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1. 发明专利

JP2002327283A FORMATION OF SELF-ASSEMBLED MONOLAYERS 审中-公开
公开(公告)号：JP2002327283A
公开(公告)日：2002-11-15
申请号：JP2001370544
申请日：2001-12-04
申请人： SEIKO EPSON CORP , UNIV CAMBRIDGE TECH
发明人： FUKUSHIMA HITOSHI , MIYASHITA SATORU , ISHIDA MASAYA , HOLMES ANDREW , HUCK WILHELM , LUSCOMBE CHRISTINE KEIKO
IPC分类号： B41J2/16 , B05D1/18 , C23C26/00 , H01L51/00 , H01L51/30 , H01L51/50 , H05B33/10 , H05B33/14
摘要： PROBLEM TO BE SOLVED: To provide a method for forming self-assembled monolayers(SAM) on a substrate, and products having this sort of monolayers. SOLUTION: The self-assembled monolayers(SAM) are formed by using a compound containing semi-fluorinated sulfur or derivatives of semi-fluorinated silane, and compressed carbon dioxide(CO2 ) as a solvent. The molecule packing density of the monolayers is improved by changing temperature and/or pressure of the compressed CO2 during the formation. By employing the compressed CO2 as the solvent, the monolayers with superior molecule packing density are formed comparatively rapidly, without employing an unfavorable solvent for the environment.

2. 发明申请

WO2007003969A3 DIVALENT METAL ION PHOSPHATES AND USES THEREOF 审中-公开
标题翻译：二价金属离子磷酸盐及其用途
公开(公告)号：WO2007003969A3
公开(公告)日：2007-07-05
申请号：PCT/GB2006050193
申请日：2006-07-06
申请人： UNIV CAMBRIDGE TECH , MACPHEE CAIT , WRIGHT DAVID
发明人： MACPHEE CAIT , WRIGHT DAVID
IPC分类号： C01B25/32 , C01B25/34 , C01B25/37
CPC分类号： C01B25/32 , B01J20/048 , B01J20/282 , C01B25/34 , C01B25/37 , C01B25/377
摘要： The present invention provides a tubular assembly comprising one or more phases of nanocrystalline divalent metal ion phosphate. The invention also relates to methods for making the divalent metal ion phosphates and miscellaneous uses thereof.
摘要翻译：本发明提供了包含一个或多个纳米晶体二价金属离子磷酸盐相的管状组件。本发明还涉及制备二价金属离子磷酸盐的方法及其各种用途。

3. 发明申请

WO2007057718A2 MAGNETIC TAGGING TECHNIQUES 审中-公开
标题翻译：磁性标签技术
公开(公告)号：WO2007057718A2
公开(公告)日：2007-05-24
申请号：PCT/GB2006050406
申请日：2006-11-21
申请人： UNIV CAMBRIDGE TECH , UNIV SOUTHAMPTON , BLAND JAMES ANTHONY CHARLES , LLANDRO JUSTIN , ZHELUDEV NIKOLAY , VAN BELLE FRIEDA
发明人： BLAND JAMES ANTHONY CHARLES , LLANDRO JUSTIN , ZHELUDEV NIKOLAY , VAN BELLE FRIEDA
IPC分类号： G06K19/06 , B01J19/00 , B01L3/00 , B07C3/16 , B07C5/34 , G01N35/00
CPC分类号： G06K19/06187 , B01J2219/00509 , B01J2219/00563 , B01L3/502761 , B01L3/545 , B01L2200/0636 , B01L2200/0647 , B07C5/3412 , B82Y10/00 , B82Y25/00 , B82Y30/00
摘要： This invention relates to microfluidic apparatus for reading, writing and sorting magnetic tags attached to chemical and biological molecules and other entities. We describe apparatus for separating chemical or biological molecules or moieties each individually attached to a MBM tag miniature multi-bit magnetic tag capable of adopting a plurality of remanent magnetic configurations corresponding to binary information, the apparatus comprising: at least one input for said tagged molecules or moieties; at least two outputs for said tagged molecules or moieties; a microfluidic flow channel incorporating: magnetic readers to read said binary information; magnetic writers to write said binary information; and a switch to direct said tagged molecules or moieties to a selected said output responsive to said binary information.
摘要翻译：本发明涉及用于阅读，书写和分选连接到化学和生物分子以及其他实体的磁性标签的微流体装置。我们描述了用于分离化学或生物分子或部分的装置，所述化学或生物分子或部分各自独立地连接到能够采用对应于二元信息的多个剩余磁配置的MBM标签小型多位磁性标签，所述装置包括：用于所述标签化分子的至少一个输入或部分; 用于所述标记的分子或部分的至少两个输出; 微流体流动通道，其结合有：磁读取器以读取所述二进制信息; 磁写入器写入所述二进制信息; 以及响应于所述二进制信息将所述标记的分子或部分引导至选定的所述输出的开关。

4. 发明申请

WO2006109044A3 SELECTIVE MODULATION OF TUMOUR NECROSIS FACTOR RECEPTORS IN THERAPY 审中-公开
标题翻译：肿瘤坏死因子受体在治疗中的选择性调节
公开(公告)号：WO2006109044A3
公开(公告)日：2006-12-21
申请号：PCT/GB2006001313
申请日：2006-04-11
申请人： UNIV YALE , UNIV CAMBRIDGE TECH , BRADLEY JOHN , POBER JORDAN , CLARK PAUL , MIN WANG , KLUGER MARTIN
发明人： BRADLEY JOHN , POBER JORDAN , CLARK PAUL , MIN WANG , KLUGER MARTIN
IPC分类号： G01N33/68 , A61K38/19 , A61K39/395 , A61K48/00
CPC分类号： G01N33/6863 , A61K38/191 , A61K48/005 , G01N33/6893 , G01N2333/715 , G01N2500/00 , G01N2500/04 , G01N2800/32 , G01N2800/347
摘要： This invention relates to the identification and characterisation of specific cellular responses which are associated with tumour necrosis factor receptor 1 (TNFRl) and tumour necrosis factor receptor 2 (TNFR2). Selective modulations of these responses may be useful in the promotion or inhibition of cell growth, for example, in the treatment of disease conditions, including cardiovascular and kidney diseases. Therapeutic methods employed selective TNFRl and TNFR2 modulators are provided, along with screening methods for the identification of selective TNFRl and TNFR2 modulators useful in such methods.
摘要翻译：本发明涉及与肿瘤坏死因子受体1（TNFR1）和肿瘤坏死因子受体2（TNFR2）相关的特异性细胞反应的鉴定和表征。这些反应的选择性调节可用于促进或抑制细胞生长，例如治疗疾病状况，包括心血管和肾脏疾病。提供了使用选择性TNFR1和TNFR2调节剂的治疗方法，以及用于鉴定在这些方法中有用的选择性TNFR1和TNFR2调节剂的筛选方法。

5. 发明申请

WO2005095607A3 ANTI-SENSE OLIGONUCLEOTIDES DIRECTED TOWARDS THE HIV ? DOMAIN 审中-公开
标题翻译：针对艾滋病毒感染的抗感染性寡核苷酸？域
公开(公告)号：WO2005095607A3
公开(公告)日：2006-06-01
申请号：PCT/GB2005001273
申请日：2005-03-31
申请人： UNIV CAMBRIDGE TECH , MEDICAL RES COUNCIL , GAIT MICHAEL , LEVER ANDREW , BROWN DOUGLAS
发明人： GAIT MICHAEL , LEVER ANDREW , BROWN DOUGLAS
IPC分类号： C12N15/113
CPC分类号： C12N15/1132 , C12N2310/11 , C12N2310/321 , C12N2310/3231 , C12N2310/3521
摘要： Anti-sense oligonucleotides directed at the ? domain of the HIV genome, in particular, the SL3 loop/stem region of the HIV ? domain, are shown herein to disrupt the interaction of the ? domain with Gag NC, thereby inhibiting genome encapsidation and reducing the production of infectious HIV particles. These anti-sense oligonucleotides are useful as anti-retroviral therapeutics.
摘要翻译：反义寡核苷酸 HIV基因组的领域，特别是HIV的SL3环/干区域？域，这里显示的是破坏了结合Gag NC，从而抑制基因组壳化并降低感染性HIV颗粒的产生。这些反义寡核苷酸可用作抗逆转录病毒治疗剂。

6. 发明申请

WO2005098959A3 DUAL-GATE TRANSISTORS 审中-公开
标题翻译：双门极晶体管
公开(公告)号：WO2005098959A3
公开(公告)日：2006-04-27
申请号：PCT/GB2005001309
申请日：2005-04-05
申请人： UNIV CAMBRIDGE TECH , CHUA LAY-LAY , HO PETER KIAN HOON , FRIEND RICHARD HENRY
发明人： CHUA LAY-LAY , HO PETER KIAN HOON , FRIEND RICHARD HENRY
IPC分类号： H01L51/10 , H01L27/28 , H01L29/00
CPC分类号： H01L51/0508 , H01L27/283 , H01L51/0512 , H01L51/0554
摘要： A field Effect transistor device comprising: a source electrode (13 or 14); a drain electrode (13 or 14); a semiconductive region comprising an organic semiconductor material and defining a channel (12) of the device between the source electrode and the drain electrode; a first gate structure comprising a first gate electrode (10 or 16) and a first dielectric region (11 or 15) located between the first gate electrode and the semiconductive region; and a second gate structure comprising a second gate electrode (10 or 16) and a second dielectric region (11 or 15) located between the second gate electrode and the semiconductive region; whereby the conductance of the semiconductor region in the channel can be influenced by potentials applied separately or to both the first gate electrode and the second gate electrode.
摘要翻译：场效应晶体管器件，包括：源电极（13或14）; 漏电极（13或14）; 半导体区域，包括有机半导体材料并且限定在所述源电极和所述漏电极之间的所述器件的沟道（12）; 第一栅极结构，包括位于第一栅极电极和半导体区域之间的第一栅电极（10或16）和第一介电区域（11或15）以及第二栅极结构，包括位于所述第二栅电极和所述半导体区之间的第二栅电极（10或16）和第二电介质区（11或15）由此沟道中的半导体区域的电导可以受单独施加的电位或第一栅极电极和第二栅极电极的影响。

7. 发明申请

WO2005059660A3 VIDEO HOLOGRAPHIC APPARATUS AND METHOD 审中-公开
标题翻译：视频全息设备和方法
公开(公告)号：WO2005059660A3
公开(公告)日：2006-02-02
申请号：PCT/GB2004005253
申请日：2004-12-15
申请人： UNIV CAMBRIDGE TECH , CABLE ADRIAN JAMES , BUCKLEY EDWARD
发明人： CABLE ADRIAN JAMES , BUCKLEY EDWARD
IPC分类号： G03H1/08 , G03H1/22 , G03H1/32
CPC分类号： G03H1/2645 , G03H1/0808 , G03H1/0841 , G03H1/2205 , G03H1/2249 , G03H1/2286 , G03H1/2294 , G03H2001/0816 , G03H2001/085 , G03H2001/2215 , G03H2001/2218 , G03H2001/2231 , G03H2001/2255 , G03H2001/2271 , G03H2001/2297 , G03H2001/261 , G03H2001/306 , G03H2210/20 , G03H2210/30 , G03H2210/40 , G03H2210/454 , G03H2222/35 , G03H2223/13 , G03H2223/55 , G03H2225/25 , G03H2225/31 , G03H2225/32 , G03H2225/52 , G03H2225/55 , G03H2225/60 , G03H2225/61 , G03H2226/02 , G03H2240/41 , G03H2240/42 , G03H2240/51
摘要： The invention relates to a method of and apparatus for displaying a holographically generated video image having plural video frames. For each frame there is provided and computed (20) a respective sequential plurality of holograms. Each said sequential plurality of holograms of the plural video frames are sequentially displayed on a diffractive element (12) for viewing the replay field thereof, and the noise variance of each frame is perceived as attenuated by averaging across said plurality of holograms.
摘要翻译：本发明涉及用于显示具有多个视频帧的全息产生的视频图像的方法和装置。对于每个帧，提供并计算（20）相应的顺序多个全息图。多个视频帧中的每个所述顺序多个全息图被顺序地显示在用于观看其重放场的衍射元件（12）上，并且通过在所述多个全息图之间的平均来感知每帧的噪声方差被衰减。

8. 发明申请

WO2005053702A3 ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：抗炎药物
公开(公告)号：WO2005053702A3
公开(公告)日：2005-09-15
申请号：PCT/GB2004005030
申请日：2004-11-30
申请人： UNIV CAMBRIDGE TECH , GRAINGER DAVID JOHN , FOX DAVID JOHN
发明人： GRAINGER DAVID JOHN , FOX DAVID JOHN
IPC分类号： A61K31/55 , C07D223/10 , A61P19/10 , A61P25/28 , A61P29/00 , A61P37/00
CPC分类号： C07D223/12 , A61K31/55
摘要： The invention relates to the use of 3-aminocaprolactam derivatives for preparing a medicament intended to prevent or treat inflammatory disorders, and uses compounds of general formula (I) or a pharmaceutically acceptable salts thereof; wherein X is -CO-R or-SO2-R , and R and R are carbonaceous substituents.
摘要翻译：本发明涉及3-氨基己内酰胺衍生物用于制备预防或治疗炎症性疾病的药物的用途，并且使用通式（I）的化合物或其药学上可接受的盐; 其中X是-CO-R 1或-SO 2 -R 2，R 1和R 2是含碳取代基。

9. 发明申请

WO2004078914A3 A FLUORINASE ENZYME AND USE THEREOF IN FLUORINATION SYNTHESIS 审中-公开
标题翻译：荧光素酶及其在荧光合成中的应用
公开(公告)号：WO2004078914A3
公开(公告)日：2004-12-23
申请号：PCT/GB2004000880
申请日：2004-03-03
申请人： UNIV ST ANDREWS , UNIV CAMBRIDGE TECH , O'HAGAN DAVID , NAISMITH JAMES , SCHAFFRATH CHRISTOPHE , DONG CHANGJIANG , SPENCER JONATHAN BRIAN , HUANG FANGLU
发明人： O'HAGAN DAVID , NAISMITH JAMES , SCHAFFRATH CHRISTOPHE , DONG CHANGJIANG , SPENCER JONATHAN BRIAN , HUANG FANGLU
IPC分类号： A61K51/04 , C12N1/21 , C12N9/10 , C12P19/40 , A61K31/7076 , A61K51/00 , C12N15/54 , C12N15/63 , G06F19/00
CPC分类号： C12P19/40 , A61K51/04 , A61K51/0491 , C07K2299/00 , C12N9/1085
摘要： The present invention relates to a polypeptide having a fluorinase enzymatic activity, to a process of producing the polypeptide and to the use of such a polypeptide. The polypeptide originated from Streptomyces cattleya and has been crystallised.
摘要翻译：本发明涉及具有氟酶酶活性的多肽，涉及产生多肽的方法以及使用这种多肽。多肽起源于牛链霉菌（Streptomyces cattleya），并已经结晶。

10. 发明申请

WO2004089369A2 METHODS AND MEANS FOR TREATING PROTEIN CONFORMATIONAL DISORDERS 审中-公开
标题翻译：用于治疗蛋白质一致性疾病的方法和手段
公开(公告)号：WO2004089369A2
公开(公告)日：2004-10-21
申请号：PCT/GB2004000690
申请日：2004-02-24
申请人： UNIV CAMBRIDGE TECH , RUBINSZTEIN DAVID , RAVIKUMAR BRINDA , WEBB JULIE
发明人： RUBINSZTEIN DAVID , RAVIKUMAR BRINDA , WEBB JULIE
IPC分类号： A61K31/00 , A61K31/436 , A61P25/16 , A61P25/28 , A61P43/00 , G01N33/50 , G01N33/68
CPC分类号： G01N33/5026 , A01K2217/05 , A01K2267/0318 , A61K31/00 , A61K31/436 , A61K31/4745 , G01N33/5008 , G01N33/502 , G01N33/5058 , G01N33/5085 , G01N33/5088 , G01N33/6893 , G01N33/6896
摘要： This invention relates to the recognition that autophagy plays a key role in the clearance of the intracellular protein aggregates which characterise Protein Conformational Disorders, such as Huntington's disease and Parkinson's disease. Methods and uses of autophagy inducing agents, such as rapamycin macrolides, in the treatment of Protein Conformational Disorders, are described herein.
摘要翻译：本发明涉及认识到自噬在清除蛋白质构象紊乱（例如亨廷顿病和帕金森病）的细胞内蛋白质聚集体中起关键作用。本文描述了自噬诱导剂如雷帕霉素大环内酯在治疗蛋白质构象紊乱中的方法和用途。

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