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1. 发明授权

US5968817A DNA encoding serotonin receptors 失效
标题翻译：编码血清素受体的DNA
公开(公告)号：US5968817A
公开(公告)日：1999-10-19
申请号：US31538
申请日：1993-03-15
申请人： J. Gregor Sutcliffe , Mark G. Erlander , Timothy W. Lovenberg
发明人： J. Gregor Sutcliffe , Mark G. Erlander , Timothy W. Lovenberg
IPC分类号： C07K14/705 , C12N15/12
CPC分类号： C07K14/70571
摘要： The present invention describes nucleic acid molecules encoding human serotonin receptors, recombinant serotonin receptor proteins, cultured cells expressing recombinant serotonin receptor proteins, antibodies immunoreactive with serotonin receptor proteins, polypeptide serotonin receptor antagonists, oligonucleotide probes used for detecting nucleic acids which encode a human serotonin receptor, and nonhuman transgenic animals which express recombinant human serotonin receptor. Also disclosed are methods for screening for ligand binding to the described serotonin receptors and for serotonin receptor agonists and antagonists, for detection of serotonin receptors in tissues, and for therapeutic treatments involving the described human serotonin receptors.
摘要翻译：本发明描述了编码人5-羟色胺受体的核酸分子，重组5-羟色胺受体蛋白，表达重组5-羟色胺受体蛋白的培养细胞，与5-羟色胺受体蛋白免疫反应的抗体，多肽血清素受体拮抗剂，用于检测编码人血清素受体的核酸的寡核苷酸探针，以及表达重组人血清素受体的非人类转基因动物。还公开了筛选与所述5-羟色胺受体和5-羟色胺受体激动剂和拮抗剂结合的配体，用于检测组织中的5-羟色胺受体以及涉及所述人血清素受体的治疗性治疗的方法。

2. 发明授权

US06723841B2 Corticotropin-releasing factor2 receptors 失效
标题翻译：促肾上腺皮质激素释放因子2受体
公开(公告)号：US06723841B2
公开(公告)日：2004-04-20
申请号：US09881401
申请日：2001-06-13
申请人： Timothy W. Lovenberg , Tilman Oltersdorf , Chen Wang Liaw , Dimitri E. Grigoriadis , Derek T. Chalmers , Errol B. DeSouza
发明人： Timothy W. Lovenberg , Tilman Oltersdorf , Chen Wang Liaw , Dimitri E. Grigoriadis , Derek T. Chalmers , Errol B. DeSouza
IPC分类号： C12N1563
CPC分类号： C07K14/72 , A61K38/2228
摘要： The present invention provides isolated nucleic acid molecules encoding CRF2 receptors, recombinant expression vectors and host cells suitable for expressing such receptors, as well as compositions and methods which utilize such receptors.
摘要翻译：本发明提供编码CRF2受体的分离的核酸分子，适用于表达这种受体的重组表达载体和宿主细胞，以及利用这种受体的组合物和方法。

3. 发明授权

US06413743B1 DNA encoding a human histamine receptor of the H3 subtype 有权
公开(公告)号：US06413743B1
公开(公告)日：2002-07-02
申请号：US09642855
申请日：2000-08-21
申请人： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
发明人： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
IPC分类号： C12N510
CPC分类号： C07K14/723 , C12N2799/026
摘要： DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

4. 发明授权

US06291476B1 Pyrazole carboxamides useful for the treatment of obesity and other disorders 失效
标题翻译：用于治疗肥胖症和其他疾病的吡唑甲酰胺
公开(公告)号：US06291476B1
公开(公告)日：2001-09-18
申请号：US09563190
申请日：2000-05-02
申请人： Cheryl P. Kordik , Timothy W. Lovenberg , Allen B. Reitz
发明人： Cheryl P. Kordik , Timothy W. Lovenberg , Allen B. Reitz
IPC分类号： C07D40112
CPC分类号： C07D401/12 , C07D231/14 , C07D403/12 , C07D405/12 , C07D417/12 , C07D473/34
摘要： Pyrazole carboxamide derivatives of the formula: which are ligands for the neuropeptide Y, subtype 5 receptor, and pharmaceutical compositions containing a pyrazole carboxamide derivative as the active ingredient are described. The pyrazole carboxamides are useful in the treatment of disorders and diseases associated with the NPY receptor subtype Y5.
摘要翻译：描述了下式的吡唑甲酰胺衍生物：其是神经肽Y，亚型5受体的配体和含有吡唑甲酰胺衍生物作为活性成分的药物组合物。吡唑甲酰胺可用于治疗与NPY受体亚型Y5相关的疾病和疾病。

5. 发明授权

US6140354A N-substituted aminotetralins as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders 有权
标题翻译：作为用于治疗肥胖症和其他疾病的神经肽Y Y5受体的配体的N-取代的氨基四氢萘酮
公开(公告)号：US6140354A
公开(公告)日：2000-10-31
申请号：US290651
申请日：1999-04-12
申请人： Scott L. Dax , Timothy W. Lovenberg , James McNally , Allen B. Reitz , Mark A. Youngman
发明人： Scott L. Dax , Timothy W. Lovenberg , James McNally , Allen B. Reitz , Mark A. Youngman
IPC分类号： A61K31/18 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/415 , A61K31/4164 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/12 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07C311/05 , C07C311/15 , C07C311/18 , C07C311/20 , C07C311/21 , C07C311/22 , C07C311/25 , C07C311/29 , C07C311/37 , C07C311/41 , C07C317/14 , C07D213/16 , C07D213/38 , C07D233/54 , C07D233/64 , C07D307/52 , C07D333/20 , C07D333/34 , A61K31/505 , C07D211/82 , C07D307/08
CPC分类号： C07D233/64 , C07C311/18 , C07C311/29 , C07C311/37 , C07C317/14 , C07D213/38 , C07D307/52 , C07D333/20 , C07D333/34
摘要： .beta.-Aminotetralin derivatives of the formula: ##STR1## which are ligands for the neuropeptide Y Y5 (NPY5) receptor, methods of preparation and pharmaceutical compositions containing a .beta.-aminotetralin derivative as the active ingredient are described. The .beta.-aminotetralins are useful in the treatment of disorders and diseases associated with NPY receptor subtype Y5.
摘要翻译：描述了下式的β-阿米托蒽衍生物：其是神经肽Y Y5（NPY5）受体的配体，制备方法和含有β-氨基三氢化萘衍生物作为活性成分的药物组合物。 β-aminotetralins可用于治疗与NPY受体亚型Y5相关的疾病和疾病。

6. 发明授权

US08148056B2 Methods of identifying modulators of GPR81 receptors 有权
标题翻译：鉴定GPR81受体调节剂的方法
公开(公告)号：US08148056B2
公开(公告)日：2012-04-03
申请号：US12080448
申请日：2008-04-01
申请人： Changlu Liu , Timothy W. Lovenberg , Jiejun Wu
发明人： Changlu Liu , Timothy W. Lovenberg , Jiejun Wu
IPC分类号： C12Q1/00 , G01N33/53
CPC分类号： C07K14/705 , G01N33/566
摘要： Complexes of GPR81 receptor components and ligand components, such as L-lactate or GHB, may be used as an assay reagent for screening for modulators of GPR81 receptor activity.
摘要翻译： GPR81受体组分和配体组分如L-乳酸盐或GHB的复合物可用作筛选GPR81受体活性调节剂的测定试剂。

7. 发明申请

US20110104711A1 GPR81-Ligand complexes and their preparation and use 有权
标题翻译： GPR81配体配合物及其制备与应用
公开(公告)号：US20110104711A1
公开(公告)日：2011-05-05
申请号：US12080448
申请日：2008-04-01
申请人： Changlu Liu , Timothy W. Lovenberg , Jiejun Wu
发明人： Changlu Liu , Timothy W. Lovenberg , Jiejun Wu
IPC分类号： G01N33/53 , C07K14/00 , C07H21/04
CPC分类号： C07K14/705 , G01N33/566
摘要： Complexes of GPR81 receptor components and ligand components, such as L-lactate or GHB, may be used as an assay reagent for screening for modulators of GPR81 receptor activity.
摘要翻译： GPR81受体组分和配体组分如L-乳酸盐或GHB的复合物可用作筛选GPR81受体活性调节剂的测定试剂。

8. 发明授权

US07618786B2 Method for identifying modulators of human orexin-2 receptor 有权
标题翻译：鉴别人食欲素-2受体调节剂的方法
公开(公告)号：US07618786B2
公开(公告)日：2009-11-17
申请号：US10537732
申请日：2003-12-11
申请人： Steven W. Sutton , Timothy W. Lovenberg
发明人： Steven W. Sutton , Timothy W. Lovenberg
IPC分类号： G01N33/53 , G01N33/566 , G01N33/567 , C12N15/85 , C12N5/08
CPC分类号： G01N33/6893 , C07K14/70571 , G01N33/566 , G01N2500/04 , G01N2800/2864
摘要： The present invention provides a new method for identifying modulators of human orexin-2 receptor without utilizing recombinantly produced nucleic acid molecules encoding human orexin receptor protein. This method combines and utilizes known methods and cell lines selected for their natural expression of orexin-2 receptors to carry out the methods of the present invention. Exemplary methods of the present invention utilize PFSK-1 cells to produce non-recombinant human orexin-2 receptor protein.
摘要翻译：本发明提供了用于鉴别人食欲素-2受体调节剂的新方法，而不使用重组产生的编码人食欲素受体蛋白的核酸分子。该方法结合并利用为食欲素-2受体天然表达而选择的已知方法和细胞系，以实现本发明的方法。本发明的示例性方法利用PFSK-1细胞产生非重组人食欲素-2受体蛋白。

9. 发明授权

US06437100B1 DNA encoding a human histamine receptor of the H3 subtype 有权
标题翻译：编码H3亚型人体组胺受体的DNA
公开(公告)号：US06437100B1
公开(公告)日：2002-08-20
申请号：US09642514
申请日：2000-08-21
申请人： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
发明人： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
IPC分类号： C07K1628
CPC分类号： C07K14/723 , C12N2799/026
摘要： DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译：已经克隆并表征了编码人组胺H3受体的DNA。重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。重组蛋白也从重组宿主细胞中纯化。此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。

10. 发明授权

US06436939B2 Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as H3 antagonists 失效
标题翻译：使用2-芳氧基烷基氨基苯并唑和2-芳氧基烷基氨基苯并噻唑作为H3拮抗剂的方法
公开(公告)号：US06436939B2
公开(公告)日：2002-08-20
申请号：US09821215
申请日：2001-03-29
申请人： Nicholas I. Carruthers , Xiaobing Li , Timothy W. Lovenberg
发明人： Nicholas I. Carruthers , Xiaobing Li , Timothy W. Lovenberg
IPC分类号： A61K31495
CPC分类号： C07D209/12 , A61K31/423 , A61K31/428 , C07D401/12 , C07D403/12 , C07D471/04
摘要： The invention features methods of using pharmaceutically-active 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzthiazoles and derivatives.
摘要翻译：本发明的特征在于使用药用活性2-芳氧基烷基氨基苯并唑和2-芳氧基烷基氨基苯并噻唑及其衍生物的方法。

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