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1. 发明授权

US07445027B2 Multilayer microfluidic-nanofluidic device 有权
标题翻译：多层微流体纳米流体装置
公开(公告)号：US07445027B2
公开(公告)日：2008-11-04
申请号：US11375525
申请日：2006-03-14
申请人： Bruce R. Flachsbart , Mark A. Shannon , Paul W. Bohn , Jonathan V Sweedler
发明人： Bruce R. Flachsbart , Mark A. Shannon , Paul W. Bohn , Jonathan V Sweedler
IPC分类号： F15C1/00 , F15C1/04
CPC分类号： B01L3/502707 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2400/0421 , Y10T137/206 , Y10T137/2196 , Y10T137/2224 , Y10T156/10
摘要： A method of bonding layers to form a structure, comprises curing a first adhesive while squeezing a first layer and a multilayer structure together between a first backing and a second backing. The multilayer structure comprises a substrate and a second layer, and the first adhesive is between and in contact with the first layer and the second layer. Furthermore, the first layer and the second layer each have a thickness of at most 100 μm, and at least one of the first backing and the second backing comprises a first elastic polymer.
摘要翻译：粘合层以形成结构的方法包括固化第一粘合剂，同时在第一背衬和第二背衬之间挤压第一层和多层结构。多层结构包括基底和第二层，第一粘合剂在第一层和第二层之间并与之接触。此外，第一层和第二层各自具有至多100μm的厚度，并且第一背衬和第二背衬中的至少一个包括第一弹性聚合物。

2. 发明授权

US5466589A Coated substrates employing oriented layers of mutant heme proteins and methods of making and using same 失效
标题翻译：使用突变血红素蛋白取向层的涂覆底物及其制造和使用方法
公开(公告)号：US5466589A
公开(公告)日：1995-11-14
申请号：US945291
申请日：1992-09-11
申请人： Jill M. Olinger , Stephen G. Sligar , Mark A. McLean , Paul W. Bohn , Patrick Stayton
发明人： Jill M. Olinger , Stephen G. Sligar , Mark A. McLean , Paul W. Bohn , Patrick Stayton
IPC分类号： C07K14/80 , C07K14/805 , C12N15/10 , C12N11/02 , C12M1/14 , G01N21/41 , G01N27/327
CPC分类号： C12N15/1058 , C07K14/80 , C07K14/805 , Y10S435/808 , Y10S435/817 , Y10S530/81
摘要： The present invention is directed to coated substrates having a coating of biological macromolecules, preferably proteins, which are capable of being immobilized on a substrate surface and have a marker. These proteins usually are mutant proteins obtained by mutagenesis of the gene encoding a random positioning protein. When a mutant protein molecule is immobilized on the substrate, the marker of the mutant protein molecule is in a select spatial relationship with both the substrate and the markers of adjacent protein molecules. A substrate coated with an oriented layer of the mutant proteins exhibits improved or different properties when compared to a substrate having a randomly positioned layer of proteins thereon.
摘要翻译：本发明涉及具有能够固定在基材表面上并具有标记物的生物大分子（优选蛋白质）的涂层的涂布基材。这些蛋白质通常是通过编码随机定位蛋白质的基因的诱变获得的突变蛋白质。当突变蛋白分子被固定在底物上时，突变蛋白分子的标记物与底物和相邻蛋白质分子的标记物处于选择的空间关系。当与其上具有随机定位的蛋白质层的底物相比时，涂覆有突变蛋白的取向层的底物表现出改善的或不同的性质。

3. 发明授权

US5556528A Structures with field responsive permeation control 失效
标题翻译：具有场响应渗透控制的结构
公开(公告)号：US5556528A
公开(公告)日：1996-09-17
申请号：US240244
申请日：1994-05-10
申请人： Paul W. Bohn , Wenyuan Lu
发明人： Paul W. Bohn , Wenyuan Lu
IPC分类号： A61K9/00 , A61N1/30 , G01N27/447 , G01N27/26
CPC分类号： A61K9/0009 , A61N1/30 , G01N27/4473
摘要： Devices are useful to capture or dispense target molecules and include an electric field-responsive valve unit. The valve unit includes an active control structure having at least one monomolecular layer and being up to about 10 nm thick. The active control structure is formed by a majority of molecular species with a dipolar moment greater than about 5 Debye, and operable in response to an electric field at a threshold value. A particularly preferred embodiment has the active control structure carried on a microporous membrane with pores in the nanometer range. Applications for inventive embodiments include drug delivery and target molecule capture during electrophoresis separations.
摘要翻译：器件可用于捕获或分配靶分子，并包括电场响应阀单元。阀单元包括具有至少一个单分子层并且高达约10nm厚的主动控制结构。主动控制结构由大多数具有大于约5德拜的偶极矩的分子物质形成，并且响应于阈值处的电场而可操作。特别优选的实施方案具有在具有纳米范围内的孔的微孔膜上承载的主动控制结构。用于发明实施方案的应用包括电泳分离期间的药物递送和靶分子捕获。

4. 发明授权

US07220345B2 Hybrid microfluidic and nanofluidic system 有权
标题翻译：混合微流体和纳流体系统
公开(公告)号：US07220345B2
公开(公告)日：2007-05-22
申请号：US10273935
申请日：2002-10-18
申请人： Paul W. Bohn , Jonathan V. Sweedler , Mark A. Shannon , Tzu-chi Kuo
发明人： Paul W. Bohn , Jonathan V. Sweedler , Mark A. Shannon , Tzu-chi Kuo
IPC分类号： B67D5/00
CPC分类号： B01D57/02 , B01J19/0093 , B01J2219/00783 , B01J2219/00907 , B01J2219/0093 , B01L3/502707 , B01L3/502761 , B01L2200/027 , B01L2300/0681 , B01L2300/0874 , B01L2300/0896 , B01L2400/0415 , B01L2400/06 , B01L2400/0627 , B82Y30/00 , G01N27/4473 , G01N27/44791
摘要： A fluid circuit includes a membrane having a first side, a second side opposite the first side, and a pore extending from the first side to the second side. The circuit also includes a first channel containing fluid extending along the first side of the membrane and a second channel containing fluid extending along the second side of the membrane and crossing the first channel. The circuit also includes an electrical source in electrical communication with at least one of the first fluid and second fluid for selectively developing an electrical potential between fluid in the first channel and fluid in the second channel. This causes at least one component of fluid to pass through the pore in the membrane from one of the first channel and the second channel to the other of the first channel and the second channel.
摘要翻译：流体回路包括具有第一侧，与第一侧相对的第二侧和从第一侧向第二侧延伸的孔的膜。电路还包括含有沿着膜的第一侧延伸的流体的第一通道和包含沿膜的第二侧延伸并与第一通道交叉的流体的第二通道。电路还包括与第一流体和第二流体中的至少一个电连通的电源，用于选择性地在第一通道中的流体和第二通道中的流体之间形成电势。这使得流体的至少一个成分从第一通道和第二通道中的一个通过膜中的孔到第一通道和第二通道中的另一个。

5. 发明授权

US06762134B2 Metal-assisted chemical etch to produce porous group III-V materials 有权
标题翻译：金属辅助化学蚀刻产生多孔III-V族材料
公开(公告)号：US06762134B2
公开(公告)日：2004-07-13
申请号：US09989050
申请日：2001-11-20
申请人： Paul W. Bohn , Xiuling Li , Jonathan V. Sweedler , Ilesanmi Adesida
发明人： Paul W. Bohn , Xiuling Li , Jonathan V. Sweedler , Ilesanmi Adesida
IPC分类号： H01L21302
CPC分类号： H01L21/30612 , H01L21/0332 , H01L21/3081 , H01L33/18 , H01L33/30
摘要： A thin discontinuous layer of metal such as Au, Pt, or Au/Pd is deposited on a Group III-V material surface. The surface is then etched in a solution including HF and an oxidant for a preferably brief period, as little as a couple seconds to one hour. A preferred oxidant is H2O2. Morphology and light emitting properties of porous Group III-V material can be selectively controlled as a function of the type of metal deposited, doping type, doping level, metal thickness, whether emission is collected on or off the metal coated areas and/or etch time. Electrical assistance is unnecessary during the chemical etching of the invention, which may be conducted in the presence or absence of illumination.
摘要翻译：在III-V族材料表面上沉积诸如Au，Pt或Au / Pd之类的金属薄的不连续层。然后将表面蚀刻在包含HF和氧化剂的溶液中，优选短暂的时间，几小时至几小时。优选的氧化剂是H 2 O 2。可以选择性地控制多孔III-V族材料的形态和发光性质，作为金属沉积类型，掺杂类型，掺杂水平，金属厚度，是否在金属涂层区域或/或金属涂层区域上收集发射的函数的函数时间。在本发明的化学蚀刻期间不需要电辅助，其可以在存在或不存在照明的情况下进行。

6. 发明授权

US06790785B1 Metal-assisted chemical etch porous silicon formation method 有权
标题翻译：金属辅助化学蚀刻多孔硅的形成方法
公开(公告)号：US06790785B1
公开(公告)日：2004-09-14
申请号：US09662682
申请日：2000-09-15
申请人： Xiuling Li , Paul W. Bohn , Jonathan V. Sweedler
发明人： Xiuling Li , Paul W. Bohn , Jonathan V. Sweedler
IPC分类号： H01L21302
CPC分类号： H01L21/0203
摘要： A thin discontinuous layer of metal such as Au, Pt, or Au/Pd is deposited on a silicon surface. The surface is then etched in a solution including HF and an oxidant for a brief period, as little as a couple seconds to one hour. A preferred oxidant is H2O2. Morphology and light emitting properties of porous silicon can be selectively controlled as a function of the type of metal deposited, Si doping type, silicon doping level, and/or etch time. Electrical assistance is unnecessary during the chemical etching of the invention, which may be conducted in the presence or absence of illumination.
摘要翻译：金属如Au，Pt或Au / Pd的薄的不连续层沉积在硅表面上。然后将表面在包含HF和氧化剂的溶液中蚀刻短暂时间，只需几秒至1小时。优选的氧化剂是H 2 O 2。可以选择性地控制多孔硅的形态和发光性质，作为沉积金属，Si掺杂类型，硅掺杂水平和/或蚀刻时间的函数。在本发明的化学蚀刻期间不需要电辅助，其可以在存在或不存在照明的情况下进行。

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