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1. 发明授权

US09557554B2 Wavelength-variable interference filter, optical module, and optical analysis device 有权
标题翻译：波长可变干涉滤光片，光模块和光学分析装置
公开(公告)号：US09557554B2
公开(公告)日：2017-01-31
申请号：US13211667
申请日：2011-08-17
申请人： Teruyuki Nishimura , Akira Sano , Seiji Yamazaki
发明人： Teruyuki Nishimura , Akira Sano , Seiji Yamazaki
IPC分类号： G02B26/00
CPC分类号： G02B26/001
摘要： An etalon includes a fixed mirror disposed on a first substrate, a movable mirror disposed on a second substrate to face the fixed mirror with a gap interposed therebetween, a first electrode disposed on the surface of the first substrate facing the second substrate, a second electrode disposed on a first surface of the second substrate facing the first substrate and separated from the first electrode, and a warp preventing film disposed on a second surface of the second substrate so as to cover at least the movable mirror in a plan view. The direction of an internal stress acting in the in-plane direction of the warp preventing film is parallel to the direction of an internal stress acting in the in-plane direction of the movable mirror and the second electrode.
摘要翻译：标准具包括设置在第一基板上的固定反射镜，设置在第二基板上以与介于其间的间隙面向固定反射镜的可移动反射镜，设置在面向第二基板的第一基板的表面上的第一电极，设置在所述第二基板的面向所述第一基板并与所述第一电极分离的第一表面上，以及设置在所述第二基板的第二表面上的经翘曲膜，以便在俯视图中至少覆盖所述可移动反射镜。在翘曲防止膜的面内方向作用的内部应力的方向与在可动镜和第二电极的面内方向作用的内部应力的方向平行。

2. 发明授权

US08917451B2 Variable wavelength interference filter, optical module, and optical analyzer 有权
标题翻译：可变波长干涉滤波器，光学模块和光学分析仪
公开(公告)号：US08917451B2
公开(公告)日：2014-12-23
申请号：US13372946
申请日：2012-02-14
申请人： Teruyuki Nishimura , Akira Sano
发明人： Teruyuki Nishimura , Akira Sano
IPC分类号： G02B27/00 , G01J3/26 , G02B26/00 , G01J3/50
CPC分类号： G02B26/001 , G01J3/26 , G01J3/50 , G02B26/06
摘要： A variable wavelength interference filter includes: a first reflective film disposed on a face of a first substrate facing a second substrate; a second reflective film disposed on a face of the second substrate facing the first substrate and the first reflective film; a first electrode disposed on the face of the first substrate; and a second electrode disposed on the face of the second substrate. The second substrate includes a movable portion on which the second reflective film is disposed and a connection maintaining portion maintaining the movable portion to be movable in a substrate thickness direction, the connection maintaining portion circumscribes the movable portion and is thinner than the movable portion, and the second electrode is disposed on a portion of the second substrate that is thicker than the connection maintaining portion.
摘要翻译：可变波长干涉滤光器包括：第一反射膜，设置在面向第二基板的第一基板的表面上; 第二反射膜，设置在面对第一基板的第二基板的表面和第一反射膜上; 设置在所述第一基板的表面上的第一电极; 以及设置在第二基板的表面上的第二电极。第二基板包括可移动部分，第二反射膜设置在该可动部分上，连接保持部分将可移动部分保持在基板厚度方向上可移动，连接保持部分限定可动部分，并且比可动部分薄; 第二电极设置在比连接保持部分厚的第二基板的一部分上。

3. 发明授权

US08338460B2 2-pyridinecarboxamide derivative having GK-activating effect 有权
标题翻译：具有GK活化作用的2-吡啶甲酰胺衍生物
公开(公告)号：US08338460B2
公开(公告)日：2012-12-25
申请号：US11973240
申请日：2007-10-05
申请人： Noriaki Hashimoto , Yufu Sagara , Masanori Asai , Teruyuki Nishimura
发明人： Noriaki Hashimoto , Yufu Sagara , Masanori Asai , Teruyuki Nishimura
IPC分类号： A61K31/433 , A61K31/4439 , C07D417/14 , C07D417/10
CPC分类号： C07D417/14
摘要： Compounds of a formula (I) and their pharmaceutically-acceptable salts are disclosed. The compounds have glucokinase-activating effect and are therefore useful for treatment of diabetes and obesity. R1 and R2 each independently represent a lower alkyl group; X1 represent a group of a formula (II-1): wherein: R11 and R12 each independently represent a hydrogen atom or a lower alkyl group, or taken together with the nitrogen atom to which they bond, R11 and R12 may form a 4- to 7-membered nitrogen-containing aliphatic ring (one carbon atom constituting the 4- to 7-membered nitrogen-containing aliphatic ring may be replaced by an oxygen atom), or taken together with a carbon atom in (CH2)m, R11 and R12 may form a 4- to 7-membered nitrogen-containing aliphatic ring; m indicates an integer of from 1 to 3.
摘要翻译：公开了式（I）化合物及其药学上可接受的盐。该化合物具有葡糖激酶活化作用，因此可用于治疗糖尿病和肥胖症。 R1和R2各自独立地表示低级烷基; X 1表示式（II-1）的基团：其中：R 11和R 12各自独立地表示氢原子或低级烷基，或与它们所键合的氮原子一起，R 11和R 12可以形成4- 至7元含氮脂肪族环（构成4〜7元含氮脂肪族环的一个碳原子可以被氧原子取代），或与（CH 2）m，R 11和 R12可以形成4-至7-元含氮脂族环; m表示1〜3的整数。

4. 发明申请

US20120287438A1 OPTICAL FILTER, OPTICAL FILTER MODULE, AND PHOTOMETRIC ANALYZER 有权
标题翻译：光学过滤器，光学过滤器模块和光学分析仪
公开(公告)号：US20120287438A1
公开(公告)日：2012-11-15
申请号：US13467360
申请日：2012-05-09
申请人： Teruyuki NISHIMURA , Nozomu HIROKUBO
发明人： Teruyuki NISHIMURA , Nozomu HIROKUBO
IPC分类号： G01B9/02 , G02B5/28
CPC分类号： G02B26/001
摘要： An optical filter includes a first substrate, a second substrate opposed to the first substrate, a first optical film provided on a surface of the first substrate facing the second substrate, a second optical film provided on the second substrate and opposed to the first optical film via a gap, a first electrode provided on the surface of the first substrate facing the second substrate, and a second electrode provided on the second substrate and opposed to the first electrode, wherein a first charged body film with charge is formed on top of the first optical film, a second charged body film with charge is formed on top of the second optical film, and the first charged body film and the second charged body film are charged with the same polarity and opposed.
摘要翻译：光滤波器包括第一基板，与第一基板相对的第二基板，设置在面向第二基板的第一基板的表面上的第一光学膜，设置在第二基板上并与第一光学膜相对的第二光学膜通过间隙，设置在面向第二基板的第一基板的表面上的第一电极和设置在第二基板上并与第一电极相对的第二电极，其中在第一基板的顶部形成有带电的第一带电体膜第一光学膜，在第二光学膜的顶部上形成带电的第二带电体膜，并且第一带电体膜和第二带电体膜以相同的极性充电并且相反。

5. 发明申请

US20110065739A1 NOVEL ISOXAZOLE DRIVATIVE 审中-公开
标题翻译：新的异丙唑驱动剂
公开(公告)号：US20110065739A1
公开(公告)日：2011-03-17
申请号：US12992387
申请日：2009-05-28
申请人： Makoto Ishikawa , Tasuku Haketa , Chisato Nakama , Teruyuki Nishimura , Jun Shibata , Tadashi Shimamura , Takeru Yamakawa
发明人： Makoto Ishikawa , Tasuku Haketa , Chisato Nakama , Teruyuki Nishimura , Jun Shibata , Tadashi Shimamura , Takeru Yamakawa
IPC分类号： A61K31/506 , C07D261/12 , A61K31/42 , A61P3/10 , A61P3/04 , A61P3/06 , C07D413/04 , A61K31/4439
CPC分类号： C07D261/12 , C07D413/04 , C07D413/12
摘要： Disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, which has an agonistic activity on GPR120 and is therefore useful for the treatment of diabetes, obesity or hyperlipemia. [In formula (I), the A represents a phenyl group which may be substituted by a lower alkoxy group or the like; the 13 represents a bivalent group produced by removing two hydrogen atoms from a benzene ring which may be substituted by a halogen atom or the like; X represents a lower alkylene group having 2 to 4 carbon atoms in its main chain or the like, wherein a carbon atom constituting the main chain may be substituted by an oxygen atom or the like; and Y represents a hydrogen atom or the like.]
摘要翻译：公开了由式（I）表示的化合物或其药学上可接受的盐，其对GPR120具有激动作用，因此可用于治疗糖尿病，肥胖症或高脂血症。 [式（I）中，A表示可被低级烷氧基等取代的苯基， 13表示通过从可被卤素原子等取代的苯环除去2个氢原子而生成的二价基团; X表示其主链等中具有2〜4个碳原子的低级亚烷基，其中构成主链的碳原子可以被氧原子等取代; Y表示氢原子等。]

6. 发明申请

US20100261699A1 N-PYRAZOLE-2-PYRIDINE CARBOXAMIDE DERIVATIVE 审中-公开
标题翻译： N-吡咯-2-吡啶酰胺衍生物
公开(公告)号：US20100261699A1
公开(公告)日：2010-10-14
申请号：US12746567
申请日：2008-12-15
申请人： Noriaki Hashimoto , Teruyuki Nishimura , Yufu Sagara
发明人： Noriaki Hashimoto , Teruyuki Nishimura , Yufu Sagara
IPC分类号： A61K31/4439 , C07D401/14 , A61P3/10
CPC分类号： A61K31/155 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K38/28 , A61K38/31 , C07D401/14 , A61K2300/00
摘要： The present invention relates to a compound represented by the formula: or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are each independently a lower alkyl group, X is CH or the like, and X1 is an aminoalkoxy group or the like, which has a glucokinase-activating effect and thus is useful in the treatment of diabetes, obesity, and the like.
摘要翻译：本发明涉及由下式表示的化合物或其药学上可接受的盐，其中R1和R2各自独立地为低级烷基，X为CH等，X1为氨基烷氧基等，其具有葡糖激酶活化作用，因此可用于治疗糖尿病，肥胖症等。

7. 发明申请

US20080125429A1 Aryloxy-Substituted Benzimidazole Derivatives 有权
标题翻译：芳氧基取代的苯并咪唑衍生物
公开(公告)号：US20080125429A1
公开(公告)日：2008-05-29
申请号：US11666555
申请日：2005-11-01
申请人： Noriaki Hashimoto , Keiji Takahashi , Chisato Nakama , Yoshio Ogino , Fumiko Sakai , Teruyuki Nishimura , Jun-ichi Eiki
发明人： Noriaki Hashimoto , Keiji Takahashi , Chisato Nakama , Yoshio Ogino , Fumiko Sakai , Teruyuki Nishimura , Jun-ichi Eiki
IPC分类号： A61K31/5377 , C07D213/02 , C07D221/00 , C07D239/06 , C07D241/10 , C07D295/00 , A61P3/10 , A61K31/4439 , A61K31/4545 , A61K31/444 , A61K31/506 , A61K31/497
CPC分类号： A61K38/31 , A61K31/155 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K38/28 , A61K45/06 , C07D401/04 , C07D401/14 , C07D413/06 , C07D413/14 , A61K2300/00
摘要： A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided.The invention relates to a compound of a formula (I): [wherein R1 and R2 represent a hydrogen, etc.; R3 represents a hydrogen atom, a halogen atom, etc.; R4 each independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); R5 and R6 each represent a hydrogen atom, a lower alkyl group, etc.; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group β; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of X1 to X4 are carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.
摘要翻译：提供葡糖激酶活化剂; 提供糖尿病的治疗和/或预防，或治疗和/或预防糖尿病如视网膜病，肾病，神经症，缺血性心脏病，动脉硬化，以及进一步的治疗和/或预防肥胖症。本发明涉及式（I）的化合物：其中R 1和R 2代表氢等; R 3表示氢原子，卤素原子等; R 4各自独立地表示氢原子，低级烷基等; Q表示碳原子，氮原子或硫原子（硫原子可以被氧代基单取代或二取代）。 R 5和R 6各自表示氢原子，低级烷基等; X 1，X 2，X 3和X 4各自独立地表示碳原子或氮原子; Z表示氧原子，硫原子或氮原子; Ar表示任选被选自取代基组β的基团单取代至三取代的芳基或杂芳基; 环A表示5-或6-元含氮杂芳基; m表示1〜6的整数， n表示0〜3的整数， p表示0〜2的整数（条件是X 1〜X 4中的至少2个为碳原子）; q表示0或1]或其药学上可接受的盐，其具有葡糖激酶活化的作用，并且可用作糖尿病的治疗。

8. 发明申请

US20080070928A1 Novel 2-Heteroaryl-Substituted Benzimidazole Derivative 有权
标题翻译：新型2-杂芳基取代的苯并咪唑衍生物
公开(公告)号：US20080070928A1
公开(公告)日：2008-03-20
申请号：US10582564
申请日：2004-12-28
申请人： Katsumasa Nonoshita , Makoto Ishikawa , Hiroshi Nakashima , Daisuke Tsukahara , Yoshio Ogino , Fumiko Sakai , Yoshikazu Nagae , Keisuke Arakawa , Teruyuki Nishimura , Jun-Ichi Eiki
发明人： Katsumasa Nonoshita , Makoto Ishikawa , Hiroshi Nakashima , Daisuke Tsukahara , Yoshio Ogino , Fumiko Sakai , Yoshikazu Nagae , Keisuke Arakawa , Teruyuki Nishimura , Jun-Ichi Eiki
IPC分类号： A61K31/497 , A61K31/4184 , A61K31/422 , A61K31/4245 , A61K31/427 , A61P3/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/02 , C07D413/02 , C07D403/02 , A61P3/10 , A61K31/506 , A61K31/433 , A61K31/4439 , A61K31/444
CPC分类号： C07D401/14 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04
摘要： A glucokinase activator is provided; and a remedy and/or a preventive for diabetes, or a remedy and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a remedy and/or a preventive for obesity are provided.A glucokinase activator characterized by containing a 2-heteroaryl-substituted benzimidazole derivative of a general formula (I-0) or its pharmaceutically-acceptable salt: [in the formula, X represents a carbon atom or a nitrogen atom; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; the ring A represents a 5- or 6-membered nitrogen-containing aromatic hetero ring of a formula (II): (in the formula, X represents a carbon atom or a nitrogen atom); R1 represents an aryl, etc.; R2 represents a hydroxy, etc.; R3 represents a —C1-6 alkyl, etc.; R4 represents a —C1-6 alkyl, etc.; X5 represents —O—, etc.; a indicates an integer of 1, 2 or 3; q indicates an integer of from 0 to 2; m indicates an integer of from 0 to 2].
摘要翻译：提供葡糖激酶活化剂; 提供了糖尿病的补救措施和/或预防，糖尿病的补救和/或预防，如视网膜病变，肾病，神经症，缺血性心脏病，动脉硬化，以及进一步的补救措施和/或预防肥胖症。一种葡糖激酶活化剂，其特征在于含有通式（I-0）的2-杂芳基取代的苯并咪唑衍生物或其药学上可接受的盐：[式中X表示碳原子或氮原子; X 1，X 2，X 3和X 4各自独立地表示碳原子或氮原子; 环A表示式（II）的5-或6-元含氮芳族杂环：（式中，X表示碳原子或氮原子）; R 1表示芳基等; R 2表示羟基等; R 3表示-C 1-6烷基等; R 4表示-C 1-6烷基等; X 5表示-O-等; a表示1,2或3的整数; q表示0〜2的整数， m表示0〜2的整数]。

9. 发明申请

US20060258701A1 Novel 2-pyridinecarboxamide derivatives 有权
标题翻译：新型2-吡啶甲酰胺衍生物
公开(公告)号：US20060258701A1
公开(公告)日：2006-11-16
申请号：US10545424
申请日：2004-02-13
申请人： Morihiro Mitsuya , Makoto Bamba , Fumio Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
发明人： Morihiro Mitsuya , Makoto Bamba , Fumio Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
IPC分类号： A61K31/4745 , A61K31/444 , A61K31/4439 , C07D498/02 , C07D417/14
CPC分类号： C07D471/04 , C07D417/14
摘要： The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R and R3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及具有葡糖激酶活化作用并可用作糖尿病治疗剂的化合物，其由式（I）表示：其中X 1表示氮原子，硫原子，氧原子等; R 1表示6至10元芳基，5至7元杂芳基等; D表示氧原子或硫原子; R和R 3相同或不同，各自表示氢原子，低级烷基等; 式（II）表示任选取代的5〜7元杂芳基等; 式（III）表示单环或双环杂芳基]或其药学上可接受的盐。

10. 发明授权

US06777410B2 Isoindole derivatives 失效
标题翻译：异吲哚衍生物
公开(公告)号：US06777410B2
公开(公告)日：2004-08-17
申请号：US10408220
申请日：2003-04-08
申请人： Toshio Nagase , Tomoharu Iino , Yoshiyuki Sato , Teruyuki Nishimura , Jun-ichi Eiki
发明人： Toshio Nagase , Tomoharu Iino , Yoshiyuki Sato , Teruyuki Nishimura , Jun-ichi Eiki
IPC分类号： A61K31423
CPC分类号： C07D498/04
摘要： This invention relates to compounds represented by the general formula [I] wherein, R represents an azido group, etc., R1 and R2 are the same or different and represent hydrogen atoms, etc., R3 and R4 are the same or different and represent hydrogen atoms, etc., X1 represents an oxygen atom, etc., X2 represents an oxygen atom, etc., Y represents an oxygen atom, etc., and Z represents a condensed aryl group, etc., or a pharmaceutically acceptable salt thereof, preparation processes thereof, and an agent for treating diabetes, a prophylactic agent for chronic complications of diabetes or a drug against obesity, containing, as an effective ingredient, the compound or the pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及由通式[I]表示的化合物，其中R表示叠氮基等，R 1和R 2相同或不同，表示氢原子等，R 3，和R 4相同或不同，表示氢原子等，X 1表示氧原子等，X 2表示氧原子等，Y表示氧原子等，Z表示缩合芳基等，或其药学上可接受的盐，其制备方法和用于治疗糖尿病的药物，用于糖尿病慢性并发症的预防剂或抗肥胖药物，其含有作为有效成分的化合物或药学上可接受的盐其可接受的盐。

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