anthracis protective antigen for use in vaccines 有权
标题翻译：制备用于疫苗的炭疽芽孢杆菌保护性抗原的方法
公开(公告)号：US07763451B2
公开(公告)日：2010-07-27
申请号：US10290712
申请日：2002-11-08
申请人： Joseph Shiloach , Stephen H. Leppla , Delia M. Ramirez , Rachel Schneerson , John B. Robbins , S. Dana Hsu , Mary Jo Rosovitz
发明人： Joseph Shiloach , Stephen H. Leppla , Delia M. Ramirez , Rachel Schneerson , John B. Robbins , S. Dana Hsu , Mary Jo Rosovitz
IPC分类号： C12N1/00 , C12N1/20 , C12P1/00 , A61K39/38 , A61K39/02 , A61K39/07
CPC分类号： C07H21/04 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/32
摘要： The invention relates to improved methods of producing and recovering B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
摘要翻译：本发明涉及生产和回收炭疽芽孢杆菌保护性抗原（PA），特别是蛋白酶抗性的经修饰的PA的改进方法，以及使用这些PA或编码这些PA的核酸在人体中引发免疫原性应答的方法，包括对炭疽杆菌细菌感染提供保护或降低其严重程度的反应，其可用于预防和/或治疗由炭疽芽孢杆菌引起的疾病，例如吸入性炭疽，皮肤炭疽和胃肠道炭疽。

6. 发明申请

US20100150954A1 VACCINES AGAINST INFLUENZA VIRUS 失效
标题翻译：疫苗对流感病毒
公开(公告)号：US20100150954A1
公开(公告)日：2010-06-17
申请号：US12541804
申请日：2009-08-14
申请人： Mark A. Miller , Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Zuzana Biesova , Jerry Keith
发明人： Mark A. Miller , Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Zuzana Biesova , Jerry Keith
IPC分类号： A61K39/385 , A61P31/16 , C07K17/06
CPC分类号： C07K17/06 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55505 , A61K2039/6037 , C07K14/005 , C07K14/34 , C12N2760/16122 , C12N2760/16134
摘要： Disclosed are immunogenic conjugates having the general formula: M2e-Cys-S—CH2—C(O)—NH—CH2—CH2-C(O—)NH-Lys-Pr, were M2e is the influenza M2 ectodomain (M2e) peptide; Cys is a cysteine amino acid residue present in the M2e peptide; S the sulfur present in the cysteine amino acid residue; CH2-CO—NH—CH2-CH2-CO the linking group; NH the amine group present in a lysine residue of the carrier; Lys is a lysine amino acid residue and Pr the carrier protein. Also disclosed are isolated immunogens that include an immunogenic fragment of an influenza HA protein including the polybasic cleavage site, wherein the immunogenic fragment of the influenza HA protein has been modified to remove an N-terminal leader amino acid sequence and a C-terminal transmembrane domain. Also disclosed are methods producing an influenza vaccine specific for an identified influenza strain.
摘要翻译：公开了具有以下通式的免疫原性缀合物：M2e-Cys-S-CH2-C（O）-NH-CH2-CH2-C（O-NH-Lys-Pr），M2e是流感M2胞外域（M2e）肽 ; Cys是存在于M2e肽中的半胱氨酸氨基酸残基; S存在于半胱氨酸氨基酸残基中的硫; CH2-CO-NH-CH2-CH2-CO连接基团; NH存在于载体的赖氨酸残基中的胺基; Lys是赖氨酸氨基酸残基，Pr是载体蛋白。还公开了分离的免疫原，其包括包括多碱性切割位点的流感HA蛋白的免疫原性片段，其中已经修饰了流感HA蛋白的免疫原性片段以除去N-末端前导氨基酸序列和C-末端跨膜结构域。还公开了产生针对所鉴定的流感病毒株特异的流感疫苗的方法。

7. 发明申请

US20100062023A1 CHOLESTEROL-CONTAINING COMPOUNDS AND THEIR USE AS IMMUNOGENS AGAINST BORRELIA BURGDORFERI 审中-公开
标题翻译：含有胆固醇的化合物及其作为免疫球蛋白对抗BORGDORFERI
公开(公告)号：US20100062023A1
公开(公告)日：2010-03-11
申请号：US12511337
申请日：2009-07-29
申请人： Gil Ben-Menachem , Joanna Kubler-Kielb , Rachel Schneerson , John B. Robbins , Vince Pozsgay
发明人： Gil Ben-Menachem , Joanna Kubler-Kielb , Rachel Schneerson , John B. Robbins , Vince Pozsgay
IPC分类号： A61K39/02 , C07J41/00 , A61K31/7028
CPC分类号： A61K39/0225 , A61K47/6415 , A61K47/643 , A61K2039/6037 , C07J9/00 , C07J17/00 , Y02A50/401
摘要： Unique compounds that can be used for inducing an immune response to Borrelia burgdorferi in a subject by administering a therapeutically effective amount of the glycolipid to the subject. Such administration is particularly useful for preventing or treating Lyme disease in a subject. The compounds(s), and therapeutically acceptable salts thereof, may be formulated into pharmaceutical or immunogenic compositions.
摘要翻译：独特的化合物可以通过向受试者施用治疗有效量的糖脂而在受试者中诱导针对博氏疏螺旋体的免疫应答。这种给药对于预防或治疗受试者中的莱姆病特别有用。化合物及其治疗上可接受的盐可以配制成药物或免疫原性组合物。

8. 发明授权

US07553490B2 Vaccines against Escherichia coli O157 infection 失效
标题翻译：针对大肠杆菌O157感染的疫苗
公开(公告)号：US07553490B2
公开(公告)日：2009-06-30
申请号：US10987428
申请日：2004-11-12
申请人： Shousun Chen Szu , John B. Robbins , Yvonne Ageyman Konadu, legal representative
发明人： Edward Konadu
IPC分类号： A61K39/02 , A61K39/108 , C07K14/245
CPC分类号： A61K39/0258 , A61K2039/6037 , Y02A50/474
摘要： This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including responses which provide protection against, or reduce the severity of, bacterial infections. More particularly it relates to the use of polysaccharides containing the tetrasaccharide repeat unit: (→3)-α-DGalpNAc-(1→2)-α-D-PerpNAc-(1→3) -α-L-Fucp-(1→4)-β-D-Glcp-(1→), and conjugates thereof, to induce serum antibodies having bactericidal (killing) activity against hemolytic-uremic syndrome (HUS) causing E. coli, in particular E. coli O157. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies which have bactericidal or bacteriostatic activity against E. coli, in particular E. coli O157, and are useful to prevent and/or treat illnesses caused by E. coli O157.The invention further relates to the antibodies which immunoreact with the O-specific polysaccharide of E. coli O157 and/or the carrier, that are induced by these conjugates and/or compositions thereof. The invention also relates to methods and kits using one or more of the polysaccharides, conjugates or antibodies described above.
摘要翻译：本发明涉及大肠杆菌O157的O-特异性多糖与载体及其组合物的缀合物，以及这些缀合物和/或其组合物在哺乳动物中引发免疫原性应答的方法，包括提供保护的应答反对或减轻细菌感染的严重性。更具体地说，涉及使用含有四糖重复单元的多糖：（→3）-alpha-DGalpNAc-（1-> 2）-alpha-D-PerpNAc-（1-> 3）-alpha-L-Fucp - （1-> 4）-β-D-Glcp-（1->）及其缀合物，以诱导对引起大肠杆菌的溶血性尿毒综合征（HUS）具有杀菌（杀伤）活性的血清抗体，特别是E 大肠杆菌O157。缀合物及其组合物可用作诱导对大肠杆菌特别是大肠杆菌O157具有杀菌或抑菌活性的血清抗体的疫苗，并且可用于预防和/或治疗由大肠杆菌O157引起的疾病。本发明还涉及与这些缀合物和/或其组合物诱导的大肠杆菌O157和/或载体的O-特异性多糖免疫反应的抗体。本发明还涉及使用上述一种或多种多糖，缀合物或抗体的方法和试剂盒。

9. 发明授权

US06858211B1 Vaccines against Escherichia coli O157 infection 失效
标题翻译：针对大肠杆菌O157感染的疫苗
公开(公告)号：US06858211B1
公开(公告)日：2005-02-22
申请号：US09744289
申请日：1998-07-20
申请人： Shousun Chen Szu , John B. Robbins , Yvonne Ageyman Konadu
发明人： Edward Konadu
IPC分类号： A61K39/02 , A61K39/108 , A61K39/385
CPC分类号： A61K39/0258 , A61K2039/6037 , Y02A50/474
摘要： This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including responses which provide protection against, or reduce the severity of, bacterial infections. More particularly it relates to the use of polysaccharides containing the tetrasaccharide repeat unit: (→3)-α-D-GalpNAc-(1→2)-α-D-PerpNAc-(1→3)-α-L-Fucp-(1→4)-β-D-Glcp-(1→), and conjugates thereof, to induce serum antibodies having bactericidal (killing) activity against hemolytic-uremic syndrome (HUS) causing E. coli, in particular E. coli O157. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies which have bactericidal or bacteriostatic activity against against E. coli, in particular E. coli O157, and are useful to prevent and/or treat illnesses caused by E. coli O157.The invention further relates to the antibodies which immunoreact with the O-specific polysaccharide of E. coli O157 and/or the carrier, that are induced by these conjugates and/or compositions thereof. The invention also relates to methods and kits using one or more of the polysaccharides, conjugates or antibodies described above.
摘要翻译：本发明涉及大肠杆菌O157的O-特异性多糖与载体及其组合物的缀合物，以及这些缀合物和/或其组合物在哺乳动物中引发免疫原性应答的方法，包括提供保护的应答反对或减轻细菌感染的严重性。更具体地说，涉及使用含有四糖重复单元的多糖：（→3）-al-D-GalpNAc-（1-> 2）-alpha-D-PerpNAc-（1-> 3）-alpha-L （1-> 4）-β-D-Glcp-（1->）及其缀合物，以诱导对引起大肠杆菌的溶血性尿毒综合征（HUS）具有杀菌（杀伤）活性的血清抗体，特异的大肠杆菌O157。缀合物及其组合物可用作诱导对大肠杆菌特别是大肠杆菌O157具有杀菌或抑菌活性的血清抗体的疫苗，并且可用于预防和/或治疗由大肠杆菌O157引起的疾病。本发明还涉及与这些缀合物和/或其组合物诱导的大肠杆菌O157和/或载体的O-特异性多糖免疫反应的抗体。本发明还涉及使用上述一种或多种多糖，缀合物或抗体的方法和试剂盒。

10. 发明授权

US06797275B1 Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine 有权
公开(公告)号：US06797275B1
公开(公告)日：2004-09-28
申请号：US09653433
申请日：2000-09-01
申请人： Zuzana Kossaczka , Shousun Chen Szu , John B. Robbins
发明人： Zuzana Kossaczka , Shousun Chen Szu , John B. Robbins
IPC分类号： A61K39112
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies againt S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.

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