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1. 发明授权

US5132406A Method of producing immunoglobulin preparations for intravenous injection 失效
标题翻译：生产用于静脉注射的免疫抑制素制剂的方法
公开(公告)号：US5132406A
公开(公告)日：1992-07-21
申请号：US348139
申请日：1989-05-05
申请人： Yahiro Uemura , Katuhiro Uriyu , Kazuo Takechi , Yutaka Hirao , Tadakazu Suyama
发明人： Yahiro Uemura , Katuhiro Uriyu , Kazuo Takechi , Yutaka Hirao , Tadakazu Suyama
IPC分类号： A61K39/395 , A61K38/00 , A61L2/00 , C07K16/00
CPC分类号： C07K16/00 , A61L2/0023 , A61K38/00
摘要： A method of producing immunoglobulin preparations for intravenous injection which starts with an immunoblobulin-containing fraction and comprises the treatment steps of:(a) treating said fraction with 4-10 weight/volume percent of polyethylene glycol having a molecular weight of 1,000-10,000 under conditions of pH 4-6, ion strength 0.0001-0.1M and temperature 0.degree.-4.degree. C. and recovering the supernatant,(b) treating the supernatant obtained in step (a) with 10-15 weight/volume percent of polyethylene glycol having a molecular weight of 1,000-10,000 under conditions of pH 6-9, ion strength 0.0001-0.1M and temperature 0.degree.-4.degree. C. and recovering the resulting precipitate, and(c) heat-treating, in any desired step, said immunoglobulin in the presence of a stabilizer under conditions sufficient to inactivate contaminant viruses.The preparations obtained according to the invention retain immunoglobulins without substantial inactivation thereof, and are substantially free of such contaminants as anti-human blood group substance antibodies. With contaminant viruses inactivated as a result of the heat treatment, said preparations have good solubility and are sufficiently low in anticomplement activity.
摘要翻译：一种生产用于静脉注射的免疫球蛋白制剂的方法，其起始于含免疫球蛋白的级分，并且包括以下处理步骤：（a）用4-10重量/体积％的分子量为1,000-10,000的聚乙二醇处理所述级分，条件pH 4-6，离子强度0.0001-0.1M，温度0℃-4℃，回收上清液，（b）用10-15重量/体积％聚乙二醇处理步骤（a）中得到的上清液在pH 6-9，离子强度为0.0001-0.1M，温度为0〜-4℃的条件下分子量为1,000〜10,000，回收所得沉淀物，（c）在任何所需步骤中热处理，所述免疫球蛋白在足以灭活污染性病毒的条件下在稳定剂存在下进行。根据本发明获得的制剂保留免疫球蛋白而基本上不灭活，并且基本上不含抗人血型物质抗体等污染物。随着由于热处理而灭活的污染物病毒，所述制剂具有良好的溶解性并且抗补体活性足够低。

2. 发明授权

US4959320A Monoclonal antibody, process for preparing same, reagent for detecting cancer antigen containing the monoclonal antibody and process for preparing same 失效
标题翻译：单克隆抗体，其制备方法，用于检测含有单克隆抗体的癌抗原的试剂及其制备方法
公开(公告)号：US4959320A
公开(公告)日：1990-09-25
申请号：US763587
申请日：1985-08-08
申请人： Yahiro Uemura , Kazumi Fukuyama , Takashi Kobayashi , Yoshiaki Kanou , Ryutaro Yamana , Eiji Kashiwagi , Tomokuni Taniguchi , Kazuaki Nakura , Masahiro Watanabe , Masayuki Nishida , Tadakazu Suyama
发明人： Yahiro Uemura , Kazumi Fukuyama , Takashi Kobayashi , Yoshiaki Kanou , Ryutaro Yamana , Eiji Kashiwagi , Tomokuni Taniguchi , Kazuaki Nakura , Masahiro Watanabe , Masayuki Nishida , Tadakazu Suyama
IPC分类号： G01N33/574 , A61K38/00 , A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/30 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K16/3046 , C07K16/303 , A61K38/00
摘要： A monoclonal antibody is described, having a specific reactivity with a cancer-associated antigen selected from pancreas cancer-associated antigen, intestinum crassum cancer-associated antigen and hepatoma-associated antigen and has the following characteristics:(1) it exists in a blood serum of pancreas cancer, intestinum crassum cancer and hepatoma patients;(2) it comprises glycoproteins;(3) it has a molecular weight of about 700,000 to 1,500,000, as measured by gel-filtration and determined by comparison with that of a known protein;(4) it has a maximum absorption of 2800 nm when dissolved in 0.1 M acetic acid buffer solution (pH 4.5); and(5) it is released at least in a cultured supernatant medium of establihed cell line of COLO-201, TE-1, TE-2, TE-3, NRC-12, MKN-45 and KATO III. The monoclonal antibody is utilized as a reagent for detecting pancreas cancer, intestinum crassum cancer and hepatoma. A process for preparing the monoclonal antibody and a process for preparing the reagent are also disclosed.
摘要翻译：描述了与选自胰腺癌相关抗原，肠um癌相关抗原和肝癌相关抗原的癌相关抗原具有特异性反应性的单克隆抗体，具有以下特征：（1）其存在于血清的胰腺癌，肠um癌和肝癌患者; （2）它包含糖蛋白; （3）通过凝胶过滤测定，其分子量约为700,000至1,500,000，并与已知蛋白质的比较确定; （4）当溶于0.1M乙酸缓冲溶液（pH 4.5）时，其最大吸收为2800nm; 至少在COLO-201，TE-1，TE-2，TE-3，NRC-12，MKN-45和KATO III的建立细胞系的培养上清培养基中释放。单克隆抗体用作检测胰腺癌，肠um癌和肝癌的试剂。还公开了制备单克隆抗体的方法和制备该试剂的方法。

3. 发明授权

US4542147A Perfluoro-1-azatricyclic amine compound 失效
标题翻译：全氟-1-氮杂环胺化合物
公开(公告)号：US4542147A
公开(公告)日：1985-09-17
申请号：US505322
申请日：1983-06-17
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
IPC分类号： A61K9/00 , C07D453/02 , C07D471/08 , C07D487/08 , C25B3/08 , C07D209/94 , A61K31/40
CPC分类号： A61K9/0026 , C07D453/02 , C07D471/08 , C07D487/08 , C25B3/08 , Y10S514/832 , Y10S514/833
摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 to 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.
摘要翻译：一种下式的新化合物，其中k为0或1〜2的整数，j为1〜3的整数，l和m分别为0或1〜3的整数，n为通过使与其对应的全氟化合物与氟反应来制备环A，B和C任选被至少一个三氟甲基或四氟乙基取代的整数。该化合物可用作能够在水性乳液中携带氧气的材料，用于挽救患有大量出血的患者和用于在移植中保存内部器官。

4. 发明授权

US4526969A Trifluoromethyl substituted perfluoro quinolizines 失效
标题翻译：三氟甲基取代全氟喹嗪
公开(公告)号：US4526969A
公开(公告)日：1985-07-02
申请号：US454108
申请日：1982-12-28
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Tadakazu Suyama
IPC分类号： A61K9/00 , A61K31/40 , A61K31/435 , A61P7/08 , C07D455/02 , C07D471/04 , C07D487/04 , C25B3/08
CPC分类号： A61K9/0026 , C07D455/02 , C07D471/04 , C07D487/04 , C25B3/08
摘要： A perfluorobicyclo compound of the general formula: ##STR1## wherein either or both of Ring A and Ring B may optionally be substituted with lower perfluoroalkyl group(s) and m and n each represent 3 or 4.
摘要翻译：一种具有下列通式的全氟二环化合物：其中环A和环B中的任一个或两者可以任选地被低级全氟烷基取代，m和n各自表示3或4。

5. 发明授权

US4526782A Process for recovering interferon 失效
标题翻译：干扰素回收方法
公开(公告)号：US4526782A
公开(公告)日：1985-07-02
申请号：US432909
申请日：1982-09-27
申请人： Yahiro Uemura , Hirofumi Arimura , Hiroshi Morise , Satoshi Funakoshi , Tadakazu Suyama
发明人： Yahiro Uemura , Hirofumi Arimura , Hiroshi Morise , Satoshi Funakoshi , Tadakazu Suyama
IPC分类号： C07K14/56 , A61K45/02 , C07G7/00 , C12P21/00
CPC分类号： C07K14/56
摘要： Interferon can be recovered simply by contacting an aqueous solution containing interferon which is induced and produced from cells of human origin capable of producing interferon, with a siliceous substance to adsorb interferon on it and eluting the adsorbed interferon with an aqueous solution containing a nonionic surfactant, preferably further containing an acriflavine such as acrinol.
摘要翻译： PCT No.PCT / JP81 / 00030 Sec。 371日期1982年9月27日 102（e）日期1982年9月27日PCT提交1981年2月17日PCT公布。出版物WO82 / 02834 日本1982年9月2日。通过将含有可产生干扰素的人源细胞诱导和产生的含有干扰素的水溶液与硅质物质接触，可以简单地回收地塞米松，以吸附干扰素并用吸附的干扰素含有非离子表面活性剂的水溶液，优选还含有吖啶如Acrinol。

6. 发明授权

US4442037A Water-soluble cholesterol derivative 失效
标题翻译：水溶性胆固醇衍生物
公开(公告)号：US4442037A
公开(公告)日：1984-04-10
申请号：US432938
申请日：1982-09-28
申请人： Yoshio Arakawa , Atsuyuki Takanabe , Yahiro Uemura , Satoshi Funakoshi , Tadakazu Suyama
发明人： Yoshio Arakawa , Atsuyuki Takanabe , Yahiro Uemura , Satoshi Funakoshi , Tadakazu Suyama
IPC分类号： C07J9/00 , C07J41/00
CPC分类号： C07J9/00 , C07J41/0055
摘要： Complexes of albumin combined with organic dibasic acid half esters, such as those of succinic acid and phthalic acid, of 7-hydroxycholesterol are soluble in water and have excellent immunosuppressive and anti-inflammatory action.
摘要翻译： PCT No.PCT / JP81 / 00056 Sec。 371日期1982年9月28日 102（e）日期1982年9月28日PCT提交1981年3月13日PCT公布。公开号WO82 / 03175 日期为1982年9月30日。与7-羟基胆固醇的琥珀酸和邻苯二甲酸的有机二元酸半酯结合的复合物可溶于水，具有优异的免疫抑制和抗炎作用。

7. 发明授权

US4423061A Perfluorocycloamine emulsion preparation 失效
标题翻译：全氟环丙胺乳液制剂
公开(公告)号：US4423061A
公开(公告)日：1983-12-27
申请号：US454106
申请日：1982-12-28
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
IPC分类号： A61K9/107 , A61K31/40 , A61P7/08 , B01F17/14 , C07D207/10
CPC分类号： C07D207/10 , Y10S514/832
摘要： A perfluorocycloamine emulsion preparation having oxygen carrying ability containing a perfluorocycloamine of the general formula: ##STR1## wherein any position may optionally be substituted with a perfluoromethyl group as an oxygen carrying component.
摘要翻译：一种全氟环丙胺乳液制剂，其具有含有以下通式的全氟环丙胺的含氧载体：其中任何位置可任选被全氟甲基取代为携氧组分。

8. 发明授权

US4340594A Fat emulsion containing steroid 失效
标题翻译：包含类固醇的脂肪乳液
公开(公告)号：US4340594A
公开(公告)日：1982-07-20
申请号：US260607
申请日：1981-05-06
申请人： Yutaka Mizushima , Kazumasa Yokoyama , Kiichiro Nabeta , Noboru Yamada , Tadakazu Suyama
发明人： Yutaka Mizushima , Kazumasa Yokoyama , Kiichiro Nabeta , Noboru Yamada , Tadakazu Suyama
IPC分类号： A61K9/10 , A61K9/107 , A61K9/14 , A61K31/57 , A61K31/704 , A61P29/00 , A61K31/56
CPC分类号： A61K9/1075 , A61K31/57
摘要： A fat emulsion containing a steroid having an anti-inflammatory activity, comprising an effective quantity of a steroid having an anti-inflammatory activity, 5 to 50% (W/V) of soybean oil, a phospholipid in a weight ratio of 1-50 to 100 of said soybean oil, and a proper quantity of water. This fat emulsion exhibits a long-lasting activity in the region of inflammation and is especially useful in the therapeutic or prophylactic treatment of rheumatism, immunological hemolytic anemia, idiopathic thrombocytopenic purpura, and Paget disease, or in conjunction with kidney transplantation.
摘要翻译：含有具有抗炎活性的类固醇的脂肪乳剂，其包含有效量的具有抗炎活性的类固醇，大豆油为5〜50％（W / V），重量比为1〜50的磷脂至100份所述大豆油，并加入适量的水。这种脂肪乳剂在炎症区域表现出持久的活性，特别可用于治疗或预防性治疗风湿病，免疫性溶血性贫血，特发性血小板减少性紫癜和佩吉特病，或与肾移植有关。

9. 发明授权

US4286063A Method for producing thrombolytic preparation 失效
标题翻译：溶栓制剂的制备方法
公开(公告)号：US4286063A
公开(公告)日：1981-08-25
申请号：US105116
申请日：1979-12-19
申请人： Tadakazu Suyama
发明人： Tadakazu Suyama
IPC分类号： A61K38/00 , C12N9/72
CPC分类号： C12N9/6462 , C12Y304/21073 , A61K38/00 , Y10S435/814 , Y10S435/815
摘要： A method for producing a thrombolytic preparation characterized in that among treatment conditions in the urokinase production pH is maintained within the neutral or weakly alkaline range throughout each treatment step to produce a thrombolytic preparation containing urokinase having a molecular weight of 54,000.+-.10,000 as major ingredient.
摘要翻译：一种血栓溶解制剂的制造方法，其特征在于，在每个处理步骤中，在尿激酶产生pH的处理条件下，保持在中性或弱碱性范围内，以产生含有分子量为54,000 +/- 10,000的尿激酶的血栓溶解制剂作为主要成分。

10. 发明授权

US5171566A Flurbiprofen derivative ophthalmic preparation 失效
标题翻译：氟比洛芬衍生物眼用制剂
公开(公告)号：US5171566A
公开(公告)日：1992-12-15
申请号：US667354
申请日：1991-03-06
申请人： Yutaka Mizushima , Hiroyuki Okamoto , Shigetoshi Sugio , Kazumasa Yokoyama , Tadakazu Suyama , Masao Tohno , Makoto Okumura , Yoshiaki Konishi , Kiyonoshin Ichikawa , Katsuhiro Uchida
发明人： Yutaka Mizushima , Hiroyuki Okamoto , Shigetoshi Sugio , Kazumasa Yokoyama , Tadakazu Suyama , Masao Tohno , Makoto Okumura , Yoshiaki Konishi , Kiyonoshin Ichikawa , Katsuhiro Uchida
IPC分类号： A61K9/00 , A61K9/107 , A61K31/19
CPC分类号： A61K31/19 , A61K9/0048 , A61K9/1075
摘要： There is provided an ophthalmic preparation comprising a fat emulsion containing flurbiprofen or its derivative such as ester as an active ingredient.
摘要翻译：提供了包含含有氟比洛芬或其衍生物如酯作为活性成分的脂肪乳剂的眼用制剂。

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