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1. 发明申请

WO2010106781A1 METHOD OF CONTINUOUSLY MEASURING SUBSTRATE CONCENTRATION 审中-公开
标题翻译：连续测量基板浓度的方法
公开(公告)号：WO2010106781A1
公开(公告)日：2010-09-23
申请号：PCT/JP2010/001834
申请日：2010-03-15
申请人： ARKRAY, Inc. , KATSUKI, Koji , TSUKADA, Masashi
发明人： KATSUKI, Koji , TSUKADA, Masashi
IPC分类号： A61B5/1473 , A61B5/1486 , G01N27/327 , G01N27/416 , G01N33/66
CPC分类号： C12Q1/006 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6849
摘要： Analysis equipment is provided, which is capable of fulfilling a demand for miniaturization and ensuring high sensitivity, and which can be produced easily. The present invention relates to a method of continuously measuring a substrate concentration based on a response when a voltage is applied to a sensor. The present invention includes a response voltage application step of applying a response voltage E2 at which a response attributed to a substrate is obtained and a non-response voltage application step of applying a non-response voltage E1 at which the response attributed to the substrate is not obtained or is not substantially obtained. Preferably, the response voltage application step and the non-response voltage application step are repeated alternately.
摘要翻译：提供分析设备，其能够满足小型化的需求并确保高灵敏度，并且可以容易地制造。本发明涉及一种当将电压施加到传感器时基于响应连续测量衬底浓度的方法。本发明包括：响应电压施加步骤，其施加响应电压E2，在该响应电压E2获得归因于基板的响应;以及非响应电压施加步骤，其施加响应归因于该基板的非响应电压E1 未获得或基本不获得。优选地，交替地重复响应电压施加步骤和非响应电压施加步骤。

2. 发明公开

EP2517625A1 MEASUREMENT DEVICE AND SENSOR PLACEMENT METHOD 审中-公开
标题翻译： MESSVORRICHTUNG UND SENSORPLATZIERUNGSVERFAHREN
公开(公告)号：EP2517625A1
公开(公告)日：2012-10-31
申请号：EP10839128.5
申请日：2010-11-25
申请人： Arkray, Inc.
发明人： TSUKADA, Masashi , KUSAKA, Yasuhide , YAMAMOTO, Akihiro
IPC分类号： A61B5/1486
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/7207 , A61B2560/063
摘要： Provided are a measurement device, a sensor unit, and a sensor placement method using those, which enable the suppression of the occurrence of a situation in which when a measurement is carried out with a sensor implanted under the skin, the implanted sensor becomes faulty. A sensor unit (2) is used for measuring numerical information relating to a substance contained in a body fluid in a body The sensor unit (2) is provided with a sensor (15) a part of which is placed under the skin and generates a signal according to the state of the substance, a base (10) which is disposed on the skin and holds the sensor (15), a variable mechanism (11) which is attached to the base (10) and enables the position and/or the direction of the sensor (15) with reference to the base (10) to be varied, and an external terminal (12) which is provided in the base (10) and leads the signal generated by the sensor (15) to the outside.
摘要翻译：提供了一种使用这些的测量装置，传感器单元和传感器放置方法，其能够抑制当植入在皮肤下植入的传感器进行测量时发生的情况，植入的传感器变得有缺陷。传感器单元（2）用于测量与体内体液中包含的物质有关的数值信息。传感器单元（2）设置有传感器（15），其一部分放置在皮肤下面，并产生根据物质的状态的信号，设置在皮肤上并保持传感器（15）的基部（10），可变机构（11），其连接到基座（10）并且使得位置和/或相对于要改变的基座（10）的传感器（15）的方向和设置在基座（10）中并将由传感器（15）产生的信号引导到外部的外部端子（12）。

3. 发明公开

EP4067483A1 MUTANT GLUCOSE DEHYDROGENASE HAVING IMPROVED THERMAL STABILITY, AND USE THEREOF 审中-公开
公开(公告)号：EP4067483A1
公开(公告)日：2022-10-05
申请号：EP21204332.7
申请日：2021-10-22
申请人： The University of North Carolina at Chapel Hill , ARKRAY, Inc.
发明人： SODE, Koji , SHIMAZAKI, Junko , KOJIMA, Katsuhiro , TSUKADA, Masashi
IPC分类号： C12N9/02 , C12Q1/54 , C12Q1/32 , G01N33/66 , C07K14/195
摘要： The present invention provides a mutant FAD-dependent glucose dehydrogenase comprising: a catalytic subunit; an electron transfer subunit; and a hitchhiker subunit; wherein each of the amino acid sequence of the catalytic subunit and the amino acid sequence of the electron transfer subunit comprises a cysteine residue introduced therein, the catalytic subunit and the electron transfer subunit being bound to each other through a disulfide bond between the cysteine residues to achieve improved thermal stability of the FAD-dependent glucose dehydrogenase.

4. 发明公开

EP2540224A1 ANALYSIS DEVICE, ANALYSIS METHOD, AND ANALYSIS SYSTEM 审中-公开
标题翻译： ANALYSEVORRICHTUNG，ANALYSEVERFAHREN SOWIE ANALYSESYSTEM
公开(公告)号：EP2540224A1
公开(公告)日：2013-01-02
申请号：EP11747142.5
申请日：2011-02-01
申请人： Arkray, Inc.
发明人： TSUKADA, Masashi , KUSAKA, Yasuhide
IPC分类号： A61B5/1486 , A61B5/1473 , G01N27/26 , G01N27/416
CPC分类号： G01R35/00 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B2560/0242 , G16B99/00
摘要： Provided is a technology capable of acquiring a measurement result with high reliability under a condition exhibiting a large fluctuation in ambient temperature when measuring numerical value information on a specified substance in a sample. An analysis apparatus includes: a signal detection unit to continuously detect signal values detected from a first sample; a measuring unit to measure numerical value information on a specified substance in a second sample; a first temperature detection unit to capture a first temperature value defined as temperature information on the first sample; a second temperature detection unit to capture a second temperature value defined as temperature information on the second sample; and a calculation unit to calibrate to the numerical value information on the specified substance in the first sample from the signal value by referring to the numerical value information on the specified substance in the second sample in accordance with the first temperature value and the second temperature value.
摘要翻译：提供了当测量样品中特定物质的数值信息时，能够在环境温度波动大的条件下获得具有高可靠性的测量结果的技术。分析装置包括：信号检测单元，用于连续地检测从第一样本检测的信号值; 测量单元，用于测量第二样品中指定物质的数值信息; 第一温度检测单元，用于捕获定义为第一样品上的温度信息的第一温度值; 第二温度检测单元，捕获定义为第二样品的温度信息的第二温度值; 以及计算单元，根据所述第一温度值和所述第二温度值，参照所述第二样品中的所述特定物质的数值信息，从所述信号值校正所述第一样品中的所述特定物质的数值信息。

5. 发明授权

EP2545853B1 ELECTROCHEMICAL SENSOR 有权
公开(公告)号：EP2545853B1
公开(公告)日：2017-10-25
申请号：EP11753263.0
申请日：2011-03-03
申请人： ARKRAY, Inc.
发明人： TSUKADA, Masashi
IPC分类号： A61B5/1486 , G01N27/28 , G01N27/327 , G01N27/416
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/6833 , A61B2562/0209 , A61B2562/043

6. 发明授权

EP2395348B1 Electrochemical sensor and method for manufacturing same. 有权
标题翻译：电化学传感器和方法，用于其生产。
公开(公告)号：EP2395348B1
公开(公告)日：2014-01-22
申请号：EP10738602.1
申请日：2010-02-04
申请人： Arkray, Inc.
发明人： KATSUKI, Koji , FUJINAWA, Yoshiaki , TSUKADA, Masashi , MURASE, Yosuke
IPC分类号： C12Q1/00 , C12Q1/32
CPC分类号： C12Q1/006 , C12Q1/32 , G01N2333/902

7. 发明公开

EP2450699A1 ANALYSIS DEVICE AND ANALYSIS METHOD 审中-公开
标题翻译： ANALYSEVORRICHTUNG UND ANALYSEVERFAHREN
公开(公告)号：EP2450699A1
公开(公告)日：2012-05-09
申请号：EP10794086.8
申请日：2010-06-25
申请人： Arkray, Inc.
发明人： NAKANISHI, Hiroyuki , UEHATA, Yoshiharu , KAWANISHI, Masako , MURASE, Yosuke , TSUKADA, Masashi
IPC分类号： G01N27/26 , G01N27/28 , G01N27/327 , G01N27/416
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2560/0252 , G01N27/3274
摘要： Provided is an analysis device or an analysis method, by which highly reliable analysis results can be obtained even in the circumstances where environment temperature changes, while reducing load on the user. The analysis device (1) is provided with a determining means (13) which determines whether environmental temperature measured by means of a temperature measuring means (6) is within a predetermined temperature range or not. The determining means (13) is so configured as to determine whether the environmental temperature is within the predetermined temperature range or not, even in the circumstances where information relating to a target substance in a sample cannot be obtained from the analysis device.
摘要翻译：提供了一种分析装置或分析方法，即使在环境温度变化的情况下也可以获得高度可靠的分析结果，同时降低用户的负担。分析装置（1）具有确定装置（13），其确定通过温度测量装置（6）测量的环境温度是否在预定的温度范围内。即使在不能从分析装置获取与样本中的目标物质有关的信息的情况下，判定装置（13）被配置为确定环境温度是否在预定温度范围内。

8. 发明公开

EP2395348A1 ELECTROCHEMICAL SENSOR AND METHOD FOR MANUFACTURING SAME 有权
标题翻译： Elektrochemischer传感器和Verfahren zu seiner Herstellung。
公开(公告)号：EP2395348A1
公开(公告)日：2011-12-14
申请号：EP10738602.1
申请日：2010-02-04
申请人： Arkray, Inc.
发明人： KATSUKI, Koji , FUJINAWA, Yoshiaki , TSUKADA, Masashi , MURASE, Yosuke
IPC分类号： G01N27/327 , C12M1/40 , G01N27/416
CPC分类号： C12Q1/006 , C12Q1/32 , G01N2333/902
摘要： The present invention provides an electrochemical sensor comprising a substrate, an electrically conductive layer made of carbon particles which is disposed on the substrate, a cell membrane mimetic structure layer containing an enzyme at least one of inside the cell membrane mimetic structure layer and on the interface of the cell membrane mimetic structure layer which is disposed on the electrically conductive layer.
摘要翻译：本发明提供一种电化学传感器，其包括基板，由设置在基板上的碳颗粒制成的导电层，包含细胞膜模拟结构层内部和界面上的至少一个的酶的细胞膜模拟结构层的细胞膜模拟结构层，其设置在导电层上。

9. 发明公开

EP3640344A1 DIRECT ELECTRON TRANSFER-TYPE OXIDOREDUCTASE-MODIFIED MOLECULAR RECOGNITION ELEMENT 审中-公开
公开(公告)号：EP3640344A1
公开(公告)日：2020-04-22
申请号：EP19201172.4
申请日：2019-10-02
申请人： ARKRAY, Inc. , Ultizyme International Ltd.
发明人： SODE, Koji , TAKAHASHI, Yuka , SHIMAZAKI, Junko , TSUKADA, Masashi , MURASE, Yosuke
IPC分类号： C12Q1/68 , C07K19/00 , G01N33/573
摘要： A molecular recognition element comprising a target molecule-recognizing portion, and a direct electron transfer-type oxidoreductase linked to the target molecule-recognizing portion.

10. 发明授权

EP2540224B1 ANALYSIS DEVICE, ANALYSIS METHOD, AND ANALYSIS SYSTEM 有权
公开(公告)号：EP2540224B1
公开(公告)日：2020-04-01
申请号：EP11747142.5
申请日：2011-02-01
申请人： ARKRAY, Inc.
发明人： TSUKADA, Masashi , KUSAKA, Yasuhide
IPC分类号： A61B5/1486 , A61B5/1473 , G01N27/26 , G01N27/416 , A61B5/1495

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