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1. 发明授权

US3442891A Steroidal 4,6-dien-3-ones having c6 substituents and process for preparing same 失效
标题翻译：具有C6取代基的STEROIDAL 4,6-DIEN-3-ONES及其制备方法
公开(公告)号：US3442891A
公开(公告)日：1969-05-06
申请号：US3442891D
申请日：1966-02-08
申请人： BRITISH DRUG HOUSES LTD
发明人： BURN DEREK , COOMBS ROBERT VICTOR , PETROW VLADIMIR
IPC分类号： C07J1/00 , C07J5/00 , C07J31/00 , C07J41/00 , C07J75/00 , C07C173/00 , C07C169/22 , C07C169/34
CPC分类号： C07J41/00 , C07J1/00 , C07J5/00 , C07J31/00 , C07J75/00

2. 发明授权

US3427389A D-homo aromatic steroids 失效
标题翻译： D-HOMO AROMATIC STEROIDS
公开(公告)号：US3427389A
公开(公告)日：1969-02-11
申请号：US3427389D
申请日：1965-04-05
申请人： BRITISH DRUG HOUSES LTD
发明人： BURN DEREK , PETROW VLADIMIR
IPC分类号： C07J63/00 , A61K27/00 , C07C41/00 , C07C43/00
CPC分类号： C07J63/008

3. 发明专利

DE1518615A1 未知
公开(公告)号：DE1518615A1
公开(公告)日：1969-02-20
申请号：DE1518615
申请日：1965-12-01
申请人： BRITISH DRUG HOUSES LTD
发明人： BURN DEREK , PETROW VLADIMIR
IPC分类号： A61K31/568 , A61K31/5685 , A61K31/569 , A61K31/57 , C07J1/00 , C07J5/00 , C07J53/00 , C07J75/00 , G06F11/32 , G06F13/40
摘要： 1,116,450. Multicomputer systems; indicators. ASSOCIATED ELECTRICAL INDUSTRIES Ltd. 17 Nov., 1966 [19 Nov., 1965], No. 49166/65. Heading G4A. A visual indicator indicates when a peripheral device is connected to a computer and to which computer of a multi-computer installation it is connected. In a two-computer system as shown (Fig. 2), plug P1 of a peripheral device P may be inserted into either socket S1 or socket S2 connected respectively by way of buses 1 and 2 to computers A and B. A lead extending to an indicator board IB (see also Fig. 1, not shown) illuminates either a lamp A or a lamp B, of different colours. Corresponding circuits and lamp pairs may be provided for other peripheral devices (not shown). The computers themselves may be connected to the buses by plug-and. socket connections pA and pB. Means other than plugs and sockets may be provided, e.g. manual switches, relays or a diode system.

4. 发明专利

DE1234713B 未知
公开(公告)号：DE1234713B
公开(公告)日：1967-02-23
申请号：DEB0070470
申请日：1963-01-24
申请人： BRITISH DRUG HOUSES LTD
发明人： ELLIS BERNARD , BURN DEREK , PETROW VLADIMIR
IPC分类号： C07J1/00 , C07J5/00

5. 发明专利

DE1203258B 未知
公开(公告)号：DE1203258B
公开(公告)日：1965-10-21
申请号：DEB0070180
申请日：1962-12-29
申请人： BRITISH DRUG HOUSES LTD
发明人： BURN DEREK , PETROW VLADIMIR
IPC分类号： C07J1/00 , C07J5/00 , C07J7/00 , C07J75/00

6. 发明专利

CA626430A 21-ALKYL DERIVATIVES OF 17.beta.-HYDROXY-17.alpha.-PREGN-20-YNE 未知
公开(公告)号：CA626430A
公开(公告)日：1961-08-29
申请号：CA626430D
申请人： BRITISH DRUG HOUSES LTD
发明人： PETROW VLADIMIR , COOLEY GEORGE , BARTON SUZANNE P , ELLIS BERNARD , STUART-WEBB ISOBEL A , BURN DEREK

7. 发明专利

DE1568115A1 未知
公开(公告)号：DE1568115A1
公开(公告)日：1970-07-23
申请号：DE1568115
申请日：1966-05-17
申请人： BRITISH DRUG HOUSES LTD
发明人： BURN DEREK , VICTOR COOMBS ROBERT , PETROW VLADIMIR
IPC分类号： C07J1/00 , C07J5/00 , C07J7/00 , C07J71/00 , C07J75/00 , C07C169/22
摘要： 6 - Halomethyl - D 4,6 - 3 - oxo - steroids wherein the halogen is chlorine, bromine or iodine are prepared from the corresponding 6-methylene - D 4 - 3 - oxo steroids and a hypohalous acid, preferably generated in situ from an N-halo-amide or -imide and a strong acid. Examples describe the preparation of the novel 17b - acetoxy - 6 - iodomethylandrosta-4,6 - dien - 3 - one and 21 - acetoxy - 6 - bromomethyl - 17a - hydroxypregna - 4,6 - dien-3,11,20-trione and other 6-halomethyl-D 4,6- 3-oxo-steroids which may contain hydroxy, alkoxy and acyloxy groups in rings C and D and the 17-side chain, the hydroxy groups preferably being protected by acylation or conversion to, for example, a 17a ,20 :20,21-bismethylenedioxy group; carbonyl, carbalkoxy, cyano, alkyl, methylene, halomethylene and ethylidene groups at various positions of the steroid nucleus or 17-side chain; halogen atoms; 17-spirolactone rings; and spiroketal side chains attached to ring D.

8. 发明专利

DE1568076A1 未知
公开(公告)号：DE1568076A1
公开(公告)日：1970-05-06
申请号：DE1568076
申请日：1966-02-08
申请人： BRITISH DRUG HOUSES LTD
发明人： BURN DEREK , VICTOR COOMBS ROBERT , PETROW VLADIMIR
IPC分类号： C07J1/00 , C07J5/00 , C07J7/00 , C07J71/00 , C07J75/00 , C07C167/22

9. 发明专利

CA811142A 6-HALOMETHYL-3-OXO-4,6-DIENIC STEROIDS AND THEIR PREPARATION 未知
公开(公告)号：CA811142A
公开(公告)日：1969-04-22
申请号：CA811142D
申请人： BRITISH DRUG HOUSES LTD
发明人： BURN DEREK , COOMBS ROBERT V , PETROW VLADIMIR

10. 发明专利

GB997940A Steroids containing a carbocyclic ring fused to the 16- and 17-positions 未知
公开(公告)号：GB997940A
公开(公告)日：1965-07-14
申请号：GB1444763
申请日：1963-04-10
申请人： BRITISH DRUG HOUSES LTD
发明人： ALLISON JAMES MACFARLANE , BURN DEREK , PETROW VLADIMIR
IPC分类号： C07J53/00 , C07J75/00
摘要： The invention comprises steroids having, apart from optional additional substituents and unsaturated linkages in rings C and D, the partial formula (wherein R is hydrogen, C1-6 alkyl or aryl) and their preparation by condensing a similar steroid of the partial formula (wherein R1 is H or CO2 alkyl and which, when R1 is H, may be in the 16-hydroxy-methylene form) with methyl vinyl ketone or an analogue thereof under basic conditions to yield a similar steroid of the partial formula and then cyclizing this with a strong basic reagent. Hydroxy, aryloxy, alkoxy, formyl, alkyl, cycloalkyl, cycloalkylene, cyano, dialkylaminomethyl, alkenyl, alkynyl, and halo-alkynyl groups, halogen atoms and double bonds may be present at most other positions in the nucleus of the androstane or oestrane starting materials. Keto groups must be protected by reduction to ols, ketals or enol ethers. In the products 5-en-3-ols may be converted to 4-en-3-ones. The steroids may also have carboxylic or heterocyclic rings fused thereto, particularly to ring A. Examples are given, some of the hydroxy substituted products being converted to their acetates 21-Oximes, and 21-acetates of the 21-ols formed by reduction, are also described. Steroids of the second partial formula above are prepared by treating the corresponding 16-unsubstituted-17-keto steroids with methyl or ethyl formate or diethyl oxalate in the presence of sodium hydride or sodium methoxide. 3,3 - Ethylenedioxy - 11b - hydroxyandrost - 5 - en - 17 - one is prepared by reducing the ketal of cortisone acetate with sodium borohydride under vigorous conditions and oxidizing the product with sodium metaperiodate. 3,3-Ethylenedioxy - androst - 5 - en - 11,17 - dione is similarly prepared using mild reduction conditions. 3,3 - Ethylenedioxy - 11a - hydroxyandrost - 5 - en - 17 - one is prepared similarly. 16 - (31 - Oxobutyl) - androsta - 1,4 - diene - 3,17-dione is prepared by oxidizing 16-(31-oxo-butyl) - 3b - hydroxy - androst - 5en - 17 - one to give 16 - (31 - oxobutyl) - androst - 5 - ene - 3,17 - dione, converting this to 16 - (31 - oxobutyl) - androst - 4 - ene - 3,17 - dione and dehydrogenating this. 11b - hydroxy - 16 - (31 - oxobutyl) - androsta - 1,4 - diene - 3,17 - dione is prepared by dekalizing 3,3-ethylenedioxy-11b -hydroxy-16 - (31 - oxobutyl) - androst - 5 - en - 17 - one to give 11b -hydroxy-16-(31-oxobutyl)-androst-4-ene-3,17 -dione, and then dehydrogenating this with dichlorodicyanoquinone. Dehydrogenation with chloranil gives 11b -hydroxy-16-(31-oxo-butyl) - androsta - 4,6 - diene - 3,17 - dione. 6 - Formyl - 11b - hydroxy - 3 - methoxyandrosta-3,5-dien-17-one is prepared from the corresponding 6-unsubstituted compound and the Vilsmeier reagent, the product being treated with methanolic potassium hydroxide. 6-Cyano-11b - hydroxy - 3 - methoxyandrosta - 3,5 - dien -17-one is prepared by treating the above 6-formyl compound with hydroxylamine hydrochloride to give the 6-hydroxyiminomethyl compound, acetylating this, and heating the product at 175 DEG C.

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