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1. 发明申请

US20100008879A1 Whitening agent 审中-公开
标题翻译：美白剂
公开(公告)号：US20100008879A1
公开(公告)日：2010-01-14
申请号：US12585271
申请日：2009-09-10
申请人： Kenichi Umishio , Kazuhisa Maeda , Koji Kobayashi
发明人： Kenichi Umishio , Kazuhisa Maeda , Koji Kobayashi
IPC分类号： A61K8/97 , A61Q19/02
CPC分类号： A61Q19/02 , A61K8/97
摘要： A whitening agent containing a solvent extract of a plant Elephantopus mollis H. B. & K. belonging to Compositae having a superior whitening action and having a superior effect in lightening and whitening pigmentation after suntans, senile lentigo, freckles, melasma, is provided.
摘要翻译：本发明提供含有具有优异的美白作用并且在晒黑，老年性斑疹，雀斑，黑斑病之后的减轻和增白色素沉着的优异效果的植物的属于菊科植物的Elephantopus mollis H.B.＆K.的溶剂提取物的增白剂。

2. 发明申请

US20080003189A1 Whitening Agent 审中-公开
标题翻译：美白剂
公开(公告)号：US20080003189A1
公开(公告)日：2008-01-03
申请号：US11662284
申请日：2005-09-15
申请人： Kenichi Umishio , Kazuhisa Maeda , Koji Kobayashi
发明人： Kenichi Umishio , Kazuhisa Maeda , Koji Kobayashi
IPC分类号： A61K36/28 , A61K127/00 , A61K129/00 , A61Q19/02 , A61K131/00
CPC分类号： A61Q19/02 , A61K8/97
摘要： A whitening agent containing a solvent extract of a plant Elephantopus mollis H. B. & K. belonging to Compositae having a superior whitening action and having a superior effect in lightening and whitening pigmentation after suntans, senile lentigo, freckles, melasma, is provided.
摘要翻译：本发明提供含有具有优异的美白作用并且在晒黑，老年性斑疹，雀斑，黑斑病之后的减轻和增白色素沉着的优异效果的植物的属于菊科植物的Elephantopus mollis H.B.＆K.的溶剂提取物的增白剂。

3. 发明申请

US20070172444A1 Hair tonics and method of screening the same 审中-公开
标题翻译：发质和筛选方法相同
公开(公告)号：US20070172444A1
公开(公告)日：2007-07-26
申请号：US11649279
申请日：2007-01-04
申请人： Toshihiko Hibino , Yumiko Tsuji , Tsutomu Soma , Sumiko Denda , Jotaro Nakanishi , Tadahito Takahashi , Kenichi Umishio , Koji Kobayashi
发明人： Toshihiko Hibino , Yumiko Tsuji , Tsutomu Soma , Sumiko Denda , Jotaro Nakanishi , Tadahito Takahashi , Kenichi Umishio , Koji Kobayashi
IPC分类号： A61K8/97 , A61K36/82 , A61K36/899 , A61K36/48 , A61K36/87
CPC分类号： A61Q5/00 , A61K8/498 , A61K8/64 , A61K8/97 , A61K31/366 , A61K36/185 , A61K36/30 , A61K36/48 , A61K36/53 , A61K36/73 , A61K36/82 , A61K36/87 , A61K36/8994 , A61K38/06 , A61K38/55 , A61K45/06 , A61K2800/782 , A61Q7/00 , A61K2300/00
摘要： There is provided a hair tonic comprising at least two of an inhibitor against 5α reductase type 2, an inhibitor against transforming growth factor β2, and an inhibitor against caspase-3; a method comprising screening for at least two of inhibition against 5α reductase type 2, inhibition against transforming growth factor β2, and inhibition against caspase-3, or comprising screening for inhibition against caspase-3 and then for apoptosis inhibition, and a hair loss inhibitor having the effect of inhibiting caspase-3, and a hair loss inhibitor having the effect of inhibiting caspase-3 and of inhibiting apoptosis.
摘要翻译：提供了包含至少两种抑制剂5型5α还原酶2型抑制剂，抗转化生长因子β2的抑制剂和抗半胱天冬酶-3抑制剂的滋补剂; 一种方法包括筛选至少两种对2型5α还原酶的抑制，对转化生长因子β2的抑制和对半胱天冬酶-3的抑制，或包括筛选对半胱天冬酶-3的抑制，然后筛选凋亡抑制，以及脱发抑制剂具有抑制半胱天冬酶-3的效果，以及具有抑制半胱天冬酶-3的作用并抑制细胞凋亡的脱发抑制剂。

4. 发明申请

US20060153794A1 Hair tonics and method of screening the same 审中-公开
标题翻译：发质和筛选方法相同
公开(公告)号：US20060153794A1
公开(公告)日：2006-07-13
申请号：US11312549
申请日：2005-12-21
申请人： Toshihiko Hibino , Yumiko Tsuji , Tsutomu Soma , Sumiko Denda , Jotaro Nakanishi , Tadahito Takahashi , Kenichi Umishio , Koji Kobayashi
发明人： Toshihiko Hibino , Yumiko Tsuji , Tsutomu Soma , Sumiko Denda , Jotaro Nakanishi , Tadahito Takahashi , Kenichi Umishio , Koji Kobayashi
IPC分类号： A61K8/97 , A61K36/185
CPC分类号： A61Q5/00 , A61K8/498 , A61K8/64 , A61K8/97 , A61K31/366 , A61K36/185 , A61K36/30 , A61K36/48 , A61K36/53 , A61K36/73 , A61K36/82 , A61K36/87 , A61K36/8994 , A61K38/06 , A61K38/55 , A61K45/06 , A61K2800/782 , A61Q7/00 , A61K2300/00
摘要： There is provided a hair tonic comprising at least two of an inhibitor against 5α reductase type 2, an inhibitor against transforming growth factor β2, and an inhibitor against caspase-3; a method comprising screening for at least two of inhibition against 5α reductase type 2, inhibition against transforming growth factor β2, and inhibition against caspase-3, or comprising screening for inhibition against caspase-3 and then for apoptosis inhibition, and a hair loss inhibitor having the effect of inhibiting caspase-3, and a hair loss inhibitor having the effect of inhibiting caspase-3 and of inhibiting apoptosis.
摘要翻译：提供了包含至少两种抑制剂5型5α还原酶2型抑制剂，抗转化生长因子β2的抑制剂和抗半胱天冬酶-3抑制剂的滋补剂; 一种方法包括筛选至少两种对2型5α还原酶的抑制，对转化生长因子β2的抑制和对半胱天冬酶-3的抑制，或包括筛选对半胱天冬酶-3的抑制，然后筛选凋亡抑制，以及脱发抑制剂具有抑制半胱天冬酶-3的效果，以及具有抑制半胱天冬酶-3的作用并抑制细胞凋亡的脱发抑制剂。

5. 发明授权

US6057337A 1,2-DI-substituted piperidine derivative, hair growth promoter and external composition for skin using the same 有权
标题翻译： 1,2-DI取代的哌啶衍生物，毛发生长促进剂和使用其的皮肤外用组合物
公开(公告)号：US6057337A
公开(公告)日：2000-05-02
申请号：US239960
申请日：1999-01-29
申请人： Koji Kobayashi , Hirotada Fukunishi , Kenichi Umishio , Akihiro Ishino
发明人： Koji Kobayashi , Hirotada Fukunishi , Kenichi Umishio , Akihiro Ishino
IPC分类号： C07D211/22 , C07D211/26 , C07D401/12 , C07D521/00 , A61K7/06
CPC分类号： C07D231/12 , C07D211/22 , C07D211/26 , C07D233/56 , C07D249/08 , C07D401/12
摘要： A 1,2-di-substituted piperidine derivative or a salt thereof expressed by the following Formula (I): ##STR1## wherein one of A and B is a hydrocarbon group of C.sub.1-30 expressed by R.sup.1 and the other is --(CH.sub.2)n-NR.sup.2 R.sup.3 ; Y is --CO--, --CONR.sup.5 -- or --COO--; Z is --O--, --OCO--, --OCONR.sup.6 -- or --NR.sup.6 --; R.sup.2 and R.sup.3 individually represent a hydrogen a lower alkyl, a phenyl or a benzyl group, or together represent a heterocycle having 3-7 members; --NR.sup.5 --(CH.sub.2)n-NR.sup.2 R.sup.3 and --NR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3 of --(Y).sub.1 --A and --Z--B may be the following Group W: ##STR2## wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R.sup.2 is a hydrogen, a lower alkyl, a phenyl or a benzyl group; R.sup.4 is a hydrogen, a halogen, a lower alkyl, a lower acyl, a nitro, a cyano, a lower alkoxycarbonyl, a carbamoyl, a lower alkylcarbamoyl, a lower alkylamino, a lower acylamino, a lower alkoxy or a lower acyloxy group; each of R.sup.5 and R.sup.6 is a hydrogen, a lower alkyl, a lower acyl, a lower alkylcarbamoyl group, or a part of said ring E; l is 0 or 1; m is an integer of 2-5; and n is an integer of 0-5. The 1,2-di-substituted piperidine derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.
摘要翻译：由下式（I）表示的1,2-二取代的哌啶衍生物或其盐：其中A和B中的一个为由R1表示的C1-30的烃基，另一个为 - （CH 2）n - NR2R3; Y是-CO - ， - CONR 5 - 或-COO-; Z是-O - ， - OCO - ， - OCONR 6 - 或-NR 6 - ; R2和R3各自表示氢，低级烷基，苯基或苄基，或一起表示具有3-7个成员的杂环; - （Y）1-A和-ZB的-NR 5 - （CH 2）n -NR 2 R 3和-NR 6 - （CH 2）n -NR 2 R 3可以是以下W组：其中环E是6或7个成员的杂环，包括两个氮原子，R 2为氢，低级烷基，苯基或苄基; R4是氢，卤素，低级烷基，低级酰基，硝基，氰基，低级烷氧基羰基，氨基甲酰基，低级烷基氨基甲酰基，低级烷基氨基，低级酰基氨基，低级烷氧基或低级酰氧基。 R5和R6各自为氢，低级烷基，低级酰基，低级烷基氨基甲酰基或所述环E的一部分; l为0或1; m为2-5的整数; n为0-5的整数。 1,2-二取代的哌啶衍生物或其盐具有优异的毛发生长和再生长促进效果，其可用于哺乳动物，特别是人的护发，改善或预防脱发。

6. 发明授权

US06204264B1 Benzimidazole derivative, hair growth promoter and external composition for skin using the same 失效
标题翻译：苯并咪唑衍生物，毛发生长促进剂和皮肤外用组合物
公开(公告)号：US06204264B1
公开(公告)日：2001-03-20
申请号：US09398200
申请日：1999-09-17
申请人： Koji Kobayashi , Hirotada Fukunishi , Kenichi Umishio , Masahiro Tajima
发明人： Koji Kobayashi , Hirotada Fukunishi , Kenichi Umishio , Masahiro Tajima
IPC分类号： A61R31535
CPC分类号： C07D235/24 , A61K8/4946 , A61Q7/00 , C07D235/08
摘要： A benzimidazole derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C10-30 expressed by R1 and the other is —(CH2)n—NR2R3; R2 and R3 individually represent H, lower alkyl, phenyl or benzyl, or —NR2R3 may be a heterocycle having 3-7 members, or —CONR5—(CH2)n—NR2R3 may be the following Group (W): wherein R2 is H, lower alkyl, phenyl or benzyl and ring E is a heterocycle of 6 or 7 members; R4 is selected from the group consisting of H, halogen, cyano, trifluoromethyl, lower alkyl and etc.; R5 is H, lower alkyl, lower acyl or lower alkylcarbamoyl; m is 0 or 1; and n is an integer of 0-5. The benzimidazole derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.
摘要翻译：由下式（I）表示的苯并咪唑衍生物或其盐：其中A和B中的一个是由R 1表示的C 10-30的烃基，而另一个是 - （CH 2）n -NR 2 R 3; R 2和R 3各自表示H，低级烷基，苯基或苄基，或-NR 2 R 3可以是具有3-7个成员的杂环，或-CONR 5 - （CH 2）n -NR 2 R 3可以是下列基团（W）：其中R 2是H 苯基或苄基，环E是6或7个成员的杂环; R4选自H，卤素，氰基，三氟甲基，低级烷基等; R5是H，低级烷基，低级酰基或低级烷基氨基甲酰基; m为0或1; n为0-5的整数。苯并咪唑衍生物或其盐具有优异的毛发生长和再生长促进作用，其可用于哺乳动物，特别是人的护发，改善或预防脱发。

7. 发明授权

US6114325A 1,2-di-substituted benzene-carboxamide derivative, hair growth promoter and external composition for skin using the same 有权
公开(公告)号：US6114325A
公开(公告)日：2000-09-05
申请号：US176947
申请日：1998-10-22
申请人： Hirotada Fukunishi , Kenichi Umishio , Masahiro Tajima , Koji Kobayashi
发明人： Hirotada Fukunishi , Kenichi Umishio , Masahiro Tajima , Koji Kobayashi
IPC分类号： A61K8/42 , A61K8/44 , A61K8/49 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , C07C235/46 , C07C235/84 , C07C237/34 , C07C271/20 , C07C275/54 , C07C281/02 , C07D233/61 , C07D243/08 , C07D295/088 , C07D295/13 , C07D295/192 , C07D295/205 , C07D295/28 , A61K31/495 , A61K31/5513 , C07D241/04
CPC分类号： C07D295/32 , A61K8/42 , A61K8/44 , A61K8/49 , A61K8/4926 , A61K8/494 , A61Q7/00 , C07C235/46 , C07C235/84 , C07C237/34 , C07C271/20 , C07C275/54 , C07C281/02 , C07D243/08 , C07D295/088 , C07D295/13 , C07D295/192 , C07D295/205 , A61Q5/02
摘要： A 1,2-di-substituted benzene-carboxamide derivative or a salt thereof expressed by the following Formula (I); ##STR1## wherein each of A and B is R.sup.1 or --(CH.sub.2)n-NR.sup.2 R.sup.3, wherein when A is R.sup.1, B is --(CH.sub.2)n-NR.sup.2 R.sup.3 and when A is --(CH.sub.2)n-NR.sup.2 R.sup.3, B is R.sup.1 ; Z is --O--, --OCO--, --OCONR.sup.6 -- or --NR.sup.6 --; R.sup.1 is a hydrocarbon group of C.sub.10-30 ; R.sup.2 and R.sup.3 individually represent a hydrogen atom, a lower alkyl group, a phenyl group or a benzyl group, or together represent a heterocyclic ring having 3-7 members; when A is --(CH.sub.2)n-NR.sup.2 R.sup.3, R.sup.2 may be a hydrogen atom, a lower alkyl group, a phenyl group or a benzyl group, and R.sup.3 and R.sup.5 together may represent a heterocyclic ring of 6 or 7 members including two nitrogen atoms; when --Z--B is --OCONR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3 or --NR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3, R.sup.2 may be a hydrogen atom, a lower alkyl group, a phenyl group or a benzyl group, and R.sup.3 and R.sup.6 together may represent a heterocyclic ring of 6 or 7 members including two nitrogen atoms; R.sup.4 is selected from the group consisting of a halogen atom, a lower alkyl group, a lower acyl group, a nitro group, a cyano group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkylamino group, a lower acylamino group, a lower alkoxy group and a lower acyloxy group; R.sup.5 is a hydrogen atom, a lower alkyl group, a lower acyl group or a lower alkylcarbamoyl group, or when A is --(CH.sub.2)n-NR.sup.2 R.sup.3, R.sup.5 and R.sup.3 together may represent a heterocyclic ring of 6 or 7 members including two nitrogen atoms; R.sup.6 is a hydrogen atom, a lower alkyl group, a lower acyl group or a lower alkylcarbamoyl group, or when --Z--B is --OCONR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3 or --NR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3, R.sup.6 and R.sup.3 together may represent a heterocyclic ring of 6 or 7 members including two nitrogen atoms; l is an integer of 0-2; and n is an integer of 0-5. The 1,2-di-substituted benzene-carboxamide derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in humans.

8. 发明申请

US20080131384A1 External Preparation for Skin Whitening, Whitening Agent, Whitening Method and Method of Production of External Preparation for Skin Whitening 审中-公开
标题翻译：外用皮肤美白剂，美白剂，美白方法及外用皮肤美白剂制备方法
公开(公告)号：US20080131384A1
公开(公告)日：2008-06-05
申请号：US11792225
申请日：2005-12-16
申请人： Kazuhisa Maeda , Takeshi Nawamura , Koji Kobayashi , Nuan Chin
发明人： Kazuhisa Maeda , Takeshi Nawamura , Koji Kobayashi , Nuan Chin
IPC分类号： A61K8/97 , A61Q19/02
CPC分类号： A61K8/97 , A61Q19/02
摘要： An external preparation for skin whitening containing 0.001 to 20.0 mass % of an extract of at least one plant selected from the group consisting of Pilea cavaleriei (Urticaceae), Saururus chinensis (Saururaceae), Streptocaulon griffithii (Asclepiadaceae), Toddalia asiatica (Rutaceae) and Tadehagi triquetrum (Leguminosae).
摘要翻译：一种含有0.001至20.0质量％的至少一种植物提取物的外用制剂，所述植物提取物选自中华绒螯蟹（Pilea cavaleriei），中华，，（Saururus chinensis），藜科（Streptocaulon griffithii）（Asclepiadon asiatica）（芸香科） Tadehagi triquetrum（豆科）。

9. 发明授权

US09307109B2 Image processing apparatus, image processing system, and image processing method 有权
标题翻译：图像处理装置，图像处理系统和图像处理方法
公开(公告)号：US09307109B2
公开(公告)日：2016-04-05
申请号：US14316359
申请日：2014-06-26
申请人： Hirohisa Inamoto , Koji Kobayashi , Yuka Kihara
发明人： Hirohisa Inamoto , Koji Kobayashi , Yuka Kihara
IPC分类号： H04N1/04 , G06K9/20 , H04N1/00 , G06K9/18 , G06K9/00
CPC分类号： H04N1/04 , G06K9/00449 , G06K9/18 , G06K9/2063 , G06K2209/01 , H04N1/00968
摘要： An image processing apparatus is disclosed, including a marking position detection part and a first character recognition part. The marking position detection part detects a marking position with respect to a first sheet based on first image data scanned from the first sheet. The first character recognition part conducts a first character recognition with respect to an area specified based on the marking position, for second image data scanned from a second sheet.
摘要翻译：公开了一种图像处理装置，包括标记位置检测部分和第一字符识别部分。标记位置检测部分基于从第一片材扫描的第一图像数据来检测相对于第一片材的标记位置。第一字符识别部分对于从第二片材扫描的第二图像数据，相对于基于标记位置指定的区域进行第一字符识别。

10. 发明申请

US20140049788A1 IMAGE PROCESSING APPARATUS, IMAGE PROCESSING SYSTEM, AND IMAGE PROCESSING METHOD 审中-公开
标题翻译：图像处理设备，图像处理系统和图像处理方法
公开(公告)号：US20140049788A1
公开(公告)日：2014-02-20
申请号：US14065015
申请日：2013-10-28
申请人： Hirohisa INAMOTO , Koji Kobayashi , Yuka Kihara
发明人： Hirohisa INAMOTO , Koji Kobayashi , Yuka Kihara
IPC分类号： H04N1/00
CPC分类号： H04N1/04 , G06K9/00449 , G06K9/18 , G06K9/2063 , G06K2209/01 , H04N1/00968
摘要： An image processing apparatus is disclosed, including a marking position detection part and a first character recognition part. The marking position detection part detects a marking position with respect to a first sheet based on first image data scanned from the first sheet. The first character recognition part conducts a first character recognition with respect to an area specified based on the marking position, for second image data scanned from a second sheet.
摘要翻译：公开了一种图像处理装置，包括标记位置检测部分和第一字符识别部分。标记位置检测部分基于从第一片材扫描的第一图像数据来检测相对于第一片材的标记位置。第一字符识别部分对于从第二片材扫描的第二图像数据，相对于基于标记位置指定的区域进行第一字符识别。

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