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1. 发明申请

US20080019981A1 Viruses for the treatment of cellular proliferative disorders 有权
标题翻译：用于治疗细胞增殖性疾病的病毒
公开(公告)号：US20080019981A1
公开(公告)日：2008-01-24
申请号：US11807906
申请日：2007-05-30
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61K35/76 , A61K39/395 , A61P43/00
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering a immunosuppressive agent.
摘要翻译：公开了通过向具有活化的Ras通路的增殖细胞施用病毒来治疗细胞增殖障碍的方法。施用病毒使得其最终直接接触具有活化的Ras途径的增殖细胞。增生性疾病包括但不限于赘生物。病毒选自修饰的腺病毒，修饰的HSV，修饰的痘苗病毒和修饰的副痘病毒或病毒。还公开了通过进一步施用免疫抑制剂来治疗细胞增殖性疾病的方法。

2. 发明申请

US20080014577A1 Oncolytic viruses as phenotyping agents for neoplasms 审中-公开
标题翻译：肿瘤溶解病毒作为肿瘤的表型剂
公开(公告)号：US20080014577A1
公开(公告)日：2008-01-17
申请号：US11807771
申请日：2007-05-30
申请人： Bradley Thompson , Matthew Coffey
发明人： Bradley Thompson , Matthew Coffey
IPC分类号： C12Q1/70
CPC分类号： G01N33/574 , G01N33/5748 , G01N2333/14 , Y10S435/975
摘要： The present invention provides a method of diagnosing neoplasms having a particular phenotype by using oncolytic viruses that selectively replicate in neoplasms having the particular phenotype. For example, reovirus does not replicate in normal cells. However, reovirus selectively replicate in cells with an activated ras pathway, which leads to death of these cells. Therefore, a cell which becomes neoplastic due to, at least in part, elevated ras pathway activities can be diagnosed by its susceptibility to reovirus replication. This invention can further be applied, using other oncolytic viruses, to the diagnosis and/or treatment of other tumors, such as interferon-sensitive tumors, p53-deficient tumors and Rb-deficient tumors. Kits useful in the diagnosis or treatment disclosed herein are also provided.
摘要翻译：本发明提供了通过使用在具有特定表型的肿瘤中选择性复制的溶瘤病毒来诊断具有特定表型的赘生物的方法。例如，呼肠孤病毒不会在正常细胞中复制。然而，呼肠孤病毒在具有活化的ras途径的细胞中选择性复制，这导致这些细胞的死亡。因此，由于至少部分地升高的ras途径活性而变得肿瘤的细胞可以通过其对呼肠孤病毒复制的易感性来诊断。本发明还可以使用其他溶瘤病毒来应用于其它肿瘤如干扰素敏感性肿瘤，p53缺陷型肿瘤和Rb缺陷型肿瘤的诊断和/或治疗。还提供了在本文公开的诊断或治疗中有用的试剂盒。

3. 发明申请

US20080075729A1 Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders 失效
标题翻译：用于预防呼肠孤病毒识别用于治疗细胞增殖性疾病的方法
公开(公告)号：US20080075729A1
公开(公告)日：2008-03-27
申请号：US11809195
申请日：2007-05-30
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61K39/395 , A61K35/76 , A61P43/00
CPC分类号： A61K35/765 , A61K38/13 , C07K16/081 , C07K16/10 , C07K16/4216 , C12N9/1205 , C12N2720/12232 , Y10S435/948 , Y10S435/975 , A61K2300/00
摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The mammal may be selected from dogs, cats, sheep, goats, cattle, horses, pigs, mice, humans and non-human primates. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. In particular, the methods provide for reovirus treatment of immunosuppressed or immuno-deficient mammals to treat the proliferative disorders. Immunosuppression, immunoinhibition or otherwise inducing an immunodeficient state in a mammal renders the reovirus more effective. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells. Immune systems may be compromised by one or more of the following: an HIV infection; as a side effect of chemotherapy or radiation therapy; by selective removal of B and/or T cell populations; by removal of antibodies (anti-antireovirus antibodies or all antibodies), and the like.
摘要翻译：本发明涉及在哺乳动物中治疗细胞增殖性疾病，特别是ras介导的细胞增殖性疾病中预防呼肠孤病毒识别的方法。哺乳动物可以选自狗，猫，绵羊，山羊，牛，马，猪，小鼠，人和非人灵长类动物。该方法包括抑制或以其他方式抑制哺乳动物的免疫系统，并且同时或随后在导致增殖细胞的实质性裂解的条件下向增殖细胞施用有效量的一种或多种呼吸道病毒。特别地，该方法提供了呼肠孤病毒治疗免疫抑制或免疫缺陷型哺乳动物以治疗增殖性疾病。在哺乳动物中的免疫抑制，免疫抑制或其他诱导免疫缺陷状态使呼肠孤病毒更有效。所述方法可以包括选择性去除可能干扰病毒的全身递送的免疫组分; 预防宿主免疫系统的呼肠孤病毒识别; 并在用呼肠孤病毒治疗后从免疫抑制或免疫不称职的宿主中除去病毒。或者，呼肠孤病毒可以在导致增殖细胞的实质性裂解的条件下给予具有减少的免疫应答系统的哺乳动物。免疫系统可能受到以下一种或多种感染：HIV感染; 作为化疗或放射治疗的副作用; 通过选择性去除B和/或T细胞群体; 通过除去抗体（抗 - 抗病毒抗体或全部抗体）等。

4. 发明申请

US20080031886A1 Viruses for the treatment of cellular proliferative disorders 有权
公开(公告)号：US20080031886A1
公开(公告)日：2008-02-07
申请号：US11807920
申请日：2007-05-30
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61K39/42 , A61K39/395 , A61K48/00
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.

5. 发明申请

US20080081032A1 Method for reducing pain using oncolytic viruses 审中-公开
标题翻译：使用溶瘤病毒减轻疼痛的方法
公开(公告)号：US20080081032A1
公开(公告)日：2008-04-03
申请号：US11809714
申请日：2007-06-01
申请人： Donald Morris , Matthew Coffey , Bradley Thompson
发明人： Donald Morris , Matthew Coffey , Bradley Thompson
IPC分类号： A61K48/00 , A61P25/04
CPC分类号： A61K35/765 , A61K45/06 , C12N2720/12232 , A61K2300/00
摘要： The present invention provides a method for reducing pain associated with neoplasms in a mammal, comprising administering an effective amount of one or more oncolytic viruses. Preferably, the mammal also receives an analgesic, and the amount of analgesic required by the mammal is reduced when the oncolytic virus is administered. The oncolytic virus is preferably reovirus. The mammal may be additionally subject to other therapies, such as chemotherapy, immunotherapy, hormonal and/or radiation therapy.
摘要翻译：本发明提供了减少与哺乳动物赘生物相关的疼痛的方法，包括施用有效量的一种或多种溶瘤病毒。优选地，哺乳动物还接受止痛剂，并且当施用溶瘤病毒时，哺乳动物所需的止痛剂的量减少。溶瘤病毒优选为呼肠孤病毒。哺乳动物可以另外进行其他治疗，例如化学疗法，免疫治疗，激素和/或放射治疗。

6. 发明申请

US20080019980A1 Viruses for the treatment of cellular proliferative disorders 有权
标题翻译：用于治疗细胞增殖性疾病的病毒
公开(公告)号：US20080019980A1
公开(公告)日：2008-01-24
申请号：US11807770
申请日：2007-05-30
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61K39/395 , A61K39/00 , A61P43/00
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.
摘要翻译：公开了通过向具有活化的Ras通路的增殖细胞施用病毒来治疗细胞增殖障碍的方法。施用病毒使得其最终直接接触具有活化的Ras途径的增殖细胞。增生性疾病包括但不限于赘生物。病毒选自修饰的腺病毒，修饰的HSV，修饰的痘苗病毒和修饰的副痘病毒或病毒。还公开了通过进一步施用免疫抑制剂来治疗细胞增殖性疾病的方法。

7. 发明申请

US20060165724A1 Method of producing infectious reovirus 有权
公开(公告)号：US20060165724A1
公开(公告)日：2006-07-27
申请号：US11390885
申请日：2006-03-27
申请人： Bradley Thompson , Matthew Coffey
发明人： Bradley Thompson , Matthew Coffey
IPC分类号： A61K39/15 , C12N7/02 , C12N5/08 , C12N15/86
CPC分类号： A61K35/765 , C12N7/00 , C12N2510/02 , C12N2720/12011 , C12N2720/12032 , C12N2720/12051
摘要： A simple and efficient method of producing mammalian reovirus is developed using HEK 293 cells. The method provides for fast production of reovirus in high yield. Furthermore, this method provides for a simpler purification procedure of the produced reovirus.

8. 发明申请

US20060029598A1 Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions 有权
公开(公告)号：US20060029598A1
公开(公告)日：2006-02-09
申请号：US11236059
申请日：2005-09-26
申请人： Donald Morris , Bradley Thompson , Matthew Coffey
发明人： Donald Morris , Bradley Thompson , Matthew Coffey
IPC分类号： A61K39/395
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.

9. 发明申请

US20080032279A1 Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions 有权
公开(公告)号：US20080032279A1
公开(公告)日：2008-02-07
申请号：US11807930
申请日：2007-05-30
申请人： Donald Morris , Bradley Thompson , Matthew Coffey
发明人： Donald Morris , Bradley Thompson , Matthew Coffey
IPC分类号： C12N7/01
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.

10. 发明申请

US20070190032A1 Use of Local Immune Suppression to Enhance Oncolytic Viral Therapy 审中-公开
标题翻译：使用局部免疫抑制来增强溶瘤病毒治疗
公开(公告)号：US20070190032A1
公开(公告)日：2007-08-16
申请号：US11673201
申请日：2007-02-09
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61N5/00 , A61K48/00
CPC分类号： A61N5/10 , A61K35/765 , A61N2005/1098
摘要： Provided herein are methods for treating or ameliorating a solid tumor in a subject comprising administering oncolytic viruses and immunosuppressive agents at or near the site of the tumor.
摘要翻译：本文提供了治疗或改善受试者中的实体瘤的方法，包括在肿瘤部位或其附近施用溶瘤病毒和免疫抑制剂。

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