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1. 发明申请

US20080026048A1 Reovirus for the treatment of cellular proliferative disorders 审中-公开
公开(公告)号：US20080026048A1
公开(公告)日：2008-01-31
申请号：US11807915
申请日：2007-05-30
申请人： Patrick Lee , James Strong , Matthew Coffey
发明人： Patrick Lee , James Strong , Matthew Coffey
IPC分类号： A61K9/127 , A61K48/00
CPC分类号： A61K9/0019 , A61K35/765 , C12N2720/12032 , C12N2720/12232
摘要： Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

2. 发明申请

US20080019981A1 Viruses for the treatment of cellular proliferative disorders 有权
标题翻译：用于治疗细胞增殖性疾病的病毒
公开(公告)号：US20080019981A1
公开(公告)日：2008-01-24
申请号：US11807906
申请日：2007-05-30
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61K35/76 , A61K39/395 , A61P43/00
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering a immunosuppressive agent.
摘要翻译：公开了通过向具有活化的Ras通路的增殖细胞施用病毒来治疗细胞增殖障碍的方法。施用病毒使得其最终直接接触具有活化的Ras途径的增殖细胞。增生性疾病包括但不限于赘生物。病毒选自修饰的腺病毒，修饰的HSV，修饰的痘苗病毒和修饰的副痘病毒或病毒。还公开了通过进一步施用免疫抑制剂来治疗细胞增殖性疾病的方法。

3. 发明申请

US20080014577A1 Oncolytic viruses as phenotyping agents for neoplasms 审中-公开
标题翻译：肿瘤溶解病毒作为肿瘤的表型剂
公开(公告)号：US20080014577A1
公开(公告)日：2008-01-17
申请号：US11807771
申请日：2007-05-30
申请人： Bradley Thompson , Matthew Coffey
发明人： Bradley Thompson , Matthew Coffey
IPC分类号： C12Q1/70
CPC分类号： G01N33/574 , G01N33/5748 , G01N2333/14 , Y10S435/975
摘要： The present invention provides a method of diagnosing neoplasms having a particular phenotype by using oncolytic viruses that selectively replicate in neoplasms having the particular phenotype. For example, reovirus does not replicate in normal cells. However, reovirus selectively replicate in cells with an activated ras pathway, which leads to death of these cells. Therefore, a cell which becomes neoplastic due to, at least in part, elevated ras pathway activities can be diagnosed by its susceptibility to reovirus replication. This invention can further be applied, using other oncolytic viruses, to the diagnosis and/or treatment of other tumors, such as interferon-sensitive tumors, p53-deficient tumors and Rb-deficient tumors. Kits useful in the diagnosis or treatment disclosed herein are also provided.
摘要翻译：本发明提供了通过使用在具有特定表型的肿瘤中选择性复制的溶瘤病毒来诊断具有特定表型的赘生物的方法。例如，呼肠孤病毒不会在正常细胞中复制。然而，呼肠孤病毒在具有活化的ras途径的细胞中选择性复制，这导致这些细胞的死亡。因此，由于至少部分地升高的ras途径活性而变得肿瘤的细胞可以通过其对呼肠孤病毒复制的易感性来诊断。本发明还可以使用其他溶瘤病毒来应用于其它肿瘤如干扰素敏感性肿瘤，p53缺陷型肿瘤和Rb缺陷型肿瘤的诊断和/或治疗。还提供了在本文公开的诊断或治疗中有用的试剂盒。

4. 发明申请

US20080032279A1 Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions 有权
公开(公告)号：US20080032279A1
公开(公告)日：2008-02-07
申请号：US11807930
申请日：2007-05-30
申请人： Donald Morris , Bradley Thompson , Matthew Coffey
发明人： Donald Morris , Bradley Thompson , Matthew Coffey
IPC分类号： C12N7/01
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.

5. 发明申请

US20070269856A1 Viral Purification Methods 有权
标题翻译：病毒纯化方法
公开(公告)号：US20070269856A1
公开(公告)日：2007-11-22
申请号：US11736479
申请日：2007-04-17
申请人： Matthew Coffey
发明人： Matthew Coffey
IPC分类号： C12P21/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/15 , C07K14/005 , C12N2720/12051 , C12N2720/12222 , C12N2720/12234 , C12N2720/12251
摘要： The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filtration and column chromatography. Viruses and compositions comprising the viruses prepared according to the present invention are also provided.
摘要翻译：本发明涉及一种纯化病毒，特别是呼肠弧病毒的改进方法。可以用洗涤剂从细胞培养物中提取传染病毒以产生高滴度的病毒，然后可以通过简单的步骤如过滤和柱层析纯化病毒。还提供了包含根据本发明制备的病毒的病毒和组合物。

6. 发明申请

US20070190032A1 Use of Local Immune Suppression to Enhance Oncolytic Viral Therapy 审中-公开
标题翻译：使用局部免疫抑制来增强溶瘤病毒治疗
公开(公告)号：US20070190032A1
公开(公告)日：2007-08-16
申请号：US11673201
申请日：2007-02-09
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61N5/00 , A61K48/00
CPC分类号： A61N5/10 , A61K35/765 , A61N2005/1098
摘要： Provided herein are methods for treating or ameliorating a solid tumor in a subject comprising administering oncolytic viruses and immunosuppressive agents at or near the site of the tumor.
摘要翻译：本文提供了治疗或改善受试者中的实体瘤的方法，包括在肿瘤部位或其附近施用溶瘤病毒和免疫抑制剂。

7. 发明申请

US20070086984A1 Viruses for the Treatment of Cellular Proliferative Disorders 有权
标题翻译：用于治疗细胞增殖性疾病的病毒
公开(公告)号：US20070086984A1
公开(公告)日：2007-04-19
申请号：US11557467
申请日：2006-11-07
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61K48/00 , A61K35/76
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.
摘要翻译：公开了通过向具有活化的Ras通路的增殖细胞施用病毒来治疗细胞增殖障碍的方法。施用病毒使得其最终直接接触具有活化的Ras途径的增殖细胞。增生性疾病包括但不限于赘生物。病毒选自修饰的腺病毒，修饰的HSV，修饰的痘苗病毒和修饰的副痘病毒或病毒。还公开了通过进一步施用免疫抑制剂来治疗细胞增殖性疾病的方法。

8. 发明申请

US20060073166A1 Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders 有权
公开(公告)号：US20060073166A1
公开(公告)日：2006-04-06
申请号：US11255849
申请日：2005-10-21
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61K39/00 , A61K39/12 , A61K39/38
CPC分类号： A61K35/765 , A61K38/13 , C07K16/081 , C07K16/10 , C07K16/4216 , C12N9/1205 , C12N2720/12232 , Y10S435/948 , Y10S435/975 , A61K2300/00
摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The mammal may be selected from dogs, cats, sheep, goats, cattle, horses, pigs, mice, humans and non-human primates. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. In particular, the methods provide for reovirus treatment of immunosuppressed or immuno-deficient mammals to treat the proliferative disorders. Immunosuppression, immunoinhibition or otherwise inducing an immunodeficient state in a mammal renders the reovirus more effective. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells. Immune systems may be compromised by one or more of the following: an HIV infection; as a side effect of chemotherapy or radiation therapy; by selective removal of B and/or T cell populations; by removal of antibodies (anti-antireovirus antibodies or all antibodies), and the like.

9. 发明申请

US20050026289A1 Virus clearance of neoplastic cells from mixed cellular compositions 审中-公开
标题翻译：来自混合细胞组合物的肿瘤细胞的病毒清除
公开(公告)号：US20050026289A1
公开(公告)日：2005-02-03
申请号：US10931728
申请日：2004-08-31
申请人： Donald Morris , Bradley Thompson , Matthew Coffey
发明人： Donald Morris , Bradley Thompson , Matthew Coffey
IPC分类号： C12N7/00 , A61K35/12 , A61K35/14 , A61K35/23 , A61K35/28 , A61K35/34 , A61K35/36 , A61K35/38 , A61K35/39 , A61K35/407 , A61K35/52 , A61K35/54 , A61K35/76 , A61K35/765 , A61K48/00 , A61L2/00 , A61P43/00 , C12N5/00 , C12N5/09 , C12N15/861 , C12Q1/68 , C12N15/86
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N15/86 , C12N2500/70 , C12N2720/12232 , C12N2720/12243
摘要： The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.
摘要翻译：本发明涉及通过使用选择性感染和杀死肿瘤细胞的病毒，从活体外部的混合细胞组合物中去除肿瘤细胞的方法。在该方法中可以使用各种病毒以除去不同目的的肿瘤细胞，例如在移植前清除造血干细胞。还提供了根据该方法制备的组合物，以及包含可用于本发明的病毒组合的试剂盒。

10. 发明申请

US20090035278A2 REOVIRUSES HAVING MODIFIED SEQUENCES 有权
标题翻译：具有修改序列的病毒
公开(公告)号：US20090035278A2
公开(公告)日：2009-02-05
申请号：US12046095
申请日：2008-03-11
申请人： Matthew Coffey
发明人： Matthew Coffey
IPC分类号： A61K35/76 , C12N7/00 , C07K14/00 , A61P43/00 , C12N15/74 , C07H21/00
CPC分类号： A61K45/06 , A61K35/13 , A61K35/765 , C07K14/005 , C12N7/00 , C12N2720/12221 , C12N2720/12222
摘要： The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.
摘要翻译：本发明提供了修饰的呼肠孤病毒核酸序列和修饰的呼肠孤病毒多肽序列以及含有这种修饰的核酸或多肽序列的呼肠病毒。本发明还提供了包含具有修饰序列的呼肠病毒的药物组合物以及制备和使用这些呼肠孤病毒的方法。

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