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1. 发明申请

WO2007098412A1 SYSTEM AND METHOD FOR TRANSFERRING DIFFERENT TYPES OF STREAMING AND PACKETIZED DATA ACROSS AN ETHERNET TRANSMISSION LINE USING A FRAME AND PACKET STRUCTURE DEMARCATED WITH ETHERNET CODING VIOLATIONS 审中-公开
标题翻译：用于通过使用以太网编码突破的框架和分组结构通过以太网传输线传输不同类型的流动和封装数据的系统和方法
公开(公告)号：WO2007098412A1
公开(公告)日：2007-08-30
申请号：PCT/US2007/062328
申请日：2007-02-16
申请人： STANDARD MICROSYSTEMS CORPORATION , KNAPP, David, J. , MUELLER, Rainer, P. , HO, Horace, C. , HECK, Patrick , KLOS, Rainer , THIEL, Christian
发明人： KNAPP, David, J. , MUELLER, Rainer, P. , HO, Horace, C. , HECK, Patrick , KLOS, Rainer , THIEL, Christian
IPC分类号： H04L12/64 , H04J3/06
CPC分类号： H04J3/0605 , H04J3/0647 , H04J3/0658 , H04J3/1605 , H04L12/40006 , H04L12/413 , H04L12/42 , H04L25/4908
摘要： A communication system, network, interface, and port architecture are provided for transporting different types of data across a network. The network can be arranged by connecting the ports in a daisy-chain fashion to achieve a ring architecture or topology. The network forwards data according to a specific network protocol, and nodes among the network can use a recovered clock from the bitstream to drive the transmitter and create a synchronous network even thought the network can receive Ethernet packets which are typically targeted for an asynchronous network. Non-compliant data, such as Ethernet data, can be sent as packets within a frame structure. The frame is synchronized to Ethernet coding violations used to signal the beginning of each frame, and each packet can be immediately followed by a packet coding violation. The frame and packet coding violations are represented as a sequence of 4B/5B codes that are not valid codes and, therefore, not present as Ethernet encoded data.
摘要翻译：提供通信系统，网络，接口和端口架构，用于通过网络传输不同类型的数据。可以通过以菊花链方式连接端口来实现网络，以实现环形架构或拓扑。网络根据特定网络协议转发数据，网络中的节点可以使用来自比特流的恢复时钟来驱动发射机，并创建一个同步网络，甚至认为网络可以接收通常针对异步网络的以太网分组。诸如以太网数据之类的不合规数据可以作为帧结构内的分组发送。帧被同步到以太网编码违例，用于发信号通知每帧的开始，并且每个数据包可能紧随其后的是一个数据包编码违规。帧和分组编码违例被表示为不是有效代码的4B / 5B代码序列，因此不作为以太网编码数据出现。

2. 发明申请

WO2007093435A1 SYSTEM AND METHOD FOR TRANSFERRING DATA PACKETS THROUGH A COMMUNICATION SYSTEM 审中-公开
标题翻译：通过通信系统传输数据包的系统和方法
公开(公告)号：WO2007093435A1
公开(公告)日：2007-08-23
申请号：PCT/EP2007/001367
申请日：2007-02-16
申请人： SMSC EUROPE GMBH , MUELLER, Rainer, P. , HO, Horace, C. , HECK, Patrick , KNAPP, David , ROLFES, Kevin
发明人： MUELLER, Rainer, P. , HO, Horace, C. , HECK, Patrick , KNAPP, David , ROLFES, Kevin
IPC分类号： H04L12/56
CPC分类号： H04L47/10 , H04L47/18 , H04L47/263 , H04L47/266 , H04L47/30 , Y02D50/10
摘要： A communication system, network, interface, and port architecture are provided for transporting of data across a network. The network can be arranged by connecting the ports in a daisy chain fashion to achieve a ring architecture or topology. The network forwards data according to a specific network protocol. A first port forwards frames having a preemptive acknowledge field before the payload. A second port receives these frames, stores them in a frame buffer and modifies the preemptive acknowledge field according to its available frame buffer capacity. Said first port controls its a data flow according to the modified preemptive acknowledge field.
摘要翻译：提供通信系统，网络，接口和端口架构，用于通过网络传输数据。可以通过以菊花链方式连接端口来实现网络，以实现环形架构或拓扑。网络根据特定的网络协议转发数据。第一个端口在有效载荷之前转发具有抢占确认字段的帧。第二端口接收这些帧，将它们存储在帧缓冲器中，并根据其可用帧缓冲器容量修改抢占确认字段。所述第一端口根据修改的抢占确认字段控制其数据流。

3. 发明申请

WO2007031187A1 CLEAVAGE OF PRECURSORS OF INSULINS BY A VARIANT OF TRYPSIN 审中-公开
标题翻译：利用胰蛋白酶切割胰岛素前体的研究
公开(公告)号：WO2007031187A1
公开(公告)日：2007-03-22
申请号：PCT/EP2006/008380
申请日：2006-08-26
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , GEIPEL, Frank , GLASER, Stephan , HOH, Christoph , KOPETZKI, Erhard , MUELLER, Rainer , ZOCHER, Frank
发明人： GEIPEL, Frank , GLASER, Stephan , HOH, Christoph , KOPETZKI, Erhard , MUELLER, Rainer , ZOCHER, Frank
IPC分类号： C07K14/81
CPC分类号： C07K14/62 , C12N9/6427
摘要： The present invention relates to the production of a variant of recombinant trypsin with increased substrate specificity for arginine versus lysine in non-animal host organisms. Moreover, the present invention relates to a variant of recombinant trypsin and their production. Also provided are use of recombinant porcine pancreatic trypsin variants for cleavage of precursors of insulins, and kits containing the variant of trypsin.
摘要翻译：本发明涉及在非动物宿主生物体中生产对精氨酸与赖氨酸的底物特异性增加的重组胰蛋白酶的变体。而且，本发明涉及重组胰蛋白酶的变体及其生产。还提供了用于裂解胰岛素前体的重组猪胰腺胰蛋白酶变体和含有胰蛋白酶变体的试剂盒。

4. 发明申请

WO2005068258A3 INSULATION STRUCTURE FOR THE INTERNAL INSULATION OF A VEHICLE 审中-公开
标题翻译：汽车内部绝缘的绝缘结构
公开(公告)号：WO2005068258A3
公开(公告)日：2006-04-27
申请号：PCT/EP2005000039
申请日：2005-01-05
申请人： AIRBUS GMBH , MUELLER RAINER , TURANSKI PETER , OESTEREICH WILKO , REINELT THORSTEN
发明人： MUELLER RAINER , TURANSKI PETER , OESTEREICH WILKO , REINELT THORSTEN
IPC分类号： B60R13/08 , A62C2/06 , A62C3/08 , B64C1/40
CPC分类号： B60R13/0815 , A62C2/06 , B64C1/40
摘要： The present invention relates to an insulation structure for the internal insulation of a vehicle. The insulation structure will contribute to ensuring the fire protection for interior regions of the vehicle from a (conceivable) fire incursion from outside the vehicle environment, so that evacuation of the passengers from the vehicle is made significantly easier. Intended modifications to a typical insulation package will implement an elevation of the fire protection safety for separated interior regions lying proximal to a structure external skin. The insulation structure for the internal insulation of a vehicle comprises an insulation package, which is implemented using an insulation, and a film, which is positioned inside an intermediate space that includes internal paneling and an external skin of the vehicle. The insulation package is implemented homogeneously using a first insulation, whose insulation material is bum-through safe. Otherwise, the insulation package is constructed using distinct insulation regions, which are implemented using the first insulation and a second insulation, whose insulation material is burn-through unsafe. These insulation regions are positioned along a finite series and laid next to one another up to a terminating insulation region, whose insulation material is exchanged in alternating sequence. Otherwise, the insulation package is implemented homogeneously using a second insulation, whose insulation material is burn-through unsafe (fire endangered, flammable), multiple burn-through safe barrier layers being integrated in the second insulation.
摘要翻译：本发明涉及一种用于车辆内部绝缘的绝缘结构。隔热结构将有助于确保车辆内部区域的防火保护从车辆外部的（可设想的）火灾侵入，从而使乘客从车辆撤离变得容易得多。对典型的隔热包进行预期的修改将实现位于结构外部皮肤附近的分离的内部区域的防火安全性的提升。用于车辆内部绝缘的绝缘结构包括使用绝缘体实现的绝缘封装和位于包括车辆的内部面板和外部表皮的中间空间内的膜。绝缘封装采用第一种绝缘材料均匀地实施，其绝缘材料是安全的。否则，绝缘封装使用不同的绝缘区域构建，这些绝缘区域使用第一绝缘和第二绝缘来实现，绝缘材料的绝缘材料是烧穿不安全的。这些绝缘区域沿着有限序列放置并且彼此相邻放置直至终端绝缘区域，绝缘材料以交替顺序交换。否则，使用绝缘材料为不安全（火灾危险，易燃）的绝缘材料，集成在第二绝缘中的多个烧穿安全阻挡层的第二绝缘材料均匀地实施绝缘封装。

5. 发明申请

WO0103652A2 UV RADIATION REFLECTING OR ABSORBING AGENTS, PROTECTING AGAINST HARMFUL UV RADIATION AND REINFORCING THE NATURAL SKIN BARRIER 审中-公开
标题翻译：意味着紫外线辐射吸收剂和/或涉及健康有害的紫外线辐射皮肤天然屏障的保护和加固作用映
公开(公告)号：WO0103652A2
公开(公告)日：2001-01-18
申请号：PCT/EP0006534
申请日：2000-07-10
申请人： PHARMASOL GMBH , MUELLER RAINER HELMUT , WISSING SYLVIA , MAEDER KARSTEN
发明人： MUELLER RAINER HELMUT , WISSING SYLVIA , MAEDER KARSTEN
IPC分类号： A61K8/30 , A61K8/00 , A61K8/04 , A61K8/19 , A61K8/20 , A61K8/23 , A61K8/24 , A61K8/25 , A61K8/29 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/365 , A61K8/368 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/60 , A61K8/64 , A61K8/65 , A61K8/67 , A61K8/72 , A61K8/73 , A61K8/81 , A61K8/86 , A61K8/96 , A61K8/97 , A61Q1/06 , A61Q5/00 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61K7/00
CPC分类号： A61Q17/04 , A61K8/0295 , A61K8/342 , A61K8/35 , A61K8/37 , A61K2800/56
摘要： The invention concerns UV radiation reflecting or absorbing agents, designed to be applied on the skin, the mucous membranes, the scalp and the hair for protection against harmful UV radiation and to reinforce the natural skin barrier. The inventive agents comprise polymorphous, crystalline or semicrystalline solid polymeric or lipidic particles.
摘要翻译：本发明涉及一种具有紫外线辐射吸收和/或反射应用在皮肤上，粘膜，头皮和头发免受有害紫外线辐射的防护作用和加强天然皮肤屏障包含固体，多晶型结晶或部分结晶的脂质和/剂或聚合物颗粒包括。

6. 发明申请

WO2007051520A3 METHOD AND DEVICE FOR PRODUCING VERY FINE PARTICLES AND COATING SUCH PARTICLES 审中-公开
标题翻译：方法和设备用于生产高细颗粒和涂料这样的粒子
公开(公告)号：WO2007051520A3
公开(公告)日：2008-01-03
申请号：PCT/EP2006009930
申请日：2006-10-13
申请人： ABBOTT GMBH & CO KG , MUELLER RAINER HELMUT , MOESCHWITZER JAN
发明人： MUELLER RAINER HELMUT , MOESCHWITZER JAN
IPC分类号： A61K9/14 , B01F5/06 , B01J2/00
CPC分类号： B01J2/003 , B01F5/0256 , B01F5/0451 , B01F5/0646 , B01F5/0647 , B01F5/0652 , B01F5/0685 , B01F7/00775 , B01F11/0258 , B01F15/0203 , B01J2/02 , B01J2/18
摘要： Disclosed are methods and devices for producing very fine particles which are then coated with protective polymers in another step of the process. The particles are produced using a method in which a liquid flow comprising a particle-free liquid 1 that contains the active substance in a dissolved form is combined with a second liquid flow comprising a liquid 2 in a high-energy zone or no sooner than two seconds before reaching the high-energy zone. Said two liquids can be mixed with each other while the active substance dissolved in liquid 1 is insoluble or more difficult to dissolve in liquid 2 than in liquid 1 and settles in the form of particles in the high-energy zone or within a maximum of 2 seconds before reaching the high-energy zone when the two liquids are mixed. The obtained particles are introduced into an aqueous outer phase which contains the coating materials in a dissolved form and are then subjected to a drying step such that said materials settle on the particles as a closed coating. The coated particles are protected from damaging influences and are provided with modified release kinetics compared to uncoated particles.
摘要翻译：有用于生产非常细的颗粒，然后将其涂覆在用保护性聚合物进一步的处理步骤的描述的方法和装置。所述颗粒是通过一种方法，其中从一无微粒，活性剂的流体流溶于含有1液体中的高能量区域到达高能量区之前制备，与第二液体流从液体2，或至少2秒钟在一起时，两种液体彼此和溶解在液体中的活性物质可混溶的不为1或到达高能量区域的两种液体作为粒子的混合之前少在可溶的和沉淀物或最多2秒内的液体2。将如此制备的颗粒被引入到含有溶解形式的涂层或涂料的水性外相，然后进行干燥步骤，由此这些材料作为颗粒上的连续涂层沉淀。将如此涂覆的颗粒免受有害影响，并具有改进的释放动力学，而不是无包膜颗粒。

7. 发明申请

WO2007031187A8 CLEAVAGE OF PRECURSORS OF INSULINS BY A VARIANT OF TRYPSIN 审中-公开
标题翻译：通过一系列TRYPSIN对胰岛素前列腺进行清除
公开(公告)号：WO2007031187A8
公开(公告)日：2007-08-16
申请号：PCT/EP2006008380
申请日：2006-08-26
申请人： SANOFI AVENTIS DEUTSCHLAND , HOFFMANN LA ROCHE , ROCHE DIAGNOSTICS GMBH , GEIPEL FRANK , GLASER STEPHAN , HOH CHRISTOPH , KOPETZKI ERHARD , MUELLER RAINER , ZOCHER FRANK
发明人： GEIPEL FRANK , GLASER STEPHAN , HOH CHRISTOPH , KOPETZKI ERHARD , MUELLER RAINER , ZOCHER FRANK
IPC分类号： C07K14/81
CPC分类号： C07K14/62 , C12N9/6427
摘要： The present invention relates to the production of a variant of recombinant trypsin with increased substrate specificity for arginine versus lysine in non-animal host organisms. Moreover, the present invention relates to a variant of recombinant trypsin and their production. Also provided are use of recombinant porcine pancreatic trypsin variants for cleavage of precursors of insulins, and kits containing the variant of trypsin.
摘要翻译：本发明涉及在非动物宿主生物中生产具有增加的对精氨酸与赖氨酸的底物特异性的重组胰蛋白酶的变体。此外，本发明涉及重组胰蛋白酶的变体及其制备。还提供了重组猪胰胰蛋白酶变体用于切割胰岛素前体的试剂，以及含有胰蛋白酶变体的试剂盒。

8. 发明申请

WO2007031321B1 AIRCRAFT FUSELAGE 审中-公开
标题翻译：飞机配件
公开(公告)号：WO2007031321B1
公开(公告)日：2007-05-10
申请号：PCT/EP2006008979
申请日：2006-09-14
申请人： AIRBUS GMBH , MUELLER RAINER
发明人： MUELLER RAINER
IPC分类号： B64C1/00 , B64C1/40 , B64D45/00
CPC分类号： B64C1/12 , B64C1/403 , B64D7/00 , B64D45/0015 , B64D2045/005 , F41H5/0471 , F41H5/0485 , Y02T50/46
摘要： The present invention provides an aircraft fuselage which comprises a bulletproof layer in at least partial areas, an aircraft fuselage being understood as both a primary fuselage structure of an aircraft, i.e., sheeting and associated frames and stringers (519), aircraft fuselage insulation (504), and also cabin internal paneling (509), which encloses a pressurized cabin on the outside toward the primary fuselage structure. In this way, it may be possible to ensure bulletproof security (511, 512) of the aircraft fuselage and thus prevent danger to passengers (510) and/or flight-relevant systems of the aircraft.
摘要翻译：本发明提供了一种飞机机身，其包括在至少部分区域中的防弹层，飞行器机身被理解为飞机的主要机身结构，即片材和相关联的框架和桁条（519），飞机机身绝缘（504 ）以及机舱内部镶板（509），其将外部的加压舱围绕主机身结构。以这种方式，可以确保飞机机身的防弹安全（511,512），从而防止对飞机的乘客（510）和/或飞行相关系统的危险。

9. 发明申请

WO2005068289A3 FUSELAGE 审中-公开
标题翻译：机身
公开(公告)号：WO2005068289A3
公开(公告)日：2005-12-01
申请号：PCT/EP2005000038
申请日：2005-01-05
申请人： AIRBUS GMBH , MUELLER RAINER , TURANSKI PETER , OESTEREICH WILKO , REINELT THORSTEN
发明人： MUELLER RAINER , TURANSKI PETER , OESTEREICH WILKO , REINELT THORSTEN
IPC分类号： A62C3/08 , B64C1/00 , B64C1/40
CPC分类号： B64C1/066 , B32B15/08 , B64C2001/0072 , B64C2001/0081 , Y02T50/433
摘要： The fuselage is conceived in such a way as to prevent the spread of flames produced by a source of fire and acting on the fuselage from outside the aircraft environment. The fuselage concept takes into account materials or material combinations that will scarcely allow protection of the cabin area of an aircraft (upon emergency landing) to be violated by flames spreading from outside the aircraft environment, which may facilitate an evacuation of passengers from the aircraft. An aircraft fuselage, whose fuselage structure, in addition to other structural elements that are components of the mechanical strength bracing of the fuselage and help absorb its forces, encompasses an exterior skin (2) consisting of various respective materials, which are designed to be resistant to shear, and incorporated as a bearing element into the mechanical strength bracing (6,7,8) to absorb and transfer the forces and torques acting thereupon. The exterior skin (2) is fabricated from a burn-through resistant semi-finished material consisting of a non-metallic material or a fireproof metallic material, wherein the semi-finished material can be molded through further processing. Also, the exterior skin may be realized by a semi-finished material combining a non-metallic material and a metallic material, wherein the produced exterior skin product is a hybrid material that can be molded and joined through further processing.
摘要翻译：机身的设计方式是防止火源产生的火焰蔓延，并从飞机环境外面对机身作用。机身概念考虑到材料或材料组合，几乎不允许保护飞机机舱区域（在紧急着陆时）被从飞机环境外部扩散的火焰所侵犯，这可能有助于乘客从飞机上撤离。飞机机身的机身结构除机身强度支撑机构的其他结构元件外，还有助于吸收机身的力，包括由各种各样的材料组成的外部皮肤（2）剪切，并作为轴承元件结合到机械强度支撑件（6,7,8）中以吸收和转移作用在其上的力和转矩。外部皮肤（2）由耐金属的半成品由非金属材料或耐火金属材料制成，其中半成品可以通过进一步加工成型。此外，外部皮肤可以通过组合非金属材料和金属材料的半成品材料来实现，其中所制造的外部皮肤产品是可以通过进一步加工成型和连接的混合材料。

10. 发明申请

WO02072634A3 RECOMBINANT PROTEINASE K 审中-公开
标题翻译：重组蛋白酶K
公开(公告)号：WO02072634A3
公开(公告)日：2003-03-13
申请号：PCT/EP0201322
申请日：2002-02-08
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , MUELLER RAINER , THALHOFER JOHANN-PETER , REXER BERNHARD , SCHMUCK RAINER , GEIPEL FRANK , GLASER STEPHAN , SCHOEN HELMUT , MEIER THOMAS , RUDOLPH RAINER , LILIE HAUKE , SCHOTT BJOERN
发明人： MUELLER RAINER , THALHOFER JOHANN-PETER , REXER BERNHARD , SCHMUCK RAINER , GEIPEL FRANK , GLASER STEPHAN , SCHOEN HELMUT , MEIER THOMAS , RUDOLPH RAINER , LILIE HAUKE , SCHOTT BJOERN
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N9/58 , C12N15/55 , C07K1/113 , C12N15/70
CPC分类号： C12N9/58 , C07K2319/00 , C12Y304/21064
摘要： The invention relates to recombinant proteinase K and to a method for producing recombinant proteinase K, which is characterised by the following steps: a) transformation of a host cell containing a recombinant nucleic acid that codes for the zymogenic precursor of the proteinase K, b) cultivation of the host cell in such a way that the zymogenic precursor of proteinase K occurs in the form of inclusion bodies in said host cell, c) isolation of the inclusion bodies and re-naturing under conditions, from which the protease part of the zymogenic precursor emerges in its natural conformation, d) activation and purification of the re-natured proteinase K.
摘要翻译：在本发明中，重组蛋白酶K进行说明。此外，公开了用于生产重组蛋白酶K的方法，其特点在于：a）转化的宿主细胞用重组核酸，其编码K中蛋白酶的酶原前体，b）以一种方式培养该宿主细胞，该酶原前体通过蛋白酶K在宿主细胞“包涵体”的形式生产的，c）分离“包涵体”，和复性的条件下，其中在它们的天然构象所产生的酶原前体，D）的活化和纯化，性蛋白酶K的蛋白酶部分，

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