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1. 发明授权

US07632671B2 Molecular detection and assay by electrobiochip micro-array 失效
标题翻译：分子检测和电生物芯片微阵列测定
公开(公告)号：US07632671B2
公开(公告)日：2009-12-15
申请号：US10967592
申请日：2004-10-18
申请人： Sun-Wing Tong
发明人： Sun-Wing Tong
IPC分类号： C12M1/34 , C12M3/00 , C12Q1/68 , G01N33/53 , G01N15/06
CPC分类号： C12Q1/6825 , G01N33/54326 , G01N33/5438
摘要： The presence of a nucleic acid target, molecule or ligand can be detected by hybridization, antigen-antibody reaction or receptor-ligand binding. This is reported by the strategic positioning of a first probe and a second probe attached to a small particle of electrical conductor, which closes an electrical circuit, thereby reporting the event. A myriad of potential applications of this technique include the identification and detection of small amounts of nucleic acids by hybridization, the detection of molecules such as toxins and carcinogens by antigen-antibody reaction and the detection of other molecules by receptor-ligand interaction. The method can also be adapted to assay the quantity of a given substance using the principle of competitive binding.
摘要翻译：可以通过杂交，抗原 - 抗体反应或受体 - 配体结合来检测核酸靶，分子或配体的存在。这通过第一探针和附接到电导体的小颗粒的第二探针的战略定位来报告，其闭合电路，从而报告事件。该技术的许多潜在应用包括通过杂交鉴定和检测少量核酸，通过抗原 - 抗体反应检测分子如毒素和致癌物质，以及通过受体 - 配体相互作用检测其他分子。该方法还可以适应于使用竞争性结合原理测定给定物质的量。

2. 发明授权

US07629114B2 Method of collecting nasopharyngeal cells and secretions for diagnosis of viral upper respiratory infections and screening for nasopharyngeal cancer 失效
标题翻译：收集鼻咽细胞和分泌物用于诊断病毒性上呼吸道感染和筛选鼻咽癌的方法
公开(公告)号：US07629114B2
公开(公告)日：2009-12-08
申请号：US10923444
申请日：2004-08-20
申请人： Sun-Wing Tong , Yi-Wei Tang
发明人： Sun-Wing Tong , Yi-Wei Tang
IPC分类号： C12Q1/00
CPC分类号： A61B10/0045 , C12Q1/6806
摘要： The present invention provides a method of collecting nasopharyngeal specimens by introducing physiologic solution into the conjunctival sacs and collecting the irrigate that drains into the oroharynx. The invention further provides a kit to facilitate such a method. The present invention also provides a method of delivering a biological active to the eyes, nasal, nasopharyngeal, and oropharyngeal regions.
摘要翻译：本发明提供了一种通过将生理溶液引入结膜囊来收集鼻咽标本的方法，并收集将排泄物排入口腔的灌洗液。本发明还提供了一种促进这种方法的试剂盒。本发明还提供了将生物活性物质递送到眼睛，鼻，鼻咽和口咽部区域的方法。

3. 发明申请

US20060166333A1 Methods of collecting and transporting vaginal discharge for detection of infectious organisms and to facilitate cervical cancer screening 有权
公开(公告)号：US20060166333A1
公开(公告)日：2006-07-27
申请号：US10538954
申请日：2003-12-24
申请人： Sun-Wing Tong , Olivia Chan , Tat-Chong Chow , Vivian Yu
发明人： Sun-Wing Tong , Olivia Chan , Tat-Chong Chow , Vivian Yu
IPC分类号： C12P19/34 , A61B5/00
CPC分类号： C12Q1/6886 , A61B2010/0074 , C12Q1/708 , G01N33/528 , G01N2333/025
摘要： The present invention provides a method of testing for the presence of infectious disease agents or host genetic markers comprising applying a device comprising an absorbent and porous material onto the introitus of a female patient; encouraging air drying of at least a portion of the collected vaginal discharge while the device is proximate to the introitus; and determining the presence of infectious disease agents or host genetic markers in the at least partially dried vaginal discharge.

4. 发明授权

US07163788B2 Method of detecting molecular target by particulate binding 有权
标题翻译：通过颗粒结合检测分子靶的方法
公开(公告)号：US07163788B2
公开(公告)日：2007-01-16
申请号：US10291986
申请日：2002-11-12
申请人： Sun-Wing Tong
发明人： Sun-Wing Tong
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： G01N33/54373 , C12Q1/6816 , G01N33/54313 , G01N33/54326 , G01N33/54366 , G01N2500/04 , C12Q2565/518 , C12Q2563/143 , C12Q2537/125
摘要： A method of detecting or quantifying a molecular target in a sample utilizing the molecular interaction between molecular targets, bead-bound probes, and support-bound probes. Laser light or a magnetic sensor may be used to detect the beads after the interaction. The detection of the beads indicates the presence of the molecular target in the sample.
摘要翻译：利用分子靶，珠结合探针和支持结合探针之间的分子相互作用来检测或定量样品中的分子靶的方法。激光或磁传感器可用于在相互作用后检测珠粒。珠的检测表明样品中分子靶的存在。

5. 发明授权

US07501235B2 Methods of collecting and transporting vaginal discharge for detection of infectious organisms and to facilitate cervical cancer screening 有权
标题翻译：收集和运输阴道分泌物以检测感染性生物体并促进子宫颈癌筛查的方法
公开(公告)号：US07501235B2
公开(公告)日：2009-03-10
申请号：US10538954
申请日：2003-12-24
申请人： Sun-Wing Tong , Olivia Wai-Hing Chan , Tat-Chong Chow , Vivian Yu
发明人： Sun-Wing Tong , Olivia Wai-Hing Chan , Tat-Chong Chow , Vivian Yu
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6886 , A61B2010/0074 , C12Q1/708 , G01N33/528 , G01N2333/025
摘要： The present invention provides a method of testing for the presence of infectious disease agents or host genetic markers comprising applying a device comprising an absorbent and porous material onto the introitus of a female patient; encouraging air drying of at least a portion of the collected vaginal discharge while the device is proximate to the introitus; and determining the presence of infectious disease agents or host genetic markers in the at least partially dried vaginal discharge.
摘要翻译：本发明提供一种测试传染病病原体或宿主遗传标记物的存在的方法，包括将包含吸收剂和多孔材料的装置施用到女性患者的口腔上; 鼓励收集的阴道排泄物的至少一部分的空气干燥，同时装置接近口腔; 以及确定所述至少部分干燥的阴道分泌物中感染性疾病剂或宿主遗传标记的存在。

6. 发明申请

US20050053996A1 Molecular detection and assay by electrobiochip micro-array 失效
标题翻译：分子检测和电生物芯片微阵列测定
公开(公告)号：US20050053996A1
公开(公告)日：2005-03-10
申请号：US10967592
申请日：2004-10-18
申请人： Sun-Wing Tong
发明人： Sun-Wing Tong
IPC分类号： C12Q1/68 , G01N33/543 , G01F1/64 , G01N27/26 , G01N33/50
CPC分类号： C12Q1/6825 , G01N33/54326 , G01N33/5438
摘要： The presence of a nucleic acid target, molecule or ligand can be detected by hybridization, antigen-antibody reaction or receptor-ligand binding. This is reported by the strategic positioning of a first probe and a second probe attached to a small particle of electrical conductor, which closes an electrical circuit, thereby reporting the event. A myriad of potential applications of this technique include the identification and detection of small amounts of nucleic acids by hybridization, the detection of molecules such as toxins and carcinogens by antigen-antibody reaction and the detection of other molecules by receptor-ligand interaction. The method can also be adapted to assay the quantity of a given substance using the principle of competitive binding.
摘要翻译：可以通过杂交，抗原 - 抗体反应或受体 - 配体结合来检测核酸靶，分子或配体的存在。这通过第一探针和附接到电导体的小颗粒的第二探针的战略定位来报告，其闭合电路，从而报告事件。该技术的许多潜在应用包括通过杂交鉴定和检测少量核酸，通过抗原 - 抗体反应检测分子如毒素和致癌物质，以及通过受体 - 配体相互作用检测其他分子。该方法还可以适应于使用竞争性结合原理测定给定物质的量。

7. 发明申请

US20050048465A1 Method of collecting nasopharyngeal cells and secretions for diagnosis of viral upper respiratory infections and screening for nasopharyngeal cancer 失效
标题翻译：收集鼻咽细胞和分泌物用于诊断病毒性上呼吸道感染和筛选鼻咽癌的方法
公开(公告)号：US20050048465A1
公开(公告)日：2005-03-03
申请号：US10923444
申请日：2004-08-20
申请人： Sun-Wing Tong , Yi-Wei Tang
发明人： Sun-Wing Tong , Yi-Wei Tang
IPC分类号： A61B10/00 , C12Q1/00 , C12Q1/68 , G01N33/50 , C12Q1/70 , A61M31/00
CPC分类号： A61B10/0045 , C12Q1/6806
摘要： The present invention provides a method of collecting nasopharyngeal specimens by introducing physiologic solution into the conjunctival sacs and collecting the irrigate that drains into the oroharynx. The invention further provides a kit to facilitate such a method. The present invention also provides a method of delivering a biological active to the eyes, nasal, nasopharyngeal, and oropharyngeal regions.
摘要翻译：本发明提供了一种通过将生理溶液引入结膜囊来收集鼻咽标本的方法，并收集将排泄物排入口腔的灌洗液。本发明还提供了一种促进这种方法的试剂盒。本发明还提供了将生物活性物质递送到眼睛，鼻，鼻咽和口咽部区域的方法。

8. 发明申请

US20050042604A1 Novel nucleic acid-based tracers and their uses thereof 审中-公开
标题翻译：新型的基于核酸的示踪剂及其用途
公开(公告)号：US20050042604A1
公开(公告)日：2005-02-24
申请号：US10909445
申请日：2004-08-02
申请人： Sun-Wing Tong , Chun Liang
发明人： Sun-Wing Tong , Chun Liang
IPC分类号： C12Q1/04 , C12Q1/70 , G01N33/554 , G01N33/569
CPC分类号： C12Q1/04
摘要： The present invention relates to a method of determining whether a facility can effectively prevent the spread of an infectious disease by a) releasing an effective amount of biological tracers in or near the facility, to mimic the spread of pathogens that cause the infectious disease; and b) detecting the presence or amount of the biological tracers to determine the spread of the biological tracers in the environment of the facility. The present invention further provides a method and apparatus to generate aerosol that mimic the human sneeze and cough so as to more realistically determine the spread of an infectious disease by such a source.
摘要翻译：本发明涉及一种确定设施是否能有效防止传染病传播的方法：a）在设施内或附近释放有效量的生物示踪剂，以模拟导致感染性疾病的病原体的扩散; 和b）检测生物示踪剂的存在或数量以确定生物示踪剂在设施环境中的扩散。本发明还提供了一种产生模拟人类打喷嚏和咳嗽的气溶胶的方法和装置，以更真实地确定这种来源的传染病的传播。

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