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1. 发明申请

WO2007087572A2 AZA-PEPTIDE EPOXIDES 审中-公开
标题翻译： AZA-肽环氧化物
公开(公告)号：WO2007087572A2
公开(公告)日：2007-08-02
申请号：PCT/US2007/060991
申请日：2007-01-24
申请人： GEORGIA TECH RESEARCH CORPORATION , EMORY UNIVERSITY , POWERS, James, C. , GLASS, Jonathan
发明人： POWERS, James, C. , GLASS, Jonathan
IPC分类号： A61K38/05 , A61K38/04 , A61K31/336 , A61K31/401 , A61K31/405
CPC分类号： A61K38/05 , A61K31/336 , A61K31/401 , A61K31/405 , A61K38/06 , C07D303/48 , C07K5/0207 , C07K5/06026 , C07K5/06043 , C07K5/0808 , C07K5/0819 , C07K5/101 , C07K5/1021
摘要： Methods for treatment and/or prevention of nerve degeneration in mammals using aza-peptide epoxide caspase inhibitors are provided. Aspects of the present disclosure include aza-peptide epoxide compositions to treat or prevent diseases, for example stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuropathies, Huntington's disease, dentatorubropallidomysian atrophy, spinocerebellar atrophies, spinal bulbar muscular atrophy, diabetes, amyotrophic lateral sclerosis and other motor neuron diseases. The disclosed methods can be used in combination with calpain inhibitors to treat disease or pathological conditions related to the activity of caspases and calpain associated with a specific disease or condition. Such treatable conditions include stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuropathies, Huntington's disease, dentatorubropallidoluysian atrophy, spinocerebellar atrophies, spinal bulbar muscular atrophy, nerve degeneration associated with diabetes, amyotrophic lateral sclerosis and other motor neuron diseases, nerve degeneration secondary to primary demyelinating disorders, among others.
摘要翻译：提供了使用氮杂肽环氧化物半胱天冬酶抑制剂治疗和/或预防哺乳动物神经变性的方法。例如中风，阿尔茨海默病，帕金森病，多发性硬化症，神经病，亨廷顿舞蹈病，齿状核旁肌萎缩症，脊髓小脑萎缩症，脊髓延髓肌萎缩症，糖尿病，肌萎缩侧索组织的阿扎肽环氧化物组合物硬化和其他运动神经元疾病。所公开的方法可以与钙蛋白酶抑制剂组合用于治疗与特定疾病或病症相关的与半胱天冬酶和钙蛋白酶活性有关的疾病或病理状况。这些可治疗的病症包括中风，阿尔茨海默氏病，帕金森病，多发性硬化症，神经病，亨廷顿舞蹈病，牙齿营养不良性萎缩症，脊髓小脑萎缩，脊髓球肌萎缩，与糖尿病相关的神经退行性变，肌萎缩侧索硬化和其他运动神经元疾病，原发性脱髓鞘疾病等等。

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