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1. 发明授权

US06881558B1 Expression system for cloning toxic genes 有权
标题翻译：用于克隆有毒基因的表达系统
公开(公告)号：US06881558B1
公开(公告)日：2005-04-19
申请号：US09888860
申请日：2001-06-25
申请人： David B. Weiner , Donghui Zhang , Adam Cohen
发明人： David B. Weiner , Donghui Zhang , Adam Cohen
IPC分类号： C12N15/72 , C12P21/06 , C07H21/04 , C12N1/12 , C12N15/00 , C12P21/04
CPC分类号： C12N15/72
摘要： Methods of cloning and/or amplifying toxic genes in bacteria using a vector which amplifies the toxic gene in bacteria and also allows subsequent expression in mammalian systems is provided. A vector having an origin of replication, a first promoter, a polylinker, a second promoter in reverse orientation with respect to the first promoter, a poly adenylation signal, and a gene encoding a selectable marker, and optionally an enhancer operably connected to the first promoter, and/or a nucleotide sequence encoding a toxic protein is also provided.
摘要翻译：使用扩增细菌中的毒性基因并允许随后在哺乳动物系统中表达的载体来克隆和/或扩增细菌中的有毒基因的方法。具有复制起点的载体，第一启动子，多接头体，相对于第一启动子反向取向的第二启动子，多腺苷酸化信号和编码可选择标记的基因，以及任选地可增强的与第一启动子连接的增强子启动子，和/或编码毒性蛋白质的核苷酸序列。

2. 发明授权

US09095328B2 Endoscopes having multiple lumens for tissue acquisition and removal and related methods of use 有权
标题翻译：具有用于组织获取和去除的多个腔的内窥镜和相关的使用方法
公开(公告)号：US09095328B2
公开(公告)日：2015-08-04
申请号：US12617083
申请日：2009-11-12
申请人： F. Anthony Headley, Jr. , Robert B. DeVries , Kenneth Blair , James Weldon , Adam Cohen
发明人： F. Anthony Headley, Jr. , Robert B. DeVries , Kenneth Blair , James Weldon , Adam Cohen
IPC分类号： A61B10/00 , A61B1/00 , A61B1/12 , A61B17/24 , A61B17/26 , A61B10/04 , A61B17/221 , A61B17/22 , A61B1/018 , A61B10/02 , A61B10/06 , A61B17/30
CPC分类号： A61B10/04 , A61B1/018 , A61B1/273 , A61B10/0283 , A61B10/06 , A61B17/22 , A61B17/22031 , A61B17/221 , A61B17/320016 , A61B17/32056 , A61B2010/0225 , A61B2017/306
摘要： Embodiments of the invention include an endoscope including multiple lumens for tissue acquisition and removal and related methods of use.
摘要翻译：本发明的实施例包括一种内窥镜，其包括用于组织获取和去除的多个腔和相关的使用方法。

3. 发明申请

US20100238488A1 Method and Apparatus for Printing 审中-公开
标题翻译：打印方法和装置
公开(公告)号：US20100238488A1
公开(公告)日：2010-09-23
申请号：US12664839
申请日：2007-06-19
申请人： Nader Alaghband , Adam Cohen
发明人： Nader Alaghband , Adam Cohen
IPC分类号： G06F15/00
CPC分类号： G06F3/1222 , G06F3/1238 , G06F3/1239 , G06F3/1263 , G06F3/1288
摘要： A print server receiving a print job, adding the print job to a print queue, receive at multiple times from a print system remote from the print queue, a communication checking for the presence of a print job on the print queue, and transmitting to the print system the print job in response to the communication.A method of printing by uploading a file to a file store, selecting a remote printer from a list of available printers, and creating a print job for printing the uploaded file with the selected printer.
摘要翻译：接收打印作业的打印服务器将打印作业添加到打印队列中，从远离打印队列的打印系统多次接收打印队列上存在打印作业的通信，并且传送到打印队列打印系统响应通信打印作业。通过将文件上传到文件存储进行打印的方法，从可用打印机列表中选择远程打印机，以及使用所选打印机创建用于打印上传的文件的打印作业。

4. 发明申请

US20080105355A1 Probe Arrays and Method for Making 审中-公开
标题翻译：探针阵列和制作方法
公开(公告)号：US20080105355A1
公开(公告)日：2008-05-08
申请号：US11929597
申请日：2007-10-30
申请人： Ananda Kumar , Ezekiel Kruglick , Adam Cohen , Kieun Kim , Gang Zhang , Richard Chen , Christopher Bang , Vacit Arat , Michael Lockard , Uri Frodis , Pavel Lembrikov , Jeffrey Thompson
发明人： Ananda Kumar , Ezekiel Kruglick , Adam Cohen , Kieun Kim , Gang Zhang , Richard Chen , Christopher Bang , Vacit Arat , Michael Lockard , Uri Frodis , Pavel Lembrikov , Jeffrey Thompson
IPC分类号： B32B37/00 , B23K31/02
CPC分类号： G01R3/00 , G01R1/06761 , G01R1/07307 , Y10T29/49002 , Y10T156/10
摘要： Embodiments of invention are directed to the formation of microprobes (i.e. compliant electrical or electronic contact elements) on a temporary substrate, dicing individual probe arrays, and then transferring the arrays to space transformers or other permanent substrates. Some embodiments of the invention transfer probes to permanent substrates prior to separating the probes from a temporary substrate on which the probes were formed while other embodiments do the opposite. Some embodiments, remove sacrificial material prior to transfer while other embodiments remove sacrificial material after transfer. Some embodiments are directed to the bonding of first and second electric components together using one or more solder bumps with enhanced aspect ratios (i.e. height to width ratios) obtained as a result of surrounding the bumps at least in part with rings of a retention material. The retention material may act be a solder mask material.
摘要翻译：本发明的实施例涉及在临时衬底上形成微探针（即柔性电气或电子接触元件），切割单独的探针阵列，然后将阵列转移到空间变压器或其它永久衬底。在将探针从其上形成探针的临时基底分离出来之前，本发明的一些实施方案将探针转移到永久性基底上，而其他实施方案相反。一些实施例，在转移之前去除牺牲材料，而其它实施例在转移后去除牺牲材料。一些实施例涉及使用一个或多个具有增强的纵横比（即，高度与宽度比）的焊料凸块来将第一和第二电气部件接合在一起，这是由于至少部分地由保持材料的环围绕凸块而得到的。保留材料可以用作焊接掩模材料。

5. 发明申请

US20070219459A1 Biopsy Devices, Methods for Using, and Methods for Making 审中-公开
标题翻译：活检装置，使用方法和制作方法
公开(公告)号：US20070219459A1
公开(公告)日：2007-09-20
申请号：US11696722
申请日：2007-04-04
申请人： Adam Cohen
发明人： Adam Cohen
IPC分类号： A61B10/00
CPC分类号： A61B10/06 , A61B10/0233 , A61B10/0283 , A61B2017/00345 , A61B2017/32004
摘要： Embodiments of invention are directed to devices, and methods of forming them, that can be used for removal of small volumes of tissue from the body, as is required for biopsy procedures. The procedures may be of the image-guided or non image-guided type. The devices described herein are applicable to biopsy of many types of tissue, particularly soft tissue. Applications include biopsy of the intestines, stomach, breast, pancreas, lung, liver, brain, skin, prostate, thyroid, heart, and other organs and tissues. Embodiments are directed to devices formed from a plurality of adhered layers of deposited materials.
摘要翻译：本发明的实施方案涉及可用于从身体去除少量组织的装置及其形成方法，如活检程序所需要的。该程序可以是图像引导型或非图像引导型。本文描述的装置可应用于许多类型的组织，特别是软组织的活组织检查。应用包括肠，胃，乳腺，胰腺，肺，肝，脑，皮肤，前列腺，甲状腺，心脏和其他器官和组织的活检。实施例涉及由多个附着的沉积材料层形成的装置。

6. 发明申请

US20070100361A1 Discrete or continuous tissue capture device and method for making 失效
标题翻译：离散或连续的组织捕获装置和制造方法
公开(公告)号：US20070100361A1
公开(公告)日：2007-05-03
申请号：US11582049
申请日：2006-10-16
申请人： Adam Cohen
发明人： Adam Cohen
IPC分类号： A61B17/32 , A61B17/14
CPC分类号： A61B10/0266 , A61B10/04 , A61B17/149 , A61B17/320016 , A61B17/320783 , A61B2010/0225 , A61B2017/00243 , A61B2017/00345 , A61B2017/00526 , A61B2017/320064 , B33Y80/00
摘要： Some embodiments of the invention provide an instrument for mechanically removing segments of tissue from a patient during a minimally invasive surgical procedure. An exemplary instrument provides an inlet for receiving tissue a mechanism for cutting away received tissue and for simultaneously moving the cut away tissue away from the inlet to allow additional material to enter the inlet for removal wherein multiple specimens can be captured and eventually removed from the patient's body without the need of removing the instrument after each capture.
摘要翻译：本发明的一些实施例提供一种用于在微创手术过程中从患者机械地去除组织的部分的器械。示例性仪器提供用于接收组织的入口，用于切除接收的组织并同时移动切除组织远离入口的机构，以允许另外的材料进入入口以移除，其中可以捕获多个样本并最终从患者的组织中移除每次捕获后无需去除仪器。

7. 发明申请

US20070039828A1 Mesoscale and microscale device fabrication methods using split structures and alignment elements 失效
标题翻译：使用分裂结构和对准元件的中尺度和微米器件制造方法
公开(公告)号：US20070039828A1
公开(公告)日：2007-02-22
申请号：US11506586
申请日：2006-08-18
申请人： Adam Cohen , Michael Lockhard , Dennis Smalley
发明人： Adam Cohen , Michael Lockhard , Dennis Smalley
IPC分类号： C25D5/02
CPC分类号： C25D1/003 , B33Y10/00 , B81B2201/042 , B81C1/00293 , B81C1/00333 , B81C2201/0197 , B81C2203/0145 , C25D1/10 , C25D5/022 , G01P15/0802 , G01P15/125 , H01P1/202 , H01P3/06 , H01P5/183 , H01P11/00 , H01P11/005 , H05K3/4647 , Y10T156/10
摘要： Various embodiments of the invention are directed to formation of mesoscale or microscale devices using electrochemical fabrication techniques where structures are formed from a plurality of layers as opened structures which can be folded over or other otherwise combined to form structures of desired configuration. Each layer is formed from at least one structural material and at least one sacrificial material. The initial formation of open structures may facilitate release of the sacrificial material, ability to form fewer layers to complete a structure, ability to locate additional materials into the structure, ability to perform additional processing operations on regions exposed while the structure is open, and/or the ability to form completely encapsulated and possibly hollow structures.
摘要翻译：本发明的各种实施例涉及使用电化学制造技术形成中尺度或微尺寸器件，其中结构由多个层形成为打开的结构，其可折叠或以其他方式组合以形成所需构造的结构。每个层由至少一种结构材料和至少一种牺牲材料形成。开放结构的初始形成可以促进牺牲材料的释放，形成较少层以完成结构的能力，将附加材料定位到结构中的能力，对结构打开时暴露的区域执行附加处理操作的能力和/ 或形成完全封装和可能中空结构的能力。

8. 发明申请

US20060109016A1 Microprobe tips and methods for making 有权
标题翻译：微型笔尖和制作方法
公开(公告)号：US20060109016A1
公开(公告)日：2006-05-25
申请号：US11244817
申请日：2005-10-06
申请人： Vacit Arat , Adam Cohen , Dennis Smalley , Ezekiel Kruglick , Richard Chen , Kieun Kim
发明人： Vacit Arat , Adam Cohen , Dennis Smalley , Ezekiel Kruglick , Richard Chen , Kieun Kim
IPC分类号： G01R31/02
CPC分类号： G01R1/06711 , G01R1/06716 , G01R1/06733 , G01R1/06744 , G01R3/00
摘要： Multilayer test probe structures are electrochemically fabricated via depositions of one or more materials in a plurality of overlaying and adhered layers. In some embodiments each probe structure may include a plurality of contact arms or contact tips that are used for contacting a specific pad or plurality of pads wherein the arms and/or tips are configured in such away so as to provide a scrubbing motion (e.g. a motion perpendicular to a primary relative movement motion between a probe carrier and the IC) as the probe element or array is made to contact an IC, or the like, and particularly when the motion between the probe or probes and the IC occurs primarily in a direction that is perpendicular to a plane of a surface of the IC. In some embodiments arrays of multiple probes are provided and even formed in desired relative position simultaneously.
摘要翻译：多层测试探针结构通过在多个覆盖层和粘附层中的一种或多种材料的沉积进行电化学制造。在一些实施例中，每个探针结构可以包括用于接触特定垫或多个垫的多个接触臂或接触尖端，其中臂和/或尖端被配置成如此远离以提供擦洗运动（例如，当探针元件或阵列与探针载体和IC之间的初级相对移动运动垂直的运动）与IC等接触时，特别是当探针或探针与IC之间的运动主要发生在方向垂直于IC的表面的平面。在一些实施例中，多个探针的阵列被提供并且甚至同时形成在期望的相对位置。

9. 发明申请

US20060084265A1 Method for electrochemically fabricating three-dimensional structures including pseudo-rasterization of data 失效
公开(公告)号：US20060084265A1
公开(公告)日：2006-04-20
申请号：US11029173
申请日：2005-01-03
申请人： Adam Cohen , Jeffrey Thompson
发明人： Adam Cohen , Jeffrey Thompson
IPC分类号： H01L21/44
CPC分类号： C25D5/022 , B33Y10/00 , B33Y50/02 , C25D1/10 , C25D5/10
摘要： Some embodiments of the invention are directed to techniques for electrochemically fabricating multi-layer three-dimensional structures where selective patterning of at least one or more layers occurs via a mask which is formed using data representing cross-sections of the three-dimensional structure which has been modified to place it in a polygonal form which defines only regions of positive area. The regions of positive area are regions where structural material is to be located or regions where structural material is not to be located depending on whether the mask will be used, for example, in selectively depositing a structural material or a sacrificial material. The modified data may take the form of adjacent or slightly overlapped relative narrow rectangular structures where the width of the structures is related to a desired formation resolution. The spacing between centers of adjacent rectangles may be uniform or may be a variable. The data modification may also include the formation of duplicate copies of an original structure, scaled copies, mirrored copies, rotated copies, complementary copies, and the like.

10. 发明申请

US20060053625A1 Microprobe tips and methods for making 审中-公开
标题翻译：微型笔尖和制作方法
公开(公告)号：US20060053625A1
公开(公告)日：2006-03-16
申请号：US11177798
申请日：2005-07-07
申请人： Kieun Kim , Adam Cohen , Willa Larsen , Richard Chen , Ananda Kumar , Ezekiel Kruglick , Vacit Arat , Gang Zhang , Michael Lockard , Christopher Bang
发明人： Kieun Kim , Adam Cohen , Willa Larsen , Richard Chen , Ananda Kumar , Ezekiel Kruglick , Vacit Arat , Gang Zhang , Michael Lockard , Christopher Bang
IPC分类号： H01R43/16 , H01R43/00
CPC分类号： G01R3/00 , C25D1/003 , G01R1/073 , Y10T29/49204 , Y10T29/49222
摘要： Embodiments of the present invention are directed to the formation of microprobe tips elements having a variety of configurations. In some embodiments tips are formed from the same building material as the probes themselves, while in other embodiments the tips may be formed from a different material and/or may include a coating material. In some embodiments, the tips are formed before the main portions of the probes and the tips are formed in proximity to or in contact with a temporary substrate. Probe tip patterning may occur in a variety of different ways, including, for example, via molding in patterned holes that have been isotropically or anisotropically etched silicon, via molding in voids formed in exposed photoresist, via molding in voids in a sacrificial material that have formed as a result of the sacrificial material mushrooming over carefully sized and located regions of dielectric material, via isotropic etching of the tip material around carefully sized and placed etching shields, via hot pressing, and the like.
摘要翻译：本发明的实施例涉及形成具有各种构造的微探针尖元件。在一些实施例中，尖端由与探针本身相同的建筑材料形成，而在其它实施例中，尖端可以由不同的材料形成和/或可以包括涂层材料。在一些实施例中，尖端在探针的主要部分之前形成，并且尖端形成在临时衬底附近或与临时衬底接触。探针尖端图案化可以以各种不同的方式发生，包括例如通过在各向异性或各向异性地蚀刻硅的图案化孔中模制，通过在曝光的光致抗蚀剂中形成的空隙中模制，通过在牺牲材料中的空隙中模制，由于牺牲材料通过电介质材料的细小尺寸和定位的区域，经由热压等等仔细地尺寸和放置的蚀刻屏蔽部分上的尖端材料的各向同性蚀刻而形成。

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