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1. 发明专利

JP2006180703A Method for screening apoptosis-regulating agent 审中-公开
标题翻译：筛选调节剂的方法
公开(公告)号：JP2006180703A
公开(公告)日：2006-07-13
申请号：JP2003039715
申请日：2003-02-18
申请人： Ataru Hattori , Kunio Shioda , Weiyong Sun , Satoshi Tanaka , 邦郎塩田 , 偉勇孫 , 中服部 , 智田中
发明人： SUN WEIYONG , HATTORI ATARU , TANAKA SATOSHI , SHIODA KUNIO
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/47 , C12N15/12 , C12Q1/02 , C12Q1/37 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/68
CPC分类号： C12Q1/37 , A61K38/00 , C07K14/4702 , G01N33/6875 , G01N2510/00
摘要： PROBLEM TO BE SOLVED: To provide a method for regulating apoptosis and a method for screening an apoptosis-regulating medicine. SOLUTION: The method for screening a medicine regulating apoptosis by using PAL31 and its homolog is provided. The PAL31 has an effect of protecting cells from apoptosis. By the overexpression of the PAL31, UV- or etoposide-induced apoptosis is inhibited. The PAL31, which is the substrate of caspase 3, is cleaved by the caspase 3 and the cleaved product cannot inhibit apoptosis but, to the contrary, inhibits the anti-apoptosis activity of the PAL31. Therefore, a compound elevating the PAL31 expression level or inhibiting the decomposition of the PAL31 is available as a medicine for regulating apoptosis, while a compound lowering the PAL31 expression level or inhibiting the PAL31 activity is available as a medicine for promoting apoptosis. It is expected that compounds obtained by the screening method are usable as medicines for various diseases in which apoptosis participates. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供调节细胞凋亡的方法和筛选凋亡调节药物的方法。解决方案：提供了使用PAL31及其同系物筛选调节细胞凋亡的药物的方法。 PAL31具有保护细胞免于细胞凋亡的作用。通过PAL31的过表达，UV-或依托泊苷诱导的凋亡被抑制。作为半胱天冬酶3的底物的PAL31被胱天蛋白酶3切割，切割的产物不能抑制细胞凋亡，相反，抑制PAL31的抗凋亡活性。因此，提高PAL31表达水平或抑制PAL31分解的化合物可用作调节细胞凋亡的药物，而降低PAL31表达水平或抑制PAL31活性的化合物可用作促进细胞凋亡的药物。预期通过筛选方法获得的化合物可用作用于凋亡参与的各种疾病的药物。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2004324203A Side ditch cover having road boundary block, side ditch, and method of producing the same 有权
公开(公告)号：JP2004324203A
公开(公告)日：2004-11-18
申请号：JP2003119660
申请日：2003-04-24
申请人： Satoshi Tanaka , 智田中
发明人： TANAKA SATOSHI
IPC分类号： E01C11/22 , E03F5/04 , E03F5/046
摘要： PROBLEM TO BE SOLVED: To provide a side ditch cover which has a road boundary block on an upper portion thereof, is strong against impacts in a crossing direction and a longitudinal direction, excellent in workability, and contributes to arrangement of the road boundary blocks of various types corresponding to the local circumstances, and to provide a side ditch which has the side ditch cover mounted thereon, and a method of producing the side ditch cover and the side ditch.
SOLUTION: The side ditch has a space formed therein, and the side ditch cover is mounted on the side ditch. The side ditch cover consists of a road boundary portion and a cover plate portion, and the cover plate portion has side walls on respective end faces, and the road boundary portion has extension portions extending from the respective side walls. The side ditch includes a road boundary joint portion on which a lower portion of the side ditch cover extension portion abuts, and a cover plate fixing portion which allows the side ditch cover to be fixed thereto. The cover plate fixing portion has side walls on respective end faces thereof.
COPYRIGHT: (C)2005,JPO&NCIPI

3. 发明专利

JP2003061769A Four leg stably setting structure, and four leg horizontally setting structure 有权
标题翻译：四杆稳定结构，四杆水平定位结构
公开(公告)号：JP2003061769A
公开(公告)日：2003-03-04
申请号：JP2001250946
申请日：2001-08-22
申请人： Satoshi Tanaka , 智田中
发明人： TANAKA SATOSHI
IPC分类号： A47B91/02
摘要： PROBLEM TO BE SOLVED: To provide a four leg structure which can easily set a work being supported by four legs such as a table, a chair, a barbecue stove or a ladder stably and horizontally even on the uneven ground.
SOLUTION: In this structure wherein the work is supported by four legs, adjacent two legs 5A and 5B which are connected by a curved section 4 having an arc are connected with the work in a manner to be slidable in the arc direction. Then, confronted two legs 6A and 6B are fixed to the work, and thus, the four legs are stably set. Also, a height adjusting device 7 is provided for the two legs 6A and 6B which are fixed to the work, and the four legs are horizontally set.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种四脚架结构，即使在不平坦的地面上，也可以容易地将由桌子，椅子，烧烤炉或梯子四个腿支撑的工作稳定和水平地设置。解决方案：在这种结构中，工件由四条腿支撑，通过具有弧形的弯曲部分4连接的相邻的两个腿部5A和5B以可在电弧方向上滑动的方式与工件连接。然后，将两条腿6A和6B固定在工件上，从而稳定地设置四条腿。此外，为固定在工件上的两个支腿6A和6B设置高度调节装置7，并且四个支脚水平设置。

4. 发明专利

JP2004158420A Candlestick auxiliary tool 审中-公开
公开(公告)号：JP2004158420A
公开(公告)日：2004-06-03
申请号：JP2002357326
申请日：2002-11-05
申请人： Satoshi Tanaka , 聡田中
发明人： TANAKA SATOSHI
IPC分类号： F21V35/00
摘要： PROBLEM TO BE SOLVED: To provide a candlestick auxiliary tool for preventing falling during lighting on a candle as well as preventing insufficient insertion or a crack on the candle when setting the candle on a conventional candlestick.
SOLUTION: A support body (1) made of a noncombustible material with elasticity for supporting a part of a body part of a candle (4) is formed, and a through-hole (2) along a shape through which a core stand (5) of a candlestick (6) can be inserted is formed.
COPYRIGHT: (C)2004,JPO

5. 发明专利

JP2004143849A Spacer, variable gradient type side ditch using the spacer and its construction method 审中-公开
公开(公告)号：JP2004143849A
公开(公告)日：2004-05-20
申请号：JP2002311435
申请日：2002-10-25
申请人： Satoshi Tanaka , 田中智
发明人： TANAKA SATOSHI
IPC分类号： E03F5/04
摘要： PROBLEM TO BE SOLVED: To provide a spacer for joining an auxiliary member and a grid reinforcement to a grid reinforcement in a side wall of a side ditch, the side ditch for arranging this spacer on a side wall bottom surface, and a construction method for forming a strong structure by finishing concrete placing at one time at a construction site of a variable gradient type side ditch and a variable gradient type side ditch used in common for earth retaining.
SOLUTION: An interval holding part for the spacer is formed in a cross-sectional almost recessed shape, and the spacer is arranged on the side wall bottom surface of the variable gradient type side ditch by exposing an upper part. The reinforcement and the auxiliary member are inserted into the interval holding part, and are joined with the grid reinforcement in the side wall, and are installed on foundation crushed stones, and concrete is placed.
COPYRIGHT: (C)2004,JPO

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