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1. 发明专利

JP2012179057A Method for providing and analyzing animal population having essentially identical metabolome 有权
标题翻译：提供和分析具有基本特征代谢物的动物群体的方法
公开(公告)号：JP2012179057A
公开(公告)日：2012-09-20
申请号：JP2012116244
申请日：2012-05-22
申请人： Basf Se , ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人： RAVENZWAAY BENNARD VAN , COELHO PALERMO CUNHA GEORGIA , MELLERT WERNER , LOOSER RALF , WALK TILMANN B , WIEMER JAN C , HAAKE VOLKER
IPC分类号： A01K67/027 , A01K67/00 , C12Q1/02
CPC分类号： A01K1/031 , A01K29/00 , A01K67/02
摘要： PROBLEM TO BE SOLVED: To provide an animal population having an essentially identical metabolome suitable for a reliable metabolome study and analysis.SOLUTION: The invention relates to a method for providing an animal population having an essentially identical metabolome comprising compiling an animal population being of essentially the same age, keeping the animal population for a time period sufficient for acclimatization under the following housing conditions: (i) constant temperature, (ii) constant humidity, (iii) physical separation of the animals of the animal population, (iv) feeding ad libitum, (wherein the food to be fed is essentially free of chemical or microbial contaminants), (v) drinking ad libitum, (wherein the drinking liquid is essentially free of chemical or microbial contaminants), (vi) constant illumination period, and providing the animal population after the time period. Further, the invention relates to methods for the identification of a compound which effects the metabolome of an animal, or methods for the identification of a marker for such compounds. Moreover, the invention encompasses methods for the identification of such compounds or markers thereof comprising metabolically analyzing a sample from at least one animal of an animal population.
摘要翻译：要解决的问题：提供具有基本上相同的代谢组的动物群体，其适用于可靠的代谢组学研究和分析。解决方案：本发明涉及一种用于提供具有基本相同的代谢组的动物群体的方法，包括编译基本相同年龄的动物群体，在下列住房条件下保持动物群体足以适应适应期的时间段：（i）恒温，（ii）恒定湿度，（iii）动物群体的动物的物理分离，（iv）随意喂食（其中待进食的食物基本上不含化学或微生物污染物），（ v）随意饮用（其中饮用液体基本上不含化学或微生物污染物），（vi）恒定的照明期，并在该时间段之后提供动物群体。此外，本发明涉及用于鉴定影响动物的代谢组合物的化合物的方法或用于鉴定这些化合物的标记物的方法。此外，本发明包括用于鉴定这样的化合物或其标记物的方法，其包括代谢分析来自动物群体的至少一种动物的样品。版权所有（C）2012，JPO＆INPIT

2. 发明申请

WO2009153136A3 MEANS AND METHODS FOR ASSESSING LIVER TOXICITY 审中-公开
标题翻译：用于评估肝脏毒性的方法和方法
公开(公告)号：WO2009153136A3
公开(公告)日：2010-03-18
申请号：PCT/EP2009056367
申请日：2009-05-26
申请人： BASF SE , VAN RAVENZWAAY BENNARD , MELLERT WERNER , COELHO PALERMO CUNHA GEORGIA , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WALK TILMANN B , LOOSER RALF , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE , LEIBOLD EDGAR
发明人： VAN RAVENZWAAY BENNARD , MELLERT WERNER , COELHO PALERMO CUNHA GEORGIA , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WALK TILMANN B , LOOSER RALF , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE , LEIBOLD EDGAR
IPC分类号： G01N33/66 , G01N33/82 , G01N33/84 , G01N33/92
CPC分类号： G01N33/92 , G01N2500/00 , G01N2560/00 , G01N2800/085 , G01N2800/60 , Y02A90/26
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention- pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver toxicity markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, Hydroxyphenylpyruvic acid, alpha-Tocopherol, Cholesterol,myo-Inositol-2-monophosphate, 4-Hydroxysphinganine, Ceramide (dl8:1, C24:1), Ceramide (dl8:2, C24:0), Sphingomyelin (dl8:1, C16:0), 1, 2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, 18:1 Lyso Phosphatidylcholine, CoenzymeQ9, Glucose, Glycerol, Glycerophosphates, Phosphate, 5-Methoxysphingosine, erythrosphingosine, Threonine, Diacylglycerides and Triacylglycerides.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体地说，涉及一种诊断肝毒性的方法。它还涉及确定化合物是否能够在受试者中诱导这种肝毒性的方法以及鉴定用于治疗肝毒性的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断肝脏毒性的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者的肝脏毒性的诊断装置或组合物的用途。对于每个性别，公开了不同的代谢组织模式，即不同的分析物组。肝毒性标志物主要选自游离脂肪酸，还包括各种磷脂酰胆碱，羟基苯基丙酮酸，α-生育酚，胆固醇，肌醇-2-单磷酸，4-羟基鞘氨醇，神经酰胺（dl8：1，C24：1）神经酰胺（dl8：2，C24：0），鞘磷脂（dl8：1，C16：0），1,2-二油酰-sn-甘油-3-磷脂酰-L-丝氨酸，18:1溶血磷脂酰胆碱，辅酶Q9，葡萄糖，甘油，磷酸甘油酯，磷酸酯，5-甲氧基肌氨酸，红细胞素，苏氨酸，二酰基甘油酯和三酰基甘油酯。

3. 发明申请

WO2009153139A3 MEANS AND METHODS FOR ASSESSING INCREASED PEROXISOMAL PROLIFERATION 审中-公开
标题翻译：评估增加的过度增殖的手段和方法
公开(公告)号：WO2009153139A3
公开(公告)日：2010-02-18
申请号：PCT/EP2009056386
申请日：2009-05-26
申请人： BASF SE , VAN RAVENZWAAY BENNARD , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , WALK TILMANN B , LOOSER RALF , LEIBOLD EDGAR , KAMP HENNICKE , COELHO PALERMO CUNHA GEORGIA , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE
发明人： VAN RAVENZWAAY BENNARD , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , WALK TILMANN B , LOOSER RALF , LEIBOLD EDGAR , KAMP HENNICKE , COELHO PALERMO CUNHA GEORGIA , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE
IPC分类号： G01N33/92 , G01N33/68 , G01N33/82 , G01N33/84
CPC分类号： G01N33/487 , G01N33/50 , G01N33/68 , G01N33/6812 , G01N33/82 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/046 , G01N2800/10 , G01N2800/24 , G01N2800/60 , H01J49/0036 , Y10T436/200833 , Y10T436/24
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosis. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of diagnostic devices or compositions. The metabolite markers of the metabolome are selected from: Coenzyme Q10, 16-Methylheptadecanoic acid, 17-Methyloctadecanoic acid, Eicosatrienoic acid (C20:3), Threonine, Proline, Tyrosine, trans-4-Hydroxyprolme, Pantothenic acid, Coenzyme Q9, Glycerol, Palmitic acid (C16:0), Lmoleic acid (C18 :cis (9, 12) 2), 14-Methylhexadecanoic acid, gamma-Linoleic acid (C18 : cis (6, 9, 12) 3), Threonic acid, Cytosine, Phosphatidylcholine (C18 : 0/C22 : 6). Different multimarker sets are proposed for male and female subjects.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体而言，涉及用于（i）诊断，（ii）确定化合物是否能够诱导，（iii）鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断的系统和装置。最后，本发明涉及一组代谢物或装置用于制造诊断装置或组合物的用途。代谢组胺的代谢物标记选自：辅酶Q10,16-甲基十七烷酸，17-甲基十八烷酸，二十碳三烯酸（C20：3），苏氨酸，脯氨酸，酪氨酸，反式-4-羟基丙酸，泛酸，辅酶Q9，甘油，棕榈酸（C16：0），Lmoleic acid（C18：顺式（9,12）2），14-甲基十六烷酸，γ-亚油酸（C18：顺式（6,9,12）3），苏氨酸，，磷脂酰胆碱（C18：0 / C22：6）。男性和女性受试者提出了不同的多标记组合。

4. 发明专利

SI1909561T1 POSTOPEK ZA ZAGOTAVLJANJE IN ANALIZIRANJE Ĺ˝IVALSKE POPULACIJE Z BISTVENO IDENTIÄŚNIM METABOLOMOM 未知
公开(公告)号：SI1909561T1
公开(公告)日：2010-07-30
申请号：SI200630695
申请日：2006-07-10
申请人： BASF SE
发明人： VAN RAVENZWAAY BENNARD , COELHO PALERMO CUNHA GEORGIA , MELLERT WERNER , LOOSER RALF , WALK TILMANN B , WIEMER JAN C , HAAKE VOLKER
IPC分类号： A01K29/00 , A01K1/00 , A01K67/00

5. 发明专利

ES2343082T3 UN METODO PARA PROVEER Y ANALIZAR UNA POBLACION ANIMAL QUE TIENE UN METABOLOMA ESENCIALMENTE IDENTICO. 未知
公开(公告)号：ES2343082T3
公开(公告)日：2010-07-22
申请号：ES06777668
申请日：2006-07-10
申请人： BASF SE
发明人： RAVENZWAAY BENNARD VAN , COELHO PALERMO CUNHA GEORGIA , MELLERT WERNER , LOOSER RALF , WALK TILMANN B , WIEMER JAN C
IPC分类号： A01K1/03 , A01K29/00 , A01K67/02
摘要： Un método para proveer una población animal mamífera que tiene un metaboloma esencialmente idéntico que comprende: a) compilar una población animal mamífera siendo esencialmente de la misma edad; b) mantener dicha población animal mamífera del paso a) por un primer período suficiente para aclimatación bajo las siguientes condiciones de alojamiento: i) temperatura constante; ii) humedad constante; iii) separación física de los animales mamíferos de la población animal mamífera; iv) alimentar ad libitum, donde la comida a ser brindada es esencialmente libre de contaminantes químicos y microbianos; v) beber ad libitum, donde el líquido de bebida es esencialmente libre de contaminantes químicos o microbianos; vi) período de iluminación constante; y c) proveer la población animal mamífera del paso b) después de dicho primer período de tiempo.

6. 发明专利

CA2646209C USE OF STROBILURINS FOR TREATING MALFUNCTIONS OF THE IRON METABOLISM 未知
公开(公告)号：CA2646209C
公开(公告)日：2011-08-16
申请号：CA2646209
申请日：2007-03-27
申请人： BASF SE
发明人： VAN RAVENZWAAY BENNARD , MELLERT WERNER , COELHO PALERMO CUNHA GEORGIA , DECKARDT KLAUS , KIECZKA HEINZ
IPC分类号： A61K31/5355 , A61K31/165 , A61K31/216 , A61K31/415 , A61K31/44 , A61K31/505 , A61P7/06
摘要： Strobilurin derivatives can be employed for the treatment and/or prevention of malfunctions of the iron metabolism in mammals.

7. 发明专利

PL1909561T3 Sposób dostarczania i analizy populacji zwierząt o zasadniczo identycznym metabolomie 未知
公开(公告)号：PL1909561T3
公开(公告)日：2010-11-30
申请号：PL06777668
申请日：2006-07-10
申请人： BASF SE
发明人： RAVENZWAAY BENNARD VAN , COELHO PALERMO CUNHA GEORGIA , MELLERT WERNER , LOOSER RALF , WALK TILMANN B , WIEMER JAN C , HAAKE VOLKER
IPC分类号： A01K29/00 , A01K1/03 , A01K67/02

8. 发明专利

AU2009259535B2 Means and methods for assessing liver enzyme induction 未知
公开(公告)号：AU2009259535B2
公开(公告)日：2016-01-21
申请号：AU2009259535
申请日：2009-05-25
申请人： BASF SE
发明人： MELLERT WERNER , RAVENZWAAY BENNARD VAN , COELHO PALERMO CUNHA GEORGIA , WALK TILMANN B , WIEMER JAN C , STRAUSS VOLKER , LEIBOLD EDGAR , KAMP HENNICKE , FABIAN ERIC , HEROLD MICHAEL MANFRED , PROKOUDINE ALEXANDRE , LOOSER RALF
IPC分类号： G01N33/66 , G01N33/84 , G01N33/92
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological effects on the liver by enzyme induction in a subject and to a method of identifying a drug for treating the pro-pathological effect of liver enzyme induction. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five analytes, a data storage medium comprising said data collection, and a system and a device for diagnosing the pro-pathological effect of liver enzyme induction. Finally, the present invention pertains to the use of a group of analytes or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing the pro-pathological effect of liver enzyme induction in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver enzyme induction markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, galactose, 3- and 5-Methoxysphingosine, Cholesterol, Threonic acid, 1, 2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, Glycerol, Glycerophosphate, Dodecanol, myo-Inositol-2-monophosphate.

9. 发明专利

DE112010003259T5 Mittel und Verfahren zum Diagnostizieren einer Schilddrüsenstörung 未知
公开(公告)号：DE112010003259T5
公开(公告)日：2013-05-02
申请号：DE112010003259
申请日：2010-07-13
申请人： BASF SE
发明人： STRAUSS VOLKER , KAMP HENNICKE , COELHO PALERMO CUNHA GEORGIA , MELLERT WERNER , RAVENZWAAY BENNARD VAN , WALK TILMANN , WIEMER JAN C , LEIBOLD EDGAR , FABIAN ERIC , LOOSER RALF , HEROLD MICHAEL MANFRED , PROKOUDINE ALEXANDRE
IPC分类号： G01N33/50
摘要： Die vorliegende Erfindung betrifft ein Verfahren zum Diagnostizieren von Schilddrüsenstörungen. Sie betrifft ebenfalls ein Verfahren der Bestimmung einer Verbindung, die zur Induzierung einer Schilddrüsenstörung in einem Individuum in der Lage ist und ein Verfahren zum Identifizieren eines Arzneistoffes zum Behandeln einer Schilddrüsenstörung. Ferner betrifft die vorliegende Erfindung eine Vorrichtung zum Diagnostizieren einer Schilddrüsenstörung und diagnostische Verwendungen.

10. 发明专利

AT463159T 未知
公开(公告)号：AT463159T
公开(公告)日：2010-04-15
申请号：AT06777668
申请日：2006-07-10
申请人： BASF SE
发明人： RAVENZWAAY BENNARD VAN , COELHO PALERMO CUNHA GEORGIA , MELLERT WERNER , LOOSER RALF , WALK TILMANN B , WIEMER JAN C , HAAKE VOLKER
IPC分类号： A01K29/00 , A01K1/03 , A01K67/02
摘要： The present invention relates to a method for providing an animal population having an essentially identical metabolome comprising compiling an animal population being of essentially the same age, keeping said animal population for a time period sufficient for acclimatization under the following housing conditions: (i) constant temperature, (ii) constant humidity, (iii) physical separation of the animals of the animal population, (iv) feeding ad libitum, wherein the food to be fed is essentially free of chemical or microbial contaminance, (v) drinking libitum, wherein the drinking liquid is essentially free of chemical or microbial contaminance, (vi) constant illumination period, and providing the animal population after said time period. Further, the present invention relates to methods for the identification of a compound which effects the metabolome of an animal, or methods for the identification of a marker for such compounds. Moreover, the present invention encompasses methods for the identification of such compounds or markers thereof comprising metabolically analyzing a sample from at least one animal of an animal population.

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