专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009099416A1 HETEROCYCLIC PEPTIDE KETOAMIDES 审中-公开
标题翻译：杂环酮类酮酸酯
公开(公告)号：WO2009099416A1
公开(公告)日：2009-08-13
申请号：PCT/US2008/008650
申请日：2008-07-16
申请人： GEORGIA TECH RESEARCH CORPORATION , POWERS, James, C. , OVAT, Asli , LI, Zhaozhao
发明人： POWERS, James, C. , OVAT, Asli , LI, Zhaozhao
IPC分类号： A61K38/00
CPC分类号： C07K5/06043 , C07K5/06052
摘要： A novel class of peptide α-ketoamides useful for selectively inhibiting calpains, selectively inhibiting cysteine proteases, and generally inhibiting all cysteine proteases, having the formula M-AA 2 -AA 1 -CO-NH-(CH 2 ) n -R 3 . Processes for the synthesis of peptidyl α-ketoamide derivatives. Compositions and methods for inhibiting cysteine proteases, inhibiting calpains, and treating disease caused by cysteine proteases and calpains are provided.
摘要翻译：用于选择性抑制半胱氨酸蛋白酶，选择性抑制半胱氨酸蛋白酶和通常抑制具有式M-AA2-AA1-CO-NH-（CH2）n-R3的所有半胱氨酸蛋白酶的新颖的一类肽α-酮酰胺。肽基α-酮酰胺衍生物的合成方法。提供了抑制半胱氨酸蛋白酶，抑制钙蛋白酶和治疗由半胱氨酸蛋白酶和钙蛋白酶引起的疾病的组合物和方法。

2. 发明申请

WO2005080353A1 PROPENOYL HYDRAZIDES 审中-公开
公开(公告)号：WO2005080353A1
公开(公告)日：2005-09-01
申请号：PCT/US2005/005457
申请日：2005-02-18
申请人： GEORGIA TECH RESEARCH CORPORATION , POWERS, James, C. , ASGAIN, Juliana , EKICI, Ozlem, Dogan , GOTZ, Marion, Gabriele , JAMES, Karen, Ellis , LI, Zhao, Zhao , RUKAMP, Brian
发明人： POWERS, James, C. , ASGAIN, Juliana , EKICI, Ozlem, Dogan , GOTZ, Marion, Gabriele , JAMES, Karen, Ellis , LI, Zhao, Zhao , RUKAMP, Brian
IPC分类号： C07D249/16
CPC分类号： A61K38/05 , A61K38/06 , C07K5/02 , C07K5/06026 , C07K5/06104 , C07K5/0808 , C07K5/0819
摘要： The present disclosure provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the disclosure include a peptidyl propenoyl hydrazide compositions that inhibit proteases, for example cysteine proteases, either in vivo or in vitro.
摘要翻译：本公开提供了用于抑制蛋白酶的组合物，用于合成组合物的方法以及使用所公开的蛋白酶抑制剂的方法。本公开的方面包括在体内或体外抑制蛋白酶例如半胱氨酸蛋白酶的肽基丙烯酰酰肼组合物。

3. 发明申请

WO9400095A2 USE OF CALPAIN INHIBITORS IN THE INHIBITION AND TREATMENT OF MEDICAL CONDITIONS ASSOCIATED WITH INCREASED CALPAIN ACTIVITY 审中-公开
标题翻译：钙激素抑制剂在抑制和治疗与增加的CALPAIN活性相关的医疗条件下的使用
公开(公告)号：WO9400095A2
公开(公告)日：1994-01-06
申请号：PCT/US9306143
申请日：1993-06-24
申请人： CORTEX PHARMA INC , GEORGIA TECH RES INST , EVELETH DAVID D JR , LYNCH GARY , POWERS JAMES C , BARTUS RAYMOND T
发明人： EVELETH DAVID D JR , LYNCH GARY , POWERS JAMES C , BARTUS RAYMOND T
IPC分类号： A61K31/365 , A61K38/55 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/12 , A61P27/02 , A61P27/12 , A61P35/00 , A61P43/00 , A61K
CPC分类号： A61K31/365 , A61K38/55
摘要： The present invention provides a method of treating a medical condition associated with increased proteolytic activity of Calpain in a mammal. The method includes administering a pharmaceutical composition containing a Calpain inhibitor compound to the mammal in an amount that is pharmacologically effective to treat the condition. The inhibitor is a compound in one of the following groups of compounds: Peptide Keto-Compounds, Substituted Heterocyclic Compounds or Halo-Ketone Peptides. Examples of conditions that can be treated using the methods of the present invention include cardiac muscle tissue damage, cataracts, smooth muscle damage and vasospasm. The present invention also provides a method of inhibiting smooth muscle cell proliferation and thereby preventing the restenosis of a blood vessel which has been undergone therapeutic angioplasty. This method includes the administration of a calpain inhibitor to the blood vessel during or after the angioplasty procedure. Further, methods of blocking the establishment of the tonically contracted state in smooth muscle and relaxing tonically contracted smooth muscle are disclosed. These methods involve the administration of a calpain inhibitor, thereby reducing or preventing smooth muscle contraction associated with vasospasm and bronchospasm.
摘要翻译：本发明提供了治疗与哺乳动物中钙蛋白酶的蛋白水解活性增加相关的医学病症的方法。所述方法包括给予哺乳动物含有钙蛋白酶抑制剂化合物的药物组合物，其量为治疗该病症的药理学有效性。抑制剂是以下化合物组之一的化合物：肽酮复合物，取代的杂环化合物或卤代酮多肽。可以使用本发明的方法治疗的病症的实例包括心肌组织损伤，白内障，平滑肌损伤和血管痉挛。本发明还提供抑制平滑肌细胞增殖的方法，从而防止已经经历了治疗性血管成形术的血管的再狭窄。该方法包括在血管成形术过程中或之后向血管施用钙蛋白酶抑制剂。此外，公开了阻止平滑肌中收紧状态的建立和放松收缩的平滑肌的方法。这些方法包括施用钙蛋白酶抑制剂，从而减少或预防与血管痉挛和支气管痉挛相关的平滑肌收缩。

4. 发明申请

WO2007087572A2 AZA-PEPTIDE EPOXIDES 审中-公开
标题翻译： AZA-肽环氧化物
公开(公告)号：WO2007087572A2
公开(公告)日：2007-08-02
申请号：PCT/US2007/060991
申请日：2007-01-24
申请人： GEORGIA TECH RESEARCH CORPORATION , EMORY UNIVERSITY , POWERS, James, C. , GLASS, Jonathan
发明人： POWERS, James, C. , GLASS, Jonathan
IPC分类号： A61K38/05 , A61K38/04 , A61K31/336 , A61K31/401 , A61K31/405
CPC分类号： A61K38/05 , A61K31/336 , A61K31/401 , A61K31/405 , A61K38/06 , C07D303/48 , C07K5/0207 , C07K5/06026 , C07K5/06043 , C07K5/0808 , C07K5/0819 , C07K5/101 , C07K5/1021
摘要： Methods for treatment and/or prevention of nerve degeneration in mammals using aza-peptide epoxide caspase inhibitors are provided. Aspects of the present disclosure include aza-peptide epoxide compositions to treat or prevent diseases, for example stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuropathies, Huntington's disease, dentatorubropallidomysian atrophy, spinocerebellar atrophies, spinal bulbar muscular atrophy, diabetes, amyotrophic lateral sclerosis and other motor neuron diseases. The disclosed methods can be used in combination with calpain inhibitors to treat disease or pathological conditions related to the activity of caspases and calpain associated with a specific disease or condition. Such treatable conditions include stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuropathies, Huntington's disease, dentatorubropallidoluysian atrophy, spinocerebellar atrophies, spinal bulbar muscular atrophy, nerve degeneration associated with diabetes, amyotrophic lateral sclerosis and other motor neuron diseases, nerve degeneration secondary to primary demyelinating disorders, among others.
摘要翻译：提供了使用氮杂肽环氧化物半胱天冬酶抑制剂治疗和/或预防哺乳动物神经变性的方法。例如中风，阿尔茨海默病，帕金森病，多发性硬化症，神经病，亨廷顿舞蹈病，齿状核旁肌萎缩症，脊髓小脑萎缩症，脊髓延髓肌萎缩症，糖尿病，肌萎缩侧索组织的阿扎肽环氧化物组合物硬化和其他运动神经元疾病。所公开的方法可以与钙蛋白酶抑制剂组合用于治疗与特定疾病或病症相关的与半胱天冬酶和钙蛋白酶活性有关的疾病或病理状况。这些可治疗的病症包括中风，阿尔茨海默氏病，帕金森病，多发性硬化症，神经病，亨廷顿舞蹈病，牙齿营养不良性萎缩症，脊髓小脑萎缩，脊髓球肌萎缩，与糖尿病相关的神经退行性变，肌萎缩侧索硬化和其他运动神经元疾病，原发性脱髓鞘疾病等等。

5. 发明申请

WO2007087572A3 AZA-PEPTIDE EPOXIDES 审中-公开
标题翻译： AZA-PEPTIDE环氧化物
公开(公告)号：WO2007087572A3
公开(公告)日：2007-11-22
申请号：PCT/US2007060991
申请日：2007-01-24
申请人： GEORGIA TECH RES INST , UNIV EMORY , POWERS JAMES C , GLASS JONATHAN
发明人： POWERS JAMES C , GLASS JONATHAN
IPC分类号： A61K38/05 , A61K31/336 , A61K38/00 , C07D303/48 , C07K5/02
CPC分类号： A61K38/05 , A61K31/336 , A61K31/401 , A61K31/405 , A61K38/06 , C07D303/48 , C07K5/0207 , C07K5/06026 , C07K5/06043 , C07K5/0808 , C07K5/0819 , C07K5/101 , C07K5/1021
摘要： Methods for treatment and/or prevention of nerve degeneration in mammals using aza-peptide epoxide caspase inhibitors are provided. Aspects of the present disclosure include aza-peptide epoxide compositions to treat or prevent diseases, for example stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuropathies, Huntington's disease, dentatorubropallidomysian atrophy, spinocerebellar atrophies, spinal bulbar muscular atrophy, diabetes, amyotrophic lateral sclerosis and other motor neuron diseases. The disclosed methods can be used in combination with calpain inhibitors to treat disease or pathological conditions related to the activity of caspases and calpain associated with a specific disease or condition. Such treatable conditions include stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuropathies, Huntington's disease, dentatorubropallidoluysian atrophy, spinocerebellar atrophies, spinal bulbar muscular atrophy, nerve degeneration associated with diabetes, amyotrophic lateral sclerosis and other motor neuron diseases, nerve degeneration secondary to primary demyelinating disorders, among others.
摘要翻译：提供了使用氮杂 - 环氧化物半胱天冬酶抑制剂治疗和/或预防哺乳动物神经变性的方法。本公开的方面包括治疗或预防疾病，例如中风，阿尔茨海默病，帕金森病，多发性硬化，神经病，亨廷顿舞蹈病，齿状辅助萎缩症，脊髓性小脑萎缩症，脊髓扩张肌肉萎缩症，糖尿病，肌萎缩侧索的氮杂肽环氧化物组合物硬化症等运动神经元疾病。所公开的方法可以与钙蛋白酶抑制剂组合使用以治疗与特定疾病或病症相关的胱天蛋白酶和钙蛋白酶的活性相关的疾病或病理状况。这种可治疗的病症包括中风，阿尔茨海默氏病，帕金森病，多发性硬化症，神经病，亨廷顿舞蹈病，齿状萎缩性萎缩症，脊髓小脑萎缩，脊髓延髓肌肉萎缩，与糖尿病相关的神经变性，肌萎缩性侧索硬化等运动神经元疾病，继发于神经变性原发性脱髓鞘疾病等。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式