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1. 发明授权

US06305406B1 Spray hood protector in a fluid-based cooling system 失效
标题翻译：基于流体的冷却系统中的喷雾保护罩
公开(公告)号：US06305406B1
公开(公告)日：2001-10-23
申请号：US09089333
申请日：1998-06-02
申请人： Lennart Ståhl , John Francis Wallace, Jr. , John Cardenas Parraz , Montford Henry Clark , David Winn
发明人： Lennart Ståhl , John Francis Wallace, Jr. , John Cardenas Parraz , Montford Henry Clark , David Winn
IPC分类号： F28F2700
CPC分类号： H05K7/20345 , Y10T137/5762 , Y10T137/7306
摘要： A spray hood device for containing a fluid spray leak in a fluid-based cooling system. A cover member surrounds a given component subject to a fluid spray leak, containing fluid sprays, preventing the fluid sprays from reaching equipment therebelow and minimizing fluid leakage damage.
摘要翻译：一种用于在基于流体的冷却系统中容纳流体喷射泄漏的喷雾罩装置。覆盖构件围绕给定的部件受到流体喷射泄漏的影响，其包含流体喷雾，防止流体喷雾到达其下的设备并且最小化流体泄漏损坏。

2. 发明授权

US5975114A System, method and apparatus for purging fluid 失效
标题翻译：吹扫液体的系统，方法和装置
公开(公告)号：US5975114A
公开(公告)日：1999-11-02
申请号：US88755
申请日：1998-06-02
申请人： Lennart St.ang.hl , John Francis Wallace, Jr. , John Cardenas Parraz , Montford Henry Clark , David Winn
发明人： Lennart St.ang.hl , John Francis Wallace, Jr. , John Cardenas Parraz , Montford Henry Clark , David Winn
IPC分类号： G01M3/04 , G01M3/32 , H01L23/473 , E03B1/00
CPC分类号： G01M3/04 , G01M3/3227 , H01L23/473 , H01L2924/0002 , Y10T137/5762 , Y10T137/7306 , Y10T137/7761
摘要： A system, method and apparatus for detecting a fluid leak in a fluid based cooling system and purging the fluid therein under various conditions. The system, method and apparatus detect fluid levels in the cooling system, fluid pressure in the cooling system and fluid spraying and dripping from the cooling system. Upon an affirmative determination of low fluid levels, low fluid pressure or fluid spraying and dripping from one or more locations in the cooling system, the device automatically purges the fluid from the cooling system. Accordingly, in an overhead fluid-based cooling system, any damage to objects below from having fluid leaked thereon is minimized.
摘要翻译：一种用于检测基于流体的冷却系统中的流体泄漏并在各种条件下清洗流体的系统，方法和装置。该系统，方法和装置检测冷却系统中的液位，冷却系统中的流体压力和冷却系统中的液体喷射和滴落。当确定低液位，低流体压力或从冷却系统中的一个或多个位置流体喷射和滴落时，该装置自动从冷却系统清洗流体。因此，在基于顶液流体的冷却系统中，由于在其上泄露流体的下方对物体的任何损坏都被最小化。

3. 发明授权

US6161612A Cooling system and method for distributing cooled air 失效
标题翻译：用于分配冷却空气的冷却系统和方法
公开(公告)号：US6161612A
公开(公告)日：2000-12-19
申请号：US088958
申请日：1998-06-02
申请人： Lennart St.ang.hl , John Francis Wallace, Jr. , John Carlenas Parraz , Montford Henry Clark , David Winn
发明人： Lennart St.ang.hl , John Francis Wallace, Jr. , John Carlenas Parraz , Montford Henry Clark , David Winn
IPC分类号： H05K7/20 , F28F7/00
CPC分类号： H05K7/2059
摘要： A cooling system employing redundant system components is disclosed. The system includes multiple sets of heat: exchanger units, with each set being in fluid communication with a separate, independently operated fluid pump unit. The heat exchanger units are arranged in at least one row of heat exchanger units. The two sets of heat exchanger units are evenly interspersed with each other along the row of heat exchanger units so that a substantially uniform distribution of cooled air is provided in the event one fluid pump unit fails.
摘要翻译：公开了一种采用冗余系统组件的冷却系统。该系统包括多组热量：换热器单元，其中每个组与单独的独立操作的流体泵单元流体连通。热交换器单元布置在至少一排热交换器单元中。两组热交换器单元沿着热交换器单元排彼此均匀散布，使得在一个流体泵单元故障的情况下提供基本均匀的冷却空气分布。

4. 发明授权

US6034873A System and method for separating air flows in a cooling system 失效
标题翻译：用于在冷却系统中分离空气流的系统和方法
公开(公告)号：US6034873A
公开(公告)日：2000-03-07
申请号：US88981
申请日：1998-06-02
申请人： Lennart St.ang.hl , John Francis Wallace, Jr. , John Carlenas Parraz , Montford Henry Clark , David Winn
发明人： Lennart St.ang.hl , John Francis Wallace, Jr. , John Carlenas Parraz , Montford Henry Clark , David Winn
IPC分类号： H05K7/20
CPC分类号： H05K7/20745
摘要： A cooling system and method employing separation chutes and baffles is disclosed. The separation chutes separate the cooled air descending from a heat exchanger positioned above heat-generating equipment in an equipment room from heated air ascending from the heat-generating equipment. Separation of the airflows reduces turbulence and increases cooling efficiencies. The separation chutes are made of a variety of materials, both rigid and flexible, for a variety of applications.
摘要翻译：公开了一种使用分离槽和挡板的冷却系统和方法。分离槽将从设置在发电设备上方的发热设备上方的热交换器下降的冷却空气与从发热设备上升的加热空气分离。气流的分离减少了湍流并提高了冷却效率。分离滑道由各种材料制成，既可以是刚性又可以灵活的，用于各种应用。

5. 发明授权

US07923433B2 Activity-based probes and methods of their preparation and use 有权
标题翻译：基于活性的探针及其制备和使用方法
公开(公告)号：US07923433B2
公开(公告)日：2011-04-12
申请号：US10530646
申请日：2003-10-08
申请人： David Winn , David Alan Campbell
发明人： David Winn , David Alan Campbell
IPC分类号： A61K38/05
CPC分类号： C07D311/90 , C07D311/82 , C12Q1/37
摘要： The present invention provides compositions and methods for assessing profiles of catalytically active enzymes in compositions containing a plurality of proteins. In preferred embodiments, the enzyme is a hydrolase, most preferably a cysteine protease. The methods described herein use activity based probes (“ABPs”) that have an affinity moiety for directing the binding of the ABP to one or more catalytically active target enzymes, a reactive group for forming a covalent bond at an active site of the target enzyme(s), and a TAG (e.g., a detectable label, preferably a fluorophore). One or more ABPs may be combined with a protein-containing sample under conditions for binding and reaction of the ABP(s) with target enzyme(s) that are present in the sample. The resulting products may then be used to assess the active enzyme profile of the sample, and can be correlated to the presence, amount, or activity of one or more target enzyme(s) present in the original complex protein mixture.
摘要翻译：本发明提供了用于在含有多种蛋白质的组合物中评估催化活性酶的谱的组合物和方法。在优选的实施方案中，酶是水解酶，最优选半胱氨酸蛋白酶。本文描述的方法使用具有亲和部分的活性基探针（“ABP”），该亲和部分用于引导ABP与一种或多种催化活性靶酶的结合，用于在靶酶的活性位点形成共价键的反应性基团（例如，可检测标记，优选荧光团）。可以在ABP与样品中存在的目标酶的结合和反应的条件下，将一种或多种ABP与含蛋白质的样品组合。然后可以将所得产物用于评估样品的活性酶谱，并且可与存在于原始复合蛋白混合物中的一种或多种目标酶的存在，量或活性相关。

6. 发明申请

US20060258621A1 PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV 有权
标题翻译：吡咯啉化合物和选择性抑制DIPEPTIDYL PEPTIDASE-IV的方法
公开(公告)号：US20060258621A1
公开(公告)日：2006-11-16
申请号：US11381082
申请日：2006-05-01
申请人： David Campbell , David Winn , Juan Betancort
发明人： David Campbell , David Winn , Juan Betancort
IPC分类号： A61K31/69 , C07F5/02
CPC分类号： C07F5/025
摘要： The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV (DPP-IV) inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized via inhibition of DPP-IV including those characterized by impaired glycemic control such as Diabetes Mellitus and related conditions. The compounds can be administered alone or with another medicament that displays pharmacological activity for treatment of these and other diseases.
摘要翻译：本发明涉及显示选择性，有效的二肽基肽酶IV（DPP-IV）抑制活性的吡咯烷基氨基乙酰基吡咯烷硼酸化合物。这些化合物可用于治疗可以通过抑制DPP-IV调节或归一化的疾病，包括以血糖控制受损为特征的糖尿病和相关病症。化合物可以单独施用或与另外一种显示用于治疗这些和其它疾病的药理活性的药物一起施用。

7. 发明申请

US20060009518A1 Constrained cyano compounds 失效
标题翻译：约束氰基化合物
公开(公告)号：US20060009518A1
公开(公告)日：2006-01-12
申请号：US11179797
申请日：2005-07-12
申请人： David Campbell , Juan Betancort , David Winn
发明人： David Campbell , Juan Betancort , David Winn
IPC分类号： A61K31/277
CPC分类号： C07D513/04
摘要： Certain constrained cyano compounds are useful as inhibitors of post-proline/alanine cleaving amino-dipeptidases. Accordingly, these compounds can be employed, alone or with another therapeutic agent, to treat diabetes (especially, Type II diabetes), hyperglycemia, Syndrome X, diabetic complications, hyperinsulinemia, obesity, atherosclerosis and related diseases, as well as various immunomodulatory diseases and chronic inflammatory bowel disease.
摘要翻译：某些受限的氰基化合物可用作后脯氨酸/丙氨酸切割氨基二肽酶的抑制剂。因此，这些化合物可以单独或与另一种治疗剂一起用于治疗糖尿病（特别是II型糖尿病），高血糖症，X综合征，糖尿病并发症，高胰岛素血症，肥胖症，动脉粥样硬化和相关疾病以及各种免疫调节性疾病，以及慢性炎性肠病。

8. 发明申请

US20070299036A1 PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV 有权
标题翻译：吡咯啉化合物和选择性抑制DIPEPTIDYL PEPTIDASE-IV的方法
公开(公告)号：US20070299036A1
公开(公告)日：2007-12-27
申请号：US11833063
申请日：2007-08-02
申请人： David Campbell , David Winn , Juan Betancort
发明人： David Campbell , David Winn , Juan Betancort
IPC分类号： A61K31/69 , A61P3/10 , C12N9/99
CPC分类号： C07F5/025
摘要： The present invention is directed to a method of treatment of a malcondition that can be regulated or normalized via inhibition of DPP-IV. The method involves administration of an effective amount of a pyrrolidine compound of the invention, such as would be present in a pharmaceutical composition of the invention, to mammals, especially humans, to affect a malcondition that can be regulated or normalized via inhibition of DPP-IV.
摘要翻译：本发明涉及一种通过抑制DPP-IV来调节或归一化的病症的方法。该方法包括将有效量的本发明的吡咯烷化合物（例如将存在于本发明的药物组合物中）施用于哺乳动物，特别是人，以影响可通过抑制DPP-1调节或归一化的病症，四，

9. 发明申请

US20070060547A1 Heterocyclic boronic acid compounds 失效
标题翻译：杂环硼酸化合物
公开(公告)号：US20070060547A1
公开(公告)日：2007-03-15
申请号：US10514575
申请日：2004-11-12
申请人： David Campbell , David Winn , Juan Betancort
发明人： David Campbell , David Winn , Juan Betancort
IPC分类号： C07F5/02 , A61K31/69
CPC分类号： C07F5/025
摘要： Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CriRii, R1, R1, R3, R4 and R5 are as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.
摘要翻译：提供二肽基肽酶IV（DPP-IV）抑制化合物，其具有式I：其中n为1至3; X是CH 2 2; S; O; CF 2或C（CH 3）2）2。 Z是H; 卤素; 羟; （C 1-6）烷氧基; （C 1-12）烷基; （C 3-12）环烷基; 苯基; 或杂芳基; 其中苯基和杂芳基任选被R7单取代或独立地被二取代; 任选地，X与相邻的环碳一起形成稠合的环丙基; 并且任选地，含有X的环中的一个键是双键; 和R i，R i，R i，R i，R i，R i，R i， R 4和R 5如本文所述。使用含有这些化合物的药物组合物中的式I化合物来描述制备这些化合物的方法，以及治疗糖尿病，特别是II型糖尿病和其它相关疾病的方法。含有这些化合物与其它抗糖尿病药物的组合的药物组合物也在本文中描述。

10. 发明申请

US20060276410A1 COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV 失效
标题翻译：选择性抑制DIPEPTIDYL PEPTIDASE-IV的化合物和方法
公开(公告)号：US20060276410A1
公开(公告)日：2006-12-07
申请号：US11420273
申请日：2006-05-25
申请人： David Campbell , David Winn , Juan Betancort
发明人： David Campbell , David Winn , Juan Betancort
IPC分类号： A61K38/04 , C07F5/02 , A61K31/69
CPC分类号： C07F5/025
摘要： Compounds that selectively inhibit dipeptidyl peptidase-IV over closely related dipeptidyl peptidases are those of Formula (I): as well as pharmaceutically acceptable salts thereof, cyclic isomers thereof, prodrugs thereof, and solvates thereof, where all the variables are defined herein. These compounds can be used, alone or in combination with other drugs, for the treatment of diabetes and related diseases.
摘要翻译：选择性抑制二肽基肽酶-IV超过密切相关的二肽基肽酶的化合物是式（I）的化合物：及其药学上可接受的盐，其环状异构体，其前药和溶剂合物，其中所有变量均在本文中定义。这些化合物可以单独使用或与其他药物组合使用，用于治疗糖尿病和相关疾病。

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