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1. 发明专利

FR495673A 未知
公开(公告)号：FR495673A
公开(公告)日：1919-10-15
申请号：FR495673D
申请日：1917-10-08
申请人： LOUIS MILLER
发明人： MILLER LOUIS
IPC分类号： B63G9/00

2. 发明专利

GB1014898A Apparatus for cleaning textile fibres 未知
公开(公告)号：GB1014898A
公开(公告)日：1965-12-31
申请号：GB1621264
申请日：1964-04-20
申请人： AUGUST LOUIS MILLER , HEBER WILLIAMSON WELLER , ROGER STANLEY BROWN
IPC分类号： D01G15/34
摘要： 1,014,898. Cleaning fibrous material. A. L. MILLER, H. W. WELLER and R. S. BROWN. April 20, 1964, No. 16212/64. Heading D1N. Fibre cleaning apparatus which may be adapted for use in carding engines or fibre opening machines wherein there is a rotatable fibrecleaning cylinder has two partitions beneath and extending the full width of the cylinder to form a trash removal zone open at the bottom and, immediately following the partitions in'the direction of rotation of the cylinder, is also mounted an arcuate cover. As applied to a carding engine, Fig. 2, adjustable partitions 14, 15 are mounted beneath the licker-in 44 and form two sides of a channel open to atmosphere at the bottom. Behind the partition 14 there is adjustably secured a perforated plate 50 beneath which a suction duct may be arranged. This plate 50 may be replaced by a series of spaced bars. Another embodiment (Fig. 7 not shown), discloses three partitions. Fibre cleaning apparatus such as described in Specifications 796,568, 846,596, 849,548 and U.S.A. Specification 2,825,097 are modified by replacing grid bars beneath cleaning cylinders by partitions and arcuate covers which may be perforated or solid. Although the surfaces of the partitions are preferably smooth, they may be corrugated, curved and/or perforated. The partition edges may be flanged, square, scalloped, or shaped in any other way.

3. 发明专利

GB196477A Improvements in sanding machines for use with automobiles, or other vehicles 未知
公开(公告)号：GB196477A
公开(公告)日：1923-04-26
申请号：GB1173022
申请日：1922-04-26
申请人： LOUIS MILLER
IPC分类号： B60B39/04
摘要： 196,477. Miller, L. April 26, 1922. Sand, distributing on wheel tracks. -A sanding device for the wheel tracks of vehicles comprises a container from which lead tubes to the wheels, means for controlling the flow of sand from the container, and a sand box for carrying the weight of the sand, mounted in the container, with its bottom spaced above the means for controlling the flow of sand and perforated to feed sand into the space above the controlling means. In the container 10 is mounted the removable sand-box 31 perforated with clusters of holes 32 through which the sand passes into the space 36 in which the valve 19 slides. Tubes 16, 17 lead from the bottom of the sand container to the back and front of each wheel respectively, and the ports in the valve are arranged to uncover all the tubes leading to the front of the wheels or all the tubes leading to the back of the wheels according to the direction in which the hand lever 22 is moved. The sand is fed into the sand box by means of the cover 34 screwed into the side of the container

4. 发明授权

US08809320B2 Benzodiazepine derivatives 有权
标题翻译：苯并二氮杂衍生物
公开(公告)号：US08809320B2
公开(公告)日：2014-08-19
申请号：US13774059
申请日：2013-02-22
申请人： Wei Li , Nathan Elliott Fishkin , Robert Yongxin Zhao , Michael Louis Miller , Ravi V. J. Chari
发明人： Wei Li , Nathan Elliott Fishkin , Robert Yongxin Zhao , Michael Louis Miller , Ravi V. J. Chari
IPC分类号： C07D519/00 , A61K31/5517 , A61P35/00 , A61K47/48 , C07D487/04 , A61K38/07 , A61K45/06 , C07D498/04 , C07K5/103 , C07K16/28
CPC分类号： C07K16/2896 , A61K31/5517 , A61K38/07 , A61K45/06 , A61K47/60 , A61K47/6835 , A61K47/6849 , A61K47/6863 , A61P35/00 , C07D487/04 , C07D498/04 , C07D519/00 , C07K5/0202 , C07K5/1008 , C07K16/2803 , C07K16/46 , C07K19/00
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译：本发明涉及具有抗增殖活性的新型苯并二氮杂衍生物，更具体地涉及式（I）和（II）的新型苯并二氮杂，其中二氮杂环（B）与杂环（CD）稠合，其中杂环是双环的或其中二氮杂环（B）与杂环（C）稠合的式（III）化合物，其中杂环是单环的。本发明提供这些化合物的细胞毒二聚体。本发明还提供了单体和二聚体的共轭物。本发明还提供了使用本发明的化合物或缀合物来抑制哺乳动物异常细胞生长或治疗增殖性病症的组合物和方法。本发明还涉及将化合物或缀合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

5. 发明授权

US08802667B2 Benzodiazepine derivatives 有权
公开(公告)号：US08802667B2
公开(公告)日：2014-08-12
申请号：US13826181
申请日：2013-03-14
申请人： Wei Li , Nathan Elliott Fishkin , Robert Yongxin Zhao , Michael Louis Miller , Ravi V. J. Chari
发明人： Wei Li , Nathan Elliott Fishkin , Robert Yongxin Zhao , Michael Louis Miller , Ravi V. J. Chari
IPC分类号： C07D519/00 , A61K31/5517 , A61K31/55 , A61P35/00 , A61K47/48 , C07K5/103 , C07D498/04 , A61K38/07 , A61K45/06 , C07D487/04 , C07K16/28
CPC分类号： C07K16/2896 , A61K31/5517 , A61K38/07 , A61K45/06 , A61K47/60 , A61K47/6835 , A61K47/6849 , A61K47/6863 , A61P35/00 , C07D487/04 , C07D498/04 , C07D519/00 , C07K5/0202 , C07K5/1008 , C07K16/2803 , C07K16/46 , C07K19/00
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

6. 发明申请

US20050239730A1 Plasmodium falciparum erythrocyte binding protein baebl for use as a vaccine 审中-公开
标题翻译：恶性疟原虫红细胞结合蛋白baebl用作疫苗
公开(公告)号：US20050239730A1
公开(公告)日：2005-10-27
申请号：US10677980
申请日：2003-10-02
申请人： Ghislaine Mayer , Louis Miller
发明人： Ghislaine Mayer , Louis Miller
IPC分类号： A61K39/00 , A61P33/06 , C07K14/445 , C12N15/30 , C12P21/04 , A61K48/00 , A61K39/002
CPC分类号： C07K14/445 , A61K39/00 , Y02A50/412
摘要： The invention relates to Plasmodium falciparum Erythrocyte Binding Protein BAEBL for use as a vaccine.
摘要翻译：本发明涉及恶性疟原虫红细胞结合蛋白BAEBL用作疫苗。

7. 发明授权

US2657944A Coupling for tubular members 失效
标题翻译：用于管状构件的联接
公开(公告)号：US2657944A
公开(公告)日：1953-11-03
申请号：US9967749
申请日：1949-06-17
申请人： LOUIS MILLER
发明人： LOUIS MILLER
IPC分类号： E01B25/10 , E04G7/20 , F16B7/04
CPC分类号： E01B25/10 , E04G7/20 , F16B7/0413 , Y10T403/557 , Y10T403/7041

8. 发明授权

US2655129A Chinchilla cage 失效
标题翻译： Chin笼
公开(公告)号：US2655129A
公开(公告)日：1953-10-13
申请号：US21426551
申请日：1951-03-07
申请人： LOUIS MILLER
发明人： LOUIS MILLER
IPC分类号： A01K1/03
CPC分类号： A01K1/03

9. 发明授权

US2430524A Extension lock for bicycles and the like 失效
标题翻译：自行车的延长锁等
公开(公告)号：US2430524A
公开(公告)日：1947-11-11
申请号：US63706545
申请日：1945-12-22
申请人： LOUIS MILLER
发明人： LOUIS MILLER
IPC分类号： B62K21/12
CPC分类号： B62K21/12 , Y10T74/2078 , Y10T403/7056

10. 发明授权

US08444996B2 Multicomponent vaccine for malaria providing long-lasting immune responses against plasmodia 有权
公开(公告)号：US08444996B2
公开(公告)日：2013-05-21
申请号：US13121574
申请日：2009-10-01
申请人： Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Fathy Majadly , Christopher P. Mocca , Jerry Keith , Zuzana Biesova , Louis Miller , Ruth Nussenzweig , Darrell T. Liu
发明人： Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Fathy Majadly , Christopher P. Mocca , Jerry Keith , Zuzana Biesova , Louis Miller , Ruth Nussenzweig , Darrell T. Liu
IPC分类号： A61K39/015 , A61K39/385
CPC分类号： C07K14/00 , A61K39/015 , A61K47/646 , Y02A50/412
摘要： Disclosed are immunogenic conjugates which elicit an immune response to Plasmodium proteins. In particular examples, the Plasmodium proteins include sexual stage surface proteins, circumsporozoite protein (CSP), or immunogenic portions of CSP. Also provided herein are immunogenic compositions including one or more of the disclosed immunogenic conjugates and a pharmaceutically acceptable carrier. Further provided is a method of eliciting an immune response to Plasmodium in a subject, comprising administering to the subject an immunogenic composition disclosed herein.

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