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1. 发明专利

JP2015042985A 肝酵素誘導を評価する手段及び方法审中-公开
标题翻译：用于评估肝脏酶诱导的方法和方法
公开(公告)号：JP2015042985A
公开(公告)日：2015-03-05
申请号：JP2014208554
申请日：2014-10-10
申请人：ビーエーエスエフソシエタス・ヨーロピアBasf Se , Basf Se , ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人： RAVENZWAAY BENNARD VAN , MELLERT WERNER , GEORGIA COELHO PALERMO CUNHA , ERIC FABIAN , VOLKER STRAUSS , HENNICKE KAMP , TILMANN B WALK , LOOSER RALF , MICHAEL MANFRED HEROLD , JAN C WIEMER , ALEXANDRE PROKOUDINE , EDGER LEIBOLD
IPC分类号： G01N33/50 , G01N27/62 , G01N30/72 , G01N33/15
CPC分类号： G01N33/66 , G01N33/84 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/085 , G01N2800/50 , G01N2800/60
摘要：【課題】肝酵素を誘導する化合物の毒性を効率的かつ信頼できるように評価するための高感度かつ特異的な方法を提供する。【解決手段】雌雄各性別について、異なるメタボロームパターン、すなわち異なるアナライトセットを開示する。肝酵素誘導マーカーは、主に、遊離脂肪酸から選択されるが、様々なホスファリジルコリン、ガラクトース、3-及び5-メトキシスフィンゴシン、コレステロール、トレオン酸、1,2-ジオレオイル-sn-グリセロ-3-ホスファチジル-L-セリン、グリセロール、グリセロールリン酸、ドデカノール、ミオ-イノシトール-2-一リン酸も含む。【選択図】なし
摘要翻译：要解决的问题：提供灵敏和具体的方法，以有效和可靠的方式评估诱导肝酶的化学化合物的毒理学性质。解决方案：对于每个女性和男性，都有不同的代谢组型，公开了一组不同的分析物。肝酶诱导标记选自游离脂肪酸，还包括各种磷脂酰胆碱，半乳糖，3-和5-甲氧基鞘氨醇，胆固醇，苏糖，1,2-二油酰-sn-甘油-3-磷脂酰-L-丝氨酸，甘油，甘油磷酸酯，十二烷醇，肌醇-2-单磷酸。

2. 发明专利

JP2012179057A Method for providing and analyzing animal population having essentially identical metabolome 有权
标题翻译：提供和分析具有基本特征代谢物的动物群体的方法
公开(公告)号：JP2012179057A
公开(公告)日：2012-09-20
申请号：JP2012116244
申请日：2012-05-22
申请人： Basf Se , ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人： RAVENZWAAY BENNARD VAN , COELHO PALERMO CUNHA GEORGIA , MELLERT WERNER , LOOSER RALF , WALK TILMANN B , WIEMER JAN C , HAAKE VOLKER
IPC分类号： A01K67/027 , A01K67/00 , C12Q1/02
CPC分类号： A01K1/031 , A01K29/00 , A01K67/02
摘要： PROBLEM TO BE SOLVED: To provide an animal population having an essentially identical metabolome suitable for a reliable metabolome study and analysis.SOLUTION: The invention relates to a method for providing an animal population having an essentially identical metabolome comprising compiling an animal population being of essentially the same age, keeping the animal population for a time period sufficient for acclimatization under the following housing conditions: (i) constant temperature, (ii) constant humidity, (iii) physical separation of the animals of the animal population, (iv) feeding ad libitum, (wherein the food to be fed is essentially free of chemical or microbial contaminants), (v) drinking ad libitum, (wherein the drinking liquid is essentially free of chemical or microbial contaminants), (vi) constant illumination period, and providing the animal population after the time period. Further, the invention relates to methods for the identification of a compound which effects the metabolome of an animal, or methods for the identification of a marker for such compounds. Moreover, the invention encompasses methods for the identification of such compounds or markers thereof comprising metabolically analyzing a sample from at least one animal of an animal population.
摘要翻译：要解决的问题：提供具有基本上相同的代谢组的动物群体，其适用于可靠的代谢组学研究和分析。解决方案：本发明涉及一种用于提供具有基本相同的代谢组的动物群体的方法，包括编译基本相同年龄的动物群体，在下列住房条件下保持动物群体足以适应适应期的时间段：（i）恒温，（ii）恒定湿度，（iii）动物群体的动物的物理分离，（iv）随意喂食（其中待进食的食物基本上不含化学或微生物污染物），（ v）随意饮用（其中饮用液体基本上不含化学或微生物污染物），（vi）恒定的照明期，并在该时间段之后提供动物群体。此外，本发明涉及用于鉴定影响动物的代谢组合物的化合物的方法或用于鉴定这些化合物的标记物的方法。此外，本发明包括用于鉴定这样的化合物或其标记物的方法，其包括代谢分析来自动物群体的至少一种动物的样品。版权所有（C）2012，JPO＆INPIT

3. 发明申请

WO2013121382A3 MEANS AND METHODS FOR ASSESSING BONE DISORDERS 审中-公开
标题翻译：用于评估骨质疏松症的手段和方法
公开(公告)号：WO2013121382A3
公开(公告)日：2016-09-01
申请号：PCT/IB2013051228
申请日：2013-02-15
申请人： BASF SE , BASF (CHINA) COMPANY LTD
发明人： WALK TILMANN B , RAVENZWAAY BENNARD VAN , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WIEMER JAN C , LOOSER RALF , HEROLD MICHAEL MANFRED , PROKOUDINE ALEXANDRE
IPC分类号： C07F9/117 , C07C53/126 , C07C69/30 , C07F9/10
CPC分类号： G01N33/6893 , G01N33/5044 , G01N33/6806 , G01N33/84 , G01N33/92 , G01N2570/00 , G01N2800/108
摘要： The present invention pertains to the field of diagnostics for bone disorders and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing a bone disorder, it also relates to a method for determining whether a compound is capable of inducing such a bone disorder in a subject and to a method of identifying a drug for treating a bone disorder. Furthermore, the present invention relates to a device and a kit for diagnosing a bone disorder.
摘要翻译：本发明涉及骨骼疾病的诊断领域和化学化合物的风险分层的毒理学评估。具体地，本发明涉及诊断骨骼疾病的方法，还涉及确定化合物是否能够诱导受试者中的这种骨病的方法以及鉴定用于治疗骨病的药物的方法。此外，本发明涉及用于诊断骨骼疾病的装置和试剂盒。

4. 发明申请

WO2013132467A3 MEANS AND METHODS FOR ASSESSING LIVER DISORDERS 审中-公开
标题翻译：评估肝脏疾病的手段和方法
公开(公告)号：WO2013132467A3
公开(公告)日：2013-10-31
申请号：PCT/IB2013051862
申请日：2013-03-08
申请人： BASF SE , BASF CHINA CO LTD
发明人： WALK TILMANN B , RAVENZWAAY BENNARD VAN , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WIEMER JAN C , LOOSER RALF , HEROLD MICHAEL MANFRED , PROKOUDINE ALEXANDRE
IPC分类号： A61B5/00 , A61B19/00
CPC分类号： G01N33/6893 , G01N2500/20 , G01N2800/085
摘要： The present invention pertains to the field of diagnostics for liver disorders and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver disorders. It also relates to a method for determining whether a compound is capable of inducing such liver disorders in a subject and to a method of identifying a drug for treating liver disorders. Furthermore, the present invention relates to a device and a kit for diagnosing liver disorders.
摘要翻译：本发明涉及用于化学化合物风险分层的肝脏失调和毒理学评估的诊断领域。具体而言，涉及诊断肝脏疾病的方法。本发明还涉及确定化合物是否能够在受试者中诱导这种肝病的方法以及鉴定用于治疗肝病的药物的方法。此外，本发明涉及用于诊断肝脏疾病的装置和试剂盒。

5. 发明专利

CA2848722A1 MEANS AND METHODS FOR ASSESSING GONADAL TOXICITY 未知
公开(公告)号：CA2848722A1
公开(公告)日：2013-03-21
申请号：CA2848722
申请日：2012-09-14
申请人： BASF SE
发明人： WALK TILMANN B , RAVENZWAAY BENNARD VAN , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WIEMER JAN C , LOOSER RALF , HEROLD MICHAEL MANFRED , PROKOUDINE ALEXANDRE
IPC分类号： G01N33/49 , G01N33/64 , G01N33/68 , G01N33/70 , G01N33/74 , G01N33/92
摘要： The present invention pertains to the field of diagnostics for gonadal toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing gonadal toxicity. It also relates to a method for determining whether a compound is capable of inducing such gonadal toxicity in a subject and to a method of identifying a drug for treating gonadal toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing gonadal toxicity.

6. 发明专利

BRPI0710209A2 未知
公开(公告)号：BRPI0710209A2
公开(公告)日：2011-05-24
申请号：BRPI0710209
申请日：2007-03-27
申请人： BASF SE
发明人： RAVENZWAAY BENNARD VAN , MELLERT WENER , CUNHA GEORGIA COELHO PALERMO , DECKARDT KLAUS , KIECZKA HEINZ
IPC分类号： A61P7/06 , A61K31/165 , A61K31/216 , A61K31/415 , A61K31/44 , A61K31/505 , A61K31/5355
摘要： Strobilurin derivatives can be employed for the treatment and/or prevention of disorders of iron metabolism in mammals.

7. 发明专利

MX2008012317A USO DE ESTROBILURINAS PARA EL TRATAMIENTO DE TRASTORNOS DEL METABOLISMO DEL HIERRO. 未知
公开(公告)号：MX2008012317A
公开(公告)日：2008-10-10
申请号：MX2008012317
申请日：2007-03-27
申请人： BASF SE
发明人： RAVENZWAAY BENNARD VAN , MELLERT WERNER , DECKARDT KLAUS , KIECZKA HEINZ , CUNHA GEORGIA COELHO PALERMO
IPC分类号： A61P7/06 , A61K31/165 , A61K31/216 , A61K31/415 , A61K31/44 , A61K31/505 , A61K31/5355
摘要： Los derivados de estrobolurina se pueden emplear para el tratamiento y/o evitar el funcionamiento defectuoso del metabolismo del hierro en los mamíferos.

8. 发明专利

AU2012310102A1 Means and methods for assessing gonadal toxicity 未知
公开(公告)号：AU2012310102A1
公开(公告)日：2014-03-13
申请号：AU2012310102
申请日：2012-09-14
申请人： BASF SE
发明人： WALK TILMANN B , RAVENZWAAY BENNARD VAN , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WIEMER JAN C , LOOSER RALF , HEROLD MICHAEL MANFRED , PROKOUDINE ALEXANDRE
IPC分类号： G01N33/49 , G01N33/64 , G01N33/68 , G01N33/70 , G01N33/74 , G01N33/92
摘要： The present invention pertains to the field of diagnostics for gonadal toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing gonadal toxicity. It also relates to a method for determining whether a compound is capable of inducing such gonadal toxicity in a subject and to a method of identifying a drug for treating gonadal toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing gonadal toxicity.

9. 发明专利

DE112009001245T5 Mittel und Verfahren für die Beurteilung der Leberenzyminduktion 未知
公开(公告)号：DE112009001245T5
公开(公告)日：2012-03-15
申请号：DE112009001245
申请日：2009-05-25
申请人： BASF SE
发明人： RAVENZWAAY BENNARD VAN , MELLERT WERNER , COELO PALERNO CUNHA GEORGIA , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WALK TILMANN B , LOOSER RALF , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE , LEIBOLD EDGAR
IPC分类号： G01N33/66 , G01N33/84 , G01N33/92
摘要： Die vorliegende Erfindung betrifft das Gebiet der toxikologischen Beurteilungen für die Risikostratifizierung von chemischen Verbindungen. Genauer gesagt betrifft sie ein Verfahren zum Diagnostizieren der propathologischen Wirkung von Verbindungen, die Leberenzyme induzieren. Sie betrifft auch ein Verfahren zum Bestimmen, ob eine Verbindung fähig ist, propathologische Wirkungen der Leber durch Leberinduktion bei einem Probanden hervorzurufen sowie ein Verfahren zum Identifizieren eines Arzneistoffs zum Behandeln der propathologischen Wirkung einer Leberenzyminduktion. Weiterhin betrifft die vorliegende Erfindung eine Datensammlung umfassend Kennwerte von mindestens fünf Analyten, einen Datenträger umfassend diese Datensammlung, sowie ein System und eine Vorrichtung zum Diagnostizieren der propathologischen Wirkung einer Leberenzyminduktion. Schließlich betrifft die vorliegende Erfindung die Verwendung von einer Gruppe von Analyten oder Mitteln für deren Bestimmung für die Herstellung einer diagnostischen Vorrichtung oder Zusammensetzung zum Diagnostizieren der propathologischen Wirkung einer Leberenzyminduktion bei einem Probanden.

10. 发明专利

AU2009259535A8 Means and methods for assessing liver enzyme induction 未知
公开(公告)号：AU2009259535A8
公开(公告)日：2011-02-03
申请号：AU2009259535
申请日：2009-05-25
申请人： BASF SE
发明人： MELLERT WERNER , RAVENZWAAY BENNARD VAN , CUNHA GEORGIA COELHO PALERMO , WALK TILMANN B , WIEMER JAN C , STRAUSS VOLKER , LEIBOLD EDGAR , KAMP HENNICKE , FABIAN ERIC , HEROLD MICHAEL MANFRED , PROKOUDINE ALEXANDRE , LOOSER RALF
IPC分类号： G01N33/66 , G01N33/84 , G01N33/92
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological effects on the liver by enzyme induction in a subject and to a method of identifying a drug for treating the pro-pathological effect of liver enzyme induction. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five analytes, a data storage medium comprising said data collection, and a system and a device for diagnosing the pro-pathological effect of liver enzyme induction. Finally, the present invention pertains to the use of a group of analytes or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing the pro-pathological effect of liver enzyme induction in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver enzyme induction markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, galactose, 3- and 5-Methoxysphingosine, Cholesterol, Threonic acid, 1,2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, Glycerol, Glycerophosphate, Dodecanol, myo-Inositol-2-monophosphate.

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