专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明申请

WO1992011850A1 USE OF CALPAIN INHIBITORS IN THE INHIBITION AND TREATMENT OF NEURODEGENERATION 审中-公开
标题翻译：钙调素抑制剂在神经退行性疾病的抑制和治疗中的应用
公开(公告)号：WO1992011850A1
公开(公告)日：1992-07-23
申请号：PCT/US1991009786
申请日：1991-12-27
申请人： CORTEX PHARMACEUTICALS, INC. , GEORGIA TECH RESEARCH CORPORATION
发明人： CORTEX PHARMACEUTICALS, INC. , GEORGIA TECH RESEARCH CORPORATION , BARTUS, Raymond, T. , EVELETH, David, D., Jr. , LYNCH, Gary, S. , POWERS, James, C.
IPC分类号： A61K31/37

3. 发明申请

WO1994027603A1 ALKALINE AND ACID PHOSPHATASE INHIBITORS IN TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开
标题翻译：碱性和酸性磷酸酶抑制剂治疗神经疾病
公开(公告)号：WO1994027603A1
公开(公告)日：1994-12-08
申请号：PCT/US1994006186
申请日：1994-06-01
申请人： CORTEX PHARMACEUTICALS, INC.
发明人： CORTEX PHARMACEUTICALS, INC. , KELLEHER, Judith, A. , EVELETH, David, D., Jr.
IPC分类号： A61K31/425
CPC分类号： A61K31/19 , A61K31/00 , A61K31/305 , A61K31/425 , A61K33/00 , A61K33/16
摘要： The present invention provides a method of inhibiting beta -amyloid toxicity in brain cells. The method includes administering to the cells an amount of an alkaline phosphatase inhibitor which is pharmacologically effective to reduce degeneration in the cells. Methods of treatment of peripheral neuropathy are also provided using acid or alkaline phosphatase inhibitors.
摘要翻译：本发明提供抑制脑细胞中β-淀粉样蛋白毒性的方法。该方法包括向细胞施用一定量的碱性磷酸酶抑制剂，其在药理学上有效以减少细胞的变性。使用酸或碱性磷酸酶抑制剂也可提供治疗周围神经病变的方法。

4. 发明申请

WO1996038414A1 BENZOYL PIPERIDINES/PYRROLIDINES FOR ENHANCING SYNAPTIC RESPONSE 审中-公开
标题翻译：用于增强反应的苯甲酰哌啶/吡咯烷酮
公开(公告)号：WO1996038414A1
公开(公告)日：1996-12-05
申请号：PCT/US1996007607
申请日：1996-05-23
申请人： CORTEX PHARMACEUTICALS, INC.
发明人： CORTEX PHARMACEUTICALS, INC. , ROGERS, Gary, A. , NILSSON, Lena
IPC分类号： C07D211/16
CPC分类号： C07D211/16 , C07D211/14
摘要： Benzoyl piperidines and pyrrolidines and compounds of related structure (Formula I) are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number or strength of excitatory synapses or in the number of AMPA receptors. The compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors, for improving the performance of subjects with memory deficiencies, for treating depression, alcoholism and schizophrenia, and for improving memory encoding.
摘要翻译：公开了苯甲酰哌啶类和吡咯烷类和相关结构的化合物（式I）用于增强由AMPA受体介导的突触反应。由于兴奋性突触的数量或强度的缺乏或AMPA受体的数量的不足，这些化合物对于遭受神经或智力功能受损的受试者是有效的。这些化合物还可用于治疗非受损受试者，以增强感觉运动和认知任务的性能，这取决于使用AMPA受体的脑网络，改善记忆缺陷的受试者的表现，用于治疗抑郁症，酒精中毒和精神分裂症，并用于改善内存编码。

5. 发明申请

WO1994027602A1 USE OF METABOTROPIC RECEPTOR AGONISTS IN PROGRESSIVE NEURODEGENERATIVE DESEASES 审中-公开
标题翻译：代谢性受体激动剂在进展性神经营养因子中的应用
公开(公告)号：WO1994027602A1
公开(公告)日：1994-12-08
申请号：PCT/US1994005751
申请日：1994-05-20
申请人： CORTEX PHARMACEUTICALS, INC.
发明人： CORTEX PHARMACEUTICALS, INC. , EVELETH, David, D. , KELLEHER, Judith, A. , COTMAN, Carl, W.
IPC分类号： A61K31/42
CPC分类号： A61K31/66 , A61K31/195 , A61K31/198 , A61K31/42
摘要： A pharmaceutical composition comprising a metabotropic receptor agonist, such as trans-ACPD or 1S,3R-ACPD, for use in treating a mammal with a neurodegenerative disease which is caused at least in part by beta -amyloid protein neurotoxicity.
摘要翻译：一种药物组合物，其包含代谢型受体激动剂，例如反式ACPD或1S，3R-ACPD，用于治疗至少部分由β-淀粉样蛋白神经毒性引起的具有神经变性疾病的哺乳动物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式