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1. 发明申请

US20110021624A1 Alpha-Amino-N-Substituted Amides, Pharmaceutical Composition Containing Them and Uses Thereof 有权
标题翻译： α-氨基-N-取代酰胺，含有它们的药物组合物及其用途
公开(公告)号：US20110021624A1
公开(公告)日：2011-01-27
申请号：US12747485
申请日：2008-12-11
申请人： Fajun Nan , Jia Li , Jian Ding , Gang Liu , Chuanming Xie , Zehong Miao , Wanyi Tai
发明人： Fajun Nan , Jia Li , Jian Ding , Gang Liu , Chuanming Xie , Zehong Miao , Wanyi Tai
IPC分类号： A61K31/34 , C07C237/00 , A61K31/164 , C07C69/74 , A61K31/215 , C07C69/96 , A61K31/265 , C07D307/20 , C07D307/94 , A61P35/00
CPC分类号： C07C237/22 , C07C247/12 , C07C271/22 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/74 , C07D209/14 , C07D209/20 , C07D233/54 , C07D307/24 , C07D307/94
摘要： Disclosed are a series of α-amino-N-substituted amide compounds having a structure of the following formula, the pharmaceutically acceptable salts thereof, and the pharmaceutical composition comprising the same. The α-amino-N-substituted amide compounds or the pharmaceutically acceptable salts thereof according to the present invention have anti-tumor and/or anti-cancer activities in vivo and in vitro, can effectively depress the growth of various tumor cells and/or cancer cells, and thus can be used in preparing drugs for treating tumors and/or cancers.
摘要翻译：公开了一系列具有下式结构的α-氨基-N-取代酰胺化合物及其药学上可接受的盐，以及包含它们的药物组合物。根据本发明的α-氨基-N-取代的酰胺化合物或其药学上可接受的盐在体内和体外具有抗肿瘤和/或抗癌活性，可以有效地抑制各种肿瘤细胞的生长和/或癌细胞，因此可用于制备用于治疗肿瘤和/或癌症的药物。

2. 发明授权

US08470763B2 Alpha-amino-N-substituted amides, pharmaceutical composition containing them and uses thereof 有权
标题翻译： α-氨基-N-取代的酰胺，含有它们的药物组合物及其用途
公开(公告)号：US08470763B2
公开(公告)日：2013-06-25
申请号：US12747485
申请日：2008-12-11
申请人： Fajun Nan , Jia Li , Jian Ding , Gang Liu , Chuanming Xie , Zehong Miao , Wanyi Tai
发明人： Fajun Nan , Jia Li , Jian Ding , Gang Liu , Chuanming Xie , Zehong Miao , Wanyi Tai
IPC分类号： C07D345/00
CPC分类号： C07C237/22 , C07C247/12 , C07C271/22 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/74 , C07D209/14 , C07D209/20 , C07D233/54 , C07D307/24 , C07D307/94
摘要： Disclosed are a series of α-amino-N-substituted amide compounds having a structure of the following formula, the pharmaceutically acceptable salts thereof, and the pharmaceutical composition comprising the same. The α-amino-N-substituted amide compounds or the pharmaceutically acceptable salts thereof according to the present invention have anti-tumor and/or anti-cancer activities in vivo and in vitro, can effectively depress the growth of various tumor cells and/or cancer cells, and thus can be used in preparing drugs for treating tumors and/or cancers.
摘要翻译：公开了一系列具有下式结构的α-氨基-N-取代酰胺化合物及其药学上可接受的盐，以及包含它们的药物组合物。根据本发明的α-氨基-N-取代的酰胺化合物或其药学上可接受的盐在体内和体外具有抗肿瘤和/或抗癌活性，可以有效抑制各种肿瘤细胞的生长和/或癌细胞，因此可用于制备用于治疗肿瘤和/或癌症的药物。

3. 发明授权

US09216962B2 Thiazole compounds, methods for preparation and use thereof 有权
标题翻译：噻唑化合物，其制备方法和用途
公开(公告)号：US09216962B2
公开(公告)日：2015-12-22
申请号：US14116944
申请日：2012-05-07
申请人： Fajun Nan , Fei Chen , Yangming Zhang , Jia Li , Yubo Zhou , Mingbo Su , Jian Ding , Linghua Meng , Xin Xie , Shixian Wang
发明人： Fajun Nan , Fei Chen , Yangming Zhang , Jia Li , Yubo Zhou , Mingbo Su , Jian Ding , Linghua Meng , Xin Xie , Shixian Wang
IPC分类号： C07D417/00 , C07D277/56 , C07D277/58 , C07D277/60 , C07D417/14 , C07D417/04
CPC分类号： C07D277/56 , C07D277/58 , C07D277/60 , C07D417/04 , C07D417/14
摘要： The present invention relates to thiazole compounds of formula I, the method for preparation and use thereof. More specifically, the present invention relates to novel derivatives of natural product largazole, the method for preparing them and their uses for treatments against tumor and multiple sclerosis as inhibitors of histone deacetylase.
摘要翻译：本发明涉及式I的噻唑化合物，其制备方法和用途。更具体地，本发明涉及天然产物大唑的新衍生物，其制备方法及其用于治疗肿瘤和多发性硬化的用途，作为组蛋白脱乙酰酶的抑制剂。

4. 发明授权

US07683073B2 Isoquinoline-1,3,4-trione compounds, the synthetic method and the use thereof 失效
标题翻译：异喹啉-1,3,4-三酮化合物，其合成方法及其应用
公开(公告)号：US07683073B2
公开(公告)日：2010-03-23
申请号：US11301638
申请日：2005-12-13
申请人： Fajun Nan , Jia Li , Yihua Chen , Yahui Zhang , Min Gu , Huajie Zhang
发明人： Fajun Nan , Jia Li , Yihua Chen , Yahui Zhang , Min Gu , Huajie Zhang
IPC分类号： C07D217/22 , A61K31/47
CPC分类号： C07D417/04 , C07D217/24
摘要： The invention relates to various substituted isoquinoline-1,3,4-trione, the synthetic method thereof and the use for treating neurodegenerative diseases, especially as the medicine for Alzheimer's disease, apoplexy and brain ischemic injuries.
摘要翻译：本发明涉及各种取代的异喹啉-1,3,4-三酮，其合成方法和治疗神经变性疾病的用途，特别是作为阿尔茨海默氏病，中风和脑缺血性损伤的药物。

5. 发明申请

US20100197927A1 Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof 失效
标题翻译：蛋白酪氨酸磷酸酶1B抑制剂，其制备方法和用途
公开(公告)号：US20100197927A1
公开(公告)日：2010-08-05
申请号：US12530281
申请日：2008-02-26
申请人： Fajun Nan , Jia Li , Yi Wei , Wei Zhang , Jingya Li , Lei Shi
发明人： Fajun Nan , Jia Li , Yi Wei , Wei Zhang , Jingya Li , Lei Shi
IPC分类号： C07D277/30 , C07D417/12
CPC分类号： C07D277/30 , C07D417/12
摘要： PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors.
摘要翻译：具有以下结构的PTP1B抑制剂（式I）。实验表明，这些抑制剂能有效抑制蛋白酪氨酸磷酸酶1B（PTP1B）的活性。它们可以用作胰岛素敏化剂。它们可用于预防，延迟或治疗与PTP1B介导的胰岛素拮抗相关的疾病，特别是II型糖尿病和肥胖症。本发明还提供了制备这些抑制剂的方法。

6. 发明申请

US20060135557A1 Isoquinoline-1,3,4-trione compounds, the synthetic method and the use thereof 失效
标题翻译：异喹啉-1,3,4-三酮化合物，其合成方法及其应用
公开(公告)号：US20060135557A1
公开(公告)日：2006-06-22
申请号：US11301638
申请日：2005-12-13
申请人： Fajun Nan , Jia Li , Yihua Chen , Yahui Zhang , Min Gu , Huajie Zhang
发明人： Fajun Nan , Jia Li , Yihua Chen , Yahui Zhang , Min Gu , Huajie Zhang
IPC分类号： A61K31/47 , C07D217/22
CPC分类号： C07D417/04 , C07D217/24
摘要： The invention relates to various substituted isoquinoline-1,3,4-trione, the synthetic method thereof and the use for treating neurodegenerative diseases, especially as the medicine for Alzheimer's disease, apoplexy and brain ischemic injuries.
摘要翻译：本发明涉及各种取代的异喹啉-1,3,4-三酮，其合成方法和治疗神经变性疾病的用途，特别是作为阿尔茨海默氏病，中风和脑缺血性损伤的药物。

7. 发明授权

US08183383B2 Protein tyrosine phosphatase 1B inhibitor, preparation methods and uses thereof 失效
标题翻译：蛋白酪氨酸磷酸酶1B抑制剂，其制备方法和用途
公开(公告)号：US08183383B2
公开(公告)日：2012-05-22
申请号：US12530281
申请日：2008-02-26
申请人： Fajun Nan , Jia Li , Yi Wei , Wei Zhang , Jingya Li , Lei Shi
发明人： Fajun Nan , Jia Li , Yi Wei , Wei Zhang , Jingya Li , Lei Shi
IPC分类号： C07D277/30 , C07D263/34 , C07D233/00 , C07D233/61 , C07D417/10 , C07D413/10 , C07D401/10 , A61K31/445 , A61K31/44 , A61K31/425 , A61K31/42 , A61K31/415
CPC分类号： C07D277/30 , C07D417/12
摘要： PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors.
摘要翻译：具有以下结构的PTP1B抑制剂（式I）。实验表明，这些抑制剂能有效抑制蛋白酪氨酸磷酸酶1B（PTP1B）的活性。它们可以用作胰岛素敏化剂。它们可用于预防，延迟或治疗与PTP1B介导的胰岛素拮抗相关的疾病，特别是II型糖尿病和肥胖症。本发明还提供了制备这些抑制剂的方法。

8. 发明授权

US09776123B2 System and method for purifying mother liquid steam of polytetrafluoroethylene dispersion liquid 有权
公开(公告)号：US09776123B2
公开(公告)日：2017-10-03
申请号：US14378632
申请日：2012-08-02
申请人： Jingang Zhang , Jia Li , Jinsong Zhang , Yong Xu , Xiulin Chen
发明人： Jingang Zhang , Jia Li , Jinsong Zhang , Yong Xu , Xiulin Chen
IPC分类号： B01D19/02 , B01D53/14 , B01D50/00 , B01D19/00 , B01D53/70 , B01D53/78
CPC分类号： B01D50/00 , B01D19/0036 , B01D19/0042 , B01D19/02 , B01D53/1418 , B01D53/145 , B01D53/70 , B01D53/78 , B01D2257/2066
摘要： A system for purifying mother liquid steam of polytetrafluoroethylene dispersion liquid comprises a concentration kettle (1), a defoaming pot (2), a gas-liquid separator (3) and a falling film absorption tower (4). A steam exit of the concentration kettle (1) is connected to an entrance of the defoaming pot (2). An exit of the defoaming pot (2) is connected to a feeding port of the gas-liquid separator (3). A gas exit of the gas-liquid separator (3) is connected to the falling film absorption tower (4). A liquid exit of the gas-liquid separator (3) is connected to the concentration kettle (1). A method for purifying mother liquid steam of polytetrafluoroethylene dispersion liquid by using the system is further provided.

9. 发明申请

US20150165363A1 SYSTEM AND METHOD FOR PURIFYING MOTHER LIQUID STEAM OF POLYTETRAFLUOROETHYLENE DISPERSION LIQUID 有权
标题翻译：用于净化聚四氟乙烯分散液的母液液体的系统和方法
公开(公告)号：US20150165363A1
公开(公告)日：2015-06-18
申请号：US14378632
申请日：2012-08-02
申请人： Jingang Zhang , Jia Li , Jinsong Zhang , Yong Xu , Xiulin Chen
发明人： Jingang Zhang , Jia Li , Jinsong Zhang , Yong Xu , Xiulin Chen
IPC分类号： B01D50/00 , B01D19/02 , B01D53/14
CPC分类号： B01D50/00 , B01D19/0036 , B01D19/0042 , B01D19/02 , B01D53/1418 , B01D53/145 , B01D53/70 , B01D53/78 , B01D2257/2066
摘要： A system for purifying mother liquid steam of polytetrafluoroethylene dispersion liquid comprises a concentration kettle (1), a defoaming pot (2), a gas-liquid separator (3) and a falling film absorption tower (4). A steam exit of the concentration kettle (1) is connected to an entrance of the defoaming pot (2). An exit of the defoaming pot (2) is connected to a feeding port of the gas-liquid separator (3). A gas exit of the gas-liquid separator (3) is connected to the falling film absorption tower (4). A liquid exit of the gas-liquid separator (3) is connected to the concentration kettle (1). A method for purifying mother liquid steam of polytetrafluoroethylene dispersion liquid by using the system is further provided.
摘要翻译：用于净化聚四氟乙烯分散液的母液蒸汽的系统包括浓缩釜（1），消泡罐（2），气液分离器（3）和降膜吸收塔（4）。浓缩釜（1）的蒸汽出口连接到消泡罐（2）的入口。消泡罐（2）的出口与气液分离器（3）的进料口连接。气液分离器（3）的气体出口连接到降膜吸收塔（4）。气液分离器（3）的液体出口与浓缩釜（1）连接。还提供了一种通过使用该系统来净化聚四氟乙烯分散液的母液蒸汽的方法。

10. 发明授权

US08755596B2 Studying aesthetics in photographic images using a computational approach 有权
标题翻译：使用计算方法学习摄影图像中的美学
公开(公告)号：US08755596B2
公开(公告)日：2014-06-17
申请号：US13542326
申请日：2012-07-05
申请人： Ritendra Datta , Jia Li , James Z. Wang
发明人： Ritendra Datta , Jia Li , James Z. Wang
IPC分类号： G06K9/62
CPC分类号： G06K9/6228 , G06K9/00624 , G06K9/4652 , G06K9/4671
摘要： The aesthetic quality of a picture is automatically inferred using visual content as a machine learning problem using, for example, a peer-rated, on-line photo sharing Website as data source. Certain visual features of images are extracted based on the intuition that they can discriminate between aesthetically pleasing and displeasing images. A one-dimensional support vector machine is used to identify features that have noticeable correlation with the community-based aesthetics ratings. Automated classifiers are constructed using the support vector machines and classification trees, with a simple feature selection heuristic being applied to eliminate irrelevant features. Linear regression on polynomial terms of the features is also applied to infer numerical aesthetics ratings.
摘要翻译：使用例如同行评级的在线照片共享网站作为数据源，使用视觉内容作为机器学习问题自动推断图片的美学品质。基于它们可以在美学上令人不愉快的图像之间区分的直觉来提取图像的某些视觉特征。一维支持向量机用于识别与基于社区的美学评级具有显着相关性的特征。使用支持向量机和分类树构建自动分类器，并采用简单的特征选择启发式来消除不相关的特征。特征的多项式项的线性回归也用于推断数字美学评级。

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