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1. 发明申请

US20070087519A1 METHOD AND STRUCTURE FOR DOUBLE LINING FOR SHALLOW TRENCH ISOLATION 有权
标题翻译：用于浅层隔离的双层衬垫的方法和结构
公开(公告)号：US20070087519A1
公开(公告)日：2007-04-19
申请号：US11536458
申请日：2006-09-28
申请人： Liu Chi-Kang , Xin Wang , Ze Li
发明人： Liu Chi-Kang , Xin Wang , Ze Li
IPC分类号： H01L21/76 , H01L29/76 , H01L29/94 , H01L31/00
CPC分类号： H01L21/76232
摘要： A method of forming an integrated circuit device structure having a design rule of less than 0.13 micron. The method includes providing a substrate and forming a pad oxide layer overlying the substrate. The method includes forming a nitride layer overlying the pad oxide layer and patterning the nitride layer and pad oxide layer. A trench structure is formed within a thickness of the substrate using the patterned nitride layer and pad oxide layer as hard mask. The method forms a first thickness of liner oxide within the trench structure using at least thermal oxidation of an exposed region of the trench structure to cover the trench structure. Such thermal oxidation causes a rounding region near corners of the trench structure. The method selectively removes the thickness of liner oxide within the trench structure. The method forms a second thickness of liner oxide within the trench structure using at least thermal oxidation to cover the trench structure. The thermal oxidation causes a further rounding of the rounded region near corners of the trench structure. The method also selectively removes the patterned nitride layer while the second thickness of liner oxide protects the substrate in the trench region.
摘要翻译：一种形成设计规则小于0.13微米的集成电路器件结构的方法。该方法包括提供衬底和形成覆盖衬底的衬垫氧化物层。该方法包括形成覆盖衬垫氧化物层的氮化物层，并对氮化物层和焊盘氧化物层进行构图。使用图案化氮化物层和衬垫氧化物层作为硬掩模，在衬底的厚度内形成沟槽结构。该方法使用沟槽结构的暴露区域的至少热氧化覆盖沟槽结构，在沟槽结构内形成衬垫氧化物的第一厚度。这种热氧化导致沟槽结构的拐角附近的圆形区域。该方法选择性地去除了沟槽结构内的衬里氧化物的厚度。该方法使用至少热氧化覆盖沟槽结构在沟槽结构内形成衬垫氧化物的第二厚度。热氧化导致沟槽结构的拐角附近的圆形区域进一步的圆化。该方法还选择性地去除图案化的氮化物层，同时衬垫氧化物的第二厚度保护沟槽区域中的衬底。

2. 发明授权

US09200323B2 Hybridization methods using natural base mismatches 有权
标题翻译：使用天然碱基错配的杂交方法
公开(公告)号：US09200323B2
公开(公告)日：2015-12-01
申请号：US12162286
申请日：2007-02-06
申请人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Li Li , Chuanzan Zhao , Gengxin Lan , Tao Guo , Bin Cai , Jing Cheng
发明人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Li Li , Chuanzan Zhao , Gengxin Lan , Tao Guo , Bin Cai , Jing Cheng
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6832 , C12Q2600/156 , C12Q2535/131 , C12Q2527/107
摘要： The present invention provides an improved nucleic acid hybridization process employing a modified oligonucleotide probe comprising naturally occurring nucleotide bases. At least one nucleotide in the modified oligonucleotide is artificially mismatched relative to the control nucleic acid in addition to any mismatches arising from a variant nucleic acid target containing a sequence variation. The artificial mismatch and the sequence variation positions are separated from one another on the oligonucleotide by six to nine nucleotide positions.
摘要翻译：本发明提供使用包含天然存在的核苷酸碱基的修饰的寡核苷酸探针的改进的核酸杂交方法。除了由含有序列变异的变体核酸靶产生的任何错配之外，修饰寡核苷酸中至少一个核苷酸相对于对照核酸人为错配。将人工错配和序列变异位置在寡核苷酸上彼此分开6至9个核苷酸位置。

3. 发明申请

US20050155104A1 Toxin complex proteins and genes from Xenorhabus bovienii 有权
标题翻译：来自Xenorhabus bovienii的毒素复合蛋白和基因
公开(公告)号：US20050155104A1
公开(公告)日：2005-07-14
申请号：US11020848
申请日：2004-12-23
申请人： Patricia Apel-Birkhold , Timothy Hey , Robin Thompson , Thomas Meade , Ze Li , Sean Russell , Joel Sheets , Justin Lira , Kristin Fencil , Jon Mitchell
发明人： Patricia Apel-Birkhold , Timothy Hey , Robin Thompson , Thomas Meade , Ze Li , Sean Russell , Joel Sheets , Justin Lira , Kristin Fencil , Jon Mitchell
IPC分类号： A01H1/00 , A01H5/00 , A01N63/00 , A01N63/02 , C07H21/04 , C07K14/24 , C12N5/04 , C12N15/82
CPC分类号： C12N15/8286 , A01N63/00 , A01N63/02 , C07H21/04 , C07K14/24 , C12N15/8279 , Y02A40/162 , Y10S530/825
摘要： The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus bovienii strain ILM104.
摘要翻译：本发明涉及新型异戊酰梭菌毒素复合物（TC）蛋白质和编码这些蛋白质的基因。更具体地，本发明涉及从Xenorhabdus bovienii菌株ILM104获得的TC基因和蛋白质。

4. 发明申请

US20090143245A1 MICROARRAYS FOR GENOTYPING AND METHODS OF USE 审中-公开
标题翻译：用于基因组的微阵列和使用方法
公开(公告)号：US20090143245A1
公开(公告)日：2009-06-04
申请号：US12093504
申请日：2006-02-20
申请人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Chuanzan Zhao , Li Li , Gengxin Lan , Tao Guo , Bin Cai , Wanli Xing , Yuxiang Zhou , Jing Cheng
发明人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Chuanzan Zhao , Li Li , Gengxin Lan , Tao Guo , Bin Cai , Wanli Xing , Yuxiang Zhou , Jing Cheng
IPC分类号： C40B30/10 , C40B40/08 , C40B50/06
CPC分类号： C12Q1/6881 , C12Q1/6837 , C12Q2600/156
摘要： The present invention provides a microarray for detecting a genotype at a polymorphic site in a plurality of nucleic acid samples, comprising a first set of nucleic acid fragments derived from the samples and a second set of nucleic acid fragments derived from a plurality of references immobilized thereon. The invention also provides a microarray comprising a set of nucleic acid fragments immobilized on the surface of the microarray, wherein the nucleic acid fragments are derived from the samples by amplifying a region in the sample containing the polymorphism through asymmetric PCR amplification. Methods of using and making the microarrays are also provided.
摘要翻译：本发明提供了用于检测多个核酸样品中多态性位点处的基因型的微阵列，其包含衍生自样品的第一组核酸片段和衍生自多个固定在其上的参考文献的第二组核酸片段。本发明还提供了一种微阵列，其包含固定在微阵列表面上的一组核酸片段，其中通过不对称PCR扩增扩增含有多态性的样品中的区域，来从样品衍生出核酸片段。还提供了使用和制造微阵列的方法。

5. 发明申请

US20090156419A1 HYBRIDIZATION METHODS USING NATURAL BASE MISMATCHES 有权
标题翻译：使用自然基因杂交的杂交方法
公开(公告)号：US20090156419A1
公开(公告)日：2009-06-18
申请号：US12162286
申请日：2007-02-06
申请人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Li Li , Chuanzan Zhao , Gengxin Lan , Tao Guo , Bin Cai , Jing Cheng
发明人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Li Li , Chuanzan Zhao , Gengxin Lan , Tao Guo , Bin Cai , Jing Cheng
IPC分类号： C40B30/04
CPC分类号： C12Q1/6881 , C12Q1/6832 , C12Q2600/156 , C12Q2535/131 , C12Q2527/107
摘要： The present invention provides an improved nucleic acid hybridization process employing a modified oligonucleotide probe comprising naturally occurring nucleotide bases. At least one nucleotide in the modified oligonucleotide is artificially mismatched relative to the control nucleic acid in addition to any mismatches arising from a variant nucleic acid target containing a sequence variation. The artificial mismatch and the sequence variation positions are separated from one another on the oligonucleotide by six to nine nucleotide positions.
摘要翻译：本发明提供使用包含天然存在的核苷酸碱基的修饰的寡核苷酸探针的改进的核酸杂交方法。除了由含有序列变异的变体核酸靶产生的任何错配之外，修饰寡核苷酸中至少一个核苷酸相对于对照核酸人为错配。将人工错配和序列变异位置在寡核苷酸上彼此分开6至9个核苷酸位置。

6. 发明申请

US20070042350A1 Methods and compositions for detecting sars virus and other infectious agents 审中-公开
标题翻译：用于检测莎草病毒和其他感染因子的方法和组合物
公开(公告)号：US20070042350A1
公开(公告)日：2007-02-22
申请号：US10564378
申请日：2003-07-14
申请人： Ze Li , Shengee Tao , Jing Cheng
发明人： Ze Li , Shengee Tao , Jing Cheng
IPC分类号： C12Q1/70 , C12Q1/68 , C12M3/00
CPC分类号： C12Q1/701 , C12Q1/6837 , C12Q1/686 , Y02A50/54
摘要： This invention relates generally to the field of virus detection. In particular, the invention provides chips, probes, primers, kits and methods for amplifying and detecting SARS-CoV nucleotides sequence. The clinical and other uses of the present chips, probes, primers, kits and methods are also contemplated.
摘要翻译：本发明一般涉及病毒检测领域。特别地，本发明提供用于扩增和检测SARS-CoV核苷酸序列的芯片，探针，引物，试剂盒和方法。还考虑了本发明芯片，探针，引物，试剂盒和方法的临床和其它用途。

7. 发明申请

US20070037140A1 Methods and compositions for detecting sars virus 审中-公开
标题翻译：检测萨尔病毒的方法和组成
公开(公告)号：US20070037140A1
公开(公告)日：2007-02-15
申请号：US10556182
申请日：2003-05-09
申请人： Ze Li , Yiming Zhou , Shengce Tao , Jing Cheng , Jianwei Wang , Tao Hong , Yun Cheng , Quanzhong Shan
发明人： Ze Li , Yiming Zhou , Shengce Tao , Jing Cheng , Jianwei Wang , Tao Hong , Yun Cheng , Quanzhong Shan
IPC分类号： C12Q1/70 , C12Q1/68 , C12M1/34
CPC分类号： C07H21/00 , C12Q1/701
摘要： This invention relates generally to the field of virus detection. In particular, the invention provides chips, probes, primers, kits and methods for amplifying and detecting SARS-CoV nucleotide sequence. The clinical and other uses of the present chips, probes, primers, kits and methods are also contemplated.
摘要翻译：本发明一般涉及病毒检测领域。特别地，本发明提供用于扩增和检测SARS-CoV核苷酸序列的芯片，探针，引物，试剂盒和方法。还考虑了本发明芯片，探针，引物，试剂盒和方法的临床和其它用途。

8. 发明申请

US20060169261A1 Ball feeder for ball serving machine 失效
标题翻译：球服机器球送料机
公开(公告)号：US20060169261A1
公开(公告)日：2006-08-03
申请号：US11318834
申请日：2005-12-28
申请人： Lin Yao , Ze Li
发明人： Lin Yao , Ze Li
IPC分类号： F41F1/00
CPC分类号： A63B47/002 , A63B69/40 , A63B2047/004
摘要： A ball feeder for ball serving machine includes a seat consisting of a hollow transfer frame and a shaft bear, a rotating unit mounted to one side of the seat and having a ball scoop extended from an end thereof, and a plurality of guide sections sequentially rotatably connected at an end to the shaft bearing. The guide sections may be turned about the shaft bearing in the same direction to form a nonlinearly inclined spiral ball guide path. A ball put in the top guide section automatically rolls down along the ball guide path and falls into the transfer frame to be caught by the ball scoop. When the ball scoop is turned by the rotating unit to face downward, the-ball on the ball scoop falls into a feeding mouth on a body of the ball serving machine and is automatically served.
摘要翻译：一种用于球服务机的球供料器包括由中空转运框架和轴承座组成的座椅，旋转单元安装在座椅的一侧并且具有从其端部延伸的球铲，以及多个引导部件，在轴承的一端连接。引导部分可以在相同方向上绕轴承转动以形成非线性倾斜的螺旋滚珠引导路径。放置在顶部引导部分中的球自动沿着球引导路径向下滚动并落入转移框架中以被球勺捕获。当球勺被旋转单元转动以面向下时，球勺上的球落入球服务机身的进料口，并自动供给。

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