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1. 发明专利

JP2006180703A Method for screening apoptosis-regulating agent 审中-公开
标题翻译：筛选调节剂的方法
公开(公告)号：JP2006180703A
公开(公告)日：2006-07-13
申请号：JP2003039715
申请日：2003-02-18
申请人： Ataru Hattori , Kunio Shioda , Weiyong Sun , Satoshi Tanaka , 邦郎塩田 , 偉勇孫 , 中服部 , 智田中
发明人： SUN WEIYONG , HATTORI ATARU , TANAKA SATOSHI , SHIODA KUNIO
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/47 , C12N15/12 , C12Q1/02 , C12Q1/37 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/68
CPC分类号： C12Q1/37 , A61K38/00 , C07K14/4702 , G01N33/6875 , G01N2510/00
摘要： PROBLEM TO BE SOLVED: To provide a method for regulating apoptosis and a method for screening an apoptosis-regulating medicine. SOLUTION: The method for screening a medicine regulating apoptosis by using PAL31 and its homolog is provided. The PAL31 has an effect of protecting cells from apoptosis. By the overexpression of the PAL31, UV- or etoposide-induced apoptosis is inhibited. The PAL31, which is the substrate of caspase 3, is cleaved by the caspase 3 and the cleaved product cannot inhibit apoptosis but, to the contrary, inhibits the anti-apoptosis activity of the PAL31. Therefore, a compound elevating the PAL31 expression level or inhibiting the decomposition of the PAL31 is available as a medicine for regulating apoptosis, while a compound lowering the PAL31 expression level or inhibiting the PAL31 activity is available as a medicine for promoting apoptosis. It is expected that compounds obtained by the screening method are usable as medicines for various diseases in which apoptosis participates. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供调节细胞凋亡的方法和筛选凋亡调节药物的方法。解决方案：提供了使用PAL31及其同系物筛选调节细胞凋亡的药物的方法。 PAL31具有保护细胞免于细胞凋亡的作用。通过PAL31的过表达，UV-或依托泊苷诱导的凋亡被抑制。作为半胱天冬酶3的底物的PAL31被胱天蛋白酶3切割，切割的产物不能抑制细胞凋亡，相反，抑制PAL31的抗凋亡活性。因此，提高PAL31表达水平或抑制PAL31分解的化合物可用作调节细胞凋亡的药物，而降低PAL31表达水平或抑制PAL31活性的化合物可用作促进细胞凋亡的药物。预期通过筛选方法获得的化合物可用作用于凋亡参与的各种疾病的药物。版权所有（C）2006，JPO＆NCIPI

2. 发明申请

US20070036775A1 Method of modulating or examining Ku70 levels in cells 审中-公开
标题翻译：调节或检测细胞中Ku70水平的方法
公开(公告)号：US20070036775A1
公开(公告)日：2007-02-15
申请号：US11580478
申请日：2006-10-13
申请人： Shigemi Matsuyama , Weiyong Sun
发明人： Shigemi Matsuyama , Weiyong Sun
IPC分类号： A61K48/00 , C12Q1/68
CPC分类号： C12Q1/6886 , A61K38/00 , C12N15/113 , C12N2310/111 , C12Q2600/106 , C12Q2600/158
摘要： A method of predicting whether cells would respond to therapies which are mediated through Bax-regulated apoptosis is disclosed. In one embodiment, the method comprises the step of: (a) examining the intensity of the expression of the Bax protein or mRNA in a cell relative to a control, and (b) based on that intensity level, predicting whether cells will respond to therapies which are mediated through Bax-regulated apoptosis, wherein a high Bax level indicates that one may lower Ku70 levels and increase sensitivity to apoptosis. In another embodiment, the invention is a method of sensitizing cells to cancer therapy, comprising the step of reducing the cell's native Ku70 protein level. In another embodiment the invention is method of treating cell death-related diseases comprising the step of increasing cellular Ku70 protein level.
摘要翻译：公开了一种预测细胞是否对通过Bax调节的凋亡介导的治疗作出反应的方法。在一个实施方案中，该方法包括以下步骤：（a）检查细胞中相对于对照的Bax蛋白或mRNA表达的强度，和（b）基于该强度水平，预测细胞是否将对通过Bax调节的凋亡介导的疗法，其中高Bax水平表明可以降低Ku70水平并增加对细胞凋亡的敏感性。在另一个实施方案中，本发明是使细胞对癌症治疗敏感的方法，包括降低细胞的天然Ku70蛋白水平的步骤。在另一个实施方案中，本发明是治疗细胞死亡相关疾病的方法，其包括增加细胞Ku70蛋白水平的步骤。

3. 发明申请

US20050026201A1 Method of modulating or examining Ku70 levels in cells 审中-公开
标题翻译：调节或检测细胞中Ku70水平的方法
公开(公告)号：US20050026201A1
公开(公告)日：2005-02-03
申请号：US10924060
申请日：2004-08-23
申请人： Shigemi Matsuyama , Weiyong Sun
发明人： Shigemi Matsuyama , Weiyong Sun
IPC分类号： A61K38/00 , C12N15/113 , C12Q1/68 , G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： C12Q1/6886 , A61K38/00 , C12N15/113 , C12N2310/111 , C12Q2600/106 , C12Q2600/158
摘要： A method of predicting whether cells would respond to therapies which are mediated through Bax-regulated apoptosis is disclosed. In one embodiment, the method comprises the step of: (a) examining the intensity of the expression of the Bax protein or mRNA in a cell relative to a control, and (b) based on that intensity level, predicting whether cells will respond to therapies which are mediated through Bax-regulated apoptosis, wherein a high Bax level indicates that one may lower Ku70 levels and increase sensitivity to apoptosis. In another embodiment, the invention is a method of sensitizing cells to cancer therapy, comprising the step of reducing the cell's native Ku70 protein level. In another embodiment the invention is method of treating cell death-related diseases comprising the step of increasing cellular Ku70 protein level.
摘要翻译：公开了一种预测细胞是否对通过Bax调节的凋亡介导的治疗作出反应的方法。在一个实施方案中，该方法包括以下步骤：（a）检查细胞中相对于对照的Bax蛋白或mRNA表达的强度，和（b）基于该强度水平，预测细胞是否将对通过Bax调节的凋亡介导的疗法，其中高Bax水平表明可以降低Ku70水平并增加对细胞凋亡的敏感性。在另一个实施方案中，本发明是使细胞对癌症治疗敏感的方法，包括降低细胞的天然Ku70蛋白水平的步骤。在另一个实施方案中，本发明是治疗细胞死亡相关疾病的方法，其包括增加细胞Ku70蛋白水平的步骤。

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