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1. 发明授权

US06176865B1 Apparatus and method for incising 有权
标题翻译：切割装置及方法
公开(公告)号：US06176865B1
公开(公告)日：2001-01-23
申请号：US09429551
申请日：1999-10-28
申请人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
发明人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
IPC分类号： A61B1732
CPC分类号： A61B10/0233 , A61B5/14514 , A61B5/150022 , A61B5/150137 , A61B5/15016 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/150511 , A61B5/15121 , A61B5/15142 , A61B10/0266 , A61B17/32002 , A61B17/32053 , A61B17/32093 , A61B17/3476
摘要： A multi-shaft apparatus for incising a substrate of soft resilient material such as a body tissue. The incising apparatus includes two or more incision shafts each having a distal edge. The shafts are not affixed to each other and are allowed to slide against each other to drive the distal edges alternately against the substrate to incise the substrate. In the case of incising a body tissue, such alternate motion would result in less pain to the patient than a puncture resulting from a sharp jab by a sharp shaft of similar size to the shafts.
摘要翻译：一种用于切割诸如身体组织的软弹性材料的基底的多轴装置。切割装置包括两个或更多个切口轴，每个切口具有远端边缘。轴彼此不固定并且允许彼此滑动以将远端边缘交替地驱动抵靠基板以切割基板。在切割身体组织的情况下，这种交替运动将导致比通过与轴相似尺寸的尖锐的尖锐刺戳导致的穿刺更少的疼痛。

2. 发明授权

US6139562A Apparatus and method for incising 失效
标题翻译：切割装置及方法
公开(公告)号：US6139562A
公开(公告)日：2000-10-31
申请号：US50748
申请日：1998-03-30
申请人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
发明人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
IPC分类号： A61B5/151 , A61B5/15 , A61B10/00 , A61B10/02 , A61B17/32 , A61B17/34 , A61B17/14
CPC分类号： A61B10/0233 , A61B10/0266 , A61B17/32053 , A61B17/32093 , A61B5/14514 , A61B5/150022 , A61B5/150137 , A61B5/15016 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/150511 , A61B5/15121 , A61B5/15142 , A61B17/32002 , A61B17/3476
摘要： A multi-shaft apparatus for incising a substrate of soft resilient material such as a body tissue. The incising apparatus includes two or more incision shafts each having a distal edge. The shafts are not affixed to each other and are allowed to slide against each other to drive the distal edges alternately against the substrate to incise the substrate. In the case of incising a body tissue, such alternate motion would result in less pain to the patient than a puncture resulting from a sharp jab by a sharp shaft of similar size to the shafts.
摘要翻译：一种用于切割诸如身体组织的软弹性材料的基底的多轴装置。切割装置包括两个或更多个切口轴，每个切口具有远端边缘。轴彼此不固定并且允许彼此滑动以将远端边缘交替地驱动抵靠基板以切割基板。在切割身体组织的情况下，这种交替运动将导致比通过与轴相似尺寸的尖锐的尖锐刺戳导致的穿刺更少的疼痛。

3. 发明授权

US06171325B2 Apparatus and method for incising 有权
公开(公告)号：US06171325B2
公开(公告)日：2001-01-09
申请号：US09420988
申请日：1999-10-20
申请人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
发明人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
IPC分类号： A61B1732
CPC分类号： A61B10/0233 , A61B5/14514 , A61B5/150022 , A61B5/150137 , A61B5/15016 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/150511 , A61B5/15121 , A61B5/15142 , A61B10/0266 , A61B17/32002 , A61B17/32053 , A61B17/32093 , A61B17/3476
摘要： A multi-shaft apparatus for incising a substrate of soft resilient material such as a body tissue. The incising apparatus includes two or more incision shafts each having a distal edge. The shafts are not affixed to each other and are allowed to slide against each other to drive the distal edges alternately against the substrate to incise the substrate. In the case of incising a body tissue, such alternate motion would result in less pain to the patient than a puncture resulting from a sharp jab by a sharp shaft of similar size to the shafts.

4. 发明授权

US06276196B1 Thermometric vapor sensor with evaporation surface having micropores 有权
公开(公告)号：US06276196B1
公开(公告)日：2001-08-21
申请号：US09733511
申请日：2000-12-07
申请人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
发明人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
IPC分类号： G01N700
摘要： A sensor for sensing in a gas stream a vapor of a liquid. The sensor includes a micropore and a wet temperature sensor. The micropore has an evaporation end and has a lumen to conduct liquid from a supply of the liquid for evaporation at the evaporation end. The wet temperature sensor has a heat sensitive part in contact with the liquid in the micropore. The heat sensitive part circumscribes the micropore and forms part of the lumen. Heat loss due to evaporation of the liquid when the wet temperature sensor wet with the liquid is placed in the gas stream will result in the temperature sensed by the wet temperature sensor being lower than the non-evaporative temperature of the gas stream. This lowering in temperature can be measured to determine the concentration of the vapor in the gas stream. An example of such a sensor has a thermocouple junction having micropores passing through the thermocouple junction.

5. 发明授权

US06202480B1 Thermometric vapor sensor with evaporation surface having micropores 失效
标题翻译：具有蒸发表面的微孔蒸气传感器具有微孔
公开(公告)号：US06202480B1
公开(公告)日：2001-03-20
申请号：US09054852
申请日：1998-04-02
申请人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
发明人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
IPC分类号： G01N2562
CPC分类号： G01N25/64
摘要： A sensor for sensing in a gas stream a vapor of a liquid. The sensor includes a micropore and a wet temperature sensor. The micropore has an evaporation end and has a lumen to conduct liquid from a supply of the liquid for evaporation at the evaporation end. The wet temperature sensor has a heat sensitive part in contact with the liquid in the micropore. The heat sensitive part circumscribes the micropore and forms part of the lumen. Heat loss due to evaporation of the liquid when the wet temperature sensor wet with the liquid is placed in the gas stream will result in the temperature sensed by the wet temperature sensor being lower than the non-evaporative temperature of the gas stream. This lowering in temperature can be measured to determine the concentration of the vapor in the gas stream. An example of such a sensor has a thermocouple junction having micropores passing through the thermocouple junction.
摘要翻译：一种传感器，用于在气流中检测液体的蒸汽。该传感器包括微孔和湿温度传感器。微孔具有蒸发端，并且具有内腔以在蒸发端从用于蒸发的液体供应源输送液体。湿式温度传感器具有与微孔中的液体接触的热敏部分。热敏部分围绕微孔并形成管腔的一部分。将潮湿的温度传感器用液体湿润时液体的蒸发导致的热损失被放置在气流中将导致由湿式温度传感器感测到的温度低于气流的非蒸发温度。可以测量这种温度降低以确定气流中的蒸气的浓度。这种传感器的示例具有热电偶结，其具有穿过热电偶结的微孔。

6. 发明授权

US07344894B2 Thermal regulation of fluidic samples within a diagnostic cartridge 有权
标题翻译：诊断墨盒内流体样品的热调节
公开(公告)号：US07344894B2
公开(公告)日：2008-03-18
申请号：US09981440
申请日：2001-10-16
申请人： Michael Greenstein , Frederick Stawitcke , Vladimir Drbal , Ganapati R. Mauze , Rick Pittaro , Richard Pering , Ed Verdonk , Don Alden , Frank Ingle , Klaus Stefan Drese , Hans-Joachim Hartmann , Olaf Soerensen
发明人： Michael Greenstein , Frederick Stawitcke , Vladimir Drbal , Ganapati R. Mauze , Rick Pittaro , Richard Pering , Ed Verdonk , Don Alden , Frank Ingle , Klaus Stefan Drese , Hans-Joachim Hartmann , Olaf Soerensen
IPC分类号： G01N33/543
CPC分类号： B01L7/00 , B01L3/5027 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2300/1872
摘要： A method and miniature analytical device with thermal regulation of reactant using a localized heat source capable of emitting electromagnetic radiation, such as light emitting diodes (“LED”s) and vertical cavity surface emitting lasers (“VCSEL”s), generating internal heat, such as resistive, inductive and Peltier heaters, or external heating. The miniature analytical device comprises of array of temperature-controlled zones to restrict the volume heated and localize the heating by having the localized heat source comprise an array of emitters or heaters.
摘要翻译：使用能够发射电磁辐射的局部热源的反应物的热调节方法和微型分析装置，例如发光二极管（“LED”）和垂直腔表面发射激光器（“VCSEL”），产生内部热量，例如电阻式，感应型和珀耳帖式加热器，或外部加热。微型分析装置包括温度控制区的阵列，以通过使局部热源包括发射器或加热器的阵列来限制加热的体积并定位加热。

7. 发明授权

US07056475B2 Fluidically isolated pumping and metered fluid delivery system and methods 失效
公开(公告)号：US07056475B2
公开(公告)日：2006-06-06
申请号：US10058797
申请日：2002-01-30
申请人： Paul Lum , Ganapati R. Mauze , Catherine K. Templin
发明人： Paul Lum , Ganapati R. Mauze , Catherine K. Templin
IPC分类号： G01N33/00
CPC分类号： B01L3/50273 , B01L2300/0816 , B01L2400/0481 , B01L2400/0633 , F04B43/043 , F04B43/082 , F04B43/1223 , G01N1/38 , Y10T436/2575
摘要： An apparatus and method for pumping and optionally mixing of small quantities of biological fluid wherein the pumping mechanism is segregated from the biological fluid being pumped. The micro-pump pushes the biological fluid by compressing a cartridge housing the blood and reagents with collapsible walls with a roller or ball bearing, synchronized perpendicular plungers, or an acutely-angled member to push the biological fluid by collapsing the walls of the cartridge in the direction of flow.

8. 发明授权

US06375627B1 Physiological fluid extraction with rapid analysis 有权
标题翻译：生理流体萃取快速分析
公开(公告)号：US06375627B1
公开(公告)日：2002-04-23
申请号：US09517711
申请日：2000-03-02
申请人： Ganapati R. Mauze , Paul Lum , Dominique Freeman
发明人： Ganapati R. Mauze , Paul Lum , Dominique Freeman
IPC分类号： A61B500
CPC分类号： A61B5/14539 , A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150099 , A61B5/150282 , A61B5/150358 , A61B5/150389 , A61B5/150511 , A61B5/150717 , A61B5/15087 , A61B5/15107 , A61B5/15186
摘要： A device for sampling and analyzing a physiological fluid from the skin of a patient by puncture. The device includes a body and sensors. The body has a needle with a point for puncturing a physiological tissue and a channel in the body for conducting the physiological fluid away from the point. The sensors are located in the body and are accessible to the physiological fluid conducting along the channel for physiological fluid analysis. The device can be used to lance the skin and obtain a representative sample of the physiological fluid, with relatively simple procedures and quick analysis to minimize the exposure of the physiological fluid sample to air.
摘要翻译：用于通过穿刺从患者皮肤取样和分析生理液体的装置。该装置包括主体和传感器。身体具有用于刺穿生理组织的点和身体中的通道，用于将生理流体远离该点。传感器位于身体中，并且可以沿着通道传导的生理流体进入生理流体分析。该装置可以用于刺激皮肤并获得生理液体的代表性样品，具有相对简单的程序和快速分析，以使生理液体样品暴露于空气。

9. 发明授权

US07393693B2 Methods and procedures for stabilization and performance optimization of multi-layer sol-gel chemical and biochemical sensors 有权
标题翻译：多层溶胶 - 凝胶化学和生物化学传感器的稳定和性能优化的方法和程序
公开(公告)号：US07393693B2
公开(公告)日：2008-07-01
申请号：US10159301
申请日：2002-05-31
申请人： David J. Anvar , Ganapati R. Mauze , Dan-Hui Yang
发明人： David J. Anvar , Ganapati R. Mauze , Dan-Hui Yang
IPC分类号： G01N30/00
CPC分类号： G01N33/6803 , Y10T436/25 , Y10T436/2525
摘要： A sensor and method for making a sensor includes providing a substrate having an adhesion layer with a first functional group operatively associated with a sol-gel composition having a second functional group, and at least one linker material for connecting the first functional group to the second functional group. In another embodiment, a sensor and method for making the sensor includes providing a sol-gel layer operatively associated with a sol-gel precursor solution that includes at least one co-polymer and at least one solvent adapted to resist the deformation of the sol-gel layer by decreasing evaporation, decreasing cross-linking, increasing intermolecular forces, or increasing elasticity.
摘要翻译：用于制造传感器的传感器和方法包括提供具有粘附层的基底，其具有与具有第二官能团的溶胶 - 凝胶组合物操作性相关联的第一官能团，以及用于将第一官能团连接到第二官能团的至少一种连接材料功能组。在另一个实施方案中，用于制造传感器的传感器和方法包括提供可操作地与溶胶 - 凝胶前体溶液相关联的溶胶 - 凝胶层，所述溶胶 - 凝胶层包括至少一种共聚物和至少一种适于抵抗溶胶 - 凝胶前体溶液变形的溶剂 - 凝胶层通过减少蒸发，减少交联，增加分子间力或增加弹性。

10. 发明授权

US07049129B2 Electro-optical devices and methods for hybridization and detection 失效
标题翻译：电光装置和杂交和检测方法
公开(公告)号：US07049129B2
公开(公告)日：2006-05-23
申请号：US10414719
申请日：2003-04-15
申请人： Ganapati R. Mauze , Dan-Hui Yang
发明人： Ganapati R. Mauze , Dan-Hui Yang
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/20 , G01N33/00
CPC分类号： C12Q1/6825 , Y10S435/81 , Y10S436/80 , Y10S436/805 , Y10T436/143333 , C12Q2565/607 , C12Q2563/137
摘要： The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to form an initial complex, a metal ion for doping the initial complex and forming a final complex, and a potential means for providing a potential to the final complex to produce a detectable signal indicating the presence of the target after redox reaction. The method of the invention teaches the steps of hybridizing a probe with an attached label to the target to produce an initial complex, adding a metal ion to the initial complex to form a final complex and applying a potential to the final complex to produce a measurable signal.
摘要翻译：本发明提供了用于检测靶分子的装置和方法。该装置包括标记有过渡金属 - 配体络合物的探针，其与靶杂交以形成初始复合物，用于掺杂初始络合物并形成最终复合物的金属离子，以及为最终复合物提供潜力的潜在手段以产生表明氧化还原反应后靶的存在的可检测信号。本发明的方法教导了将探针与附着的标记物杂交到靶标以产生初始复合物的步骤，向最初的复合物中加入金属离子以形成最终的复合物并向潜在的复合物施加潜能以产生可测量的信号。

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