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    • 6. 发明申请
    • Interleukin-12 as an adjuvant for paramyxoviridae vaccines
    • 白细胞介素-12作为副粘病毒疫苗的佐剂
    • US20070087016A1
    • 2007-04-19
    • US11607073
    • 2006-12-01
    • Barney GrahamYi-Wei Tang
    • Barney GrahamYi-Wei Tang
    • A61K39/395A61K39/12
    • C07K16/1027A61K39/12A61K39/155A61K39/39A61K2039/5252A61K2039/55538A61K2039/57C07K2317/52C12N2760/18534
    • A method is disclosed of reducing viral replication of a virus of the paramyxoviridae family in a host, comprising administering to the host an antigen of the virus in combination with an effective adjuvant amount of interleukin-12 (IL-12). Human viruses of the paramyxoviridae family include paramyxoviruses (e.g., parainfluenza virus 1, parainfluenza virus 2, parainfluenza virus 3 and parainfluenza virus 4), morbilliviruses (e.g., measles virus) and pneumoviruses (e.g., respiratory syncytial virus); other non-human viruses of the paramyxoviridae family include canine distemper virus, bovine respiratory syncytial virus, Newcastle disease virus and rhinderpest virus. A composition is also disclosed comprising a mixture of an antigen of a virus of the Paramyxoviridae family and an effective adjuvant amount of interleukin-12 (IL-12).
    • 公开了减少宿主中副粘病毒科病毒的病毒复制的方法,包括向宿主施用病毒抗原与有效佐剂量的白细胞介素-12(IL-12)组合。 副粘病毒科的人类病毒包括副粘病毒(例如副流感病毒1,副流感病毒2,副流感病毒3和副流感病毒4),斑疹病毒(例如麻疹病毒)和肺炎链球菌(例如呼吸道合胞病毒); 副粘病毒科其他非人类病毒包括犬瘟热病毒,牛呼吸道合胞病毒,新城疫病毒和牛瘟病毒。 还公开了一种组合物,其包含副粘病毒科的病毒抗原与有效佐剂量的白细胞介素-12(IL-12)的混合物。