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1. 发明申请

US20070038082A1 Medical diagnostic ultrasound transducer system for harmonics 有权
标题翻译：医用诊断超声波传感器系统谐波
公开(公告)号：US20070038082A1
公开(公告)日：2007-02-15
申请号：US11192857
申请日：2005-07-28
申请人： Jian-Hua Mo , Timothy Proulx , Charles Bradley
发明人： Jian-Hua Mo , Timothy Proulx , Charles Bradley
IPC分类号： A61B8/00 , A61B8/14
CPC分类号： B06B1/064 , G01S7/52038 , G01S15/8952
摘要： A medical diagnostic ultrasound transducer system has at least a first and a second set of transducer layers of an element. Each set has one or more transducer layers with independent electrical access. A transmit event through a first set of transducer layers with broadband electrical signals generates acoustic signals containing at least two different frequency bands, and a receive event through a second and different set of transducer layers receives multiple tissue harmonic signals to generate a wide bandwidth response. Fundamental signals can be reduced with a pulse inversion technique through a second transmit event of inverted pulses, a second receive event and superposition of signals from the two receive events.
摘要翻译：医疗诊断超声换能器系统具有元件的至少第一和第二组换能器层。每组具有一个或多个具有独立电接入的换能器层。通过具有宽带电信号的第一组换能器层的发射事件产生包含至少两个不同频带的声学信号，并且通过第二和不同组的换能器层的接收事件接收多个组织谐波信号以产生宽带宽响应。可以通过脉冲反转技术通过反向脉冲的第二发送事件，第二接收事件和来自两个接收事件的信号的叠加来减少基本信号。

2. 发明申请

US20070167752A1 Ultrasound imaging transducer array for synthetic aperture 有权
标题翻译：用于合成孔径的超声成像换能器阵列
公开(公告)号：US20070167752A1
公开(公告)日：2007-07-19
申请号：US11295794
申请日：2005-12-07
申请人： Timothy Proulx , Christopher Daft , J. Mohr , Walter Wilser , Charles Bradley , Paul Wagner , Igal Ladabaum
发明人： Timothy Proulx , Christopher Daft , J. Mohr , Walter Wilser , Charles Bradley , Paul Wagner , Igal Ladabaum
IPC分类号： A61B8/00
CPC分类号： G01S7/52095 , A61B8/483 , G01S15/892 , G01S15/8925 , G01S15/8927 , G01S15/8959 , G01S15/8995 , G01S15/8997
摘要： Synthetic transmit aperture is provided for three-dimensional ultrasound imaging. A transducer may have separate transmit and receive elements. Broad beams are transmitted, allowing fewer transmit elements and/or more rapid scanning. A multidimensional receive array generates data in response to sequential transmissions, such as transmissions from different angles. The data is combined to increase resolution. A transducer array with offset transmit elements for forming a transmit line source may be used.
摘要翻译：为三维超声成像提供合成发射孔径。传感器可以具有单独的发射和接收元件。传输宽波束，允许更少的发射元件和/或更快速的扫描。多维接收阵列响应于顺序传输产生数据，例如来自不同角度的传输。数据被组合以提高分辨率。可以使用具有用于形成发射线源的偏移发射元件的换能器阵列。

3. 发明申请

US20130274281A1 METHODS OF TREATING METASTATIC BREAST CANCER WITH 4-IODO-3-NITROBENZAMIDE AND IRINOTECAN 审中-公开
标题翻译：用4-碘代-3-硝基苯甲酰胺和紫杉醇治疗异位乳腺癌的方法
公开(公告)号：US20130274281A1
公开(公告)日：2013-10-17
申请号：US13811193
申请日：2011-07-19
申请人： Charles Bradley
发明人： Charles Bradley
IPC分类号： A61K31/4745 , A61K31/166
CPC分类号： A61K31/4745 , A61K31/166 , A61K31/555 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： Provided herein are methods, compositions and kits for the treatment of locally advanced or metastatic breast cancer or breast cancer brain metastases. The method comprises administration of 4-iodo-3-nitrobenzamide, a metabolite or salt thereof in combination with irinotecan. The method of treating locally advanced or metastatic breast cancer comprises at least one 21 day treatment cycle.
摘要翻译：本文提供了用于治疗局部晚期或转移性乳腺癌或乳腺癌脑转移的方法，组合物和试剂盒。该方法包括与伊立替康联合施用4-碘-3-硝基苯甲酰胺，其代谢物或盐。治疗局部晚期或转移性乳腺癌的方法包括至少21天的治疗周期。

4. 发明授权

US06221018B1 Medical ultrasonic diagnostic imaging method and apparatus 有权
标题翻译：医用超声诊断成像方法及装置
公开(公告)号：US06221018B1
公开(公告)日：2001-04-24
申请号：US09634115
申请日：2000-08-08
申请人： Bhaskar S. Ramamurthy , Charles Bradley , Ken Sawatari , Danhua Zhao , Stuart L. Carp , Stirling S. Dodd , David J. Hedberg , Samuel H. Maslak , Daniel E. Need
发明人： Bhaskar S. Ramamurthy , Charles Bradley , Ken Sawatari , Danhua Zhao , Stuart L. Carp , Stirling S. Dodd , David J. Hedberg , Samuel H. Maslak , Daniel E. Need
IPC分类号： A61B800
CPC分类号： A61B8/481 , G01S7/5202 , G01S7/52038 , G01S15/8915 , G01S15/8927 , G01S15/895
摘要： A medical diagnostic ultrasonic imaging method and system subdivide the transmit aperture into two or more subapertures, each subaperture having at least four adjacent transducer elements. The subapertures are phased differently with respect to one another to selectively reduce either fundamental components or harmonic components of echoes from tissue. These techniques can be used to improve contrast agent harmonic imaging as well as tissue harmonic imaging, depending upon the phase shift selected.
摘要翻译：医学诊断超声成像方法和系统将发射孔径细分为两个或更多个子孔径，每个子孔径具有至少四个相邻的换能器元件。子孔径相对于彼此不同地相位选择性地降低来自组织的回波的基本分量或谐波分量。这些技术可以用于根据选择的相移来改善造影剂谐波成像以及组织谐波成像。

5. 发明授权

US07732491B2 Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents 失效
标题翻译：用PARP抑制剂单独或与抗肿瘤剂组合治疗乳腺癌
公开(公告)号：US07732491B2
公开(公告)日：2010-06-08
申请号：US12269024
申请日：2008-11-11
申请人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
发明人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
IPC分类号： A61K31/166
CPC分类号： A61K31/166 , A61K31/00 , A61K31/282 , A61K31/337 , A61K31/555 , A61K31/7068 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要翻译：一方面，本发明提供一种治疗对于ER，PR或HER2中的至少一种呈阴性的乳腺癌的方法，包括向受试者施用至少一种PARP抑制剂。另一方面，本发明提供了一种治疗乳腺癌的方法，其包括向受试者施用至少一种PARP抑制剂与至少一种抗肿瘤剂的组合。

6. 发明申请

US20090123419A1 TREATMENT OF UTERINE CANCER AND OVARIAN CANCER WITH A PARP INHIBITOR ALONE OR IN COMBINATION WITH ANTI-TUMOR AGENTS 审中-公开
标题翻译：用PARP抑制剂治疗子宫癌和卵巢癌与抗肿瘤药物联合治疗
公开(公告)号：US20090123419A1
公开(公告)日：2009-05-14
申请号：US12269833
申请日：2008-11-12
申请人： Barry M. Sherman , Charles Bradley , Valeria Ossovskaya
发明人： Barry M. Sherman , Charles Bradley , Valeria Ossovskaya
IPC分类号： A61K38/21 , A61K31/166 , A61P35/00 , A61K31/505 , A61K31/337 , A61K31/513 , A61K39/395 , C12Q1/68
CPC分类号： A61K31/505 , A61K31/166 , A61K31/337 , A61K31/513 , A61K38/212 , A61K38/215 , A61K38/217 , A61K45/06 , C12Q1/6886 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要翻译：一方面，本发明提供一种治疗子宫癌，子宫内膜癌或卵巢癌的方法，包括向受试者施用至少一种PARP抑制剂。另一方面，本发明提供了一种治疗子宫癌，子宫内膜癌或卵巢癌的方法，包括向受试者施用至少一种PARP抑制剂与至少一种抗肿瘤剂组合。

7. 发明申请

US20070083109A1 Adaptive line synthesis for ultrasound 审中-公开
标题翻译：自适应线合成超声波
公开(公告)号：US20070083109A1
公开(公告)日：2007-04-12
申请号：US11238889
申请日：2005-09-28
申请人： Kutay Ustuner , D-L Liu , Lewis Thomas , Charles Bradley , Anming Cai , Robert Phelps , John Lazenby
发明人： Kutay Ustuner , D-L Liu , Lewis Thomas , Charles Bradley , Anming Cai , Robert Phelps , John Lazenby
IPC分类号： A61B8/00
CPC分类号： G01S7/52046 , G01S7/5209 , G01S7/52095 , G01S15/8959
摘要： Adaptive line synthesis is provided. Line synthesis of collinear receive beams responsive to spatially distinct transmit beams is a function of many parameters, such as spatial or temporal frequency response of one or more of the receive beams, synthesis function, number of receive beams synthesized, or acquisition sequence. One or more of these parameters is set or adapts as a function of processor estimated or user provided information. By adapting the line synthesis, the performance and image quality is optimized as appropriate for the received data or desired imaging, such as detail resolution, contrast resolution, temporal resolution, shift-invariance and penetration.
摘要翻译：提供自适应线合成。响应于空间不同的发射波束的共线接收波束的线路合成是许多参数的函数，例如接收波束中的一个或多个的合成函数，合成函数，接收波束的数量或采集序列的空间或时间频率响应。这些参数中的一个或多个被设置或根据处理器估计或用户提供的信息进行调整。通过适应线路合成，根据接收到的数据或所需的成像（如细节分辨率，对比度分辨率，时间分辨率，偏移不变性和穿透），性能和图像质量得到优化。

8. 发明授权

US07509885B2 Transmission auxiliary unit timed shift inhibitor 有权
标题翻译：变速器辅助单元定时变速抑制器
公开(公告)号：US07509885B2
公开(公告)日：2009-03-31
申请号：US11284668
申请日：2005-11-22
申请人： Kurt Gerlofs , Dave Stevens , Mark Hirsch , Charles Bradley , Michael J. Huggins , Gerard F. Smith , Michael E. Lemon
发明人： Kurt Gerlofs , Dave Stevens , Mark Hirsch , Charles Bradley , Michael J. Huggins , Gerard F. Smith , Michael E. Lemon
IPC分类号： F16H59/68
CPC分类号： F16H61/705 , F16H61/16 , F16H61/702 , F16H63/34 , F16H63/36 , F16H2306/20 , Y10T74/19167 , Y10T74/19219 , Y10T74/19223 , Y10T74/19233 , Y10T74/19251 , Y10T74/19284
摘要： An embodiment provides a shift inhibitor apparatus. At least a portion of the range actuating assembly is moveable between a range first ratio and a range second ratio. The portion of the range actuating assembly is moveable, at least in part, in response to a fluid pressure. The range chamber is selectively in fluid communication with a vent. The shift inhibitor includes a main section neutral interlock having an interlock chamber. At least a portion of the main section neutral interlock is moveable between a first condition and a second condition. The interlock chamber is selectively in fluid communication with the vent. The range chamber can be exhausted such that the range section is selectively switched from the first ratio to the second ratio. The interlock chamber can be exhausted such that the main section neutral interlock is selectively switched from the first condition to the second condition.
摘要翻译：一个实施例提供了一种换挡抑制装置。范围致动组件的至少一部分可在范围第一比率和范围第二比例之间移动。范围致动组件的部分至少部分地响应于流体压力是可移动的。范围室选择性地与排气口流体连通。换档抑制器包括具有互锁室的主部分中空互锁。主部分中空联锁的至少一部分可在第一状态和第二状态之间移动。互锁室选择性地与排气口流体连通。范围室可以被耗尽，使得范围部分被选择性地从第一比率切换到第二比率。联锁室可以被排出，使得主区段中立互锁从第一状态选择性地切换到第二状态。

9. 发明申请

US20060241454A1 Transmit multibeam for compounding ultrasound data 审中-公开
标题翻译：发送复合超声数据的多波束
公开(公告)号：US20060241454A1
公开(公告)日：2006-10-26
申请号：US11099866
申请日：2005-04-05
申请人： Kutay Ustuner , Anming Cai , Charles Bradley
发明人： Kutay Ustuner , Anming Cai , Charles Bradley
IPC分类号： A61B8/00
CPC分类号： G01S15/8995 , A61B8/00 , A61B8/4483 , G01S7/5209 , G01S7/52092 , G01S7/52095
摘要： Transmit multibeams insonify an object with multiple noncollinear transmit beams fired substantially simultaneously. The noncollinear beams are along different scan lines of same scan geometry, or they belong to scan lines of different scan geometries. One or more receive beams are formed in parallel in response to each of the noncollinear beams. The scan geometry and/or center frequency is varied between the noncollinear transmit beams of a transmit event. By scanning the transmit multibeam, and varying the scan geometry and/or frequency between the noncollinear transmit beams of a transmit event, multiple component images are generated for compounding. The component images are scan-converted (if scan geometries are different), weighted and combined after envelope detection.
摘要翻译：发射多波束使多个基本同时发射的非共线发射波束对象物体失真。非共线光束沿相同扫描几何的不同扫描线，或者它们属于不同扫描几何形状的扫描线。一个或多个接收波束响应于每个非共线波束平行地形成。扫描几何和/或中心频率在发射事件的非共线发射波束之间变化。通过扫描发射多波束，并改变发射事件的非共线发射波束之间的扫描几何形状和/或频率，生成多个分量图像进行复合。组件图像进行扫描转换（如果扫描几何不同），在包络检测后加权和组合。

10. 发明申请

US20060185456A1 Transmission auxiliary unit timed shift inhibitor 有权
公开(公告)号：US20060185456A1
公开(公告)日：2006-08-24
申请号：US11284668
申请日：2005-11-22
申请人： Kurt Gerlofs , Dave Stevens , Mark Hirsch , Charles Bradley , Michael Huggins , Gerard Smith , Michael Lemon
发明人： Kurt Gerlofs , Dave Stevens , Mark Hirsch , Charles Bradley , Michael Huggins , Gerard Smith , Michael Lemon
IPC分类号： F16H3/08
CPC分类号： F16H61/705 , F16H61/16 , F16H61/702 , F16H63/34 , F16H63/36 , F16H2306/20 , Y10T74/19167 , Y10T74/19219 , Y10T74/19223 , Y10T74/19233 , Y10T74/19251 , Y10T74/19284
摘要： An embodiment provides a shift inhibitor apparatus. At least a portion of the range actuating assembly is moveable between a range first ratio and a range second ratio. The portion of the range actuating assembly is moveable, at least in part, in response to a fluid pressure. The range chamber is selectively in fluid communication with a vent. The shift inhibitor includes a main section neutral interlock having an interlock chamber. At least a portion of the main section neutral interlock is moveable between a first condition and a second condition. The interlock chamber is selectively in fluid communication with the vent. The range chamber can be exhausted such that the range section is selectively switched from the first ratio to the second ratio. The interlock chamber can be exhausted such that the main section neutral interlock is selectively switched from the first condition to the second condition.

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