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1. 发明专利

IL250793D0 Detection of patent ductus arteriosus using photoplethysmography 未知
公开(公告)号：IL250793D0
公开(公告)日：2017-04-30
申请号：IL25079317
申请日：2017-02-26
申请人： JERUSALEM COLLEGE OF TECH , THE FEINSTEIN INST MEDICAL RES , ROBERT KOPPEL , MEIR NITZAN
发明人： ROBERT KOPPEL , MEIR NITZAN
IPC分类号： A61B5/352 , A61B5/366
摘要： Methods and systems are described for detecting the likelihood of patent ductus arteriosus (PDA) in an infant using electrocardiogram and photoplethysmographic pulse signals obtained from the upper body and foot of the infant.

2. 发明专利

IL250793A Detection of patent ductus arteriosus using photoplethysmography 未知
公开(公告)号：IL250793A
公开(公告)日：2020-11-30
申请号：IL25079317
申请日：2017-02-26
申请人： JERUSALEM COLLEGE OF TECH , FEINSTEIN INST MEDICAL RES , ROBERT KOPPEL , MEIR NITZAN
发明人： ROBERT KOPPEL , MEIR NITZAN
IPC分类号： A61B5/00 , A61B5/02 , A61B5/024 , A61B5/352 , A61B5/366
摘要： Methods and systems are described for detecting the likelihood of patent ductus arteriosus (PDA) in an infant using electrocardiogram and photoplethysmographic pulse signals obtained from the upper body and foot of the infant.

3. 发明专利

IL247811D0 Detection of aortic coarctation using photoplethysmography 未知
公开(公告)号：IL247811D0
公开(公告)日：2016-11-30
申请号：IL24781116
申请日：2016-09-14
申请人： MEIR NITZAN , FEINSTEIN INST MEDICAL RES , JERUSALEM COLLEGE OF TECH , ROBERT KOPPEL
发明人： MEIR NITZAN , ROBERT KOPPEL
IPC分类号： A61B20060101
摘要： Methods and systems are described for detecting the likelihood of an aortic coarctation in an infant using photoplethysmographic pulse signals obtained from the hand and foot of the infant.

4. 发明专利

IL247811A Detection of aortic coarctation using photoplethysmography 未知
公开(公告)号：IL247811A
公开(公告)日：2021-03-25
申请号：IL24781116
申请日：2016-09-14
申请人： FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH , JERUSALEM COLLEGE OF TECH , MEIR NITZAN , ROBERT KOPPEL
发明人： MEIR NITZAN , ROBERT KOPPEL
IPC分类号： A61B5/00 , A61B5/02 , A61B5/021 , A61B5/024 , A61B5/026 , A61B5/0295 , A61B5/1455 , G16H50/20 , G16H50/30
摘要： Methods and systems are described for detecting the likelihood of an aortic coarctation in an infant using photoplethysmographic pulse signals obtained from the hand and foot of the infant.

5. 发明申请

US20130310669A1 PULMONARY PULSE OXIMETRY METHOD FOR THE MEASUREMENT OF OXYGEN SATURATION IN THE MIXED VENOUS BLOOD 审中-公开
标题翻译：用于测量混合血管内氧气饱和度的脉冲脉冲氧化方法
公开(公告)号：US20130310669A1
公开(公告)日：2013-11-21
申请号：US13475988
申请日：2012-05-20
申请人： Meir Nitzan
发明人： Meir Nitzan
IPC分类号： A61B5/1455 , A61B6/00 , A61B5/1459 , A61B5/02
CPC分类号： A61B5/0059 , A61B5/14551 , A61B5/14552 , A61B5/1459 , A61B5/6823 , G01N21/3151 , G01N21/359 , G01N33/4925 , G01N2021/3144 , G01N2021/3181 , G01N2201/08
摘要： A method for obtaining diagnostic information relating to the lungs of a subject includes directing into tissue of the lungs of the subject light of a first wavelength and detecting part of the light that has passed primarily through microcirculatory tissue of the lungs and generating a signal which is a function of intensity of the detected light. The signal is then processed to derive a PPG curve for pulmonary microcirculatory arteries. The method is implemented using various locations for a light source and a detector, including various combinations of positioning on the thoracic wall, insertion into the esophagus, and in some cases, insertion of a probe through the thoracic wall to a position adjacent to the pulmonary pleura. Use of two different wavelengths allows derivation of mixed venous blood oxygen saturation.
摘要翻译：用于获得与受试者的肺相关的诊断信息的方法包括将第一波长的受试者的光的肺部引导到主要通过肺的微循环组织的一部分光，并产生一个信号，该信号是检测光的强度的函数。然后处理信号以得到肺微循环动脉的PPG曲线。该方法使用用于光源和检测器的各种位置来实现，包括在胸壁上定位的各种组合，插入食道中，并且在一些情况下，将探针通过胸壁插入邻近肺部的位置胸膜。使用两种不同的波长可以推导混合静脉血氧饱和度。

6. 发明授权

US07544168B2 Measuring systolic blood pressure by photoplethysmography 有权
标题翻译：通过光谱体积描记法测量收缩压
公开(公告)号：US07544168B2
公开(公告)日：2009-06-09
申请号：US10952815
申请日：2004-09-30
申请人： Meir Nitzan
发明人： Meir Nitzan
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/7239
摘要： The present invention relates to cuff-based method for the measurement of systolic blood pressure (SBP) by measuring photoplethysmographic (PPG) signals in peripheral blood vessels distal to the cuff and to a method for cuffless measurement of SBP by analyzing PPG signals in peripheral blood vessels, after suitable calibration by the cuff-based PPG method for the measurement of SBP.
摘要翻译：本发明涉及通过测量袖带远端外周血管中的光学体积描记术（PPG）信号来测量收缩压（SBP）的袖带方法，以及通过分析外周血中的PPG信号来无缝测量SBP的方法血管，经适当的校准后通过基于袖带的PPG法测量SBP。

7. 发明申请

US20060074322A1 Measuring systolic blood pressure by photoplethysmography 有权
公开(公告)号：US20060074322A1
公开(公告)日：2006-04-06
申请号：US10952815
申请日：2004-09-30
申请人： Meir Nitzan
发明人： Meir Nitzan
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/7239
摘要： The present invention relates to cuff-based method for the measurement of systolic blood pressure (SBP) by measuring photoplethysmographic (PPG) signals in peripheral blood vessels distal to the cuff and to a method for cuffless measurement of SBP by analyzing PPG signals in peripheral blood vessels, after suitable calibration by the cuff-based PPG method for the measurement of SBP.

8. 发明授权

US4802489A Method for carrying out blood flow measurements and a probe therefor 失效
标题翻译：用于进行血流测量的方法及其探头
公开(公告)号：US4802489A
公开(公告)日：1989-02-07
申请号：US76785
申请日：1987-07-23
申请人： Meir Nitzan
发明人： Meir Nitzan
IPC分类号： A61B5/00 , A61B5/026 , A61B5/02
CPC分类号： A61B5/01 , A61B5/026
摘要： A probe for regional blood flow measurement, comprising a housing of low thermal conduction and heat capacity, at least one face of which is adapted to make contact with a tissue region investigated, the face being provided with a recessed portion, a relatively thin plate made of a material of high thermal conductivity, located in the recess and being substantially flush with the tissue-contacting face of the housing, a temperature-sensing means in thermal contact with the plate and adapted to transfer temperature-related information to the outside of the housing, wherein the respective configurations of the plate and the housing are such as to minimize the area of contact between them relative to the area of contact between the plate and the tissue region, in order to minimize heat flow between the plate and the housing. A method for carrying out regional blood flow measurements is also disclosed.
摘要翻译：一种用于局部血流测量的探针，包括具有低热传导和热容量的壳体，其至少一个面适于与所研究的组织区域接触，所述面部设置有凹部，制成相对薄的板具有高导热性的材料，位于所述凹部中并且基本上与所述壳体的所述组织接触面齐平，所述温度感测装置与所述板热接触并且适于将温度相关信息传递到所述壳体的外部壳体，其中板和壳体的相应构造使得它们之间的接触面积相对于板和组织区域之间的接触面积最小化，以便最小化板和壳体之间的热流。还公开了进行局部血流测量的方法。

9. 发明授权

US6120459A Method and device for arterial blood pressure measurement 失效
标题翻译：用于动脉血压测量的方法和装置
公开(公告)号：US6120459A
公开(公告)日：2000-09-19
申请号：US328406
申请日：1999-06-09
申请人： Meir Nitzan , Louis Bloch
发明人： Meir Nitzan , Louis Bloch
IPC分类号： A61B5/0225 , A61B5/0285 , A61B5/02
CPC分类号： A61B5/6826 , A61B5/02125 , A61B5/02225 , A61B5/02255 , A61B5/0285 , A61B5/6838 , A61B5/0295
摘要： A method of measurement of arterial diastolic blood pressure includes generating first and second signals indicative, respectively, of cardiac induced pulsatile variations in tissue blood volume in a first region and a second region of the subject's body. These signals are then processed to derive values of a delay between pulses in the first signal and corresponding pulses in second signal. A baseline value of the delay is evaluated, preferably in the absence of externally applied pressure. A variable pressure is applied to a third region of the subject's body so as to affect blood flow through at least one artery in the third region, the variable pressure being varied as a function of time. The first, second and third regions of the subject's body are chosen such that the delay varies as a function of the variable pressure. The diastolic pressure is then identified as a value of the variable pressure corresponding to a predefined non-zero value of the delay measured relative to the baseline value.
摘要翻译：测量动脉舒张压的方法包括产生分别指示受试者身体的第一区域和第二区域中心脏引起的组织血液体积的脉动变化的第一和第二信号。然后处理这些信号以导出第一信号中的脉冲之间的延迟值和第二信号中的相应脉冲。评估延迟的基准值，优选在没有外部施加的压力的情况下。可变压力被施加到受检者身体的第三区域，以便影响通过第三区域中的至少一个动脉的血流，可变压力随着时间而变化。选择对象身体的第一，第二和第三区域使得延迟作为可变压力的函数而变化。然后将舒张压识别为对应于相对于基线值测量的延迟的预定非零值的可变压力的值。

10. 发明授权

US5862805A Apparatus and method for measuring the variability of cardiovascular parameters 失效
标题翻译：用于测量心血管参数变异性的装置和方法
公开(公告)号：US5862805A
公开(公告)日：1999-01-26
申请号：US744816
申请日：1996-11-06
申请人： Meir Nitzan
发明人： Meir Nitzan
IPC分类号： A61B5/024 , A61B19/00
CPC分类号： A61B5/02416
摘要： Apparatus for measuring the variability of cardiovascular parameters, having a photoplethysmographic (PPG) probe, including a modulated first light source and a photodetector, a demodulator connected to the photodetector for demodulating PPG signals detected by the photodetector, an analog to digital converter for digitizing the demodulated signals, and a processor for repeatedly analysing the PPG signals for a predetermined number of times. A method for measuring the variability of cardovascular parameters.
摘要翻译：用于测量心血管参数的变异性的装置，具有包括调制的第一光源和光电检测器的光电体积描记术（PPG）探针，连接到光电检测器的解调器，用于解调由光电检测器检测的PPG信号;模数转换器，解调信号，以及用于反复分析PPG信号预定次数的处理器。一种测量心血管参数变异性的方法。

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