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1. 发明申请

US20140083422A1 INHALER 审中-公开
标题翻译：吸入器
公开(公告)号：US20140083422A1
公开(公告)日：2014-03-27
申请号：US13811100
申请日：2011-07-19
申请人： Lars Rune Gustav Arvidsson , William Bakewell , John Phillip Briant , Patrick Campbell , Charles Cooke , Christopher Groombridge , James Daniel John , Orest Lastow , Trevor John Penhallurick , Nicholas Smartt , Märtin Svensson , Björn Ullbrand
发明人： Lars Rune Gustav Arvidsson , William Bakewell , John Phillip Briant , Patrick Campbell , Charles Cooke , Christopher Groombridge , James Daniel John , Orest Lastow , Trevor John Penhallurick , Nicholas Smartt , Märtin Svensson , Björn Ullbrand
IPC分类号： A61M15/00 , A61M15/08
CPC分类号： A61M15/0045 , A61M15/0021 , A61M15/0043 , A61M15/0048 , A61M15/0075 , A61M15/0081 , A61M15/0091 , A61M15/08 , A61M2202/064
摘要： A dry powder inhaler comprises a disc-shaped assembly (14) having cavities (16) filled with medicament powder for inhalation. The assembly is rotatably mounted in a housing (6, 8) on which is mounted a rotatable external casing (11, 12). A mouthpiece (10) is movably mounted on the housing (6, 8) allowing it to be brought into and out of engagement with the edge of the disc (14) whereby the mouthpiece acts as a brake to prevent or permit rotational movement of the disc (14). The inhaler is opened by rotating the housing with respect to the casing (11, 12) to expose the mouthpiece (10). As the inhaler is opened and closed, cam followers (105) on the mouthpiece move along cam tracks (109) in the casing (11, 12), causing the mouthpiece to move against or away from the disc (14). A gap is defined between the disc and mouthpiece to allow a flow of bypass air to enter the mouthpiece.
摘要翻译：干粉吸入器包括具有填充有用于吸入的药物粉末的空腔（16）的盘形组件（14）。组件可旋转地安装在壳体（6,8）中，其上安装有可旋转的外壳（11,12）。吸嘴（10）可移动地安装在壳体（6,8）上，允许其与盘（14）的边缘进入和离开接合，由此接口作为制动器来防止或允许光盘（14）。通过相对于壳体（11,12）旋转壳体来打开吸入器以暴露接口（10）。当吸入器打开和关闭时，口部上的凸轮从动件（105）沿壳体（11,12）中的凸轮轨道（109）移动，使得接口件能够抵靠或远离盘片（14）移动。在盘和接口之间限定间隙，以允许旁路空气流进入接口。

2. 发明申请

US20120125330A1 INHALATION DEVICE AND METHOD OF DISPENSING MEDICAMENT 有权
标题翻译：吸入装置和药物分配方法
公开(公告)号：US20120125330A1
公开(公告)日：2012-05-24
申请号：US13129393
申请日：2009-10-07
申请人： John Briant , Patrick Campbell , Charles Cooke , Christopher Groombridge , James Daniel John , Nicholas Smartt , William Bakewell , Nicholas Harrison , Orest Lastow
发明人： John Briant , Patrick Campbell , Charles Cooke , Christopher Groombridge , James Daniel John , Nicholas Smartt , William Bakewell , Nicholas Harrison , Orest Lastow
IPC分类号： A61M16/10 , A61M15/08 , A61M15/00
CPC分类号： A61M15/0091 , A61M15/0003 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/0093 , A61M15/0096 , A61M2202/064 , A61M2205/073
摘要： The present invention relates to an inhaler, comprising a base having at least one air-tight, foil-sealed cavity containing medicament. An actuator is engagable with a separating element attached to the foil, the actuator having an energized position in which it is biased towards an unloaded position so as to cause the separating element and attached foil to be moved away from the cavity. A latch has a first position, in which it latches the actuator in said energized position, wherein the latch is at least partly arranged in a flow path such that an inhalation flow through the flow path affects the latch to move from the first position to the second position. The invention also relates to a method of dispensing a medicament from a sealed cavity inside an inhaler.
摘要翻译：吸入器技术领域本发明涉及一种吸入器，其包括具有至少一个包含药物的气密的箔密封空腔的底座。致动器可接合附接到箔的分离元件，致动器具有通电位置，在该位置中，致动器被朝向卸载位置偏置，以使分离元件和附着的箔片远离腔体移动。闩锁具有第一位置，其中致动器在所述通电位置中锁定，其中闩锁至少部分地布置在流动路径中，使得通过流动路径的吸入流动影响闩锁从第一位置移动到第二名本发明还涉及从吸入器内部的密封空腔分配药物的方法。

3. 发明授权

US09095670B2 Inhalation device and method of dispensing medicament 有权
标题翻译：吸入装置及分配药物的方法
公开(公告)号：US09095670B2
公开(公告)日：2015-08-04
申请号：US13129393
申请日：2009-10-07
申请人： John Briant , Patrick Campbell , Charles Cooke , Christopher Groombridge , James Daniel John , Nicholas Smartt , William Bakewell , Nicholas Harrison , Orest Lastow
发明人： John Briant , Patrick Campbell , Charles Cooke , Christopher Groombridge , James Daniel John , Nicholas Smartt , William Bakewell , Nicholas Harrison , Orest Lastow
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61M15/0003 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/0093 , A61M15/0096 , A61M2202/064 , A61M2205/073
摘要： An inhaler, including a base having at least one air-tight, foil-sealed cavity containing medicament is disclosed. An actuator is engagable with a separating element attached to the foil, the actuator having an energized position in which it is biased towards an unloaded position so as to cause the separating element and attached foil to be moved away from the cavity. A latch has a first position, in which it latches the actuator in said energized position, wherein the latch is at least partly arranged in a flow path such that an inhalation flow through the flow path affects the latch to move from the first position to the second position. A method of dispensing a medicament from a sealed cavity inside an inhaler is also disclosed.
摘要翻译：公开了一种吸入器，其包括具有至少一个气密的，箔密封腔的含有药物的底座。致动器可接合附接到箔的分离元件，致动器具有通电位置，在该位置中，致动器被朝向卸载位置偏置，以使分离元件和附着的箔片远离腔体移动。闩锁具有第一位置，其中致动器在所述通电位置中锁定，其中闩锁至少部分地布置在流动路径中，使得通过流动路径的吸入流动影响闩锁从第一位置移动到第二名还公开了一种从吸入器内的密封空腔分配药物的方法。

4. 发明申请

US20110083667A1 DISPENSER AND METHOD FOR ENTRAINING POWDER IN AN AIRFLOW 537 有权
标题翻译：用于在气流中加入粉末的分配器和方法537
公开(公告)号：US20110083667A1
公开(公告)日：2011-04-14
申请号：US12809155
申请日：2008-12-18
申请人： John Briant , Orest Lastow , Johan Remmelgas
发明人： John Briant , Orest Lastow , Johan Remmelgas
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： The invention relates to a method for entraining in an airflow a medicament powder contained in a cavity having a cavity opening. Large airflow vortices are provided, for instance, by means of an obstacle in a flow passage. The airflow with large vortices is arranged to by-pass the cavity opening, thereby generating an eddy in the cavity which contributes to entraining the powder in said airflow. The invention also relates to a medical dispenser, for instance an inhaler, in which said method may be performed.
摘要翻译：本发明涉及一种在气流中夹带药物粉末的方法，所述药物粉末包含在具有空腔开口的空腔中。例如，通过流动通道中的障碍物提供大气流涡流。具有大涡流的气流布置成绕过空腔开口，从而在空腔中产生涡流，这有助于将粉末夹带在所述气流中。本发明还涉及一种医疗分配器，例如吸入器，其中可以执行所述方法。

5. 发明授权

US08393322B2 Inhaler comprising a base having a plurality of medicament containing sealed cavities 有权
公开(公告)号：US08393322B2
公开(公告)日：2013-03-12
申请号：US12867423
申请日：2009-02-11
申请人： Orest Lastow
发明人： Orest Lastow
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0043 , A61M15/0048 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M2202/062 , A61M2202/064
摘要： An inhaler which comprises a base having a plurality of consecutive sealed cavities containing medicament. Foil portions are on one side attached to the base for sealing the medicament within respective associated cavities. A plurality of separating elements are attached to the other side of the foil portions, each separating element being associated with a respective cavity for separating a foil portion from that cavity. Each separating element can be moved-away from its associated cavity so that the sealing foil portion is separated from the cavity which is thereby uncovered so that medicament contained therein is enabled to become entrained in a fluid flow, and then returned with the attached foil portion to cover its associated cavity. A method of operating an inhaler is also disclosed.

6. 发明申请

US20110226243A1 DEVICE AND METHOD FOR DEAGGREGATING POWDER 854 有权
标题翻译：用于去除粉末的装置和方法854
公开(公告)号：US20110226243A1
公开(公告)日：2011-09-22
申请号：US12809157
申请日：2008-12-18
申请人： Orest Lastow , Johan Remmelgas
发明人： Orest Lastow , Johan Remmelgas
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： The present disclosure relates to a device for inhalation of at least one air stream carrying a dose of medicament powder. The device comprises a flow passage passing a powder-containing cavity. A part of said flow passage propagates along a generally flat surface region. The flat surface region comprises a cavity opening into said powder-containing cavity. The passing of an air stream along said flat surface region and outside said cavity generates an eddy in the cavity and the generated eddy contributes to deaggregation of the powder in said cavity and emptying of the powder from said cavity. Furthermore, the present disclosure relates to the use of a shear driven cavity principle on such a device and a method of releasing medicament powder.
摘要翻译：本公开涉及用于吸入携带一定剂量的药物粉末的至少一种气流的装置。该装置包括通过含粉末的腔的流动通道。所述流动通道的一部分沿着大致平坦的表面区域传播。平坦表面区域包括通向所述含粉末的空腔的空腔。沿着所述平坦表面区域和所述空腔外部的空气流的通过在空腔中产生涡流，并且产生的涡流有助于粉末在所述空腔中的解聚和从所述空腔排空粉末。此外，本公开涉及在这种装置上使用剪切驱动腔原理以及释放药物粉末的方法。

7. 发明申请

US20090250058A1 Inhalation System and Delivery Device for the Administration of a Drug in the Form of Dry Powder 审中-公开
标题翻译：以粉末形式给药的吸入系统和输送装置
公开(公告)号：US20090250058A1
公开(公告)日：2009-10-08
申请号：US12373720
申请日：2007-07-12
申请人： Orest Lastow , Lars Arvidsson
发明人： Orest Lastow , Lars Arvidsson
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M11/002 , A61M15/0003 , A61M15/0043 , A61M15/0086 , A61M15/0096 , A61M2202/064 , A61M2205/071 , A61M2205/6045 , A61M2206/14
摘要： The administration of at least one drug in the form of dry powder by inhalation through an air flow path may be accomplished by an inhalation system including a delivery device having a mouthpiece through which the powder is inhaled. The inhalation system includes a dose cassette defining at least one drug cavity containing dry powder of a dose to be delivered and being sealed by a lid. Further, the inhalation system includes a resilient member configured to be introduced into the air flow path to guide/direct the air flow into the drug cavity upon removal of the lid.
摘要翻译：通过空气流动路径吸入至少一种干粉形式的药物可以通过吸入系统来实现，所述吸入系统包括具有吸嘴的输送装置，通过该口部吸入粉末。吸入系统包括限定至少一个药物腔的剂量盒，其含有待递送剂量的干燥粉末并由盖子密封。此外，吸入系统包括弹性构件，该弹性构件构造成在移除盖时被引入空气流动路径中以引导/引导空气流入药物腔。

8. 发明申请

US20060150901A1 Powder generating apparatus and method for producing powder 审中-公开
标题翻译：粉末生成装置及其制造方法
公开(公告)号：US20060150901A1
公开(公告)日：2006-07-13
申请号：US10546636
申请日：2004-02-25
申请人： Orest Lastow
发明人： Orest Lastow
IPC分类号： B05B5/025 , B05D1/04 , F23D11/32
CPC分类号： B05B5/0255 , B01J2/04 , B05B5/025
摘要： Powder generating apparatus for the generation of a powder in particular but not solely for the production of medicinal drug powder. The apparatus comprises a fluid supply means (13), droplet generation means having a dispensing nozzle (20), a surrounding grounding means and a reactor characterised in that said dispensing nozzle of said droplet generation means is less than 3 millimetres.
摘要翻译：用于产生粉末的粉末产生装置，特别是但不仅仅是用于生产药用粉末。该装置包括流体供应装置（13），具有分配喷嘴（20），周围接地装置和反应器的液滴产生装置，其特征在于，所述液滴产生装置的分配喷嘴小于3毫米。

9. 发明授权

US09283337B2 Dispenser and method for entraining powder in an airflow 有权
标题翻译：在气流中夹带粉末的分配器和方法
公开(公告)号：US09283337B2
公开(公告)日：2016-03-15
申请号：US12809155
申请日：2008-12-18
申请人： Orest Lastow , Johan Remmelgas , John Briant
发明人： Orest Lastow , Johan Remmelgas , John Briant
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： The present disclosure relates to a method for entraining in an airflow a medicament powder contained in a cavity having a cavity opening. Large airflow vortices are provided, for instance, by use of an obstacle in a flow passage, The airflow with large vortices is arranged to by-pass the cavity opening, thereby generating an eddy in the cavity which contributes to entraining the powder in said airflow. The present disclosure also relates to a medical dispenser, for instance an inhaler, in which the method may be performed.
摘要翻译：本公开内容涉及一种用于夹带在具有空腔开口的空腔中的药物粉末的气流中的方法。例如，通过使用流动通道中的障碍物来提供大气流涡流。具有大涡流的气流被布置成绕过空腔开口，从而在空腔中产生涡流，这有助于将粉末夹带在所述空气流中。本公开还涉及可以执行该方法的医疗分配器，例如吸入器。

10. 发明授权

US08397718B2 Inhaler comprising a base having at least one sealed cavity containing medicament 有权
标题翻译：吸入器包括具有至少一个包含药物的密封腔的底座
公开(公告)号：US08397718B2
公开(公告)日：2013-03-19
申请号：US12867466
申请日：2009-02-11
申请人： Orest Lastow
发明人： Orest Lastow
IPC分类号： A61M15/00 , A61M15/08 , A61M16/10
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M2202/062 , A61M2202/064
摘要： An inhaler which comprises a base having at least one sealed cavity containing medicament and a foil portion comprising two sides, one side being attached to the base for sealing the medicament within the cavity. A separating element is attached to the other side of the foil portion for separating the foil portion from the cavity, the separating element having a first end and an opposite second end, wherein the separating element is movable to an intermediate tilted position in which said first end is moved-away from the cavity. The separating element is further movable from the intermediate tilted position to a removed position in which also said second end is moved-away from the cavity so that the foil portion is removed from the cavity which is thereby uncovered so that medicament contained therein is enabled to become entrained in a fluid flow.
摘要翻译：一种吸入器，其包括具有至少一个包含药物的密封空腔的基座和包括两侧的箔片部分，一侧连接到所述底座上以将所述药物密封在所述空腔内。分离元件附接到箔部分的另一侧，用于将箔片部分与空腔分离，分离元件具有第一端和相对的第二端，其中分离元件可移动到中间倾斜位置，其中所述第一端部从腔体移开。分离元件还可以从中间倾斜位置移动到去除位置，在该位置中，所述第二端也从空腔移开，使得箔部分从空腔移除，从而使其不被覆盖，使得其中包含的药物能够被变成夹带在流体流中。

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