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1. 发明申请

US20050175691A1 Pramipexole once-daily dosage form 有权
标题翻译：普拉克索每日一次剂型
公开(公告)号：US20050175691A1
公开(公告)日：2005-08-11
申请号：US10626275
申请日：2003-07-24
申请人： Ernest Lee , Gerard Bredael , John Baldwin , Steven Cox , Mark Heintz
发明人： Ernest Lee , Gerard Bredael , John Baldwin , Steven Cox , Mark Heintz
IPC分类号： A61K9/20 , A61K9/28 , A61K31/426 , A61K31/428 , A61K31/4745 , A61P25/16 , A61P43/00
CPC分类号： A61K31/428 , A61K9/2054 , A61K9/2059 , A61K9/28 , A61K9/2866 , A61K31/4745
摘要： An orally deliverable pharmaceutical composition comprises a therapeutically effective amount of pramipexole or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient, said composition exhibiting at least one of (a) an in vitro release profile wherein on average no more than about 20% of the pramipexole is dissolved within 2 hours after placement of the composition in a standard dissolution test; and (b) an in vivo pramipexole absorption profile following single dose administration to healthy adult humans wherein the time to reach a mean of 20% absorption is greater than about 2 hours and/or the time to reach a mean of 40% absorption is greater than about 4 hours. The composition is useful for oral administration, not more than once daily, to a subject having a condition or disorder for which a dopamine receptor agonist is indicated.
摘要翻译：可口服递送的药物组合物包含治疗有效量的普拉克索或其药学上可接受的盐和至少一种药学上可接受的赋形剂，所述组合物显示以下至少一种：（a）体外释放曲线，其平均不超过约20％的普拉克索在将组合物放入标准溶出试验后2小时内溶解; 并且（b）对健康成年人单剂量给药后的体内普拉克索吸收曲线，其中达到平均20％吸收的时间大于约2小时和/或达到平均40％吸收的时间更大超过约4小时。该组合物可用于每天不超过一次给予具有指示多巴胺受体激动剂的病症或病症的受试者。

2. 发明授权

US08722864B2 Glycosylated acetaminophen pro-drug analogs 失效
标题翻译：糖基化对乙酰氨基酚前药类似物
公开(公告)号：US08722864B2
公开(公告)日：2014-05-13
申请号：US13183222
申请日：2011-07-14
申请人： Brian Shull , John Baldwin , Ramesh Gopalaswamy , Zishan Haroon
发明人： Brian Shull , John Baldwin , Ramesh Gopalaswamy , Zishan Haroon
IPC分类号： C07H15/203
CPC分类号： C07H15/203
摘要： The present invention relates to methods and compositions for the synthesis, production, and use of pro-drug analogs of the analgesic acetaminophen. This invention relates to a method for the production of a broad group of glycosides of acetaminophen derivatives.
摘要翻译：本发明涉及用于合成，制备和使用止痛对乙酰氨基酚的前药类似物的方法和组合物。本发明涉及一种生产广泛的对乙酰氨基酚衍生物糖苷的方法。

3. 发明申请

US20070188962A1 Surge protector life cycle monitor system and method 有权
标题翻译：浪涌保护器生命周期监控系统及方法
公开(公告)号：US20070188962A1
公开(公告)日：2007-08-16
申请号：US11354230
申请日：2006-02-15
申请人： John Baldwin
发明人： John Baldwin
IPC分类号： H02H9/06
CPC分类号： H02H3/048 , H02H1/0053
摘要： A system and method are provided for determining an expected life of an electric surge protection component. The system and method monitors preferably each surge that an electric surge protection component experiences. Each surge is measured to determine magnitude and duration, and a cumulative surge measurement history is maintained for each component. Based upon an analysis of the cumulative surge measurement history, an expected life of the component is determined, and an end user is alerted at or preferably near an end of the expected life of the device.
摘要翻译：提供了一种用于确定电涌保护组件的预期寿命的系统和方法。该系统和方法优选地监测电涌保护组件经历的每个浪涌。测量每个浪涌以确定幅度和持续时间，并且为每个组件维持累积浪涌测量历史。基于对累积浪涌测量历史的分析，确定组件的预期寿命，并且终端用户在设备的预期寿命结束时或优选地接近终端。

4. 发明申请

US20070021494A1 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译： 3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体
公开(公告)号：US20070021494A1
公开(公告)日：2007-01-25
申请号：US11500739
申请日：2006-08-08
申请人： Arthur Taveras , Cynthia Aki , Richard Bond , Jianping Chao , Michael Dwyer , Johan Ferreira , Jianhua Chao , Younong Yu , John Baldwin , Bernd Kaiser , Ge Li , J. Merritt , Purakkattle Biju , Kingsley Nelson , Laura Rokosz , Gaifa Lai , James Jakway , Minglang Wu , Evan Hecker , Daniel Lundell , Jay Fine
发明人： Arthur Taveras , Cynthia Aki , Richard Bond , Jianping Chao , Michael Dwyer , Johan Ferreira , Jianhua Chao , Younong Yu , John Baldwin , Bernd Kaiser , Ge Li , J. Merritt , Purakkattle Biju , Kingsley Nelson , Laura Rokosz , Gaifa Lai , James Jakway , Minglang Wu , Evan Hecker , Daniel Lundell , Jay Fine
IPC分类号： A61K31/4709 , A61K31/4436 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/381 , C07D409/02 , C07D413/02 , C07D417/02
CPC分类号： C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译：公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。

5. 发明授权

US5205941A Feeding equalization for sludge presses 失效
标题翻译：泥浆压榨机的进料均衡
公开(公告)号：US5205941A
公开(公告)日：1993-04-27
申请号：US739472
申请日：1991-08-02
申请人： Erwin Funk , John Bolles , John Baldwin
发明人： Erwin Funk , John Bolles , John Baldwin
IPC分类号： B30B9/02
CPC分类号： B30B9/02
摘要： In a dewatering press having a number of rotors rotatable in a cylindrical press housing with an inlet channel defining an inlet for a humid mass into the housing, a mechanism for equalizing the amount of mass fed to the inlet channels. A screw feeder is associated with each inlet channel, and equalization is accomplished by providing opening communication between the screw feeders at their pressure ends, adjacent the inlet channels. A module having a conduit associated with each inlet channel, and a cross over tunnel at the portion of the module adjacent the press housing, is disposed between the feeder screw housing and the press housing.
摘要翻译：在具有多个转子的脱水压榨机中，其具有可在圆筒形压力机壳体中旋转的入口通道，所述入口通道限定用于潮湿质量进入壳体的入口，用于均衡供给到入口通道的质量的量的机构。螺旋进料器与每个入口通道相关联，并且通过在螺旋进料器的压力端，邻近入口通道处提供开口连通来实现均衡。具有与每个入口通道相关联的管道的模块以及邻近压力机壳体的模块部分处的交叉通道设置在进料螺杆壳体和压力机壳体之间。

6. 发明授权

US4772797A Ceiling mounted passive infrared intrusion detector with prismatic window 失效
标题翻译：天花板安装的带有棱镜窗的被动红外入侵检测器
公开(公告)号：US4772797A
公开(公告)日：1988-09-20
申请号：US905166
申请日：1986-09-08
申请人： William Kahl , John Baldwin
发明人： William Kahl , John Baldwin
IPC分类号： G08B13/193 , G01J5/08
CPC分类号： G08B13/193 , Y10S250/01
摘要： A ceiling mounted passive infrared intrusion detector includes a window which has an exterior surface with ridges formed of intersecting planes, which are arranged to provide internal reflection of radiation received from selected angles with respect to the optical axis of the device and to deflect such radiation into a direction parallel to the optical axis. Focusing means arranged as part of the detector focuses the parallel infrared radiation onto a detecting element within the device.
摘要翻译：天花板安装的无源红外入侵检测器包括具有外表面的窗口，所述外表面具有由相交平面形成的脊部，所述窗口被布置成提供相对于所述装置的光轴从选定角度接收的辐射的内部反射并且将所述辐射偏转平行于光轴的方向。被布置为检测器的一部分的聚焦装置将平行的红外辐射聚焦到装置内的检测元件上。

7. 发明授权

US09023813B2 Synthesis and use of glycoside derivatives of propofol 有权
标题翻译：异丙酚糖苷衍生物的合成与应用
公开(公告)号：US09023813B2
公开(公告)日：2015-05-05
申请号：US13442485
申请日：2012-04-09
申请人： Brian Shull , John Baldwin , Ramesh Gopalaswamy , Zishan Haroon
发明人： Brian Shull , John Baldwin , Ramesh Gopalaswamy , Zishan Haroon
IPC分类号： C07H15/18 , C07H5/10 , A61K31/7028 , C07H15/04 , C07H15/203 , C07H15/26
CPC分类号： C07H15/18 , A61K31/7028 , C07H5/10 , C07H15/04 , C07H15/203 , C07H15/26
摘要： The present invention relates to methods and compositions for the synthesis, production, and use of pro-drug propofol analogs. This invention relates to a method for the production of a broad group of glycosylated propofol carbohydrate derivatives.
摘要翻译：本发明涉及前药异丙酚类似物的合成，生产和使用的方法和组合物。本发明涉及生产广泛的糖基化丙泊酚碳水化合物衍生物的方法。

8. 发明申请

US20120264702A1 Synthesis And Use Of Glycoside Derivatives of Propofol 有权
标题翻译：异丙酚糖苷衍生物的合成与应用
公开(公告)号：US20120264702A1
公开(公告)日：2012-10-18
申请号：US13442485
申请日：2012-04-09
申请人： Brian Shull , John Baldwin , Ramesh Gopalaswamy , Zishan Haroon
发明人： Brian Shull , John Baldwin , Ramesh Gopalaswamy , Zishan Haroon
IPC分类号： A61K31/7034 , C07H15/18 , A61P23/00 , A61K31/7016 , A61K31/702 , C07H1/00 , C07H99/00 , A61K31/70
CPC分类号： C07H15/18 , A61K31/7028 , C07H5/10 , C07H15/04 , C07H15/203 , C07H15/26
摘要： The present invention relates to methods and compositions for the synthesis, production, and use of pro-drug propofol analogs. This invention relates to a method for the production of a broad group of glycosylated propofol carbohydrate derivatives.
摘要翻译：本发明涉及前药异丙酚类似物的合成，生产和使用的方法和组合物。本发明涉及生产广泛的糖基化丙泊酚碳水化合物衍生物的方法。

9. 发明申请

US20080051423A1 NITROGEN HETEROCYCLE BIARYLS FOR OSTEOPOROSIS AND OTHER DISEASES 审中-公开
标题翻译：用于骨质疏松症和其他疾病的氮杂交异构体
公开(公告)号：US20080051423A1
公开(公告)日：2008-02-28
申请号：US11843897
申请日：2007-08-23
申请人： Jeffrey Letourneau , Vidyahar Paradkar , Michael Ohlmeyer , Lawrence Dillard , John Baldwin , Christopher Riviello , Angela Wong , Yaing Rong
发明人： Jeffrey Letourneau , Vidyahar Paradkar , Michael Ohlmeyer , Lawrence Dillard , John Baldwin , Christopher Riviello , Angela Wong , Yaing Rong
IPC分类号： C07D235/06 , A61K31/4184 , A61K31/428 , A61K31/47 , A61K31/4985 , A61P19/00 , C07D487/02 , C07D277/82 , A61P27/00 , A61P3/00 , A61P35/00 , C07D215/38
CPC分类号： C07D215/38 , C07D235/30 , C07D401/12 , C07D403/12 , C07D405/12 , C07D487/04
摘要： Nitrogen heterocycle biaryls having a carboxylate terminus are useful for treating endometriosis, osteoporosis, restenosis following angioplasty, rheumatoid arthritis, cancer, macular degeneration and obesity. Compounds of formula: are disclosed. A representative example is
摘要翻译：具有羧酸酯末端的氮杂环联芳烃可用于治疗子宫内膜异位症，骨质疏松症，血管成形术后的再狭窄，类风湿性关节炎，癌症，黄斑变性和肥胖症。公开了式的化合物。一个代表性的例子是

10. 发明申请

US20070264230A1 Thiadiazoledioxides and thiadiazoleoxides as CXC- and CC-chemokine receptor ligands 失效
标题翻译：噻二唑二氧化物和噻二唑氧化物作为CXC-和CC-趋化因子受体配体
公开(公告)号：US20070264230A1
公开(公告)日：2007-11-15
申请号：US11651128
申请日：2007-01-09
申请人： Arthur Taveras , Jianhua Chao , Purakkattle Biju , Younong Yu , Jay Fine , William Hipkin , Cynthia Aki , J. Merritt , Ge Li , John Baldwin , Gaifa Lai , Minglang Wu , Evan Hecker
发明人： Arthur Taveras , Jianhua Chao , Purakkattle Biju , Younong Yu , Jay Fine , William Hipkin , Cynthia Aki , J. Merritt , Ge Li , John Baldwin , Gaifa Lai , Minglang Wu , Evan Hecker
IPC分类号： A61K31/433 , A61K31/395 , A61K31/4406 , A61K31/497 , A61K31/50 , A61K31/513 , A61K31/56 , A61K31/695 , A61K38/08 , A61K38/10 , A61K38/21 , A61K39/395 , A61P1/00 , A61P11/00 , A61P13/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P27/02 , A61P27/16 , A61P31/12 , A61P35/00 , A61P37/06 , A61P41/00 , A61P43/00 , A61P7/06 , A61P9/00 , C07D417/12
CPC分类号： C07D285/10 , C07D417/02 , C07D417/12 , C07D417/14
摘要： Disclosed are novel compounds of the formula: and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula IA.
摘要翻译：公开了下式的新化合物及其药学上可接受的盐和溶剂合物。包含取代基A的基团的实例包括杂芳基，芳基，杂环烷基，环烷基，芳基，炔基，烯基，氨基烷基，烷基或氨基。包含取代基B的基团的实例包括芳基和杂芳基。还公开了治疗趋化因子介导的疾病如癌症，血管生成，血管生成性眼病，肺部疾病，多发性硬化，类风湿性关节炎，骨关节炎，中风和心脏再灌注损伤，急性疼痛，急性和慢性炎性疼痛的方法，以及使用式IA化合物的神经性疼痛。

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