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1. 发明授权

KR790001861B1 PROCESS FOR PRODUCING THIAZOLIDINE DERIVATIVES 失效
公开(公告)号：KR790001861B1
公开(公告)日：1979-12-26
申请号：KR750000855
申请日：1975-04-23
申请人： HOECHST AG
发明人： MUSCHAWECK R , LANG H-J
IPC分类号： C07D239/70
摘要： Thiazolidine derivs. (I; R1 = / ≠ R2 = C1-C8 alkyl, C3-C8 cycloalkyl, C3-C6 alkenyl, etc., R3 = H, C1-C4 alkyl, R4 = / ≠ R5 = C1-C6 alkyl, C3-C8 cycloalkyl, C3-C6 alkenyl, etc.) and their pharmaceutically acceptable salts for diuretic and saliuretic, were prepd. by reacting II with thiourea (III) to give I, treating I with acids to convert to their acid salts, or reacting their acid salts with base to convert to the free basic compd.

2. 发明授权

KR810001154B1 PROCESS FOR PREPARING 5-SULFAMOYL-ORTHANILIC ACIDS 失效
公开(公告)号：KR810001154B1
公开(公告)日：1981-09-22
申请号：KR780001255
申请日：1978-04-26
申请人： HOECHST AG
发明人： STURM K , MUSCHAWECK R
IPC分类号： C07D307/06 , C07D333/06
摘要： 5-Sulfamoyl-orthanilic acids (I; R = cl, Br, methyl, phenoxy, phenylthio radical; Ar = furyl, thienyl radical; Z = H, metallic ion, ammounium ion, alkyline metallic ion; X = halogen; ph = substituted aromatic radical; Hal = halogen, Zl = H, metal, ammounium, ter-ammonium), having diuretic activity, were prepd. by reacting compd.(IV) with benzene sulfonic acid (V). The compd. (IV) was obtained from the reaction of compd. (II) and phenyl benzene sulfonate(III).

3. 发明授权

US3751448A Basically substituted isobornyl urethanes 失效
标题翻译：基本上取代ISOBORNYL URETHANES
公开(公告)号：US3751448A
公开(公告)日：1973-08-07
申请号：US3751448D
申请日：1972-01-19
申请人： HOECHST AG
发明人： JAGER G , GEIGER R , MUSCHAWECK R
IPC分类号： C07D20060101 , C07D29/26
摘要： BASICALLY SUBSTITUTED ISOBORNYL URETHANES OF THE GENERAL FORMULA I

IB-OOC-NH-CH2-CH(-R)-CH2-N
IN WHICH IB REPRESENTS THE ISOBRONYL RADICAL, R REPRESENTS HYDROGEN OR THE OH-GROUP, R1 AND R2 REPRESENTS AN ALKYL RADICAL HAVING 1 TO 4 CARBON ATOMS OR N, R1, R2 REPRESENT THE PYRROLIDINO OR PIPERIDINO RADICAL AND THEIR SALTS WITH PHYSIOLOGICALLY TOLERATED ACIDS, HAVING LOCAL ANAESTHETIC ACTION.

4. 发明授权

US3855243A 3-aminoacylamino thiophenes 失效
标题翻译： 3-氨基亚氨基硫醇
公开(公告)号：US3855243A
公开(公告)日：1974-12-17
申请号：US40238273
申请日：1973-10-01
申请人： HOECHST AG
发明人： RUSCHIG H , SCHORR M , MUSCHAWECK R , RIPPEL R
IPC分类号： C07D333/36 , A61K27/00 , C07D63/12 , C07D63/16
CPC分类号： C07D333/42 , Y10S514/818
摘要： 3-Aminoacylamino-thiophenes of the formula

AND THEIR PHYSIOLOGICALLY TOLERATED SALTS, USEFUL AS LOCAL ANESTHETICS. Methods of making these compounds. In the formula, R1 may be hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, cycloalkenyl, or alkenyl; R2 is alkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, or alkenyl; R1 and R2, taken together, may also form a saturated heterocyclic ring with the nitrogen atom to which they are attached, which ring may also contain an oxygen atom, a methylimino group, or a further nitrogen atom; R3, R4, and R5 are each hydrogen, alkyl, or carbalkoxy; and A is alkylene.
摘要翻译： 3-氨基酰基氨基 - 噻吩类化合物及其生理学上可容忍的盐，有用的当地麻醉品。制备这些化合物的方法。在该式中，R 1可以是氢，烷基，羟基烷基，烷氧基烷基，环烯基或烯基; R2是烷基，羟基烷基，烷氧基烷基，环烷基或烯基; R 1和R 2一起也可以与它们所连接的氮原子形成饱和杂环，该环也可以含有氧原子，甲基亚氨基或另外的氮原子; R 3，R 4和R 5各自为氢，烷基或烷氧基; A是亚烷基。

5. 发明专利

NZ205469A SULFAMOYLBENZOPHENONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS 未知
公开(公告)号：NZ205469A
公开(公告)日：1986-04-11
申请号：NZ20546983
申请日：1983-09-02
申请人： HOECHST AG
发明人： SEURING B , LANG H , HROPOT M , MUSCHAWECK R
IPC分类号： A61K31/255 , A61K20060101 , A61K31/18 , A61K31/19 , A61K31/215 , A61K31/41 , A61P3/00 , A61P3/12 , A61P19/06 , C07C20060101 , C07C67/00 , C07C301/00 , C07C303/40 , C07C311/29 , C07F13/00 , C07C143/78
摘要： Compounds of the formula in which R , R and R are identical or different and represent hydrogen, halogen, alkyl having 1 to 4 C atoms or alkoxy having 1 to 4 C atoms, in which however R and R cannot denote simultaneously hydrogen and in which R and R together can also denote a bridge comprising two to 5 methylene groups or methylenedioxy, R and R are identical or different and represent hydrogen or alkyl having 1 to 4 C atoms or are part of a 3- to 7-membered saturated carbocyclic ring and R represents hydrogen, alkyl having 1 to 4 C atoms which are unsubstituted or substituted by hydroxyl or alkoxy having 1 to 3 C atoms, or denotes aralkyl having 7 to 9 C atoms and their physiologically acceptable salts have uricosuric and salidiuretic effects.

6. 发明专利

SE425486B 未知
公开(公告)号：SE425486B
公开(公告)日：1982-10-04
申请号：SE7802175
申请日：1978-02-27
申请人： HOECHST AG
发明人： BORMANN D , MERKEL W , MUSCHAWECK R , MANIA D
IPC分类号： C07D207/04 , A61K20060101 , A61K31/125 , A61K31/18 , A61K31/33 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/402 , A61K31/403 , A61K31/4035 , A61K31/445 , A61K31/45 , A61K31/635 , A61P7/10 , C07C20060101 , C07D20060101 , C07D205/04 , C07D205/10 , C07D207/02 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/18 , C07D207/20 , C07D207/32 , C07D207/327 , C07D207/40 , C07D207/404 , C07D207/44 , C07D207/452 , C07D209/00 , C07D209/44 , C07D209/48 , C07D209/52 , C07D209/94 , C07D211/04 , C07D211/14 , C07D211/18 , C07D211/30 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/70 , C07D211/88 , C07D265/32 , C07D265/33 , C07D295/00 , C07D295/02 , C07D295/04 , C07D295/08 , C07D295/10 , C07D295/116 , C07D295/12 , C07D295/14 , C07D295/155 , C07D295/18 , C07D295/192 , C07D317/00 , C07D403/10 , C07D405/10 , C07D407/10 , C07D413/10
摘要： 1504505 Sulphonamides HOECHST AG 25 April 1975 [25 April 1974 27 Dec 1974] 17337/75 Heading C2C The invention comprises novel compounds (I) (including salts thereof) in which R 1 and R 2 , which may be identical or different, each represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, and, if R 1 represents a hydrogen atom, R 2 may also represent an alkoxymethyl group having from 1 to 4 carbon atoms in the alkoxy radical, a phenoxymethyl group or a phenylthiomethyl group, R 3 represents a hydrogen atom, a straight or branched chain alkyl group having from 1 to 4 carbon atoms, a cycloalkyl group, having 5 or 6 ring members, one of which may be replaced by an oxygen or sulphur atom, a phenyl or benzyl group which may be substituted in the phenyl nucleus by one or more substituents selected from nitro groups, alkyl groups having from 1 to 3 carbon atoms, alkoxy groups having from 1 to 5 carbon atoms and halogen atoms, or represents a benzhydryl group or an alkanoyloxymethyl group having 2 to 4 carbon atoms in the alkanoyl part, X represents a halogen atom, a CF 3 or CCl 3 group, a straight or branched chain, saturated or unsaturated alkyl group having from 1 to 6 carbon atoms, a benzyl group which may be substituted in the phenyl nucleus by one or more substituents selected from halogen atoms, hydroxy and amino groups, and alkyl and alkoxy groups, or represents one of the groups -O-R 4 , -S-R 4 , SO-R 4 , SO 2 -R 4 and NR 4 R 5 , in which R 4 represents a phenyl group which may be substituted by one or more substituents selected from halogen atoms, CF 3 , OH and amino groups, alkyl and alkoxy groups having from 1 to 4 carbon atoms, and SO 2 NH 2 groups, or represents a straight or branched chain alkyl group having from 1 to 4 carbon atoms which may be substituted by a phenyl, pyridyl, furyl or thienyl group, and R 5 represents a hydrogen atom, a straight or branched chain alkyl group having from 1 to 4 carbon atoms, and the group NR 4 R 5 may represent a saturated, heterocyclic, 5- or 6-membered ring which may be interrupted by an O-, N- or S- atom, A represents a single bond, or an alkylene chain of 1 to 3 carbon atoms which may be unsaturated, interrupted by O-, N- or S-atoms or substituted by halogen atoms and/or substituted by alkyl, aralkyl, aryl groups or by mono-nuclear hetero-aromatic rings, or A represents an ortho-phenylene radical or the grouping in which Y represents a single bond or an alkylene group having from 1 to 4 carbon atoms, and R 6 and R 7 , which may be identical or different, each represents a hydrogen or halogen atom or an alkyl group having from 1 to 4 carbon atoms. They are made by standard methods. Pharmaceutical preparations having diuretic and saluretic action contain (I) as active ingredient. Administration is enterally or parenterally.

7. 发明专利

DK25982A 未知
公开(公告)号：DK25982A
公开(公告)日：1982-07-23
申请号：DK25982
申请日：1982-01-21
申请人： HOECHST AG
发明人： STURM K , MUSCHAWECK R , HROPOT M
IPC分类号： A61K31/63 , A61K31/635 , A61P7/10 , C07C67/00 , C07C301/00 , C07C303/40 , C07C311/39 , C07D307/52 , C07D333/20 , C07C
摘要： The invention relates to base-substituted anthranilic acids of the formula I in which R denotes furyl, thienyl or phenyl, and to physiologically acceptable salts thereof, and also to a process for their preparation, to an agent containing these and to their use as medicaments.

8. 发明专利

DK109081A 未知
公开(公告)号：DK109081A
公开(公告)日：1981-09-12
申请号：DK109081
申请日：1981-03-10
申请人： HOECHST AG
发明人： STURM K , MUSCHAWECK R
IPC分类号： A61K31/18 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/63 , A61P7/10 , C07C67/00 , C07C301/00 , C07C303/32 , C07C303/40 , C07C311/39 , C07D307/52 , C07D333/20 , C07C
摘要： The present invention relates to compounds of the formula I wherein R is furyl, thienyl or phenyl, to physiologically acceptable salts thereof, to a process for their manufacture, to a composition comprising said compounds and to their use as a medicament.

9. 发明专利

DK193980A 未知
公开(公告)号：DK193980A
公开(公告)日：1980-11-05
申请号：DK193980
申请日：1980-05-01
申请人： HOECHST AG
发明人： MERKEL W , BORMANN D , MUSCHAWECK R
IPC分类号： C07D207/06 , A61K31/40 , A61K31/4025 , A61P7/10 , C07D207/20 , C07D207/32 , C07D207/327 , C07D213/65 , C07D295/02 , C07D295/033 , C07D333/24 , C07D401/12 , C07D409/10 , C07D

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